Sandra Hirsch

Summary

Affiliation: Universidad de Chile
Country: Chile

Publications

  1. ncbi request reprint The Chilean flour folic acid fortification program reduces serum homocysteine levels and masks vitamin B-12 deficiency in elderly people
    Sandra Hirsch
    Institute of Nutrition and Food Technology, University of Chile, Santiago, Chile
    J Nutr 132:289-91. 2002
  2. ncbi request reprint Seasonal variation in insulin sensitivity in healthy elderly people
    Daniel Bunout
    Institute of Nutrition and Food Technology, University of Chile, Santiago, Chile
    Nutrition 19:310-6. 2003
  3. ncbi request reprint Functional changes in the gastrointestinal system
    S Hirsch
    Institute of Nutrition and Food Technology INTA, University of Chile, Santiago
    Nestle Nutr Workshop Ser Clin Perform Programme 6:97-106; discussion 106-8. 2002
  4. ncbi request reprint Hyperhomocysteinemia and endothelial function in young subjects: effects of vitamin supplementation
    Sandra Hirsch
    Institute of Nutrition and Food Technology, University of Chile, Santiago
    Clin Cardiol 25:495-501. 2002
  5. ncbi request reprint Endothelial function in healthy younger and older hyperhomocysteinemic subjects
    Sandra Hirsch
    INTA, Institute of Nutrition and Food Technology, University of Chile, Macul 5540, Casilla 138 11, Santiago, Chile
    J Am Geriatr Soc 50:1019-23. 2002
  6. ncbi request reprint Height reduction, determined using knee height measurement as a risk factor or predictive sign for osteoporosis in elderly women
    Daniel Bunout
    INTA, University of Chile, Santiago, Chile
    Nutrition 23:794-7. 2007
  7. ncbi request reprint Effects of vitamin D supplementation and exercise training on physical performance in Chilean vitamin D deficient elderly subjects
    Daniel Bunout
    INTA, University of Chile, Santiago, Chile
    Exp Gerontol 41:746-52. 2006
  8. ncbi request reprint Effects of a nutritional supplement on the immune response and cytokine production in free-living Chilean elderly
    Daniel Bunout
    Department of Medicine, Central Campus Faculty of Medicine, University of Chile, Santiago, Chile
    JPEN J Parenter Enteral Nutr 28:348-54. 2004
  9. ncbi request reprint Effect of a nutritional supplementation on bone health in Chilean elderly subjects with femoral osteoporosis
    Daniel Bunout
    INTA, Department of Medicine, Central Campus Facultyof Medicine, University of Chile, Santiago, Chile
    J Am Coll Nutr 25:170-7. 2006
  10. doi request reprint Relationship between protein and mitochondrial DNA oxidative injury and telomere length and muscle loss in healthy elderly subjects
    Daniel Bunout
    Institute of Nutrition and Food Technology, University of Chile, Macul 5540, Santiago, Chile
    Arch Gerontol Geriatr 48:335-9. 2009

Collaborators

Detail Information

Publications38

  1. ncbi request reprint The Chilean flour folic acid fortification program reduces serum homocysteine levels and masks vitamin B-12 deficiency in elderly people
    Sandra Hirsch
    Institute of Nutrition and Food Technology, University of Chile, Santiago, Chile
    J Nutr 132:289-91. 2002
    ..Given that vitamin B-12 deficiency was more common than folate deficiency, it may be more appropriate to add vitamin B-12 to food, at least in foods for this age group...
  2. ncbi request reprint Seasonal variation in insulin sensitivity in healthy elderly people
    Daniel Bunout
    Institute of Nutrition and Food Technology, University of Chile, Santiago, Chile
    Nutrition 19:310-6. 2003
    ..However, there is very little information about the seasonal variation in insulin sensitivity. We report the seasonal variation in insulin sensitivity in a group of elderly subjects followed for 1 y...
  3. ncbi request reprint Functional changes in the gastrointestinal system
    S Hirsch
    Institute of Nutrition and Food Technology INTA, University of Chile, Santiago
    Nestle Nutr Workshop Ser Clin Perform Programme 6:97-106; discussion 106-8. 2002
  4. ncbi request reprint Hyperhomocysteinemia and endothelial function in young subjects: effects of vitamin supplementation
    Sandra Hirsch
    Institute of Nutrition and Food Technology, University of Chile, Santiago
    Clin Cardiol 25:495-501. 2002
    ..The relationship between hyperhomocysteinemia and cardiovascular disease has not been totally elucidated...
  5. ncbi request reprint Endothelial function in healthy younger and older hyperhomocysteinemic subjects
    Sandra Hirsch
    INTA, Institute of Nutrition and Food Technology, University of Chile, Macul 5540, Casilla 138 11, Santiago, Chile
    J Am Geriatr Soc 50:1019-23. 2002
    ..To compare endothelium-dependent vasomotor response in healthy younger and older subjects without classic cardiovascular risk factors, with high and normal fasting homocysteine (tHcy) levels...
  6. ncbi request reprint Height reduction, determined using knee height measurement as a risk factor or predictive sign for osteoporosis in elderly women
    Daniel Bunout
    INTA, University of Chile, Santiago, Chile
    Nutrition 23:794-7. 2007
    ..We assessed the value of height reduction, calculated using knee height measurement, as a risk factor or predictive sign for osteoporosis in healthy elderly women...
  7. ncbi request reprint Effects of vitamin D supplementation and exercise training on physical performance in Chilean vitamin D deficient elderly subjects
    Daniel Bunout
    INTA, University of Chile, Santiago, Chile
    Exp Gerontol 41:746-52. 2006
    ..05). In conclusion, vitamin D supplementation improved gait speed and body sway, and training improved muscle strength...
  8. ncbi request reprint Effects of a nutritional supplement on the immune response and cytokine production in free-living Chilean elderly
    Daniel Bunout
    Department of Medicine, Central Campus Faculty of Medicine, University of Chile, Santiago, Chile
    JPEN J Parenter Enteral Nutr 28:348-54. 2004
    ..Immune response is impaired in the elderly. Our aim was to study the effects of a special nutritional formula on the immune response and response to influenza and pneumococcal vaccination in elderly subjects...
  9. ncbi request reprint Effect of a nutritional supplementation on bone health in Chilean elderly subjects with femoral osteoporosis
    Daniel Bunout
    INTA, Department of Medicine, Central Campus Facultyof Medicine, University of Chile, Santiago, Chile
    J Am Coll Nutr 25:170-7. 2006
    ..To study the effects of a special nutritional supplement on bone mineral density and bone turnover markers in Chilean elderly subjects with femoral osteoporosis...
  10. doi request reprint Relationship between protein and mitochondrial DNA oxidative injury and telomere length and muscle loss in healthy elderly subjects
    Daniel Bunout
    Institute of Nutrition and Food Technology, University of Chile, Macul 5540, Santiago, Chile
    Arch Gerontol Geriatr 48:335-9. 2009
    ..Telomere length, expressed as T/S ratio, was 0.06 (95% CI, 0.01-0.16), 0.06 (95% CI, 0.03-0.27) and 0.34 (95% CI, 0.1-1.34), respectively (p<0.02 or less for all comparisons between elderly and young subjects)...
  11. doi request reprint Weight increase is associated with skeletal muscle immunostaining for advanced glycation end products, receptor for advanced glycation end products, and oxidation injury
    Maria Pia De la Maza
    Institute of Nutrition and Food Technology, University of Chile, Santiago, Chile
    Rejuvenation Res 11:1041-8. 2008
    ..Tissue accumulation of advanced glycation end products (AGEs) is associated with ageing, both in diabetics and nondiabetic subjects...
  12. ncbi request reprint 5-methyltetrahydrofolic acid stimulates endothelin-1 production in low density lipoprotein-treated human endothelial cells
    Ana Maria Ronco
    Laboratorio de Hormonas y Receptores, Instituto de Nutricion y Tecnologia de los Alimentos, INTA, Universidad de Chile, Casilla 138 11, Santiago, Chile
    Nutr Metab Cardiovasc Dis 17:188-94. 2007
    ..The aim of this study is to determine the effect of folates and vitamin B12 on endothelial vasoconstriction/vasodilatation parameters in cultured human endothelial cells incubated with human low density lipoproteins (LDL)...
  13. ncbi request reprint Assessment of sarcopenia: longitudinal versus cross sectional body composition data
    Daniel Bunout
    INTA, University of Chile, 138 11 Santiago, Chile
    Aging Clin Exp Res 19:295-9. 2007
    ..An accurate diagnosis of sarcopenia is required. The aim of this study is to correlate the results of two methods to define sarcopenia using cross sectional body composition data, with actual loss of fat free mass...
  14. ncbi request reprint [Glycemic and insulin indices of tube feeding formulas in healthy adults]
    Vivien Gattas
    Instituto de Nutricion y Tecnologia de los Alimentos, Universidad de Chile, Santiago, Chile
    Rev Med Chil 135:879-84. 2007
    ..Aim: To measure the glucose and insulin responses of four commercially available enteral formulas compared with a standard meal reference product...
  15. doi request reprint Methylation status in healthy subjects with normal and high serum folate concentration
    Sandra Hirsch
    Aging and Chronic Diseases Laboratory, INTA, University of Chile, Santiago, Chile
    Nutrition 24:1103-9. 2008
    ....
  16. doi request reprint Lack of effect of diet-induced hypomethylation on endothelium-dependent relaxation in rats
    Sandra Hirsch
    Aging and chronic diseases program, INTA, University of Chile, PO Box 138 11, Santiago, Chile
    Clin Nutr 27:895-9. 2008
    ....
  17. ncbi request reprint Weight increase and overweight are associated with DNA oxidative damage in skeletal muscle
    Maria Pia De la Maza
    Institute of Nutrition and Food Technology INTA, University of Chile, Macul 5540, P O Box 138 11, Santiago, Chile
    Clin Nutr 25:968-76. 2006
    ..Weight maintenance within normal standards is recommended for prevention of conditions associated with oxidative injury. To compare oxidative damage in a post mitotic tissue, between adults differing in long-term energy balance...
  18. ncbi request reprint Hyperhomocysteinemia in healthy young men and elderly men with normal serum folate concentration is not associated with poor vascular reactivity or oxidative stress
    Sandra Hirsch
    Institute of Nutrition and Food Technology, University of Chile and Clínica Santa María, Santiago, Chile
    J Nutr 134:1832-5. 2004
    ..40, P = 0.04) and negatively with BMI in elderly men (r = -0.52, P = 0.002). In the present study, HHcy with normal serum folate concentrations was not associated with poor EDVR or oxidative stress in healthy young and elderly men...
  19. ncbi request reprint Long-term nutritional and digestive consequences of pelvic radiation
    María Pía de la Maza
    Institute of Nutrition and Food Technology INTA University of Chile, Santiago, Chile
    J Am Coll Nutr 23:102-7. 2004
    ..Two years prior to this research, these patients had been assessed twice: before external radiotherapy and 5 weeks later, at the completion of the external dose (45-50 Gy)...
  20. ncbi request reprint Effects of a nutritional supplement fortified with vitamin B-12 on well nourished, free-living elderly subjects
    Sandra Hirsch
    INTA, University of Chile, Santiago
    Int J Vitam Nutr Res 76:95-9. 2006
    ..Vitamin B-12 deficiency is prevalent among the elderly population but it is often unrecognized because the clinical manifestations are not present...
  21. doi request reprint Colon cancer in Chile before and after the start of the flour fortification program with folic acid
    Sandra Hirsch
    Aging and chronic diseases program, INTA, University of Chile, Santiago, Chile
    Eur J Gastroenterol Hepatol 21:436-9. 2009
    ..A temporal association between folic acid fortification of enriched cereal grains and an increase in the incidence of colorectal cancer in the USA and Canada has, however, been recently reported...
  22. ncbi request reprint A high body mass index protects against femoral neck osteoporosis in healthy elderly subjects
    Gladys Barrera
    Institute of Nutrition and Food Technology, University of Chile, Santiago
    Nutrition 20:769-71. 2004
    ..In a large sample of elderly subjects, we assessed the possible protective effect of obesity on the development of osteoporosis...
  23. doi request reprint [Effect of probiotic Saccharomyces boulardii on prevention of antibiotic-associated diarrhea in adult outpatients with amoxicillin treatment]
    María Verónica Bravo
    Instituto de Nutricion y Tecnologia de los Alimentos, Universidad de Chile, Santiago, Chile
    Rev Med Chil 136:981-8. 2008
    ..Among these, amoxicillin is widely indicated in ambulatory practice. One of the alternatives suggested to prevent antibiotic-associated diarrhea, is the use of the probiotic Saccharomyces boulardii...
  24. doi request reprint [Quality of life of patients subjected to gastric bypass more than one year ago: influence of socioeconomic status]
    María José Leiva
    Instituto de Nutricion y Tecnologia de los Alimentos, Universidad de Chile, Santiago, Chile
    Rev Med Chil 137:625-33. 2009
    ..The study of the effects of bariatric surgery on quality of life in patients of different socioeconomic levels (SEL) is worthwhile...
  25. ncbi request reprint Effect of homocysteine, folates, and cobalamin on endothelial cell- and copper-induced LDL oxidation
    Ana Maria Ronco
    Instituto de Nutricion y Tecnologia de los Alimentos, Universidad de Chile, Casilla 138 11, Santiago, Chile
    Lipids 40:259-64. 2005
    ..Folic acid was unable to show antioxidant properties when included in either in vitro system. The results demonstrate that 5-methyltetrahydrofolic acid and vitamin B-12 are important protective agents against LDL oxidative modifications...
  26. doi request reprint Effects of enalapril or nifedipine on muscle strength or functional capacity in elderly subjects. A double blind trial
    Daniel Bunout
    Institute of Nutrition and Food Technology INTA, University of Chile, Santiago, Chile
    J Renin Angiotensin Aldosterone Syst 10:77-84. 2009
    ..The inhibition of angiotensin-converting enzyme could be useful to avoid sarcopenia in the elderly...
  27. doi request reprint Association between sarcopenia and mortality in healthy older people
    Daniel Bunout
    Institute of Nutrition and Food Technology, University of Chile, Santiago, Chile
    Australas J Ageing 30:89-92. 2011
    ..To evaluate the association between loss of fat-free mass and mortality among older people...
  28. ncbi request reprint Serum folate and homocysteine levels in obese females with non-alcoholic fatty liver
    Sandra Hirsch
    Institute of Nutrition and Food Technology, University of Chile, Santiago, Chile
    Nutrition 21:137-41. 2005
    ..We investigated whether there is an association between serum folate and total homocysteine concentrations with the presence of non-alcoholic fatty liver disease (NAFLD) in obese subjects...
  29. ncbi request reprint Effects of prebiotics on the immune response to vaccination in the elderly
    Daniel Bunout
    Institute of Nutrition and Food Technology, Faculty of Medicine, University of Chile, Santiago
    JPEN J Parenter Enteral Nutr 26:372-6. 2002
    ..Prebiotics stimulate the growth of bifidogenic bacteria in the gut. The aim of this work was to assess the effects of a prebiotic mixture on the immune response in healthy elderly people...
  30. doi request reprint Variability of glycemic and insulin response to a standard meal, within and between healthy subjects
    Sandra Hirsch
    Institute of Nutrition and Food Technology INTA, University of Chile, Santiago, Chile
    Nutr Hosp 28:541-4. 2013
    ..To test the variability within and between subject of glycemic response test following the ingestion of a standard food...
  31. doi request reprint Natural killer cell cytotoxicity is not regulated by folic acid in vitro
    Sandra Hirsch
    Institute of Nutrition and Food Technology INTA, University of Chile, Santiago, Chile Electronic address
    Nutrition 29:772-6. 2013
    ....
  32. doi request reprint [A pilot study on physical training of patients in hemodialysis]
    María Soledad Oliveros R
    Hospital Las Higueras de Talcahuano, Santiago, Chile
    Rev Med Chil 139:1046-53. 2011
    ..Exercise training during the dialytical procedure may have positive cardiovascular effects and prevent or revert muscle wasting in patients undergoing chronic hemodialysis...
  33. ncbi request reprint Muscle strength as a predictor of loss of functional status in hospitalized patients
    Jennifer Humphreys
    Faculty of Medicine, Central Campus, University of Chile, Santiago, Chile
    Nutrition 18:616-20. 2002
    ..We evaluated the efficacy of muscle strength to predict functional derangement and detect early changes in nutrition status in hospitalized patients...
  34. doi request reprint Maternal exposure to cadmium during gestation perturbs the vascular system of the adult rat offspring
    Ana Maria Ronco
    Laboratory of Nutrition and Metabolic Regulation, Institute of Nutrition and Food Technology INTA, University of Chile, Casilla 138 11, Santiago, Chile
    Toxicol Appl Pharmacol 251:137-45. 2011
    ....
  35. ncbi request reprint Anandamide inhibits endothelin-1 production by human cultured endothelial cells: a new vascular action of this endocannabinoid
    Ana Maria Ronco
    Laboratorio de Hormonas y Receptores, Instituto de Nutricion y Tecnologia de los Alimentos, INTA, Universidad de Chile, Santiago, Chile
    Pharmacology 79:12-6. 2007
    ....
  36. ncbi request reprint Soy isoflavones affect platelet thromboxane A2 receptor density but not plasma lipids in menopausal women
    Argelia Garrido
    Instituto de Nutrición y Tecnología de los Alimentos AG, MPDLM, SH, LV, Universidad de Chile, Santiago 11, Chile
    Maturitas 54:270-6. 2006
    ..The purpose of the present research was to examine the effect of a 12-week soy isoflavone supplementation on lipoprotein status and platelet thromboxane A2 receptor density...
  37. ncbi request reprint Are we losing homocysteine as a cardiovascular risk factor?
    Daniel Bunout
    Nutrition 21:1068-9. 2005
  38. ncbi request reprint Results of a community-based weight-bearing resistance training programme for healthy Chilean elderly subjects
    Daniel Bunout
    Age Ageing 34:80-3. 2005