Research Topics
| R B MaccioniSummaryAffiliation: Universidad de Chile Country: Chile Publications
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Detail Information
Publications
The molecular bases of Alzheimer's disease and other neurodegenerative disordersR B Maccioni
Millennium Institute for Advanced Studies in Cell Biology and Biotechnology, Faculty of Sciences, University of Chile, Santiago, Chile
Arch Med Res 32:367-81. 2001..The analysis is extended to the action of neuroprotective factors including selective inhibitors of tau phosphorylating protein kinases, estrogens, and antioxidants among other molecules that apparently prevent neuronal degeneration...- Interleukin-3 prevents neuronal death induced by amyloid peptideAngara Zambrano
Instituto de Bioquimica, Facultad de Ciencias, Universidad Austral de Chile, Chile
BMC Neurosci 8:82. 2007..Although there is evidence indicating that IL-3 is expressed in some neuronal populations, its physiological role in these cells is poorly known... - Biological markers of Alzheimer's disease and mild cognitive impairmentRicardo B Maccioni
Millennium Institute for Advanced Studies CBB, Faculty of Sciences, University of Chile Edificio Milenio, Las Encinas 3370, Nunoa, Santiago, Chile
Curr Alzheimer Res 1:307-14. 2004..An increasing number of studies suggest that supplementary use of these CSF markers preferably in combination, adds to the accuracy of an AD diagnosis... - Anomalously phosphorylated tau and Abeta fragments in the CSF correlates with cognitive impairment in MCI subjectsRicardo B Maccioni
Laboratory of Cellular, Molecular Biology and Neurosciences, Millennium Institute for Advanced Studies CBB, Edificio Milenio, Las Encinas 3370, Nunoa, Santiago, Chile
Neurobiol Aging 27:237-44. 2006..5 exhibited Abeta levels (0.066+/-0.007) similar to controls. Studies highlight the relationships between anomalously phosphorylated tau markers in CSF with the information from TBS analysis of the different groups of patients... - Inhibition of tau phosphorylating protein kinase cdk5 prevents beta-amyloid-induced neuronal deathA Alvarez
Laboratory of Cellular and Molecular Biology, Faculty of Sciences, University of Chile and International Center for Cancer and Developmental Biology, Las Palmeras 3425, Nunoa, Santiago
FEBS Lett 459:421-6. 1999..These findings are of interest in the context of the pathogenesis of Alzheimer's disease... - Production of nerve growth factor by beta-amyloid-stimulated astrocytes induces p75NTR-dependent tau hyperphosphorylation in cultured hippocampal neuronsEstefanía T Sáez
Laboratory of Cellular, Molecular Biology and Neurosciences, Faculty of Sciences, Department Neurological Sciences, Faculty of Medicine, University of Chile, Santiago, Chile
J Neurosci Res 84:1098-106. 2006..These results suggest a potential role for astrocyte-derived NGF in the progression of AD... - Neuroprotective effect of TNFalpha against the beta-amyloid neurotoxicity mediated by CDK5 kinaseDaniel I Orellana
Laboratory of Cellular, Molecular Biology and Neurosciences, Faculty of Sciences, Universidad de Chile Las Encinas 3370, Nunoa, Santiago, Chile
Biochim Biophys Acta 1773:254-63. 2007..This phenomenon, taken together with other previous findings, suggests that the inflammatory response due to Abeta peptide plays a key role in the development of Alzheimer etiopathogenesis... - Novel drugs affecting tau behavior in the treatment of Alzheimer's disease and tauopathiesL P Navarrete
Laboratory of Cellular and Molecular Neurosciences, University of Chile and International Center for Biomedicine, Edificio Milenio, Las Encinas 3370, Nunoa, Santiago, Chile
Curr Alzheimer Res 8:678-85. 2011..This knowledge will allow us to identify and optimize potential inhibitors that interact with aggregated forms of tau and hyperphosphorylated tau before the formation of the NFTs, offering a possible therapeutic route for AD treatment... - Astrocytic nitric oxide triggers tau hyperphosphorylation in hippocampal neuronsT Estefanía Saez
Millennium Institute for Advanced Studies CBB, Faculty of Sciences, University of Chile, Las Encinas 3370, Nunoa, Santiago, Chile
In Vivo 18:275-80. 2004..This effect was attenuated by iNOS inhibitors, suggesting the role of overproduction of NO by reactive astrocytes in AD pathogenesis... - Interleukin-6 induces Alzheimer-type phosphorylation of tau protein by deregulating the cdk5/p35 pathwayRodrigo A Quintanilla
Millennium Institute for Advanced Studies in Cell Biology and Biotechnology CBB, Nunoa, Santiago, Chile
Exp Cell Res 295:245-57. 2004..These results support the findings of a pathologic role for IL-6 in the neuroinflammatory response as related with the pathogenesis of neuronal degeneration... - Mechanisms of tau self-aggregation and neurotoxicityG Farias
Laboratory of Cellular and Molecular Neurosciences, University of Chile and International Center for Biomedicine, Edificio Milenio, Las Encinas 3370, Nunoa, Santiago, Chile
Curr Alzheimer Res 8:608-14. 2011..Finally, we analyze the structural and functional tau alterations found in different tauopathies and how these modifications are related to the pathophysiologic mechanisms of neurodegeneration... - A Cdk5-p35 stable complex is involved in the beta-amyloid-induced deregulation of Cdk5 activity in hippocampal neuronsA Alvarez
Laboratory of Cellular and Molecular Biology, Faculty of Sciences, University of Chile and Millennium Institute for Advanced Studies in Cell Biology and Biotechnology, Las Palmeras 3425, , Santiago, Chile
Exp Cell Res 264:266-74. 2001.... - The protein kinase Cdk5. Structural aspects, roles in neurogenesis and involvement in Alzheimer's pathologyR B Maccioni
Laboratory of Cellular and Molecular Biology, Millennium Institute for Advanced Studies in Cell Biology and Biotechnology, Faculty of Sciences, University of Chile, Nunoa, Santiago
Eur J Biochem 268:1518-27. 2001.... - Expression pattern of DMAP-85 during Drosophila embryonic developmentV Cambiazo
Laboratorio de Biologia Celular y Molecular, Facultad de Ciencias, Universidad de Chile, Las Palmeras 3425, Santiago, Chile
Mech Dev 108:197-201. 2001..These observations are in agreement with previous reports on DMAP-85 functions, suggesting that DMAP-85 might be required for the stabilization and organization of cytoplasmic microtubules during embryonic development... - Tau phosphorylation by cdk5 and Fyn in response to amyloid peptide Abeta (25-35): involvement of lipid raftsPaula Hernandez
Faculty of Sciences, Universidad de Chile, Santiago, Chile
J Alzheimers Dis 16:149-56. 2009..These data suggest a role for cdk5 in the Abeta-promoted early events involving tau hyperphosphorylation, and their possible implications for AD pathogenesis... - Tau protein binds to pericentromeric DNA: a putative role for nuclear tau in nucleolar organizationMarcela K Sjöberg
Laboratory of Cellular, Molecular Biology and Neurosciences, Millennium Institute for Advanced Studies in Cell Biology and Biotechnology CBB, Faculty of Sciences, University of Chile, Las Encinas 3370, Nunoa, Santiago, Chile
J Cell Sci 119:2025-34. 2006..We discuss nucleolar tau associated with AT-rich alpha-satellite DNA sequences as a potential molecular link between trisomy 21 and AD... - Abeta1-42 stimulates actin polymerization in hippocampal neurons through Rac1 and Cdc42 Rho GTPasesAriadna Mendoza-Naranjo
Laboratory of Cellular, Molecular Biology and Neuroscience, Department of Biology, Faculty of Sciences, Universidad de Chile, Las Palmeras 3425, Nunoa, Santiago, Chile
J Cell Sci 120:279-88. 2007..These results point to Rho GTPases as one of the targets in Abeta-induced neurodegeneration in Alzheimer's disease pathology, with a role in mediating changes in the actin cytoskeletal dynamics... - AbetaPP induces cdk5-dependent tau hyperphosphorylation in transgenic mice Tg2576Carola Otth
Millennium Institute for Advanced Studies in Cell Biology and Biotechnology (CBB, Santiago, Chile
J Alzheimers Dis 4:417-30. 2002..These studies also provide further evidence on the links between extraneuronal amyloid deposition and tau pathology... - Iron-activated iron uptake: a positive feedback loop mediated by iron regulatory protein 1Marto T Núñez
Department of Biology, Faculty of Sciences, University of Chile, Casilla 653, Santiago, Chile
Biometals 16:83-90. 2003..Hence, this iron-induced iron uptake feedback loop results in the increase of intracellular iron and increased oxidative stress... - Iron-induced oxidative stress modify tau phosphorylation patterns in hippocampal cell culturesJosé Tomás Egaña
Laboratory of Cellular and Molecllar Biology, Millennium Institute for Advanced Studies in Cell Biology and Biotechnology, Faculty of Sciences, University of Chile, Las Palmeras 3425, Nunoa, Santiago, Chile
Biometals 16:215-23. 2003.... - Molecular targets in the rational design of AD specific PET tracers: tau or amyloid aggregates?L E Rojo
International Center for Biomedicine ICC and Laboratory of Cellular and Molecular Neurosciences, University of Chile Las Encinas 3370, Nunoa, Santiago, Chile
Curr Alzheimer Res 8:652-8. 2011..We analyze the current evidence and clinical implications of new imaging technologies for AD, and how tau hypothesis and the amyloid cascade hypothesis will impact on these scientific efforts in the near future... - ApoE alleles and tau markers in patients with different levels of cognitive impairmentManuel Lavados
Department of Neurological Sciences, Faculty of Medicine, University of Chile, Santiago, Chile
Arch Med Res 36:474-9. 2005.... - Role of the JAKs/STATs pathway in the intracellular calcium changes induced by interleukin-6 in hippocampal neuronsD I Orellana
Laboratory of Cellular, Molecular Biology and Neurosciences, Millennium Institute for Advanced Studies in Cell Biology and Biotechnology CBB, Department of Biology, Faculty of Sciences, Universidad de Chile, Las Encinas 3370, Nunoa, Santiago, Chile
Neurotox Res 8:295-304. 2005..These results suggest that IL-6 would induce a cascade of molecular events that produce a calcium influx through NMDA receptors, mediated by the JAKs/STATs pathway, which subsequently modifies the tau hyperphosphorylation patterns... - Oxidative stress promotes tau dephosphorylation in neuronal cells: the roles of cdk5 and PP1Cristian A Zambrano
Laboratory of Cellular and Molecular Biology, Millennium Institute for Advanced Studies in Cell Biology and Biotechnology, and Department of Biology, Faculty of Sciences, University of Chile, Santiago, Chile
Free Radic Biol Med 36:1393-402. 2004..Therefore, we propose that oxidative stress-induced activation of cdk5 leads to inhibitor-2 phosphorylation, relieving its inhibitory effect on PP1... - The damage signals hypothesis of Alzheimer's disease pathogenesisJorge A Fernandez
International Center for Biomedicine ICC, University of Chile, Santiago, Chile
J Alzheimers Dis 14:329-33. 2008.... - Tubulin, actin, and tau protein interactions and the study of their macromolecular assembliesGustavo A Farias
Laboratory of Cellular and Molecular Biology, Millennium Institute for Advanced Studies in Cell Biology and Biotechnology (CBB, Universidad de Chile, Las Palmeras 3425, , Santiago, Chile
J Cell Biochem 85:315-24. 2002..The studies provide further evidence for the involvement of tau protein in modulating the interactions of microtubules and actin polymers in the organization of the cytsokeletal network... - An oxidative stress-mediated positive-feedback iron uptake loop in neuronal cellsClaudia Núñez-Millacura
Department of Biology, Faculty of Sciences, University of Chile, Santiago
J Neurochem 82:240-8. 2002..This behavior is probably a consequence of the paradoxical activation of IRP1 at high iron concentrations, a condition that may underlie some processes associated with neuronal degeneration and death... - cdk5 modulates beta- and delta-catenin/Pin1 interactions in neuronal cellsJuan P Muñoz
Laboratory of Cellular, Molecular Biology and Neurosciences, Faculty of Sciences, Millennium Institute for Advanced Studies in Cell Biology and Biotechnology, Department of Neurological Sciences, Faculty of Medicine, University of Chile, Santiago, Chile
J Cell Biochem 100:738-49. 2007..Studies indicate that the cdk5/p35 protein kinase system is directly involved in the regulatory mechanisms of neuronal beta- and delta-catenin... - In vivo effects of 3-iodocytisine: pharmacological and genetic analysis of hypothermia and evaluation of chronic treatment on nicotinic binding sitesC A Zambrano
Laboratory of Cellular and Molecular Biology and Neuroscience, Faculty of Sciences, University of Chile, Las Encinas 3370, Santiago, Chile
Neuropharmacology 57:332-42. 2009..125)I]alpha-Bungarotoxin binding sites also exhibited up-regulation. These results give a first evaluation of in vivo consequences of 3-IC as a potent agonist with marked effects on mice... - Selective interaction of lansoprazole and astemizole with tau polymers: potential new clinical use in diagnosis of Alzheimer's diseaseLeonel E Rojo
International Center for Biomedicine ICC, Faculty of Sciences, University of Chile, Santiago, Chile
J Alzheimers Dis 19:573-89. 2010.... - The revitalized tau hypothesis on Alzheimer's diseaseRicardo B Maccioni
Laboratory of Cellular and Molecular Neurosciences, Faculty of Sciences, University of Chile and International Center for Biomedicine ICC, Edificio Milenio, Las Encinas, Nunoa, Santiago, Chile
Arch Med Res 41:226-31. 2010..Recent findings provide further support to the central role of tau in the pathogenesis of AD, so this protein has turned into a diagnostic and therapeutic target for this disease... - Insulin resistance and Alzheimer's disease: molecular links & clinical implicationsKaren F Neumann
Laboratory of Cellular and Molecular Neurosciences, University of Chile, Iquique, Chile
Curr Alzheimer Res 5:438-47. 2008..The link between insulin resistance and neurodegeneration and AD, and the possible therapeutic targets in preventing the insulin-resistance disorders are analyzed... - Microtubule-associated protein 1B interaction with tubulin tyrosine ligase contributes to the control of microtubule tyrosinationElias Utreras
Laboratory of Neurosciences, Millennium Institute for Cell Dynamics and Biotechnology ICDB, Santiago, Chile
Dev Neurosci 30:200-10. 2008..This regulation may be important for general processes involved in nervous system development such as axonal guidance and neuronal migration... - Regulation of p27 in the process of neuroblastoma N2A differentiationJuan P Muñoz
Laboratory of Cellular and Molecular Biology, Millennium Institute for Advanced Studies in Cell Biology and Biotechnology CBB, Faculty of Sciences, University of Chile, Las Palmeras 3425, Nunoa, Santiago, Chile
J Cell Biochem 89:539-49. 2003..These studies are of the utmost importance to elucidate regulatory mechanisms of molecules that play a critical role in the transition from a proliferating phenotype to differentiated cells... - Neuroinflammation: implications for the pathogenesis and molecular diagnosis of Alzheimer's diseaseLeonel E Rojo
Laboratory of Cellular and Molecular Neurosciences, Faculty of Sciences, University of Chile, Santiago, Chile
Arch Med Res 39:1-16. 2008..Elucidation of the events that control the transitions from neuroprotection to neurodegeneration should be a critical point toward elucidation of AD pathogenesis... - The role of neuroimmunomodulation in Alzheimer's diseaseRicardo B Maccioni
International Center for Biomedicine, Faculty of Sciences, University of Chile, Santiago, Chile
Ann N Y Acad Sci 1153:240-6. 2009.... - Modulation of the JNK and p38 pathways by cdk5 protein kinase in a transgenic mouse model of Alzheimer's diseaseCarola Otth
Laboratory of Cellular and Molecular Biology, Millennium Institute for Advanced Studies in Cell Biology and Biotechnology (CBB, Faculty of Sciences, Universidad de Chile, Edificio Milenio, Las Encinas 3370, , Santiago, Chile
Neuroreport 14:2403-9. 2003..This study sheds new light on the pathogenesis of neuronal degeneration processes such as those occurring in Alzheimer's disease... - Mild cognitive impairment and Alzheimer patients display different levels of redox-active CSF ironManuel Lavados
Department of Neurological Science, Faculty of Medicine, Universidad de Chile, Chile
J Alzheimers Dis 13:225-32. 2008..The decrease in redox-active iron found in AD patients may represent a terminal situation, whereby the central nervous system attempts to minimize iron-associated toxicity...