Miguel L O'Ryan

Summary

Affiliation: Universidad de Chile
Country: Chile

Publications

  1. doi request reprint Update on Rotarix: an oral human rotavirus vaccine
    Miguel O'Ryan
    Professor and Associate Director, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Santiago, Chile
    Expert Rev Vaccines 8:1627-41. 2009
  2. ncbi request reprint Enteric viruses in wastewaters: an interesting approach to evaluate the potential impact of rotavirus vaccination on viral circulation
    Miguel L O'Ryan
    University of Chile, Diagonal Paraguay 265, Office 1403, Santiago, Centro, Chile
    Expert Rev Vaccines 11:419-22. 2012
  3. doi request reprint A Multi-Component Meningococcal Serogroup B Vaccine (4CMenB): The Clinical Development Program
    Miguel O'Ryan
    Programa de Microbiología y Micología, Instituto de Ciencias Biomedicas, Facultad de Medicina, Universidad de Chile, Avda Independencia 1027, Santiago, Chile
    Drugs 74:15-30. 2014
  4. doi request reprint Dynamics of Helicobacter pylori detection in stools during the first 5 years of life in Chile, a rapidly developing country
    Miguel L O'Ryan
    Microbiology and Mycology Program, Institute of Biomedical Sciences, Universidad de Chile, Santiago, Chile
    Pediatr Infect Dis J 32:99-103. 2013
  5. ncbi request reprint Impact of rotavirus infections on outpatient clinic visits in chile
    Miguel O'Ryan
    Microbiology and Mycology Program, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile
    Pediatr Infect Dis J 26:41-5. 2007
  6. ncbi request reprint Rotarix (RIX4414): an oral human rotavirus vaccine
    Miguel O'Ryan
    Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Chile
    Expert Rev Vaccines 6:11-9. 2007
  7. doi request reprint The ever-changing landscape of rotavirus serotypes
    Miguel O'Ryan
    Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Santiago, Chile
    Pediatr Infect Dis J 28:S60-2. 2009
  8. doi request reprint Rotavirus vaccines for the developing world
    Miguel L O'Ryan
    Microbiology and Mycology Program, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Santiago, Chile
    Curr Opin Infect Dis 22:483-9. 2009
  9. doi request reprint Symptomatic and asymptomatic rotavirus and norovirus infections during infancy in a Chilean birth cohort
    Miguel L O'Ryan
    Microbiology and Mycology Program, Institute of Biomedical Sciences, Faculty of Medicine, Universidad de Chile
    Pediatr Infect Dis J 28:879-84. 2009
  10. doi request reprint An update on management of severe acute infectious gastroenteritis in children
    Miguel O'Ryan
    Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Santiago, Chile
    Expert Rev Anti Infect Ther 8:671-82. 2010

Collaborators

Detail Information

Publications32

  1. doi request reprint Update on Rotarix: an oral human rotavirus vaccine
    Miguel O'Ryan
    Professor and Associate Director, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Santiago, Chile
    Expert Rev Vaccines 8:1627-41. 2009
    ....
  2. ncbi request reprint Enteric viruses in wastewaters: an interesting approach to evaluate the potential impact of rotavirus vaccination on viral circulation
    Miguel L O'Ryan
    University of Chile, Diagonal Paraguay 265, Office 1403, Santiago, Centro, Chile
    Expert Rev Vaccines 11:419-22. 2012
    ..These results suggest that rotavirus circulation may be positively affected by vaccination and support the use of enteric viral detection in wastewaters as a useful tool to measure the impact of specific interventions...
  3. doi request reprint A Multi-Component Meningococcal Serogroup B Vaccine (4CMenB): The Clinical Development Program
    Miguel O'Ryan
    Programa de Microbiología y Micología, Instituto de Ciencias Biomedicas, Facultad de Medicina, Universidad de Chile, Avda Independencia 1027, Santiago, Chile
    Drugs 74:15-30. 2014
    ..4CMenB is conservatively estimated to provide 66-91 % coverage against meningococcal serogroup B strains worldwide. ..
  4. doi request reprint Dynamics of Helicobacter pylori detection in stools during the first 5 years of life in Chile, a rapidly developing country
    Miguel L O'Ryan
    Microbiology and Mycology Program, Institute of Biomedical Sciences, Universidad de Chile, Santiago, Chile
    Pediatr Infect Dis J 32:99-103. 2013
    ..We aimed to characterize the dynamics of H. pylori stool detection and to determine host and environmental factors and symptoms associated with persistence...
  5. ncbi request reprint Impact of rotavirus infections on outpatient clinic visits in chile
    Miguel O'Ryan
    Microbiology and Mycology Program, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile
    Pediatr Infect Dis J 26:41-5. 2007
    ..We previously estimated a yearly incidence of 8000 and 53,000 hospitalizations and emergency room visits respectively for children <or=3 years of age...
  6. ncbi request reprint Rotarix (RIX4414): an oral human rotavirus vaccine
    Miguel O'Ryan
    Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Chile
    Expert Rev Vaccines 6:11-9. 2007
    ....
  7. doi request reprint The ever-changing landscape of rotavirus serotypes
    Miguel O'Ryan
    Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Santiago, Chile
    Pediatr Infect Dis J 28:S60-2. 2009
    ..The heterogeneity and ever-changing epidemiology of rotavirus underscores the need for continued surveillance to ensure that vaccination programs provide optimal protection...
  8. doi request reprint Rotavirus vaccines for the developing world
    Miguel L O'Ryan
    Microbiology and Mycology Program, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Santiago, Chile
    Curr Opin Infect Dis 22:483-9. 2009
    ..The review will focus on the role of the vaccines for the developing world but this does not preclude the relevance of these vaccines for children living in the industrialized world...
  9. doi request reprint Symptomatic and asymptomatic rotavirus and norovirus infections during infancy in a Chilean birth cohort
    Miguel L O'Ryan
    Microbiology and Mycology Program, Institute of Biomedical Sciences, Faculty of Medicine, Universidad de Chile
    Pediatr Infect Dis J 28:879-84. 2009
    ..Comparative analysis of these infections in a birth cohort has not been performed and can provide relevant insight on clinical and viral behaviors...
  10. doi request reprint An update on management of severe acute infectious gastroenteritis in children
    Miguel O'Ryan
    Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Santiago, Chile
    Expert Rev Anti Infect Ther 8:671-82. 2010
    ..The article will also briefly discuss current preventive measures against rotavirus gastroenteritis through vaccination, a topic that has been extensively discussed elsewhere...
  11. doi request reprint Prospective characterization of norovirus compared with rotavirus acute diarrhea episodes in chilean children
    Miguel L O'Ryan
    Microbiology and Mycology Program, Institute of Biomedical Sciences, Faculty of Medicine, Universidad de Chile, Santiago, Chile
    Pediatr Infect Dis J 29:855-9. 2010
    ..Comparing epidemiologic and clinical features of norovirus to rotavirus ADE will aid in the decision-making process required to develop norovirus vaccines...
  12. doi request reprint Rotarix®: vaccine performance 6 years postlicensure
    Miguel O'Ryan
    Programa de Microbiología y Micología, Instituto de Ciencias Biomedicas, Facultad de Medicina, Universidad de Chile, Santiago, Chile
    Expert Rev Vaccines 10:1645-59. 2011
    ....
  13. ncbi request reprint New rotavirus vaccines: renewed optimism
    Miguel O'Ryan
    Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Santiago, Chile
    J Pediatr 149:448-51. 2006
  14. ncbi request reprint A millennium update on pediatric diarrheal illness in the developing world
    Miguel O'Ryan
    Microbiology and Mycology Program, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Santiago
    Semin Pediatr Infect Dis 16:125-36. 2005
    ..Preventive measures include careful personal hygiene, especially promotion of hand washing. Immunizations currently or soon to be available for Salmonella serotype Typhi, cholera prevention, and rotavirus are discussed...
  15. ncbi request reprint [New rotavirus vaccines: a reality at last]
    Miguel O'Ryan
    Programa de Microbiología y Micología, Instituto de Ciencias Biomedicas, Facultad de Medicina, Universidad de Chile
    Rev Chilena Infectol 22:345-54. 2005
    ....
  16. pmc Novel recombinant norovirus causing outbreaks of gastroenteritis in Santiago, Chile
    Roberto Vidal
    Programa de Microbiologia, Instituto de Ciencias Biomedicas ICBM, Facultad de Medicina, Universidad de Chile, Santiago, Chile
    J Clin Microbiol 44:2271-5. 2006
    ..These strains belonged to a novel genogroup by RdRp sequence and to genogroup GII/3 by capsid sequence. Determining the clinical and epidemiological impact of human calicivirus recombination will require future studies...
  17. pmc Caliciviruses and foodborne gastroenteritis, Chile
    Roberto Vidal
    Microbiology Program, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Santiago, Chile
    Emerg Infect Dis 11:1134-7. 2005
    ..Outbreaks affected ?99 persons, occurred most commonly in the home, and were associated with seafood consumption. Thirteen outbreak strains sequenced were noroviruses, including 8 GII, 2 GI, and 3 belonging to a novel genogroup...
  18. doi request reprint Immunogenicity and tolerability of a multicomponent meningococcal serogroup B (4CMenB) vaccine in healthy adolescents in Chile: a phase 2b/3 randomised, observer-blind, placebo-controlled study
    María Elena Santolaya
    Departamento de Pediatria, Hospital Dr Luis Calvo Mackenna, Facultad de Medicina, Universidad de Chile, Santiago, Chile
    Lancet 379:617-24. 2012
    ..We assessed immunogenicity and tolerability of a four-component vaccine (4CMenB) in adolescents...
  19. ncbi request reprint Clinical presentations of rotavirus infection among hospitalized children
    Mary Allen Staat
    Division of Infectious Disease, Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Pediatr Infect Dis J 21:221-7. 2002
    ..Although rotaviruses (RVs) are the most common cause of severe gastroenteritis in children, there is a lack of information detailing the spectrum of clinical manifestations of RV disease resulting in hospitalization...
  20. pmc Genetic variation of capsid protein VP7 in genotype g4 human rotavirus strains: simultaneous emergence and spread of different lineages in Argentina
    Karin Bok
    Viral Gastroenteritis Laboratory, National Institute of Infectious Diseases, Buenos Aires, Argentina
    J Clin Microbiol 40:2016-22. 2002
    ..The appearance of at least two G4 genotype (sub)lineages during 1998 demonstrates that the increased frequency of these strains was due to the synchronized emergence of different groups of strains...
  21. ncbi request reprint Nonmedical costs associated with rotavirus disease requiring hospitalization
    Brian P Lee
    Children s Hospital and Research Center at Oakland, Oakland, CA, USA
    Pediatr Infect Dis J 24:984-8. 2005
    ..Herein, we report the results from the largest prospective study in the United States determining the nonmedical costs of severe rotavirus infections...
  22. doi request reprint Efficacy of a pentavalent rotavirus vaccine in reducing rotavirus-associated health care utilization across three regions (11 countries)
    Timo Vesikari
    University of Tampere Medical School, Tampere, Finland
    Int J Infect Dis 11:S29-35. 2007
    ....
  23. ncbi request reprint On a multinational assessment of rotavirus disease in europe
    David O Matson
    J Infect Dis 195:S1-3. 2007
  24. ncbi request reprint The pentavalent rotavirus vaccine, RotaTeq
    David O Matson
    Graduate Program in Public Health, Eastern Virginia Medical School, Old Dominion University, Norfolk, VA 23501, USA
    Semin Pediatr Infect Dis 17:195-9. 2006
    ..A pentavalent rotavirus vaccine, PRV, is the second FDA-licensed rotavirus vaccine and does not signal the risk observed with RRV-TV. The properties and large safety study results of PRV are reviewed here...
  25. ncbi request reprint Safety and efficacy of a pentavalent human-bovine (WC3) reassortant rotavirus vaccine
    Timo Vesikari
    University of Tampere Medical School, Tampere, Finland
    N Engl J Med 354:23-33. 2006
    ..Rotavirus is a leading cause of childhood gastroenteritis and death worldwide...
  26. ncbi request reprint RotaShield: the ill-fated rhesus-human reassortant rotavirus vaccine
    David O Matson
    Infectious Diseases Section, Center for Pediatric Research, Norfolk, VA 23510, USA
    Pediatr Ann 35:44-50. 2006
  27. ncbi request reprint Quantitation of human astrovirus by real-time reverse-transcription-polymerase chain reaction to examine correlation with clinical illness
    Zhian Zhang
    Center for Pediatric Research, Eastern Virginia Medical School, 855 West Brambleton Avenue, Norfolk, VA 23510, USA
    J Virol Methods 134:190-6. 2006
    ..49, p=.064), but was not associated with change in age, gender, illness day, severity or breast-feeding. RT2-PCR quantitated HAstV RNA and RNACN in stool correlates with features of clinical illness...
  28. ncbi request reprint Prevalence and characterization of astroviruses in Argentinean children with acute gastroenteritis
    Carlos Espul
    Virology Laboratory, Central Hospital, Mendoza, Argentina
    J Med Virol 72:75-82. 2004
    ..HastV-4 caused 25% of HastV infections in Mendoza, although it has been detected commonly elsewhere. Distinct genetic lineages were apparent but their epidemiological significance remains to be demonstrated...
  29. ncbi request reprint Prevalence and genetic characterization of caliciviruses among children hospitalized for acute gastroenteritis in the United States
    Carmelann Zintz
    Center for Pediatric Research, Children s Hospital of the King s Daughters, Eastern Virginia Medical School, 855 West Brambleton Avenue, Norfolk, VA 23510, USA
    Infect Genet Evol 5:281-90. 2005
    ..In conclusion, NV and SV were frequent causes of hospitalization for acute gastroenteritis in young children and infecting strains were highly diverse, including newly recognized genogroups and genetic clusters within known genogroups...
  30. ncbi request reprint Rotavirus deaths: rare or unrecognized?
    Mary Allen Staat
    University of Cincinnati, Cincinnati Children s Hospital Medical Center, Department of Pediatrics, Division of Infectious Diseases, Ohio 45229, USA
    Clin Pediatr (Phila) 44:535-7. 2005
  31. pmc Rotavirus antigenemia in children is associated with viremia
    Sarah E Blutt
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas, United States of America
    PLoS Med 4:e121. 2007
    ..We aimed to analyze a defined patient population to determine if infectious virus could be detected in sera from children with rotavirus antigenemia...
  32. ncbi request reprint Sequence diversity of human caliciviruses recovered from children with diarrhea in Mendoza, Argentina, 1995-1998
    Norma Martinez
    Virology Laboratory, Central Hospital, Mendoza, Argentina
    J Med Virol 67:289-98. 2002
    ....