Andrew F G Quest

Summary

Affiliation: Universidad de Chile
Country: Chile

Publications

  1. ncbi request reprint Caveolin-1 in cell migration and metastasis
    S Nunez-Wehinger
    Independencia 1027, Facultad de Medicina, Universidad de Chile, Santiago, Chile
    Curr Mol Med 14:255-74. 2014
  2. ncbi request reprint The caveolin-1 connection to cell death and survival
    A F G Quest
    Laboratorio de Comunicaciones Celulares, Centro de Estudios Moleculares de la Célula CEMC, Facultad de Medicina, Universidad de Chile, Santiago, Chile
    Curr Mol Med 13:266-81. 2013
  3. doi request reprint Caveolin-1: an ambiguous partner in cell signalling and cancer
    Andrew F G Quest
    FONDAP Centre for Molecular Studies of the Cell, Facultad de Medicina, Universidad de Chile, Santiago, Chile
    J Cell Mol Med 12:1130-50. 2008
  4. ncbi request reprint Caveolins, caveolae, and lipid rafts in cellular transport, signaling, and disease
    Andrew F G Quest
    Centro FONDAP de Estudios Molecualrs de la Célula, Programa de Biologia Celular y Molecular, Universidad de Chile, Indepencia 1027, Santiago, Chile
    Biochem Cell Biol 82:129-44. 2004
  5. pmc Caveolin-1-mediated suppression of cyclooxygenase-2 via a beta-catenin-Tcf/Lef-dependent transcriptional mechanism reduced prostaglandin E2 production and survivin expression
    Diego A Rodriguez
    Fondo de Investigación Avanzada en Areas Prioritarias, Center for Molecular Studies of the Cell, Departmento de Cirugia, Hospital Clinico, Universidad de Chile, Santiago, Chile
    Mol Biol Cell 20:2297-310. 2009
  6. pmc Thy-1-mediated cell-cell contact induces astrocyte migration through the engagement of αVβ3 integrin and syndecan-4
    Milene Kong
    Instituto de Ciencias Biomedicas, Universidad de Chile, Santiago, Chile
    Biochim Biophys Acta 1833:1409-20. 2013
  7. pmc E-cadherin is required for caveolin-1-mediated down-regulation of the inhibitor of apoptosis protein survivin via reduced beta-catenin-Tcf/Lef-dependent transcription
    Vicente A Torres
    FONDAP Center for Molecular Studies of the Cell, Facultad de Medicina, Universidad de Chile, Av Independencia 1027, Santiago, Chile
    Mol Cell Biol 27:7703-17. 2007
  8. pmc Astrocytic αVβ3 integrin inhibits neurite outgrowth and promotes retraction of neuronal processes by clustering Thy-1
    Rodrigo Herrera-Molina
    Programa de Biologia Celular y Molecular, Instituto de Ciencias Biomedicas, Facultad de Medicina, Universidad de Chile, Santiago, Chile
    PLoS ONE 7:e34295. 2012
  9. doi request reprint Calcium and mitochondrial metabolism in ceramide-induced cardiomyocyte death
    Valentina Parra
    Centro de Estudios Moleculares de la Célula, Facultad de Ciencias Químicas y Farmacéuticas and Facultad Medicina, Universidad de Chile, Santiago, Chile
    Biochim Biophys Acta 1832:1334-44. 2013
  10. pmc Direct Thy-1/alphaVbeta3 integrin interaction mediates neuron to astrocyte communication
    Tamara Hermosilla
    Program of Cell and Molecular Biology, FONDAP, Center for Molecular Studies of the Cell CEMC, Institute of Biomedical Sciences ICBM, Facultad de Medicina, Universidad de Chile, Santiago, Chile
    Biochim Biophys Acta 1783:1111-20. 2008

Collaborators

Detail Information

Publications37

  1. ncbi request reprint Caveolin-1 in cell migration and metastasis
    S Nunez-Wehinger
    Independencia 1027, Facultad de Medicina, Universidad de Chile, Santiago, Chile
    Curr Mol Med 14:255-74. 2014
    ..Models are provided summarizing possible explanations for these dramatic changes in function, as well as mechanisms by which this may be achieved. ..
  2. ncbi request reprint The caveolin-1 connection to cell death and survival
    A F G Quest
    Laboratorio de Comunicaciones Celulares, Centro de Estudios Moleculares de la Célula CEMC, Facultad de Medicina, Universidad de Chile, Santiago, Chile
    Curr Mol Med 13:266-81. 2013
    ..Here, we will focus on discussing how Caveolin-1 modulates cell death and survival pathways and how this may contribute to a better understanding of the ambiguous role this protein plays in cancer...
  3. doi request reprint Caveolin-1: an ambiguous partner in cell signalling and cancer
    Andrew F G Quest
    FONDAP Centre for Molecular Studies of the Cell, Facultad de Medicina, Universidad de Chile, Santiago, Chile
    J Cell Mol Med 12:1130-50. 2008
    ..In particular, evidence indicating that caveolin-1 function is cell context dependent will be discussed...
  4. ncbi request reprint Caveolins, caveolae, and lipid rafts in cellular transport, signaling, and disease
    Andrew F G Quest
    Centro FONDAP de Estudios Molecualrs de la Célula, Programa de Biologia Celular y Molecular, Universidad de Chile, Indepencia 1027, Santiago, Chile
    Biochem Cell Biol 82:129-44. 2004
    ..Here, more recent data addressing the role of caveolin-1 in cellular signaling and the development of diseases like cancer will be preferentially discussed...
  5. pmc Caveolin-1-mediated suppression of cyclooxygenase-2 via a beta-catenin-Tcf/Lef-dependent transcriptional mechanism reduced prostaglandin E2 production and survivin expression
    Diego A Rodriguez
    Fondo de Investigación Avanzada en Areas Prioritarias, Center for Molecular Studies of the Cell, Departmento de Cirugia, Hospital Clinico, Universidad de Chile, Santiago, Chile
    Mol Biol Cell 20:2297-310. 2009
    ....
  6. pmc Thy-1-mediated cell-cell contact induces astrocyte migration through the engagement of αVβ3 integrin and syndecan-4
    Milene Kong
    Instituto de Ciencias Biomedicas, Universidad de Chile, Santiago, Chile
    Biochim Biophys Acta 1833:1409-20. 2013
    ....
  7. pmc E-cadherin is required for caveolin-1-mediated down-regulation of the inhibitor of apoptosis protein survivin via reduced beta-catenin-Tcf/Lef-dependent transcription
    Vicente A Torres
    FONDAP Center for Molecular Studies of the Cell, Facultad de Medicina, Universidad de Chile, Av Independencia 1027, Santiago, Chile
    Mol Cell Biol 27:7703-17. 2007
    ..Thus, the absence of E-cadherin severely compromises the ability of caveolin-1 to develop activities potentially relevant to its role as a tumor suppressor...
  8. pmc Astrocytic αVβ3 integrin inhibits neurite outgrowth and promotes retraction of neuronal processes by clustering Thy-1
    Rodrigo Herrera-Molina
    Programa de Biologia Celular y Molecular, Instituto de Ciencias Biomedicas, Facultad de Medicina, Universidad de Chile, Santiago, Chile
    PLoS ONE 7:e34295. 2012
    ..We propose that these events participate in bi-directional astrocyte-neuron communication relevant to axonal repair after neuronal damage...
  9. doi request reprint Calcium and mitochondrial metabolism in ceramide-induced cardiomyocyte death
    Valentina Parra
    Centro de Estudios Moleculares de la Célula, Facultad de Ciencias Químicas y Farmacéuticas and Facultad Medicina, Universidad de Chile, Santiago, Chile
    Biochim Biophys Acta 1832:1334-44. 2013
    ..These biochemical events increase cytosolic Ca(2+) levels and trigger cardiomyocyte death via the activation of calpains...
  10. pmc Direct Thy-1/alphaVbeta3 integrin interaction mediates neuron to astrocyte communication
    Tamara Hermosilla
    Program of Cell and Molecular Biology, FONDAP, Center for Molecular Studies of the Cell CEMC, Institute of Biomedical Sciences ICBM, Facultad de Medicina, Universidad de Chile, Santiago, Chile
    Biochim Biophys Acta 1783:1111-20. 2008
    ..This interaction was promoted by divalent cations and was species-independent. Together, these results demonstrate that the alphavbeta3 integrin heterodimer interacts directly with Thy-1 present on neuronal cells to stimulate astrocytes...
  11. pmc E-cadherin determines Caveolin-1 tumor suppression or metastasis enhancing function in melanoma cells
    Lorena Lobos-González
    Laboratorio de Comunicaciones Celulares, Centro de Estudios Moleculares de la Célula CEMC, Facultad de Medicina, Universidad de Chile, Santiago, Chile
    Pigment Cell Melanoma Res 26:555-70. 2013
    ..Finally, consistent with the notion that CAV1 participates in switching human melanomas to a more malignant phenotype, elevated levels of CAV1 expression correlated with enhanced migration and Rac-1 activation in these cells. ..
  12. doi request reprint Helicobacter pylori-induced loss of survivin and gastric cell viability is attributable to secreted bacterial gamma-glutamyl transpeptidase activity
    Manuel Valenzuela
    Laboratory of Cellular Communication, Center for Molecular Studies of the Cell, Universidad de Chile, Santiago, Chile
    J Infect Dis 208:1131-41. 2013
    ..Moreover, experiments with the GGT inhibitor 6-diazo-5-oxo-l-norleucine and purified recombinant GGT protein indicated that secreted bacterial GGT activity was required and sufficient to induce these effects. ..
  13. ncbi request reprint Caveolin-1 controls cell proliferation and cell death by suppressing expression of the inhibitor of apoptosis protein survivin
    Vicente A Torres
    Laboratory of Cellular Communications, FONDAP Center for Molecular Studies of the Cell CEMC, Facultad de Medicina, Universidad de Chile, Av Independencia 1027, Santiago, Chile
    J Cell Sci 119:1812-23. 2006
    ..Taken together, these results suggest that anti-proliferative and pro-apoptotic properties of caveolin-1 may be attributed to reduced survivin expression via a mechanism involving diminished beta-catenin-Tcf/Lef-dependent transcription...
  14. pmc Endoplasmic reticulum and the unfolded protein response: dynamics and metabolic integration
    Roberto Bravo
    Center for Molecular Studies of the Cell, University of Chile, Santiago, Chile
    Int Rev Cell Mol Biol 301:215-90. 2013
    ..Here, we review the distinct functions of the ER and UPR from a metabolic point of view, highlighting their association with prevalent pathologies...
  15. doi request reprint Ceramide-induced formation of ROS and ATP depletion trigger necrosis in lymphoid cells
    Joan Villena
    Centro FONDAP Estudios Moleculares de la Celula CEMC, Instituto Ciencias Biomedicas, Facultad de Medicina, Universidad de Chile, Santiago, Chile
    Free Radic Biol Med 44:1146-60. 2008
    ..Furthermore, ceramide-induced necrotic cell death is linked here to loss of mitochondrial membrane potential, production of ROS, and intracellular ATP depletion...
  16. doi request reprint TRPM4 enhances cell proliferation through up-regulation of the β-catenin signaling pathway
    Ricardo Armisen
    Centro de Estudios Moleculares de la Célula, Facultad de Medicina, Universidad de Chile, Santiago, Chile
    J Cell Physiol 226:103-9. 2011
    ..Our results identify TRPM4 as an important, unanticipated regulator of the β-catenin pathway, where aberrant signaling is frequently associated with cancer...
  17. pmc Caveolin-1-enhanced motility and focal adhesion turnover require tyrosine-14 but not accumulation to the rear in metastatic cancer cells
    Hery Urra
    Laboratory of Cellular Communication, Center for Molecular Studies of the Cell, Faculty of Medicine, Universidad de Chile, Santiago, Chile
    PLoS ONE 7:e33085. 2012
    ..Thus, expression and phosphorylation, but not polarization of caveolin-1 favor the highly mobile phenotype of metastatic cells...
  18. doi request reprint Protein kinase CK2 promotes cancer cell viability via up-regulation of cyclooxygenase-2 expression and enhanced prostaglandin E2 production
    Roger Yefi
    Institute of Biomedical Sciences ICBM, Faculty of Medicine, University of Chile, Santiago, Chile
    J Cell Biochem 112:3167-75. 2011
    ..Altogether, these findings provide new insight to the role of CK2 in cancer by up-regulating COX-2 expression and thereby PGE2 production...
  19. ncbi request reprint Beyond apoptosis: nonapoptotic cell death in physiology and disease
    Claudio A Hetz
    Instituto de Ciencias Biomedicas, Universidad de Chile, Santiago, Chile
    Biochem Cell Biol 83:579-88. 2005
    ..In this review, we discuss recent data suggesting that canonical apoptotic pathways, including death-receptor signaling, control caspase-dependent and -independent cell-death pathways...
  20. ncbi request reprint Cell death by necrosis, a regulated way to go
    Mauricio Henriquez
    Centro FONDAP de Estudios Moleculares de la Célula CEMC, Instituto de Ciencias Biomedicas, Facultad de Medicina, Universidad de Chile, Santiago, Chile
    Curr Mol Med 8:187-206. 2008
    ..Emphasis is laid on summarizing our understanding of events that permit switching between cell death modes and how they connect to necrosis. Finally, potential implications for the treatment of some disease states are mentioned...
  21. doi request reprint Aberrant localization of fusion receptors involved in regulated exocytosis in salivary glands of Sjögren's syndrome patients is linked to ectopic mucin secretion
    María José Barrera
    Faculty of Medicine, Institute of Biomedical Sciences ICBM, University of Chile, Postal Code 8389100, Santiago, Chile
    J Autoimmun 39:83-92. 2012
    ..In the context of SS, such aberrantly localized mucins are likely to favor a pro-inflammatory response, which may represent an important initial step in the pathogenesis of this disease...
  22. doi request reprint Progesterone utilizes distinct membrane pools of tissue factor to increase coagulation and invasion and these effects are inhibited by TFPI
    Soledad Henríquez
    Departamento de Fisiologia, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, Alameda 340, Santiago, Chile
    J Cell Physiol 226:3278-85. 2011
    ..However, the progesterone up-regulated TF protein may be involved in progesterone-mediated breast cancer cell invasion, which TFPI also inhibits...
  23. doi request reprint FasL-triggered death of Jurkat cells requires caspase 8-induced, ATP-dependent cross-talk between Fas and the purinergic receptor P2X(7)
    Adam Aguirre
    Centro de Estudios Moleculares de la Célula, Universidad de Chile, Santiago, Chile
    J Cell Physiol 228:485-93. 2013
    ..Thus, a hitherto unsuspected route was uncovered connecting the extrinsic to the intrinsic pathway to amplify death signals emanating from the Fas receptor in type II cells...
  24. ncbi request reprint Caveolae and caveolae-like membrane domains in cellular signaling and disease: identification of downstream targets for the tumor suppressor protein caveolin-1
    Florent Bender
    Instituto de Ciencias Biomedicas, Facultad de Medicina, Universidad de Chile, Independencia 1027, Santiago 7, Chile
    Biol Res 35:151-67. 2002
    ..Evidence demonstrating such a role for caveolin-1 in human colon carcinoma cells will be discussed together with data from microarray experiments seeking to identify caveolin-1 target genes responsible for such behavior...
  25. pmc Inverse susceptibility to oxidative death of lymphocytes obtained from Alzheimer's patients and skin cancer survivors: increased apoptosis in Alzheimer's and reduced necrosis in cancer
    Maria I Behrens
    Departamento de Neurologia y Neurocirugia, Hospital Clinico Universidad de Chile, Santiago, Chile
    J Gerontol A Biol Sci Med Sci 67:1036-40. 2012
    ....
  26. ncbi request reprint Depolarization of skeletal muscle cells induces phosphorylation of cAMP response element binding protein via calcium and protein kinase Calpha
    Cesar Cardenas
    Centro de Estudios Moleculares de la Célula, Instituto de Ciencias Biomedicas, Facultad de Medicina, Universidad de Chile, Independencia 1027, Santiago 7, Chile
    J Biol Chem 279:39122-31. 2004
    ..These results strongly implicate nuclear PKCalpha translocation in CREB phosphorylation induced by skeletal muscle membrane depolarization...
  27. doi request reprint Endoplasmic reticulum: ER stress regulates mitochondrial bioenergetics
    Roberto Bravo
    Centro Estudios Moleculares de la Célula, Facultad Ciencias Quimicas y Farmaceuticas, Universidad de Chile, Santiago, Chile
    Int J Biochem Cell Biol 44:16-20. 2012
    ..Finally, we highlight how dysregulation of ER-mitochondrial calcium homeostasis during prolonged ER stress is emerging as a novel mechanism implicated in the onset of metabolic disorders...
  28. doi request reprint Is survivin the potential Achilles' heel of cancer?
    Alvaro Lladser
    Laboratory of Gene Immunotherapy, Fundación Ciencia para la Vida, Santiago, Chile
    Adv Cancer Res 111:1-37. 2011
    ....
  29. doi request reprint Local control of nuclear calcium signaling in cardiac myocytes by perinuclear microdomains of sarcolemmal insulin-like growth factor 1 receptors
    Cristian Ibarra
    Centro de Estudios Moleculares de la Célula, Facultad de Ciencias Quimicas y Farmaceuticas, Universidad de Chile, Santiago, Chile
    Circ Res 112:236-45. 2013
    ....
  30. doi request reprint Rab5 activation promotes focal adhesion disassembly, migration and invasiveness in tumor cells
    Pablo Mendoza
    Department of Basic and Communitarian Sciences, Faculty of Dentistry, Universidad de Chile, Santiago 8380 492, Chile
    J Cell Sci 126:3835-47. 2013
    ..Taken together, these observations show that Rab5 activation is required to enhance cancer cell migration and invasion by promoting focal adhesion disassembly. ..
  31. doi request reprint Helicobacter pylori-induced loss of the inhibitor-of-apoptosis protein survivin is linked to gastritis and death of human gastric cells
    Manuel Valenzuela
    Laboratory of Cellular Communication, Fondo de Investigación Avanzada en Areas Prioritarias, Center for Molecular Studies of the Cell, Facultad de Medicina, Instituto de Ciencias Biomedicas, Universidad de Chile, Pontificia Universidad Catolica de Chile, Santiago, Chile
    J Infect Dis 202:1021-30. 2010
    ..Finally, overexpression of survivin in human gastric cells was sufficient to reduce cell death after infection. Taken together, these findings implicate survivin as an important survival factor in the gastric mucosa of humans...
  32. ncbi request reprint Aggregation of integrins and RhoA activation are required for Thy-1-induced morphological changes in astrocytes
    Ana Maria Avalos
    Programs of Morphology and Cell and Molecular Biology, FONDAP Center for Molecular Studies of the Cell, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Independencia 1027 A, Santiago, Chile
    J Biol Chem 279:39139-45. 2004
    ..Together, these results indicate that Thy-1-mediated astrocyte stimulation depended on beta(3) integrin clustering and the resulting increase in RhoA activity...
  33. doi request reprint Alterations in type I hemidesmosome components suggestive of epigenetic control in the salivary glands of patients with Sjögren's syndrome
    Sergio Gonzalez
    University of Chile, Santiago, Chile
    Arthritis Rheum 63:1106-15. 2011
  34. ncbi request reprint Cell volume regulation in response to hypotonicity is impaired in HeLa cells expressing a protein kinase Calpha mutant lacking kinase activity
    Marcela Hermoso
    Instituto de Ciencias Biomédicas and Centro de Estudios Moleculares de la Célula Facultad de Medicina, Universidad de Chile, Santiago 6530499, Santiago, Chile
    J Biol Chem 279:17681-9. 2004
    ..These findings strongly implicate PKC alpha as a critical regulatory element that is required for efficient regulatory volume decrease in HeLa cells...
  35. ncbi request reprint Introduction to supramolecular complex formation in cell signaling and disease
    Lisette Leyton
    Program of Morphology, Laboratory of Cellular Communication, ICBM Instituto de Ciencias Biomédicas Faculty of Medicine, University of Chile, Independencia 1027, Santiago, Chile
    Biol Res 35:117-25. 2002
  36. ncbi request reprint Caspase-dependent initiation of apoptosis and necrosis by the Fas receptor in lymphoid cells: onset of necrosis is associated with delayed ceramide increase
    Claudio A Hetz
    Instituto de Ciencias Biomedicas, Facultad de Medicina, Universidad de Chile, Santiago, Chile
    J Cell Sci 115:4671-83. 2002
    ..Thus, delayed elevation of ceramide is proposed to promote necrosis in those Fas-stimulated cells where caspase-8 activation was insufficient to trigger caspase-3-dependent apoptosis...
  37. ncbi request reprint Caveolin-1-mediated post-transcriptional regulation of inducible nitric oxide synthase in human colon carcinoma cells
    Emanuela Felley-Bosco
    Institute of Pharmacology and Toxicology, University of Lausanne, Lausanne, Switzerland
    Biol Res 35:169-76. 2002
    ..These observations are important in the context of tumor biology, since down-regulation of caveolin-1 is predicted to promote uncontrolled iNOS activity, genotoxic damage and thereby facilitate tumor development in humans...