Claudio A Hetz

Summary

Affiliation: Universidad de Chile
Country: Chile

Publications

  1. ncbi request reprint XBP-1 deficiency in the nervous system reveals a homeostatic switch to activate autophagy
    Soledad Matus
    Institute of Biomedical Sciences, the FONDAP Center for Molecular Studies of the Cell CEMC, and Millennium Nucleus for Neural Morphogenesis NEMO, Faculty of Medicine, University of Chile, Santiago, Chile
    Autophagy 5:1226-8. 2009
  2. doi request reprint The unfolded protein response: integrating stress signals through the stress sensor IRE1α
    Claudio Hetz
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA, USA
    Physiol Rev 91:1219-43. 2011
  3. pmc XBP-1 deficiency in the nervous system protects against amyotrophic lateral sclerosis by increasing autophagy
    Claudio Hetz
    Institute of Biomedical Sciences, The FONDAP Center for Molecular Studies of the Cell CEMC and the Millennium Nucleus for Neural Morphogenesis NEMO, University of Chile, Santiago, Chile
    Genes Dev 23:2294-306. 2009
  4. pmc Fine-tuning of the unfolded protein response: Assembling the IRE1alpha interactome
    Claudio Hetz
    The FONDAP Center for Molecular Studies of the Cell, Institute of Biomedical Sciences, University of Chile, Santiago, Chile
    Mol Cell 35:551-61. 2009
  5. pmc Unfolded protein response transcription factor XBP-1 does not influence prion replication or pathogenesis
    Claudio Hetz
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 105:757-62. 2008
  6. ncbi request reprint The daily job of night killers: alternative roles of the BCL-2 family in organelle physiology
    Claudio Hetz
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115, USA
    Trends Cell Biol 18:38-44. 2008
  7. ncbi request reprint ER stress signaling and the BCL-2 family of proteins: from adaptation to irreversible cellular damage
    Claudio A Hetz
    Department of Cellular and Molecular Biology, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile and the FONDAP Center for Molecular Studies of the Cell CEMC, Santiago, Chile
    Antioxid Redox Signal 9:2345-55. 2007
  8. pmc Perturbation of endoplasmic reticulum homeostasis facilitates prion replication
    Claudio Hetz
    Department of Neurology, University of Texas Medical Branch, Galveston, Texas 77555, USA
    J Biol Chem 282:12725-33. 2007
  9. ncbi request reprint Proapoptotic BAX and BAK modulate the unfolded protein response by a direct interaction with IRE1alpha
    Claudio Hetz
    Howard Hughes Medical Institute, Dana Farber Cancer Institute, and Harvard Medical School, Boston, MA 02115, USA
    Science 312:572-6. 2006
  10. pmc BAX inhibitor-1 is a negative regulator of the ER stress sensor IRE1alpha
    Fernanda Lisbona
    Institute of Biomedical Sciences, FONDAP Center for Molecular Studies of the Cell, University of Chile, Santiago, Chile
    Mol Cell 33:679-91. 2009

Collaborators

Detail Information

Publications19

  1. ncbi request reprint XBP-1 deficiency in the nervous system reveals a homeostatic switch to activate autophagy
    Soledad Matus
    Institute of Biomedical Sciences, the FONDAP Center for Molecular Studies of the Cell CEMC, and Millennium Nucleus for Neural Morphogenesis NEMO, Faculty of Medicine, University of Chile, Santiago, Chile
    Autophagy 5:1226-8. 2009
    ..Here, we discuss possible signaling pathways that may connect an impaired UPR with the induction of autophagy...
  2. doi request reprint The unfolded protein response: integrating stress signals through the stress sensor IRE1α
    Claudio Hetz
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA, USA
    Physiol Rev 91:1219-43. 2011
    ....
  3. pmc XBP-1 deficiency in the nervous system protects against amyotrophic lateral sclerosis by increasing autophagy
    Claudio Hetz
    Institute of Biomedical Sciences, The FONDAP Center for Molecular Studies of the Cell CEMC and the Millennium Nucleus for Neural Morphogenesis NEMO, University of Chile, Santiago, Chile
    Genes Dev 23:2294-306. 2009
    ..Our results reveal a new function of XBP-1 in the control of autophagy and indicate critical cross-talk between these two signaling pathways that can provide protection against neurodegeneration...
  4. pmc Fine-tuning of the unfolded protein response: Assembling the IRE1alpha interactome
    Claudio Hetz
    The FONDAP Center for Molecular Studies of the Cell, Institute of Biomedical Sciences, University of Chile, Santiago, Chile
    Mol Cell 35:551-61. 2009
    ..In this Review, we discuss recent evidence supporting a model where IRE1alpha signaling emerges as a highly regulated process, controlled by the formation of a dynamic scaffold onto which many regulatory components assemble...
  5. pmc Unfolded protein response transcription factor XBP-1 does not influence prion replication or pathogenesis
    Claudio Hetz
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 105:757-62. 2008
    ....
  6. ncbi request reprint The daily job of night killers: alternative roles of the BCL-2 family in organelle physiology
    Claudio Hetz
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115, USA
    Trends Cell Biol 18:38-44. 2008
    ..Here, we describe the emerging concept that BCL-2-related proteins have alternative functions beyond apoptosis to control the essential functions of the cell...
  7. ncbi request reprint ER stress signaling and the BCL-2 family of proteins: from adaptation to irreversible cellular damage
    Claudio A Hetz
    Department of Cellular and Molecular Biology, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile and the FONDAP Center for Molecular Studies of the Cell CEMC, Santiago, Chile
    Antioxid Redox Signal 9:2345-55. 2007
    ..Thus, BCL-2-related proteins are not only the "death gateway" keepers, but they also have alternative functions in essential cellular processes...
  8. pmc Perturbation of endoplasmic reticulum homeostasis facilitates prion replication
    Claudio Hetz
    Department of Neurology, University of Texas Medical Branch, Galveston, Texas 77555, USA
    J Biol Chem 282:12725-33. 2007
    ..Because PrP(Sc) induces ER stress, our data point to a vicious cycle accelerating prion replication, which may explain the rapid progression of the disease...
  9. ncbi request reprint Proapoptotic BAX and BAK modulate the unfolded protein response by a direct interaction with IRE1alpha
    Claudio Hetz
    Howard Hughes Medical Institute, Dana Farber Cancer Institute, and Harvard Medical School, Boston, MA 02115, USA
    Science 312:572-6. 2006
    ..Thus, BAX and BAK function at the ER membrane to activate IRE1alpha signaling and to provide a physical link between members of the core apoptotic pathway and the UPR...
  10. pmc BAX inhibitor-1 is a negative regulator of the ER stress sensor IRE1alpha
    Fernanda Lisbona
    Institute of Biomedical Sciences, FONDAP Center for Molecular Studies of the Cell, University of Chile, Santiago, Chile
    Mol Cell 33:679-91. 2009
    ..Our results suggest a role for BI-1 in early adaptive responses against ER stress that contrasts with its known downstream function in apoptosis...
  11. pmc Stressing out the ER: a role of the unfolded protein response in prion-related disorders
    Claudio A Hetz
    Harvard School of Public Health, Department of Immunology and Infectious Diseases, Boston, MA 02115, USA
    Curr Mol Med 6:37-43. 2006
    ..These findings have applications for developing novel strategies for treatment and early diagnosis of transmissible spongiform encephalopathies and other neurodegenerative diseases...
  12. ncbi request reprint Molecular mechanisms of neurotoxicity of pathological prion protein
    Joaquin Castilla
    University of Texas Medical Branch, Galveston, TX 77555, USA
    Curr Mol Med 4:397-403. 2004
    ....
  13. ncbi request reprint The stress rheostat: an interplay between the unfolded protein response (UPR) and autophagy in neurodegeneration
    Soledad Matus
    Program of Cellular and Molecular Biology, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Santiago, Chile
    Curr Mol Med 8:157-72. 2008
    ..The most recent evidence addressing the role of the UPR and ER stress in neurodegenerative disorders is reviewed here, along with therapeutic strategies to alleviate ER stress in a disease context...
  14. ncbi request reprint Alternative functions of the BCL-2 protein family at the endoplasmic reticulum
    Diego Rojas-Rivera
    The FONDAP Center for Molecular Studies of the Cell, Institute of Biomedical Sciences, Faculty of Medicine, and Millennium Nucleus for Neural Morphogenesis, University of Chile, Santiago, Chile
    Adv Exp Med Biol 687:33-47. 2010
    ..Here we describe the emerging concept that BCL-2 family members are important regulators of essential cellular processes beyond apoptosis...
  15. pmc Cyclophilin D is a component of mitochondrial permeability transition and mediates neuronal cell death after focal cerebral ischemia
    Anna C Schinzel
    Howard Hughes Medical Institute and Dana Farber Cancer Institute, Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 102:12005-10. 2005
    ....
  16. ncbi request reprint Converging pathways in the occurrence of endoplasmic reticulum (ER) stress in Huntington's disease
    R Vidal
    Institute of Biomedical Sciences, FONDAP Center for Molecular Studies of the Cell CEMC, Faculty of Medicine, University of Chile, Santiago, Chile
    Curr Mol Med 11:1-12. 2011
    ..Here, we review recent evidence involving ER stress in HD pathogenesis and discuss possible therapeutic strategies to target organelle function in the context of disease...
  17. ncbi request reprint In vitro generation of infectious scrapie prions
    Joaquin Castilla
    Department of Neurology, University of Texas Medical Branch, Galveston, Texas 77555, USA
    Cell 121:195-206. 2005
    ..These findings demonstrate that prions can be generated in vitro and provide strong evidence in support of the protein-only hypothesis of prion transmission...
  18. pmc Diminishing apoptosis by deletion of Bax or overexpression of Bcl-2 does not protect against infectious prion toxicity in vivo
    Andrew D Steele
    Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA
    J Neurosci 27:13022-7. 2007
    ..These results suggest that Bax and Bcl-2 mediated apoptotic pathways are not the major contributing factor to the clinical or pathological features of infectious prion disease...
  19. ncbi request reprint Emerging roles of the unfolded protein response signaling in physiology and disease
    Claudio A Hetz
    Curr Mol Med 6:1. 2006