Andrew F G Quest


Affiliation: Universidad de Chile
Country: Chile


  1. Guerrero S, Inostroza Riquelme M, Contreras Orellana P, Díaz García V, Lara P, Vivanco Palma A, et al. Curcumin-loaded nanoemulsion: a new safe and effective formulation to prevent tumor reincidence and metastasis. Nanoscale. 2018;10:22612-22622 pubmed publisher
    ..In addition, other routes of administration/protocols could also be proposed to treat/prevent malignant tumors in patients. ..
  2. Díaz García V, Guerrero S, Diaz Valdivia N, Lobos González L, Kogan M, Pérez Donoso J, et al. Biomimetic quantum dot-labeled B16F10 murine melanoma cells as a tool to monitor early steps of lung metastasis by in vivo imaging. Int J Nanomedicine. 2018;13:6391-6412 pubmed publisher
    ..The methodology described here represents a useful alternative for monitoring initial events during tumor cell metastasis. ..
  3. Diaz J, Mendoza P, Ortiz R, Diaz N, Leyton L, Stupack D, et al. Rab5 is required in metastatic cancer cells for Caveolin-1-enhanced Rac1 activation, migration and invasion. J Cell Sci. 2014;127:2401-6 pubmed publisher
    ..In summary, these studies identify a novel CAV1-Rab5-Rac1 signaling axis, whereby CAV1 prevents Rab5 inactivation, leading to increased Rac1 activity and enhanced tumor cell migration and invasion. ..
  4. Bravo Sagua R, Parra V, Ortiz Sandoval C, Navarro Marquez M, Rodriguez A, Diaz Valdivia N, et al. Caveolin-1 impairs PKA-DRP1-mediated remodelling of ER-mitochondria communication during the early phase of ER stress. Cell Death Differ. 2018;: pubmed publisher
    ..In conclusion, caveolin-1 precludes stress-induced protein kinase A-dependent remodelling of endoplasmic reticulum-mitochondria communication. ..
  5. Quest A, Gutierrez Pajares J, Torres V. Caveolin-1: an ambiguous partner in cell signalling and cancer. J Cell Mol Med. 2008;12:1130-50 pubmed publisher
    ..In particular, evidence indicating that caveolin-1 function is cell context dependent will be discussed. ..
  6. Inostroza Riquelme M, Vivanco A, Lara P, Guerrero S, Salas Huenuleo E, Chamorro A, et al. Encapsulation of Gold Nanostructures and Oil-in-Water Nanocarriers in Microgels with Biomedical Potential. Molecules. 2018;23: pubmed publisher
    ..We conclude that these results will be of interest to design hydrogel formulations with therapeutic applications. ..
  7. Lagos Cabré R, Brenet M, Diaz J, Pérez R, Pérez L, Herrera Molina R, et al. Intracellular Ca2+ Increases and Connexin 43 Hemichannel Opening Are Necessary but Not Sufficient for Thy-1-Induced Astrocyte Migration. Int J Mol Sci. 2018;19: pubmed publisher
    ..Thus, we suggest that proinflammatory stimuli prompt astrocytes to respond to migratory signals of neuronal cells. ..
  8. Wehinger S, Ortiz R, Díaz M, Aguirre A, Valenzuela M, Llanos P, et al. Phosphorylation of caveolin-1 on tyrosine-14 induced by ROS enhances palmitate-induced death of beta-pancreatic cells. Biochim Biophys Acta. 2015;1852:693-708 pubmed publisher
    ..Thus, caveolin-1 expression promotes palmitate-induced ROS-dependent apoptosis in MIN6 cells in a manner requiring Src family kinase mediated tyrosine-14 phosphorylation. ..
  9. Sanhueza C, Wehinger S, Castillo Bennett J, Valenzuela M, Owen G, Quest A. The twisted survivin connection to angiogenesis. Mol Cancer. 2015;14:198 pubmed publisher
    ..Finally, we elaborate on the possibility that this mechanism operating in cancer cells may contribute to enhanced tumor vascularization by vasculogenic mimicry together with conventional angiogenesis. ..

More Information


  1. Costantino V, Lobos González L, Ibañez J, Fernández D, Cuello Carrión F, Valenzuela M, et al. Dehydroleucodine inhibits tumor growth in a preclinical melanoma model by inducing cell cycle arrest, senescence and apoptosis. Cancer Lett. 2016;372:10-23 pubmed publisher
    ..Extrapolation beyond experimental time points revealed that DhL administration following preventive and therapeutic protocols is predicted to be more effective than simultaneous treatments with DhL in restricting tumor growth. ..
  2. Fernández J, Rodríguez D, Valenzuela M, Calderon C, Urzúa U, Munroe D, et al. Survivin expression promotes VEGF-induced tumor angiogenesis via PI3K/Akt enhanced β-catenin/Tcf-Lef dependent transcription. Mol Cancer. 2014;13:209 pubmed publisher
  3. Diaz Valdivia N, Bravo D, Huerta H, Henríquez S, Gabler F, Vega M, et al. Enhanced caveolin-1 expression increases migration, anchorage-independent growth and invasion of endometrial adenocarcinoma cells. BMC Cancer. 2015;15:463 pubmed publisher
    ..Our study shows that elevated CAV1, observed in patients with endometrial cancer, is linked to enhanced malignancy of endometrial cancer cells, as evidenced by increased migration, invasion and anchorage-independent growth. ..
  4. request reprint
    Quest A, Lobos González L, Nunez S, Sanhueza C, Fernandez J, Aguirre A, et al. The caveolin-1 connection to cell death and survival. Curr Mol Med. 2013;13:266-81 pubmed
    ..Here, we will focus on discussing how Caveolin-1 modulates cell death and survival pathways and how this may contribute to a better understanding of the ambiguous role this protein plays in cancer. ..