Hector Toledo

Summary

Affiliation: Universidad de Chile
Country: Chile

Publications

  1. ncbi Acid stress response in Helicobacter pylori
    Hector Toledo
    Programa de Biologia Celular y Molecular, ICBM, Facultad de Medicina, Universidad de Chile, Casilla 70086, Santiago, Chile
    FEMS Microbiol Lett 213:67-72. 2002
  2. ncbi Novel genotypes in Helicobacter pylori involving domain V of the 23S rRNA gene
    Leonardo Garrido
    Programa de Biologia Celular y Molecular, ICBM, Facultad de Medicina, Universidad de Chile, Avenida Independencia 1027, Casilla 70086, Santiago 7, Chile
    Helicobacter 12:505-9. 2007
  3. doi Helicobacter pylori-induced loss of survivin and gastric cell viability is attributable to secreted bacterial gamma-glutamyl transpeptidase activity
    Manuel Valenzuela
    Laboratory of Cellular Communication, Center for Molecular Studies of the Cell, Universidad de Chile, Santiago, Chile
    J Infect Dis 208:1131-41. 2013
  4. ncbi Characterization of the arginine decarboxylase gene (ORF HP0422, speA) involved in acid tolerance in Helicobacter pylori
    Manuel Valenzuela
    Faculty of Medicine, Department of Molecular and Cellular Biology, Laboratory of Molecular Microbiology, ICBM, University of Chile, Santiago, Chile Toxicology and Cancer Biology Research Group, Louvain Drug Research Institute, Universite Catholique de Louvain, Bruxelles, Belgium
    Helicobacter 19:182-93. 2014
  5. ncbi Overview on chemotaxis and acid resistance in Helicobacter pylori
    Manuel Valenzuela
    Laboratorio de Microbiologia Molecular, Programa de Biologia Celular y Molecular, ICBM, Facultad de Medicina, Universidad de Chile, Casilla 70086, Santiago 7, Chile
    Biol Res 36:429-36. 2003
  6. ncbi Helicobacter pylori strain ATCC700392 encodes a methyl-accepting chemotaxis receptor protein (MCP) for arginine and sodium bicarbonate
    Oscar Cerda
    Programa de Biologia Celular y Molecular, ICBM, Facultad de Medicina, Universidad de Chile, Casilla 70086, Santiago 7, Chile
    FEMS Microbiol Lett 224:175-81. 2003
  7. doi Arginine 66 residue of Fur is required for the regulatory function of this protein in the acid adaptation mechanism of Helicobacter pylori
    Hector Toledo
    Programa de Biologia Celular y Molecular, ICBM, Facultad de Medicina, Universidad de Chile, Avenida Independencia 1027, Casilla 70086, Santiago 7, Chile
    Helicobacter 17:16-22. 2012
  8. ncbi [Prevalence of metronidazole, clarithromycin and tetracycline resistance in Helicobacter pylori isolated from Chilean patients]
    Cristian Vallejos
    Programa de Biologia Celular y Molecular, ICBM, Facultad de Medicina, Universidad de Chile, Santiago, Chile
    Rev Med Chil 135:287-93. 2007
  9. doi Role of the 207-218 peptide region of Moloney murine leukemia virus integrase in enzyme catalysis
    Monica L Acevedo
    Programa de Virologia, Instituto de Ciencias Biomedicas, Facultad de Medicina, Universidad de Chile, Independencia 1027, Santiago, Chile
    Arch Biochem Biophys 495:28-34. 2010
  10. doi Tetracycline resistance in Chilean clinical isolates of Helicobacter pylori
    Hector Toledo
    Programa de Biologia Celular y Molecular, ICBM, Facultad de Medicina, Universidad de Chile, Avenida Independencia 1027, Casilla 70086, Santiago 7, Chile
    J Antimicrob Chemother 65:470-3. 2010

Collaborators

  • Andrew F G Quest
  • Natalia Diaz
  • Monica L Acevedo
  • Ana Maria Madrid
  • Manuel Valenzuela
  • Denisse Bravo
  • Oscar Cerda
  • Leonardo Garrido
  • Oscar Almarza
  • Cristian Vallejos
  • Aníbal Cáceres
  • Sarita Soto
  • Jimena Canales
  • Carlos Sanhueza
  • Juan P Albar
  • Alberto Paradela
  • Hery Urra
  • Gonzalo Carrasco
  • Alejandro H Corvalan
  • Guillermo Perez-Perez
  • Claudia Defilippi
  • Carlos Defilippi
  • Dante Cáceres
  • Ana Rivas

Detail Information

Publications12

  1. ncbi Acid stress response in Helicobacter pylori
    Hector Toledo
    Programa de Biologia Celular y Molecular, ICBM, Facultad de Medicina, Universidad de Chile, Casilla 70086, Santiago, Chile
    FEMS Microbiol Lett 213:67-72. 2002
    ..pylori DW504UreI-negative, a mutant strain unable to transport urea into the cell, showed a large number of proteins changed, as is typical in an acid stress response. Some of these proteins were identified by N-terminal sequencing...
  2. ncbi Novel genotypes in Helicobacter pylori involving domain V of the 23S rRNA gene
    Leonardo Garrido
    Programa de Biologia Celular y Molecular, ICBM, Facultad de Medicina, Universidad de Chile, Avenida Independencia 1027, Casilla 70086, Santiago 7, Chile
    Helicobacter 12:505-9. 2007
    ..pylori is associated with point mutations in the 23S rRNA. This study analyzes 23S rRNA gene mutations and minimum inhibitory concentration (MIC) for clarithromycin in H. pylori isolates from patients of the metropolitan region of Chile...
  3. doi Helicobacter pylori-induced loss of survivin and gastric cell viability is attributable to secreted bacterial gamma-glutamyl transpeptidase activity
    Manuel Valenzuela
    Laboratory of Cellular Communication, Center for Molecular Studies of the Cell, Universidad de Chile, Santiago, Chile
    J Infect Dis 208:1131-41. 2013
    ..Moreover, experiments with the GGT inhibitor 6-diazo-5-oxo-l-norleucine and purified recombinant GGT protein indicated that secreted bacterial GGT activity was required and sufficient to induce these effects. ..
  4. ncbi Characterization of the arginine decarboxylase gene (ORF HP0422, speA) involved in acid tolerance in Helicobacter pylori
    Manuel Valenzuela
    Faculty of Medicine, Department of Molecular and Cellular Biology, Laboratory of Molecular Microbiology, ICBM, University of Chile, Santiago, Chile Toxicology and Cancer Biology Research Group, Louvain Drug Research Institute, Universite Catholique de Louvain, Bruxelles, Belgium
    Helicobacter 19:182-93. 2014
    ..However, urease negative strains can be also isolated from clinical samples, suggesting that H. pylori presents other components involved in acid resistance...
  5. ncbi Overview on chemotaxis and acid resistance in Helicobacter pylori
    Manuel Valenzuela
    Laboratorio de Microbiologia Molecular, Programa de Biologia Celular y Molecular, ICBM, Facultad de Medicina, Universidad de Chile, Casilla 70086, Santiago 7, Chile
    Biol Res 36:429-36. 2003
  6. ncbi Helicobacter pylori strain ATCC700392 encodes a methyl-accepting chemotaxis receptor protein (MCP) for arginine and sodium bicarbonate
    Oscar Cerda
    Programa de Biologia Celular y Molecular, ICBM, Facultad de Medicina, Universidad de Chile, Casilla 70086, Santiago 7, Chile
    FEMS Microbiol Lett 224:175-81. 2003
    ..Together, these results argue that the H. pylori HP0099 gene encodes an MCP for arginine and bicarbonate...
  7. doi Arginine 66 residue of Fur is required for the regulatory function of this protein in the acid adaptation mechanism of Helicobacter pylori
    Hector Toledo
    Programa de Biologia Celular y Molecular, ICBM, Facultad de Medicina, Universidad de Chile, Avenida Independencia 1027, Casilla 70086, Santiago 7, Chile
    Helicobacter 17:16-22. 2012
    ..Like other enteric bacterial pathogens, including Salmonella enterica, H. pylori develops an acid tolerance response that is dependent on the function of the transcriptional regulator protein Fur...
  8. ncbi [Prevalence of metronidazole, clarithromycin and tetracycline resistance in Helicobacter pylori isolated from Chilean patients]
    Cristian Vallejos
    Programa de Biologia Celular y Molecular, ICBM, Facultad de Medicina, Universidad de Chile, Santiago, Chile
    Rev Med Chil 135:287-93. 2007
    ..Helicobacter pylori is a pathogenic bacterium that infects a significant number of individuals. At present, therapeutic strategies to eradicate this bacterium depend on our knowledge of its resistance to antimicrobials...
  9. doi Role of the 207-218 peptide region of Moloney murine leukemia virus integrase in enzyme catalysis
    Monica L Acevedo
    Programa de Virologia, Instituto de Ciencias Biomedicas, Facultad de Medicina, Universidad de Chile, Independencia 1027, Santiago, Chile
    Arch Biochem Biophys 495:28-34. 2010
    ..We propose that the peptide region 207-216 is a flexible loop and that H208, Y211, R212 and Q214 of this loop are involved in the correct assembly of the DNA-integrase complex during integration...
  10. doi Tetracycline resistance in Chilean clinical isolates of Helicobacter pylori
    Hector Toledo
    Programa de Biologia Celular y Molecular, ICBM, Facultad de Medicina, Universidad de Chile, Avenida Independencia 1027, Casilla 70086, Santiago 7, Chile
    J Antimicrob Chemother 65:470-3. 2010
    ..pylori clinical isolates obtained from Santiago, Chile by using a recently reported molecular assay...
  11. doi Helicobacter pylori exhibits a fur-dependent acid tolerance response
    Manuel Valenzuela
    Programa de Biologia Celular y Molecular, ICBM, Facultad de Medicina, Universidad de Chile, Casilla 70086, Santiago 7, Chile
    Helicobacter 16:189-99. 2011
    ..This two-step acid tolerance response (ATR) requires de novo protein synthesis and is dependent on the function of the global regulatory protein Fur...
  12. ncbi Helicobacter pylori-induced loss of the inhibitor-of-apoptosis protein survivin is linked to gastritis and death of human gastric cells
    Manuel Valenzuela
    Laboratory of Cellular Communication, Fondo de Investigación Avanzada en Areas Prioritarias, Center for Molecular Studies of the Cell, Facultad de Medicina, Instituto de Ciencias Biomedicas, Universidad de Chile, Pontificia Universidad Catolica de Chile, Santiago, Chile
    J Infect Dis 202:1021-30. 2010
    ..Finally, overexpression of survivin in human gastric cells was sufficient to reduce cell death after infection. Taken together, these findings implicate survivin as an important survival factor in the gastric mucosa of humans...