Ramón Rodrigo

Summary

Affiliation: Universidad de Chile
Country: Chile

Publications

  1. ncbi request reprint Diminution of tissue lipid peroxidation in rats is related to the in vitro antioxidant capacity of wine
    Ramón Rodrigo
    Laboratorio de Fisiopatologia Renal, Programa de Farmacología Molecular y Clínica, ICBM, Facultad de Medicina, Universidad de Chile, Independencia 1027, Casilla 70058, Santiago 7, Chile
    Life Sci 76:889-900. 2005
  2. ncbi request reprint Antihypertensive role of polyphenols
    Ramón Rodrigo
    Molecular and Clinical Pharmacology Program, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Santiago, Chile
    Adv Clin Chem 58:225-54. 2012
  3. ncbi request reprint The effectiveness of antioxidant vitamins C and E in reducing myocardial infarct size in patients subjected to percutaneous coronary angioplasty (PREVEC Trial): study protocol for a pilot randomized double-blind controlled trial
    Ramón Rodrigo
    Molecular and Clinical Pharmacology Program, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Santiago, Chile
    Trials 15:192. 2014
  4. pmc Prevention of postoperative atrial fibrillation: novel and safe strategy based on the modulation of the antioxidant system
    Ramón Rodrigo
    Molecular and Clinical Pharmacology Program, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile Santiago, Chile
    Front Physiol 3:93. 2012
  5. pmc Molecular basis of cardioprotective effect of antioxidant vitamins in myocardial infarction
    Ramón Rodrigo
    Molecular and Clinical Pharmacology Program, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Santiago 7, Chile
    Biomed Res Int 2013:437613. 2013
  6. doi request reprint A randomized controlled trial to prevent post-operative atrial fibrillation by antioxidant reinforcement
    Ramón Rodrigo
    Molecular and Clinical Pharmacology Program, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Santiago, Chile Electronic address
    J Am Coll Cardiol 62:1457-65. 2013
  7. ncbi request reprint Oxidative stress and pathophysiology of ischemic stroke: novel therapeutic opportunities
    Ramón Rodrigo
    Molecular and Clinical Pharmacology Program, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Independencia 1027, Casilla 70058, Santiago 7, Chile
    CNS Neurol Disord Drug Targets 12:698-714. 2013
  8. doi request reprint Cardioprotection against ischaemia/reperfusion by vitamins C and E plus n-3 fatty acids: molecular mechanisms and potential clinical applications
    Ramón Rodrigo
    Molecular and Clinical Pharmacology Program, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Santiago, Chile
    Clin Sci (Lond) 124:1-15. 2013
  9. pmc Ageing improves the antioxidant response against postoperative atrial fibrillation: a randomized controlled trial
    Ramón Rodrigo
    Molecular and Clinical Pharmacology Program, Faculty of Medicine, Institute of Biomedical Sciences, University of Chile, Santiago, Chile
    Interact Cardiovasc Thorac Surg 15:209-14. 2012
  10. doi request reprint Use of vitamins C and E as a prophylactic therapy to prevent postoperative atrial fibrillation
    Ramón Rodrigo
    Molecular and Clinical Pharmacology Program, Institute of Biomedical Sciences, University of Chile, Independencia 1027, Casilla 70058, Santiago 7, Chile
    Int J Cardiol 138:221-8. 2010

Collaborators

Detail Information

Publications55

  1. ncbi request reprint Diminution of tissue lipid peroxidation in rats is related to the in vitro antioxidant capacity of wine
    Ramón Rodrigo
    Laboratorio de Fisiopatologia Renal, Programa de Farmacología Molecular y Clínica, ICBM, Facultad de Medicina, Universidad de Chile, Independencia 1027, Casilla 70058, Santiago 7, Chile
    Life Sci 76:889-900. 2005
    ..790 for kidney, liver and lung, respectively, p <0.001). The present data provide evidence that the antioxidant capacity of wine in vitro implicates a homologous effect in vivo, thus helping to modulate tissue lipid peroxidation...
  2. ncbi request reprint Antihypertensive role of polyphenols
    Ramón Rodrigo
    Molecular and Clinical Pharmacology Program, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Santiago, Chile
    Adv Clin Chem 58:225-54. 2012
    ..However, further trials are yet needed to fully assess the molecular mechanisms of action and the appearance of adverse reactions, if a more extensive recommendation of polyphenol introduction in diet wants to be made...
  3. ncbi request reprint The effectiveness of antioxidant vitamins C and E in reducing myocardial infarct size in patients subjected to percutaneous coronary angioplasty (PREVEC Trial): study protocol for a pilot randomized double-blind controlled trial
    Ramón Rodrigo
    Molecular and Clinical Pharmacology Program, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Santiago, Chile
    Trials 15:192. 2014
    ....
  4. pmc Prevention of postoperative atrial fibrillation: novel and safe strategy based on the modulation of the antioxidant system
    Ramón Rodrigo
    Molecular and Clinical Pharmacology Program, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile Santiago, Chile
    Front Physiol 3:93. 2012
    ....
  5. pmc Molecular basis of cardioprotective effect of antioxidant vitamins in myocardial infarction
    Ramón Rodrigo
    Molecular and Clinical Pharmacology Program, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Santiago 7, Chile
    Biomed Res Int 2013:437613. 2013
    ....
  6. doi request reprint A randomized controlled trial to prevent post-operative atrial fibrillation by antioxidant reinforcement
    Ramón Rodrigo
    Molecular and Clinical Pharmacology Program, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Santiago, Chile Electronic address
    J Am Coll Cardiol 62:1457-65. 2013
    ..This study was designed to assess whether the reinforcement of the antioxidant system, through n-3 fatty acids plus antioxidant vitamin supplementation, could reduce the incidence of post-operative atrial fibrillation...
  7. ncbi request reprint Oxidative stress and pathophysiology of ischemic stroke: novel therapeutic opportunities
    Ramón Rodrigo
    Molecular and Clinical Pharmacology Program, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Independencia 1027, Casilla 70058, Santiago 7, Chile
    CNS Neurol Disord Drug Targets 12:698-714. 2013
    ....
  8. doi request reprint Cardioprotection against ischaemia/reperfusion by vitamins C and E plus n-3 fatty acids: molecular mechanisms and potential clinical applications
    Ramón Rodrigo
    Molecular and Clinical Pharmacology Program, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Santiago, Chile
    Clin Sci (Lond) 124:1-15. 2013
    ....
  9. pmc Ageing improves the antioxidant response against postoperative atrial fibrillation: a randomized controlled trial
    Ramón Rodrigo
    Molecular and Clinical Pharmacology Program, Faculty of Medicine, Institute of Biomedical Sciences, University of Chile, Santiago, Chile
    Interact Cardiovasc Thorac Surg 15:209-14. 2012
    ..Reinforcing the antioxidant defence system would be expected to protect the myocardium against ischaemia-reperfusion damage. We studied the effect of antioxidant reinforcement and ageing on the occurrence of postoperative AF...
  10. doi request reprint Use of vitamins C and E as a prophylactic therapy to prevent postoperative atrial fibrillation
    Ramón Rodrigo
    Molecular and Clinical Pharmacology Program, Institute of Biomedical Sciences, University of Chile, Independencia 1027, Casilla 70058, Santiago 7, Chile
    Int J Cardiol 138:221-8. 2010
    ..The clinical and experimental evidence supporting the view that the pharmacological use of antioxidant vitamins could contribute to prevent postoperative atrial fibrillation is presented...
  11. ncbi request reprint Clinical pharmacology and therapeutic use of antioxidant vitamins
    Ramón Rodrigo
    Laboratory of Renal Pathophysiology, Molecular and Clinical Pharmacology Program, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Independencia 1027, Casilla, Santiago, Chile
    Fundam Clin Pharmacol 21:111-27. 2007
    ....
  12. ncbi request reprint Relationship between (Na + K)-ATPase activity, lipid peroxidation and fatty acid profile in erythrocytes of hypertensive and normotensive subjects
    Ramón Rodrigo
    Laboratory of Renal Pathophysiology, Molecular and Clinical Pharmacology Program, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Independencia 1027, Casilla, 70058, Santiago 7, Chile
    Mol Cell Biochem 303:73-81. 2007
    ....
  13. ncbi request reprint Non-hypoxic preconditioning of myocardium against postoperative atrial fibrillation: mechanism based on enhancement of the antioxidant defense system
    Ramón Rodrigo
    Laboratory of Renal Pathophysiology, Molecular and Clinical Pharmacology Program, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Independencia 1027, Santiago 7, Chile
    Med Hypotheses 69:1242-8. 2007
    ....
  14. ncbi request reprint Decrease in oxidative stress through supplementation of vitamins C and E is associated with a reduction in blood pressure in patients with essential hypertension
    Ramón Rodrigo
    Laboratory of Renal Pathophysiology, Molecular and Clinical Pharmacology Program, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Santiago, Chile
    Clin Sci (Lond) 114:625-34. 2008
    ..This suggests intervention with antioxidants as an adjunct therapy for hypertension...
  15. doi request reprint Relationship between oxidative stress and essential hypertension
    Ramón Rodrigo
    Laboratory of Renal Pathophysiology, Molecular and Clinical Pharmacology Program, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Santiago, Chile
    Hypertens Res 30:1159-67. 2007
    ..These findings demonstrate a strong association between blood pressure and some oxidative stress-related parameters and suggest a possible role of oxidative stress in the pathophysiology of essential hypertension...
  16. doi request reprint Prevention of atrial fibrillation following cardiac surgery: basis for a novel therapeutic strategy based on non-hypoxic myocardial preconditioning
    Ramón Rodrigo
    Molecular and Clinical Pharmacology Program, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Santiago, Chile
    Pharmacol Ther 118:104-27. 2008
    ....
  17. doi request reprint Modulation of endogenous antioxidant system by wine polyphenols in human disease
    Ramón Rodrigo
    Institute of Biomedical Sciences, University of Chile, Santiago, Chile
    Clin Chim Acta 412:410-24. 2011
    ..Future large scale randomized clinical trials should be conducted to fully establish the therapeutic use of each individual wine polyphenol against human disease...
  18. doi request reprint The role of oxidative stress in the pathophysiology of hypertension
    Ramón Rodrigo
    Renal Pathophysiology Laboratory, Molecular and Clinical Pharmacology Program, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Santiago, Chile
    Hypertens Res 34:431-40. 2011
    ..This review discusses the mechanisms involved in ROS generation, the role of oxidative stress in the pathogenesis of vascular damage in hypertension, and the possible therapeutic strategies that could prevent or treat this disorder...
  19. ncbi request reprint Biochemical and ultrastructural lung damage induced by rhabdomyolysis in the rat
    Ramón Rodrigo
    Molecular and Clinical Pharmacology Program, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Independencia 1027, Casilla 70058, Santiago 7, Chile
    Exp Biol Med (Maywood) 231:1430-8. 2006
    ..These results provide evidence that rhabdomyolysis could induce tissue injury associated with increased oxidative stress, suggesting the contribution of oxidative stress to the pathogenic mechanism of acute lung injury...
  20. ncbi request reprint Chronic ethanol exposure does not impair urinary acidification even under stressful conditions
    Ramón Rodrigo
    Renal Pathophysiology Laboratory, Molecular and Clinical Pharmacology Program, ICBM, Facultad de Medicina, Universidad de Chile, Casilla 70058, Santiago 7, Chile
    Med Sci Monit 11:BR95-9. 2005
    ..The aim of the present study was to assess urinary acidification in rats subjected to chronic ethanol consumption and renal function stressors, such as unilateral nephrectomy and/or metabolic acidosis...
  21. ncbi request reprint Pathophysiological basis for the prophylaxis of preeclampsia through early supplementation with antioxidant vitamins
    Ramón Rodrigo
    Molecular and Clinical Pharmacology Program, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Independencia 1027, Casilla 70058, Santiago 7, Chile
    Pharmacol Ther 107:177-97. 2005
    ..This review is focused on evidence providing a pathophysiological basis for the beneficial effect of early antioxidant therapy in the prevention of PE, mainly supported by the biological effects of vitamins C and E...
  22. ncbi request reprint Oxidative stress and protective effects of polyphenols: comparative studies in human and rodent kidney. A review
    Ramón Rodrigo
    Molecular and Clinical Pharmacology Program, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Santiago, Chile
    Comp Biochem Physiol C Toxicol Pharmacol 142:317-27. 2006
    ..The aim of the present review is to examine the pathophysiological basis of the renoprotective effect of red wine in man and rodents, based on functional, biochemical and ultrastructural evidence...
  23. ncbi request reprint Amelioration of myoglobinuric renal damage in rats by chronic exposure to flavonol-rich red wine
    Ramón Rodrigo
    Laboratorio de Fisiopatologia Renal, Programa de Farmacología Molecular y Clínica, ICBM, Facultad de Medicina, Universidad de Chile, Independencia 1027, Casilla 70058, Santiago 7, Chile
    Nephrol Dial Transplant 19:2237-44. 2004
    ..Since ethanol upregulates renal antioxidant enzymes and wine polyphenols behave as antioxidants, we tested the hypothesis that red wine components would ameliorate the renal damage caused by rhabdomyolysis...
  24. doi request reprint Antioxidant therapy reduces oxidative and inflammatory tissue damage in patients subjected to cardiac surgery with extracorporeal circulation
    Rodrigo Castillo
    Molecular and Clinical Pharmacology Program, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Santiago, Chile
    Basic Clin Pharmacol Toxicol 108:256-62. 2011
    ..5% lower than that in placebo patients (p < 0.05). The combined n-3 PUFA-antioxidant vitamin protocol therapy here proposed reduced the oxidative stress and inflammation biomarkers, in patients undergoing on-pump cardiac surgery...
  25. ncbi request reprint Rat kidney antioxidant response to long-term exposure to flavonol rich red wine
    Ramón Rodrigo
    Laboratorio de Fisiopatologia Renal, Programa de Farmacología Molecular y Clínica, ICBM, Facultad de Medicina, Universidad de Chile, Independencia 1027, Casilla 70058, Santiago 7, Chile
    Life Sci 71:2881-95. 2002
    ..Both ethanol and the non-alcoholic antioxidant constituents of red wine could be responsible for these effects...
  26. doi request reprint Decreased liver fatty acid delta-6 and delta-5 desaturase activity in obese patients
    Julia Araya
    Department of Nutrition, Faculty of Medicine, University of Chile, Santiago, Chile
    Obesity (Silver Spring) 18:1460-3. 2010
    ..In conclusion, liver PUFA desaturation is diminished in obese NAFLD patients, in association with underlying insulin resistance and oxidative stress, which may play a role in altering lipid metabolism favoring fatty infiltration...
  27. doi request reprint Effects of weight loss on liver and erythrocyte polyunsaturated fatty acid pattern and oxidative stress status in obese patients with non-alcoholic fatty liver disease
    Alejandra Elizondo
    Department of Nutrition, Faculty of Medicine, Universidad de Chile, Santiago, Chile
    Biol Res 41:59-68. 2008
    ....
  28. ncbi request reprint Polyunsaturated fatty acid pattern in liver and erythrocyte phospholipids from obese patients
    Alejandra Elizondo
    Department of Nutrition, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Santiago, Chile
    Obesity (Silver Spring) 15:24-31. 2007
    ....
  29. ncbi request reprint Enhancement in liver SREBP-1c/PPAR-alpha ratio and steatosis in obese patients: correlations with insulin resistance and n-3 long-chain polyunsaturated fatty acid depletion
    Paulina Pettinelli
    Molecular and Clinical Pharmacology Program, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Santiago, Chile
    Biochim Biophys Acta 1792:1080-6. 2009
    ....
  30. ncbi request reprint Increase in long-chain polyunsaturated fatty acid n - 6/n - 3 ratio in relation to hepatic steatosis in patients with non-alcoholic fatty liver disease
    Julia Araya
    Departamento de Nutricion, Instituto de Ciencias Biomedicas, Facultad de Medicina, Universidad de Chile, Casilla 70058, Santiago 7, Santiago, Chile
    Clin Sci (Lond) 106:635-43. 2004
    ....
  31. ncbi request reprint Oxidative stress-related parameters in the liver of non-alcoholic fatty liver disease patients
    Luis A Videla
    Molecular and Clinical Pharmacology Program, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Casilla 70058, Santiago 7, Chile
    Clin Sci (Lond) 106:261-8. 2004
    ..Substantial protein oxidation is followed by proteolysis of the modified proteins, which may explain the co-existence of a diminished antioxidant capacity and protein oxidation in the liver of patients with steatohepatitis...
  32. doi request reprint Implications of oxidative stress in the pathophysiology of obstructive uropathy
    Martin Zecher
    Faculty of Medicine, Institute of Biomedical Sciences, University of Chile, Santiago, Chile
    Urol Res 37:19-26. 2009
    ..Based on this and other previous data, it could be suggested that red wine administration may prevent renal damage secondary to UUO by inducing enhanced antioxidant potential...
  33. ncbi request reprint Renal damage mediated by oxidative stress: a hypothesis of protective effects of red wine
    Ramón Rodrigo
    Renal Pathophysiology Laboratory, Molecular and Clinical Pharmacology Program, ICBM, Facultad de Medicina Universidad de Chile, Santiago, Chile
    Free Radic Biol Med 33:409-22. 2002
    ....
  34. ncbi request reprint Changes in (Na + K)-adenosine triphosphatase activity and ultrastructure of lung and kidney associated with oxidative stress induced by acute ethanol intoxication
    Ramón Rodrigo
    Instituto de Ciencias Biomedicas, Programa de Farmacología Molecular y Clínica, Facultad de Medicina, Universidad de Chile, Santiago, Chile
    Chest 121:589-96. 2002
    ....
  35. ncbi request reprint Modulation of cytochrome P450 activity in the kidney of rats following long-term red wine exposure
    Myriam Orellana
    ICBM, Programa de Farmacología Molecular y Clínica, Facultad de Medicina, Universidad de Chile, Casilla 70086, Santiago 7, Chile
    Comp Biochem Physiol C Toxicol Pharmacol 132:399-405. 2002
    ..Our results suggest that the non-alcoholic constituents of red wine could account for this modulation...
  36. pmc Oxidative stress-related biomarkers in essential hypertension and ischemia-reperfusion myocardial damage
    Ramón Rodrigo
    Molecular and Clinical Pharmacology Program, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Independencia 1027, Casilla 70058, Santiago 7, Chile
    Dis Markers 35:773-90. 2013
    ..However, data have to be validated with the analysis of the appropriate oxidative stress and/or nitrosative stress biomarkers. ..
  37. doi request reprint Oxidative damage to pre-eclamptic placenta: immunohistochemical expression of VEGF, nitrotyrosine residues and von Willebrand factor
    Cleofina Bosco
    Anatomy and Developmental Biology Programme, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Santiago, Chile
    J Matern Fetal Neonatal Med 25:2339-45. 2012
    ..To determine the relationship of biomarkers of placental damage by oxidative stress in pre-eclamptic placenta...
  38. ncbi request reprint Homocysteine and essential hypertension
    Ramón Rodrigo
    Instituto de Ciencias Biomedicas, Programa de Farmacología Molecular y Clínica, Facultad de Medicina, Universidad de Chile, Santiago, Chile
    J Clin Pharmacol 43:1299-306. 2003
    ..However, further controlled randomized trials are necessary to establish the efficacy and tolerability of these potentially therapeutic agents...
  39. doi request reprint Study of cytochrome P450 2E1 and its allele variants in liver injury of nondiabetic, nonalcoholic steatohepatitis obese women
    Nelson M Varela
    Molecular and Clinical Pharmacology Program, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Santiago, Chile
    Biol Res 41:81-92. 2008
    ..This allele may determine a higher transcriptional activity of the gene, with consequent enhancement in pro-oxidant activity of CYP2E1 thus affording liver toxicity...
  40. ncbi request reprint Effects of red wine consumption on kidney FA composition
    Julia Araya
    Departamento de Nutricion, Instituto de Ciencias Biomedicas, Facultad de Medicina, Universidad de Chile, Santiago, Chile
    Lipids 38:275-9. 2003
    ..Although ethanol increased the content of cytochrome P450 in the kidney, this effect was eliminated by the nonalcoholic components of red wine...
  41. doi request reprint Liver NF-kappaB and AP-1 DNA binding in obese patients
    Luis A Videla
    Molecular and Clinical Pharmacology Program, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Santiago, Chile
    Obesity (Silver Spring) 17:973-9. 2009
    ..001). Data presented show enhanced liver activation of the proinflammatory transcription factors NF-kappaB and AP-1 in obese patients with NASH, parameters that are significantly associated to oxidative stress and IR...
  42. ncbi request reprint Modulation of rat liver cytochrome P450 activity by prolonged red wine consumption
    Myriam Orellana
    ICBM, Programa de Farmacología Molecular y Clínica, Facultad de Medicina, Universidad de Chile, Casilla 70086, Santiago 7, Chile
    Comp Biochem Physiol C Toxicol Pharmacol 131:161-6. 2002
    ....
  43. ncbi request reprint Insulin resistance and oxidative stress interdependency in non-alcoholic fatty liver disease
    Luis A Videla
    Molecular and Clinical Pharmacology Program, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Santiago 7, Chile
    Trends Mol Med 12:555-8. 2006
    ..The improvement of the knowledge of these interrelationships should contribute to elucidate pathogenic pathways and design effective treatments for NAFLD...
  44. ncbi request reprint Screening test for preeclampsia through assessment of uteroplacental blood flow and biochemical markers of oxidative stress and endothelial dysfunction
    Mauro Parra
    Fetal Medicine Unit, Hospital Clinico Universidad de Chile, Santiago, Chile
    Am J Obstet Gynecol 193:1486-91. 2005
    ..This study was undertaken to evaluate whether screening through a uterine artery (UtA) Doppler and biochemical markers of oxidative stress and endothelial dysfunction predict preeclampsia...
  45. doi request reprint Effect of carvedilol and nebivolol on oxidative stress-related parameters and endothelial function in patients with essential hypertension
    Ramiro J Zepeda
    Molecular and Clinical Pharmacology Program, Faculty of Medicine, Biomedical Sciences Institute, Universidad de Chile, Santiago, Chile
    Basic Clin Pharmacol Toxicol 111:309-16. 2012
    ..However, carvedilol could mediate these effects by an increase in antioxidant capacity and nebivolol through the raise in NO₂ concentration. Further studies are needed to determine the molecular mechanism of these effects...
  46. ncbi request reprint Implications of oxidative stress and homocysteine in the pathophysiology of essential hypertension
    Ramón Rodrigo
    Instituto de Ciencias Biomedicas, Programa de Farmacología Molecular y Clínica, Facultad de Medicina, Universidad de Chile, Santiago, Chile
    J Cardiovasc Pharmacol 42:453-61. 2003
    ..Further studies involving long-term trials could help to assess the tolerability and efficacy of the use of these therapeutic agents...
  47. ncbi request reprint Increased production of IL-1alpha and TNF-alpha in lipopolysaccharide-stimulated blood from obese patients with non-alcoholic fatty liver disease
    Jaime Poniachik
    Department of Medicine, University of Chile Clinical Hospital, Santiago, Chile
    Cytokine 33:252-7. 2006
    ....
  48. doi request reprint Immunohistochemical expression of von Willebrand factor in the preeclamptic placenta
    Mauro Parra-Cordero
    Obstetrics and Gynaecology Department, University of Chile Clinical Hospital, Santiago, Chile
    J Mol Histol 42:459-65. 2011
    ..Cell damage in syncytiotrophoblast that occurs in preeclampsia could liberate vWF from syncytiotrophoblast to the placental intervillous space, and this may have pathogenic implications...
  49. ncbi request reprint Oxidative stress and depletion of hepatic long-chain polyunsaturated fatty acids may contribute to nonalcoholic fatty liver disease
    Luis A Videla
    Programa de Farmacología Molecular y Clínica, Instituto de Ciencias Biomedicas, Facultad de Medicina, Universidad de Chile, Chile
    Free Radic Biol Med 37:1499-507. 2004
    ....
  50. doi request reprint Biosynthesis and bioavailability of long-chain polyunsaturated fatty acids in non-alcoholic fatty liver disease
    Juan G Gormaz
    Department of Nutrition, Faculty of Medicine, University of Chile, Santiago, Chile
    Prog Lipid Res 49:407-19. 2010
    ..The present review is focused on the relationship between NAFLD and the bioavailability of LCPUFAs, with special reference to the role that oxidative stress could play in the modulation of the liver fatty acid desaturase activity...
  51. doi request reprint Novel therapeutic strategies for traumatic brain injury: acute antioxidant reinforcement
    Rodrigo Fernandez-Gajardo
    Molecular and Clinical Pharmacology Program, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Independencia 1027, Casilla, 70058, Santiago 7, Chile
    CNS Drugs 28:229-48. 2014
    ..Particular considerations and translational potential of new TBI treatments are examined and a novel therapeutic proposal for TBI is presented. ..
  52. ncbi request reprint Effect of ethanol on regulation of (Na + K)-adenosine triphosphatase by aldosterone and dexamethasone in cultured renal papillary collecting duct cells
    Ramón Rodrigo
    Laboratorio de Fisiopatologia Renal, Programa de Farmacología Molecular y Clínica, ICBM, Facultad de Medicina, Universidad de Chile, Santiago, Chile
    Endocrine 19:301-4. 2002
    ..These results suggest that ethanol treatment enhances the upregulation of (Na + K)-ATPase activity by both aldosterone and dexamethasone, in cultured renal papillary collecting duct cells...
  53. doi request reprint Oxidative stress as a novel target in pediatric sepsis management
    Bettina von Dessauer
    Pediatric Intensive Care Unit, Doctor Roberto del Río Children s Hospital, Santiago, Chile
    J Crit Care 26:103.e1-7. 2011
    ....
  54. ncbi request reprint Modulation of (Na,K)-ATPase activity by membrane fatty acid composition: therapeutic implications in human hypertension
    Ramón Rodrigo
    University of Chile, Santiago, Chile
    Clin Exp Hypertens 36:17-26. 2014
    ..Supplementation with vitamins C+E resulted in decreased OS and increased fluidity and PUFA proportion in the membrane, both of which positively modulate (Na,K)-ATPase activity, accounting for the blood pressure reduction...
  55. ncbi request reprint Placentation in the degu (Octodon degus): analogies with extrasubplacental trophoblast and human extravillous trophoblast
    Cleofina Bosco
    Programas de Anatomía y Biología del Desarrollo, ICBM, Facultad de Medicina, Universidad de Chile, Chile
    Comp Biochem Physiol A Mol Integr Physiol 146:475-85. 2007
    ..The origin of the EST in the degu placenta and its migration to maternal vessels allows us to present this animal model for the study of pregnancy pathologies related to alterations in the migration of the extravillous trophoblast...