Luis A Videla

Summary

Affiliation: Universidad de Chile
Country: Chile

Publications

  1. pmc Misregulation of PPAR Functioning and Its Pathogenic Consequences Associated with Nonalcoholic Fatty Liver Disease in Human Obesity
    Luis A Videla
    Molecular and Clinical Pharmacology Program, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Casilla 70000, Santiago 7, Chile
    PPAR Res 2012:107434. 2012
  2. pmc Metabolic basis for thyroid hormone liver preconditioning: upregulation of AMP-activated protein kinase signaling
    Luis A Videla
    Molecular and Clinical Pharmacology Program, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Santiago, Chile
    ScientificWorldJournal 2012:475675. 2012
  3. pmc Thyroid hormone-induced cytosol-to-nuclear translocation of rat liver Nrf2 is dependent on Kupffer cell functioning
    Luis A Videla
    Molecular and Clinical Pharmacology Program, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Casilla 70000, Santiago 7, Chile
    ScientificWorldJournal 2012:301494. 2012
  4. ncbi request reprint Effects of acute gamma-hexachlorocyclohexane intoxication in relation to the redox regulation of nuclear factor-kappaB, cytokine gene expression, and liver injury in the rat
    Luis A Videla
    Molecular and Clinical Pharmacology Programme, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Santiago, Chile
    Antioxid Redox Signal 6:471-80. 2004
  5. ncbi request reprint Hormetic responses of thyroid hormone calorigenesis in the liver: Association with oxidative stress
    Luis A Videla
    Molecular and Clinical Pharmacology Program, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Santiago, Chile
    IUBMB Life 62:460-6. 2010
  6. doi request reprint Cytoprotective and suicidal signaling in oxidative stress
    Luis A Videla
    Molecular and Clinical Pharmacology Program, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Santiago, Chile
    Biol Res 43:363-9. 2010
  7. ncbi request reprint Thyroid hormone calorigenesis and mitochondrial redox signaling: upregulation of gene expression
    Luis A Videla
    Molecular and Clinical Pharmacology Program, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Santiago, Chile
    Front Biosci 12:1220-8. 2007
  8. doi request reprint Liver NF-kappaB and AP-1 DNA binding in obese patients
    Luis A Videla
    Molecular and Clinical Pharmacology Program, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Santiago, Chile
    Obesity (Silver Spring) 17:973-9. 2009
  9. ncbi request reprint Oxidative stress and depletion of hepatic long-chain polyunsaturated fatty acids may contribute to nonalcoholic fatty liver disease
    Luis A Videla
    Programa de Farmacología Molecular y Clínica, Instituto de Ciencias Biomedicas, Facultad de Medicina, Universidad de Chile, Chile
    Free Radic Biol Med 37:1499-507. 2004
  10. ncbi request reprint Thyroid hormone-induced oxidative stress triggers nuclear factor-kappaB activation and cytokine gene expression in rat liver
    Gladys Tapia
    Programa de Farmacologíca Molecular y Clínica, Instituto de Ciencias Biomedicas, Universidad de Chile, Santiago, Chile
    Free Radic Biol Med 35:257-65. 2003

Collaborators

Detail Information

Publications56

  1. pmc Misregulation of PPAR Functioning and Its Pathogenic Consequences Associated with Nonalcoholic Fatty Liver Disease in Human Obesity
    Luis A Videla
    Molecular and Clinical Pharmacology Program, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Casilla 70000, Santiago 7, Chile
    PPAR Res 2012:107434. 2012
    ....
  2. pmc Metabolic basis for thyroid hormone liver preconditioning: upregulation of AMP-activated protein kinase signaling
    Luis A Videla
    Molecular and Clinical Pharmacology Program, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Santiago, Chile
    ScientificWorldJournal 2012:475675. 2012
    ....
  3. pmc Thyroid hormone-induced cytosol-to-nuclear translocation of rat liver Nrf2 is dependent on Kupffer cell functioning
    Luis A Videla
    Molecular and Clinical Pharmacology Program, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Casilla 70000, Santiago 7, Chile
    ScientificWorldJournal 2012:301494. 2012
    ..This contention is supported by suppression of the respiratory burst activity of Kupffer cells and the associated reactive oxygen species production by GdCl(3) or apocynin given prior to T(3), thus hindering Nrf2 activation...
  4. ncbi request reprint Effects of acute gamma-hexachlorocyclohexane intoxication in relation to the redox regulation of nuclear factor-kappaB, cytokine gene expression, and liver injury in the rat
    Luis A Videla
    Molecular and Clinical Pharmacology Programme, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Santiago, Chile
    Antioxid Redox Signal 6:471-80. 2004
    ....
  5. ncbi request reprint Hormetic responses of thyroid hormone calorigenesis in the liver: Association with oxidative stress
    Luis A Videla
    Molecular and Clinical Pharmacology Program, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Santiago, Chile
    IUBMB Life 62:460-6. 2010
    ....
  6. doi request reprint Cytoprotective and suicidal signaling in oxidative stress
    Luis A Videla
    Molecular and Clinical Pharmacology Program, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Santiago, Chile
    Biol Res 43:363-9. 2010
    ....
  7. ncbi request reprint Thyroid hormone calorigenesis and mitochondrial redox signaling: upregulation of gene expression
    Luis A Videla
    Molecular and Clinical Pharmacology Program, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Santiago, Chile
    Front Biosci 12:1220-8. 2007
    ..Mechanisms of expression of respiratory and redox-sensitive genes may be functionally integrated, which could be of importance to understand the complexities of TH action and the outcome of thyroid gland dysfunction...
  8. doi request reprint Liver NF-kappaB and AP-1 DNA binding in obese patients
    Luis A Videla
    Molecular and Clinical Pharmacology Program, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Santiago, Chile
    Obesity (Silver Spring) 17:973-9. 2009
    ..001). Data presented show enhanced liver activation of the proinflammatory transcription factors NF-kappaB and AP-1 in obese patients with NASH, parameters that are significantly associated to oxidative stress and IR...
  9. ncbi request reprint Oxidative stress and depletion of hepatic long-chain polyunsaturated fatty acids may contribute to nonalcoholic fatty liver disease
    Luis A Videla
    Programa de Farmacología Molecular y Clínica, Instituto de Ciencias Biomedicas, Facultad de Medicina, Universidad de Chile, Chile
    Free Radic Biol Med 37:1499-507. 2004
    ....
  10. ncbi request reprint Thyroid hormone-induced oxidative stress triggers nuclear factor-kappaB activation and cytokine gene expression in rat liver
    Gladys Tapia
    Programa de Farmacologíca Molecular y Clínica, Instituto de Ciencias Biomedicas, Universidad de Chile, Santiago, Chile
    Free Radic Biol Med 35:257-65. 2003
    ..It is concluded that T(3)-induced oxidative stress enhances the DNA-binding activity of NF-kappaB and the NF-kappaB-dependent expression of TNF-alpha and IL-10 genes...
  11. ncbi request reprint Redox up-regulated expression of rat liver manganese superoxide dismutase and Bcl-2 by thyroid hormone is associated with inhibitor of kappaB-alpha phosphorylation and nuclear factor-kappaB activation
    Virginia Fernandez
    Molecular and Clinical Pharmacology Program, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Casilla, Santiago
    J Endocrinol 186:539-47. 2005
    ....
  12. ncbi request reprint Redox regulation of thyroid hormone-induced Kupffer cell-dependent IkappaB-alpha phosphorylation in relation to inducible nitric oxide synthase expression
    Virginia Fernandez
    Molecular and Clinical Pharmacology Program, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Santiago, Chile
    Free Radic Res 39:411-8. 2005
    ....
  13. pmc N-3 PUFA supplementation triggers PPAR-α activation and PPAR-α/NF-κB interaction: anti-inflammatory implications in liver ischemia-reperfusion injury
    Jessica Zuñiga
    Faculty of Medicine, Molecular and Clinical Pharmacology Program, Institute of Biomedical Sciences, University of Chile, Santiago, Chile
    PLoS ONE 6:e28502. 2011
    ..This effect is associated with the formation of PPAR-α/NF-κBp65 complexes and enhanced cytosolic IκB-α stability, as major preconditioning mechanisms induced by n-3 PUFA supplementation against IR liver injury...
  14. doi request reprint Causal role of oxidative stress in liver preconditioning by thyroid hormone in rats
    Virginia Fernandez
    Molecular and Clinical Pharmacology Program, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Santiago 70000, Chile
    Free Radic Biol Med 44:1724-31. 2008
    ..Data presented suggest that a transient increase in the oxidative stress status of the liver is an important trigger for T(3) preconditioning, evidenced in a warm IR injury model through antioxidant intervention...
  15. ncbi request reprint Involvement of Kupffer cell-dependent signaling in T3-induced hepatocyte proliferation in vivo
    Virginia Fernandez
    Molecular and Clinical Pharmacology Program, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Santiago 7, Chile
    Biol Chem 388:831-7. 2007
    ..Since CDK-2 promotes phase S progression within the cell cycle, this response may constitute a major mechanism involved in T(3)-induced liver preconditioning to ischemia/reperfusion injury...
  16. ncbi request reprint Thyroid hormone preconditioning: protection against ischemia-reperfusion liver injury in the rat
    Virginia Fernandez
    Molecular and Clinical Pharmacology Program, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Santiago, Chile
    Hepatology 45:170-7. 2007
    ....
  17. doi request reprint Decreased liver fatty acid delta-6 and delta-5 desaturase activity in obese patients
    Julia Araya
    Department of Nutrition, Faculty of Medicine, University of Chile, Santiago, Chile
    Obesity (Silver Spring) 18:1460-3. 2010
    ..In conclusion, liver PUFA desaturation is diminished in obese NAFLD patients, in association with underlying insulin resistance and oxidative stress, which may play a role in altering lipid metabolism favoring fatty infiltration...
  18. ncbi request reprint Effects of weight loss on liver and erythrocyte polyunsaturated fatty acid pattern and oxidative stress status in obese patients with non-alcoholic fatty liver disease
    Alejandra Elizondo
    Department of Nutrition, Faculty of Medicine, Universidad de Chile, Santiago, Chile
    Biol Res 41:59-68. 2008
    ....
  19. pmc N-3 long-chain polyunsaturated fatty acid supplementation significantly reduces liver oxidative stress in high fat induced steatosis
    Rodrigo Valenzuela
    School of Nutrition and Dietetics, Faculty of Medicine, University of Chile, Santiago, Chile
    PLoS ONE 7:e46400. 2012
    ..So, repletion of liver n-3 LCPUFA levels by n-3 LCPUFA dietary supplementation in HFD obese mice reduces hepatic lipid content, with concomitant antioxidant and anti-inflammatory responses favouring insulin sensitivity...
  20. ncbi request reprint Enhancement in liver SREBP-1c/PPAR-alpha ratio and steatosis in obese patients: correlations with insulin resistance and n-3 long-chain polyunsaturated fatty acid depletion
    Paulina Pettinelli
    Molecular and Clinical Pharmacology Program, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Santiago, Chile
    Biochim Biophys Acta 1792:1080-6. 2009
    ....
  21. ncbi request reprint Thyroid hormone-induced oxidative stress in rodents and humans: a comparative view and relation to redox regulation of gene expression
    Virginia Fernandez
    Programa de Farmacología Molecular y Clínica, Instituto de Ciencias Biomedicas, Facultad de Medicina, Universidad de Chile, Casilla 70000, Santiago 7, Chile
    Comp Biochem Physiol C Toxicol Pharmacol 142:231-9. 2006
    ..In conclusion, T(3)-induced oxidative stress in the liver enhances the DNA-binding of NF-kappaB and the NF-kappaB-dependent expression of cytokines and iNOS by actions primarily exerted at the Kupffer cell level...
  22. doi request reprint Prevention of liver ischemia reperfusion injury by a combined thyroid hormone and fish oil protocol
    Marcelo Mardones
    Oxidative Stress and Hepatotoxicity Laboratory, Molecular and Clinical Pharmacology Program, Institute of Biomedical Sciences, Santiago 7, Chile
    J Nutr Biochem 23:1113-20. 2012
    ..Prevention of liver IR injury achieved by a combined protocol of T₃ and n-3 PUFA supplementation may represent a novel noninvasive preconditioning strategy with potential clinical application...
  23. doi request reprint Colloidal carbon stimulation of Kupffer cells triggers Nrf2 activation in the isolated perfused rat liver
    Bárbara Núñez
    Molecular and Clinical Pharmacology Program, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Santiago, Chile
    J Mol Histol 43:343-9. 2012
    ..It is concluded that the respiratory burst of CC-stimulated Kupffer cells triggers Nrf2 activation in the perfused liver, a response that may afford cellular protection under pro-oxidant conditions underlying Kupffer cell stimulation...
  24. doi request reprint Upregulation of liver inducible nitric oxide synthase following thyroid hormone preconditioning: suppression by N-acetylcysteine
    Virginia Fernandez
    Programa de Farmacología Molecular y Clínica, Instituto de Ciencias Biomedicas, Facultad de Medicina, Universidad de Chile, Santiago, Chile
    Biol Res 42:487-95. 2009
    ..It is concluded that T(3)-induced liver PC is associated with upregulation of iNOS expression as a protective mechanisms against IR injury, which is achieved through development of transient and reversible oxidative stress...
  25. ncbi request reprint Polyunsaturated fatty acid pattern in liver and erythrocyte phospholipids from obese patients
    Alejandra Elizondo
    Department of Nutrition, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Santiago, Chile
    Obesity (Silver Spring) 15:24-31. 2007
    ....
  26. ncbi request reprint Effects of acute lindane intoxication and thyroid hormone administration in relation to nuclear factor-kappaB activation, tumor necrosis factor-alpha expression, and Kupffer cell function in the rat
    César Valencia
    Program of Molecular and Clinical Pharmacology, Faculty of Medicine, Institute of Biomedical Sciences, University of Chile, Casilla 70000, Santiago 7, Chile
    Toxicol Lett 148:21-8. 2004
    ....
  27. ncbi request reprint Kupffer cell stimulation in the isolated perfused rat liver triggers nuclear factor-kappaB DNA binding activity
    Pamela Romanque
    Programa de Farmacología Molecular y Clínica, Instituto de Ciencias Biomedicas, Facultad de Medicina, Universidad de Chile, Santiago, Chile
    Redox Rep 8:341-6. 2003
    ....
  28. ncbi request reprint Increased production of IL-1alpha and TNF-alpha in lipopolysaccharide-stimulated blood from obese patients with non-alcoholic fatty liver disease
    Jaime Poniachik
    Department of Medicine, University of Chile Clinical Hospital, Santiago, Chile
    Cytokine 33:252-7. 2006
    ....
  29. ncbi request reprint Study of cytochrome P450 2E1 and its allele variants in liver injury of nondiabetic, nonalcoholic steatohepatitis obese women
    Nelson M Varela
    Molecular and Clinical Pharmacology Program, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Santiago, Chile
    Biol Res 41:81-92. 2008
    ..This allele may determine a higher transcriptional activity of the gene, with consequent enhancement in pro-oxidant activity of CYP2E1 thus affording liver toxicity...
  30. pmc Reestablishment of ischemia-reperfusion liver injury by N-acetylcysteine administration prior to a preconditioning iron protocol
    Virginia Fernandez
    Molecular and Clinical Pharmacology Program, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Casilla 70000, Santiago 7, Chile
    ScientificWorldJournal 2013:607285. 2013
    ..Results of this study indicate that NAC administration prior to an iron protocol reestablishes IR liver injury, supporting the role of Fe-induced transient oxidative stress in hepatoprotection and its potential clinical application...
  31. ncbi request reprint Increase in long-chain polyunsaturated fatty acid n - 6/n - 3 ratio in relation to hepatic steatosis in patients with non-alcoholic fatty liver disease
    Julia Araya
    Departamento de Nutricion, Instituto de Ciencias Biomedicas, Facultad de Medicina, Universidad de Chile, Casilla 70058, Santiago 7, Santiago, Chile
    Clin Sci (Lond) 106:635-43. 2004
    ....
  32. ncbi request reprint The role of thyroid hormone calorigenesis in the redox regulation of gene expression
    Patricia Varela
    Cellular and Molecular Biology Program, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Santiago, Chile
    Biol Res 39:611-7. 2006
    ..Mechanisms of expression of respiratory and redox-sensitive genes may be functionally integrated, which could be of importance to understand the complexities of TH action and the outcome of thyroid gland dysfunction...
  33. ncbi request reprint Insulin resistance and oxidative stress interdependency in non-alcoholic fatty liver disease
    Luis A Videla
    Molecular and Clinical Pharmacology Program, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Santiago 7, Chile
    Trends Mol Med 12:555-8. 2006
    ..The improvement of the knowledge of these interrelationships should contribute to elucidate pathogenic pathways and design effective treatments for NAFLD...
  34. ncbi request reprint The acute-phase response of the liver in relation to thyroid hormone-induced redox signaling
    Gladys Tapia
    Molecular and Clinical Pharmacology Program, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Santiago 7, Chile
    Free Radic Biol Med 40:1628-35. 2006
    ....
  35. doi request reprint Thyroid hormone administration induces rat liver Nrf2 activation: suppression by N-acetylcysteine pretreatment
    Pamela Romanque
    Molecular and Clinical Pharmacology Program, Faculty of Medicine, Institute of Biomedical Sciences, University of Chile, Santiago, Chile
    Thyroid 21:655-62. 2011
    ..Such translocation of transcription factors is considered to be an activating step...
  36. ncbi request reprint Increases in tumor necrosis factor-alpha in response to thyroid hormone-induced liver oxidative stress in the rat
    Virginia Fernandez
    Molecular and Clinical Pharmacology Program, Faculty of Medicine, Institute of Biomedical Sciences, University of Chile, Casilla 70000, Santiago 7, Chile
    Free Radic Res 36:719-25. 2002
    ....
  37. ncbi request reprint Oxidative stress-mediated hepatotoxicity of iron and copper: role of Kupffer cells
    Luis A Videla
    Molecular and Clinical Pharmacology, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Santiago, Chile
    Biometals 16:103-11. 2003
    ....
  38. ncbi request reprint Oxidative stress-related parameters in the liver of non-alcoholic fatty liver disease patients
    Luis A Videla
    Molecular and Clinical Pharmacology Program, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Casilla 70058, Santiago 7, Chile
    Clin Sci (Lond) 106:261-8. 2004
    ..Substantial protein oxidation is followed by proteolysis of the modified proteins, which may explain the co-existence of a diminished antioxidant capacity and protein oxidation in the liver of patients with steatohepatitis...
  39. ncbi request reprint Protection against in vivo liver ischemia-reperfusion injury by n-3 long-chain polyunsaturated fatty acids in the rat
    Jessica Zuñiga
    Molecular and Clinical Pharmacology Program, Institute of Biomedical Sciences, University of Chile, Santiago 7, Chile
    Free Radic Res 44:854-63. 2010
    ..In conclusion, prevention of liver IR-injury was achieved by n-3 PUFA supplementation, with suppression of oxidative stress and recovery of pro-inflammatory cytokine homeostasis and NF-kappaB functionality lost during IR...
  40. ncbi request reprint Chronic iron overload enhances inducible nitric oxide synthase expression in rat liver
    Pamela Cornejo
    Programa de Farmacología Molecular y Clínica, Instituto de Ciencias Biomedicas, Facultad de Medicina, Universidad de Chile, Casilla 70000, Santiago 7, Chile
    Nitric Oxide 13:54-61. 2005
    ....
  41. ncbi request reprint Nrf2-regulated phase-II detoxification enzymes and phase-III transporters are induced by thyroid hormone in rat liver
    Pamela Cornejo
    Faculty of Medicine, Diego Portales University, Santiago, Chile
    Biofactors 39:514-21. 2013
    ..These changes, in addition to antioxidant protein induction previously observed, may represent cytoprotective mechanisms underlying T₃ preconditioning against liver injury mediated by ROS and chemical toxicity...
  42. doi request reprint Vanillin suppresses Kupffer cell-related colloidal carbon-induced respiratory burst activity in isolated perfused rat liver: anti-inflammatory implications
    Jose E Galgani
    Department of Nutrition, Faculty of Medicine, University of Chile, Santiago, Chile
    Food Funct 3:1319-23. 2012
    ..Such a finding may have relevance in conditions underlying Kupffer cell-dependent up-regulation of the expression and release of pro-inflammatory mediators by redox-dependent mechanisms...
  43. ncbi request reprint Effects of gamma-hexachlorocyclohexane and L-3,3',5-triiodothyronine on rat liver cytochrome P4502E1-dependent activity and content in relation to microsomal superoxide radical generation
    Virginia Fernandez
    Programa de Farmacología Molecular y Clínica, Instituto de Ciencias Biomedicas, Facultad de Medicina, Universidad de Chile, Casilla 70000, Santiago 7, Chile
    Biol Res 36:359-65. 2003
    ..generation...
  44. ncbi request reprint Early histological and functional effects of chronic copper exposure in rat liver
    Felipe A Cisternas
    Instituto de Nutricion y Tecnologia de los Alimentos, Universidad de Chile, Jose Pedro Alessandri 5540, Macul, Santiago 11, Chile
    Biometals 18:541-51. 2005
    ....
  45. ncbi request reprint Hepatoprotective role of nitric oxide in an experimental model of chronic iron overload
    Pamela Cornejo
    Programa de Farmacología Molecular y Clínica, Instituto de Ciencias Biomedicas, Facultad de Medicina, Universidad de Chile, Casilla 70000, Santiago 7, Chile
    Nitric Oxide 16:143-9. 2007
    ....
  46. ncbi request reprint N-3 long-chain PUFA supplementation prevents high fat diet induced mouse liver steatosis and inflammation in relation to PPAR-α upregulation and NF-κB DNA binding abrogation
    Gladys Tapia
    Molecular and Clinical Pharmacology Program, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Santiago, Chile
    Mol Nutr Food Res 58:1333-41. 2014
    ....
  47. doi request reprint The importance of the long-chain polyunsaturated fatty acid n-6/n-3 ratio in development of non-alcoholic fatty liver associated with obesity
    Rodrigo Valenzuela
    School of Nutrition and Dietetics, Faculty of Medicine, Santiago 7, Chile
    Food Funct 2:644-8. 2011
    ..Supplementation with n-3 LCPUFA appears to reduce nutritional hepatic steatosis in adults, however, other histopathologic features of NAFLD remain to be studied...
  48. ncbi request reprint Biosynthesis and bioavailability of long-chain polyunsaturated fatty acids in non-alcoholic fatty liver disease
    Juan G Gormaz
    Department of Nutrition, Faculty of Medicine, University of Chile, Santiago, Chile
    Prog Lipid Res 49:407-19. 2010
    ..The present review is focused on the relationship between NAFLD and the bioavailability of LCPUFAs, with special reference to the role that oxidative stress could play in the modulation of the liver fatty acid desaturase activity...
  49. ncbi request reprint Reversal of high-fat diet-induced hepatic steatosis by n-3 LCPUFA: role of PPAR-α and SREBP-1c
    Camila G Dossi
    Molecular and Clinical Pharmacology Program, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Santiago, Chile
    J Nutr Biochem 25:977-84. 2014
    ..These findings may provide the rational basis for the use of normocaloric diets supplemented with n-3 LCPUFA in patients with liver steatosis. ..
  50. doi request reprint Nrf2 activation in the liver of rats subjected to a preconditioning sub-chronic iron protocol
    Paula Morales
    Molecular and Clinical Pharmacology Program, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Santiago, Chile
    Food Funct 5:243-50. 2014
    ....
  51. pmc Recent advances in liver preconditioning: Thyroid hormone, n-3 long-chain polyunsaturated fatty acids and iron
    Virginia Fernandez
    Virginia Fernández, Gladys Tapia, Luis A Videla, Molecular and Clinical Pharmacology Program, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Casilla 70000, Santiago 7, Chile
    World J Hepatol 4:119-28. 2012
    ..T(3), n-3 LCPUFA and iron are hormetic agents that trigger biologically beneficial effects in the low-dose range, whose multifactorial mechanisms of action are discussed in the work...
  52. ncbi request reprint Trace quantification of 1-octacosanol and 1-triacontanol and their main metabolites in plasma by liquid-liquid extraction coupled with gas chromatography-mass spectrometry
    Daniela Haim
    Molecular and Clinical Pharmacology Program, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Santiago 7, Chile
    J Chromatogr B Analyt Technol Biomed Life Sci 877:4154-8. 2009
    ..The method was applied successfully to study the total plasmatic concentration of 1-octacosanol, octacosanoic acid, 1-triacontanol, and triacontanoic acid, after an oral dose of policosanols mixture, using plasma samples of 100microl...
  53. ncbi request reprint Tri-iodothyronine differentially induces Kupffer cell ED1/ED2 subpopulations
    Ligia F Gomes
    Departamento de Análises Clínicas e Toxicológicas FCF USP SP, Brazil
    Mol Aspects Med 25:183-90. 2004
    ....
  54. ncbi request reprint Liver necrosis induced by acute intraperitoneal ethanol administration in aged rats
    Leandro Giavarotti
    Departamento de Bioquimica, Instituto de Quimica, Universidade de Sao Paulo, Brazil
    Free Radic Res 36:269-75. 2002
    ..In the 12,18 and 24 months old groups, there was increasing liver necrosis. These findings suggest that liver damage induced by acute ethanol administration in elderly rats may involve a lack of antioxidants...
  55. ncbi request reprint Enhancement of lindane-induced liver oxidative stress and hepatotoxicity by thyroid hormone is reduced by gadolinium chloride
    Karin A Simon-Giavarotti
    Departamento de Bioquimica, Instituto de Quimica, Universidade de Sao Paulo, Sao Paulo, Brasil
    Free Radic Res 36:1033-9. 2002
    ....
  56. ncbi request reprint [Molecular mechanisms in liver ischemic-reperfusion injury and ischemic preconditioning]
    Pamela Romanque U
    Unidad de Cirugía e Investigación Experimental, Hospital del Salvador, Chile
    Rev Med Chil 133:469-76. 2005
    ..These observations and preliminary studies in humans give a rationale for the assessment of IP in minimizing or preventing IR injury during surgery and non surgical conditions of tissue hypoperfusion...