Marcela A Hermoso
Affiliation: Universidad de Chile
De la Fuente M, MacDonald T, Hermoso M. The IL-33/ST2 axis: Role in health and disease. Cytokine Growth Factor Rev. 2015;26:615-23 pubmed publisher
..The IL-33/ST2 axis is involved in the pathogenesis of atopic and autoimmune diseases, cancer, and central nervous system disorders. Here, we review recent findings on the role of the IL-33/ST2 axis in health and disease. ..
De la Fuente M, Franchi L, Araya D, Díaz Jiménez D, Olivares M, Alvarez Lobos M, et al
. Escherichia coli isolates from inflammatory bowel diseases patients survive in macrophages and activate NLRP3 inflammasome. Int J Med Microbiol. 2014;304:384-92 pubmed publisher
..Invasiveness of intracellular E. coli strains into the intestinal mucosa and IL-1? production may contribute to CD and UC pathogenesis. ..
Díaz Jiménez D, De la Fuente M, Dubois Camacho K, Landskron G, Fuentes J, Perez T, et al
. Soluble ST2 is a sensitive clinical marker of ulcerative colitis evolution. BMC Gastroenterol. 2016;16:103 pubmed publisher
..Consecutive sST2 measurement to follow changes in inflammatory activity of UC patients who respond or not to treatment identifies sST2, like FC, as a useful biomarker in predicting clinical outcome of UC patients. ..
Díaz Jiménez D, Núñez L, De la Fuente M, Dubois Camacho K, Sepulveda H, Montecino M, et al
. A functional IL1RL1 variant regulates corticosteroid-induced sST2 expression in ulcerative colitis. Sci Rep. 2017;7:10180 pubmed publisher
..Our data indicate that IL1RL1 SNPs rs6543115(C) confer susceptibility to UC and is contained in the GRE, which may modulate glucocorticoid-induced sST2 expression. ..
Dubois Camacho K, Ottum P, Franco Muñoz D, De la Fuente M, Torres Riquelme A, Díaz Jiménez D, et al
. Glucocorticosteroid therapy in inflammatory bowel diseases: From clinical practice to molecular biology. World J Gastroenterol. 2017;23:6628-6638 pubmed publisher
..This thorough analysis of current clinical and biomedical literature may help guide physicians in determining a course of treatment for IBDs patients and identifies important areas needing further study. ..