Juan C Roa

Summary

Affiliation: Universidad de La Frontera
Country: Chile

Publications

  1. pmc Overexpression of ribosome binding protein 1 (RRBP1) in breast cancer
    Deepthi Telikicherla
    Institute of Bioinformatics, International Tech Park, Bangalore 560 066, India
    Clin Proteomics 9:7. 2012
  2. pmc Epigenetic alterations in preneoplastic and neoplastic lesions of the cervix
    Kathleen P Saavedra
    Universidad de La Frontera, School of Medicine, Department of Pathology, Molecular Pathology Laboratory, BIOREN CEGIN, Temuco, Chile
    Clin Epigenetics 4:13. 2012
  3. pmc DNA promoter methylation as a diagnostic and therapeutic biomarker in gallbladder cancer
    Pablo Letelier
    Universidad de La Frontera, School of Medicine, Department of Pathology, Molecular Pathology Laboratory, BIOREN CEGIN, Temuco, Chile
    Clin Epigenetics 4:11. 2012
  4. ncbi request reprint [Microsatellite instability and loss of heterozygosity in neoplastic and preneoplastic gastric lesions]
    Juan Carlos Roa
    Departamento de Patologia, Universidad de La Frontera, Temuco, Chile
    Rev Med Chil 131:1227-36. 2003
  5. ncbi request reprint [Microsatellite instability and human papilloma virus genotypes in preneoplastic and neoplastic uterine cervix lesions]
    Juan Carlos Roa S
    Departamento de Anatomia Patologica, Facultad de Medicina, Universidad de La Frontera, Temuco, Chile
    Rev Med Chil 135:37-44. 2007
  6. ncbi request reprint Prognostic factors of phyllodes tumor of the breast
    Juan Carlos Roa
    Department of Pathology, Universidad de La Frontera, Temuco, Chile
    Pathol Int 56:309-14. 2006
  7. ncbi request reprint [Frequency of K-ras mutation in biliary and pancreatic tumors]
    Juan Carlos Roa
    Departamento de Anatomia Patologica, Facultad de Medicina, Universidad de La Frontera
    Rev Med Chil 133:1434-40. 2005
  8. ncbi request reprint [Promoter methylation profile in gastric cancer]
    Juan Carlos Roa
    Departamento de Anatomia Patologica, Universidad de La Frontera, Temuco, Chile
    Rev Med Chil 133:874-80. 2005
  9. ncbi request reprint [Detection of bone marrow micrometastases in patients with gallbladder cancer]
    Juan C Roa
    Departamento de Anatomia Patologica, Facultad de Medicina, Universidad de La Frontera, Temuco, Chile
    Rev Med Chil 132:1489-98. 2004
  10. ncbi request reprint [Inactivation of CDKN2A gene (p16) in gallbladder carcinoma]
    Juan Carlos Roa
    Departamento de Anatomá Patológica, Universidad de La Frontera, Temuco, Chile
    Rev Med Chil 132:1369-76. 2004

Collaborators

  • Oscar Tapia
  • Ivan Roa
  • Javier Martinez
  • Asli Cakir
  • Anirban Maitra
  • Pelayo Correa
  • N Volkan Adsay
  • Seung-Mo Hong
  • Juan Carlos Araya
  • Priscilla Brebi
  • Patricia Garcia
  • Pamela Leal
  • Carmen Ili
  • Pablo Letelier
  • Hector Alvarez
  • Carmen G Ili
  • Alejandra Sandoval
  • Raul Sanchez
  • Ramon Silva
  • Deepthi Telikicherla
  • Kathleen P Saavedra
  • Roxana Schillaci
  • Pablo Guzman
  • Jaime Lopez
  • Angélica Melo
  • Juan Carlos Roa S
  • Kurt Buchegger
  • Tamara Viscarra
  • Ismael Riquelme
  • Rene Hoffstetter
  • Alejandra Andana
  • Kathleen Saavedra
  • Javier Retamal
  • Daniela León
  • Jorge Palazzi
  • Jagadeesha Maharudraiah
  • Eduardo H Charreau
  • Florencia Cayrol
  • Isabel Frahm
  • Y L Ramachandra
  • Wendy Beguelin
  • Cecilia J Proietti
  • Akhilesh Pandey
  • Manoj Kumar Kashyap
  • Sujatha Mohan
  • Viviana Pineda
  • Arivusudar Marimuthu
  • María C Díaz Flaqué
  • Priscilla M Brebi
  • Esteban Maronna
  • Patricia V Elizalde
  • Eugenio Suarez
  • Priscila Brebi
  • Italo Capurro
  • Pedram Argani
  • Alejandro Corvalan
  • Georg Feldmann
  • Alfonso Diaz
  • Luis Ibanez
  • Francisco Murillo
  • Jennifer Edwards
  • Robert Beaty
  • Michael Mullendore
  • Fernando Pimentel
  • Gregory J Riggins
  • Angélica Melo A
  • Ricardo Martínez S
  • Iván Roa E
  • Italo Capurro V
  • Sonia Montenegro
  • Gilda Ibacache S

Detail Information

Publications24

  1. pmc Overexpression of ribosome binding protein 1 (RRBP1) in breast cancer
    Deepthi Telikicherla
    Institute of Bioinformatics, International Tech Park, Bangalore 560 066, India
    Clin Proteomics 9:7. 2012
    ..This study also demonstrates how the integration of biological data from available resources in conjunction with systematic evaluation approaches can be successfully applied to clinical proteomics...
  2. pmc Epigenetic alterations in preneoplastic and neoplastic lesions of the cervix
    Kathleen P Saavedra
    Universidad de La Frontera, School of Medicine, Department of Pathology, Molecular Pathology Laboratory, BIOREN CEGIN, Temuco, Chile
    Clin Epigenetics 4:13. 2012
    ..This paper reviews recent epigenetics research progress in the CC study, and tries to depict the relationships between CC and DNA methylation, histone modification, as well as microRNA regulations...
  3. pmc DNA promoter methylation as a diagnostic and therapeutic biomarker in gallbladder cancer
    Pablo Letelier
    Universidad de La Frontera, School of Medicine, Department of Pathology, Molecular Pathology Laboratory, BIOREN CEGIN, Temuco, Chile
    Clin Epigenetics 4:11. 2012
    ..Determining DNA methylation patterns would allow them to be used as biomarkers for the early detection, diagnosis, prognosis and/or therapeutic selection in gallbladder cancer...
  4. ncbi request reprint [Microsatellite instability and loss of heterozygosity in neoplastic and preneoplastic gastric lesions]
    Juan Carlos Roa
    Departamento de Patologia, Universidad de La Frontera, Temuco, Chile
    Rev Med Chil 131:1227-36. 2003
    ..7 per 105 in males in the IX region. A chain of genetic and morphological events precedes the intestinal type of gastric carcinoma. One of them is the called multifocal atrophic gastritis often associated with intestinal metaplasia...
  5. ncbi request reprint [Microsatellite instability and human papilloma virus genotypes in preneoplastic and neoplastic uterine cervix lesions]
    Juan Carlos Roa S
    Departamento de Anatomia Patologica, Facultad de Medicina, Universidad de La Frontera, Temuco, Chile
    Rev Med Chil 135:37-44. 2007
    ..The association between some specific human papilloma virus (HPV) types and cervix cancer is well known. However, the genetic conditions that favor the development of cervical cancer are less well known...
  6. ncbi request reprint Prognostic factors of phyllodes tumor of the breast
    Juan Carlos Roa
    Department of Pathology, Universidad de La Frontera, Temuco, Chile
    Pathol Int 56:309-14. 2006
    ..00001) were prognostic factors of poor survival. Tumoral grade and some clinical-morphological characteristics of patients with phyllodes tumors have a significant impact on the prediction of its biological behavior...
  7. ncbi request reprint [Frequency of K-ras mutation in biliary and pancreatic tumors]
    Juan Carlos Roa
    Departamento de Anatomia Patologica, Facultad de Medicina, Universidad de La Frontera
    Rev Med Chil 133:1434-40. 2005
    ..The ras gene family (H-ras, N-ras and K-ras) are oncogenes that mutate frequently in human cancer, specially in tumors of the biliary tract and pancreas...
  8. ncbi request reprint [Promoter methylation profile in gastric cancer]
    Juan Carlos Roa
    Departamento de Anatomia Patologica, Universidad de La Frontera, Temuco, Chile
    Rev Med Chil 133:874-80. 2005
    ..This genetic-molecular pathway for cancer may separate a subset of patients with different prognoses and eventually different responses to specific therapies...
  9. ncbi request reprint [Detection of bone marrow micrometastases in patients with gallbladder cancer]
    Juan C Roa
    Departamento de Anatomia Patologica, Facultad de Medicina, Universidad de La Frontera, Temuco, Chile
    Rev Med Chil 132:1489-98. 2004
    ..There is a very strong documented correlation between the appearance of cancer cells in blood and occurrence of metastasis in gastrointestinal cancer...
  10. ncbi request reprint [Inactivation of CDKN2A gene (p16) in gallbladder carcinoma]
    Juan Carlos Roa
    Departamento de Anatomá Patológica, Universidad de La Frontera, Temuco, Chile
    Rev Med Chil 132:1369-76. 2004
    ..The CDKN2A gene encodes a cyclin dependent kinase inhibitor, p16, which promotes cell cycle arrest. Methylation of the promoter region transcriptionally inactivates the gene...
  11. ncbi request reprint [Promoter methylation profile in breast cancer]
    Juan Carlos Roa
    Departamento de Anatomia Patologica, Facultad de Medicina, Universidad de La Frontera, Temuco, Chile
    Rev Med Chil 132:1069-77. 2004
    ..Genomic DNA methylation, mutations and allelic deletions explain the inactivation of genes involved in cell proliferation and cell cycle control mechanisms...
  12. ncbi request reprint [Genetic changes in chronic gastritis: study of microsatellite instability and loss of heterozygosity]
    Juan Carlos Roa
    Departamento de Anatomia Patologica, Facultad de Medicina, Universidad de La Frontera, Temuco, Chile
    Rev Med Chil 131:1365-74. 2003
    ..Multifocal chronic gastritis, associated to intestinal metaplasia, is considered a preneoplastic lesion, closely associated to intestinal type gastric cancer...
  13. pmc Clinical relevance of ErbB-2/HER2 nuclear expression in breast cancer
    Roxana Schillaci
    Instituto de Biología y Medicina Experimental IBYME, CONICET, Buenos Aires, Argentina
    BMC Cancer 12:74. 2012
    ..In this study we assessed the clinical significance of ErbB-2 nuclear localization in primary invasive breast cancer. The reporting recommendations for tumor marker prognostic studies (REMARK) guidelines were used as reference...
  14. doi request reprint Immunohistochemical expression of phospho-mTOR is associated with poor prognosis in patients with gallbladder adenocarcinoma
    Pamela Leal
    Department of Pathology, School of Medicine, CEGINBIOREN, University of La Frontera, Temuco, Chile
    Arch Pathol Lab Med 137:552-7. 2013
    ..Its regulation is frequently altered in various tumors and is an attractive target for cancer therapy; however, its status in GBC remains unclear...
  15. doi request reprint Connective tissue growth factor immunohistochemical expression is associated with gallbladder cancer progression
    Patricia Garcia
    Department of Pathology, School of Medicine, CEGIN BIOREN, Universidad de La Frontera, Temuco, Chile
    Arch Pathol Lab Med 137:245-50. 2013
    ..Objective.- To evaluate the expression level of CTGF in benign and malignant lesions of gallbladder and its correlation with clinicopathologic features and GBC prognosis...
  16. pmc Inhibition of connective tissue growth factor (CTGF/CCN2) in gallbladder cancer cells leads to decreased growth in vitro
    Patricia Garcia
    Department of Pathology, School of Medicine, BIOREN CEGIN, Universidad de La Frontera, Temuco, Chile
    Int J Exp Pathol 94:195-202. 2013
    ..05). An increased p27 expression was observed in G-415 cells with loss of CTGF function. Our results suggest that high expression of this protein in gallbladder cancer may confer a growth advantage for neoplastic cells...
  17. ncbi request reprint Immunohistochemical expression of vascular endothelial growth factor a in advanced gallbladder carcinoma
    Pablo Letelier
    Molecular Pathology Laboratory, Department of Pathology, School of Medicine, Scientific and Technological Bioresource Nucleus BIOREN, Universidad de La Frontera, Temuco Department of Pathology, School of Medicine, Pontificia Universidad Catolica de Chile, Santiago, Chile
    Appl Immunohistochem Mol Morphol 22:530-6. 2014
    ....
  18. doi request reprint Genotyping of human papillomavirus in cervical intraepithelial neoplasia in a high-risk population
    Carmen G Ili
    Department of Pathology, Molecular Pathology Laboratory, School of Medicine, University of La Frontera, Temuco, Chile
    J Med Virol 83:833-7. 2011
    ..These results show that most of the preneoplastic lesions of the cervix (60%) were associated with HPV 16 and/or HPV 18, supporting the implementation of an HPV vaccination program in this high-risk population...
  19. ncbi request reprint [Human papillomavirus genotyping in cervical adenocarcinoma in the Region of La Araucania-Chile]
    Angélica Melo
    Universidad de La Frontera, Facultad de Medicina, Departamento de Anatomia Patologica
    Rev Chilena Infectol 27:297-301. 2010
    ..For viral typing restriction enzymes (Rsa I, Dde I, Pst I) and DNA sequencing were used. Viral DNA was detected by nested L1 PCR in 100% of biopsies; 38/44 cases could be typed: 81.6% HPV16; 13.2% HPV 18; 2.6% VPH 33 and 2.6% HPV 18/33...
  20. doi request reprint [Detection of human papilloma virus infection in men]
    Ramon Silva
    Universidad de La Frontera, Temuco, Chile
    Rev Chilena Infectol 30:186-92. 2013
    ..Given that the highest infection rates are in Africa and Latin America, the aim of this review is to describe the pathogenesis of HPV and its main detection techniques in men...
  21. ncbi request reprint Evaluation of ZAR1 and SFRP4 methylation status as potentials biomarkers for diagnosis in cervical cancer: exploratory study phase I
    Priscilla Brebi
    Molecular Pathology Laboratory, Department of Pathology
    Biomarkers 19:181-8. 2014
    ..001) and preneoplastics lesions (p < 0.01). Discussion: qMSP quantify methylation levels and have high sensitivity and specificity. Conclusion: ZAR1 and SFRP4 qMSP could be used as potential biomarker for CC diagnosis. ..
  22. ncbi request reprint Serial analysis of gene expression identifies connective tissue growth factor expression as a prognostic biomarker in gallbladder cancer
    Hector Alvarez
    Department of Pathology, Pontificia Universidad Catolica de Chile, Santiago, Chile
    Clin Cancer Res 14:2631-8. 2008
    ..Gallbladder cancer (GBC) is an uncommon neoplasm in the United States, but one with high mortality rates. This malignancy remains largely understudied at the molecular level such that few targeted therapies or predictive biomarkers exist...
  23. doi request reprint Squamous cell and adenosquamous carcinomas of the gallbladder: clinicopathological analysis of 34 cases identified in 606 carcinomas
    Juan C Roa
    Department of Pathology, Universidad de La Frontera, Temuco, Chile
    Mod Pathol 24:1069-78. 2011
    ..Most patients died within a few months; however, those few who were alive beyond 2 years in this cohort experienced long-term survival...