Christian Gonzalez Billault
Affiliation: Universidad de Chile
Gonzalez Billault C, Muñoz Llancao P, Henríquez D, Wojnacki J, Conde C, Caceres A. The role of small GTPases in neuronal morphogenesis and polarity. Cytoskeleton (Hoboken). 2012;69:464-85 pubmed publisher
..We will specifically address the contribution of these GTPases to support neuronal polarity and axonal elongation. ..
Wilson C, NÃºÃ±ez M, GonzÃ¡lez Billault C. Contribution of NADPH oxidase to the establishment of hippocampal neuronal polarity in culture. J Cell Sci. 2015;128:2989-95 pubmed publisher
..These results indicate that physiological levels of ROS produced by the NOX complex modulate hippocampal neuronal polarity and axonal growth in vitro. ..
Wilson C, Muñoz Palma E, Henríquez D, Palmisano I, Núñez M, Di Giovanni S, et al
. A Feed-Forward Mechanism Involving the NOX Complex and RyR-Mediated Ca2+ Release During Axonal Specification. J Neurosci. 2016;36:11107-11119 pubmed
..Collectively, our data suggest a novel mechanism that is instrumental in sustaining physiological levels of ROS required for axonal growth of hippocampal neurons. ..
Acevedo A, GonzÃ¡lez Billault C. Crosstalk between Rac1-mediated actin regulation and ROS production. Free Radic Biol Med. 2018;116:101-113 pubmed publisher
..Together, discussed evidence shed light on cellular mechanisms which requires Rac1 to direct either actin- and/or ROS-related events, helping to understand crucial roles of Rac1 dual functionality. ..
MuÃ±oz Llancao P, HenrÃquez D, Wilson C, Bodaleo F, Boddeke E, Lezoualc h F, et al
. Exchange Protein Directly Activated by cAMP (EPAC) Regulates Neuronal Polarization through Rap1B. J Neurosci. 2015;35:11315-29 pubmed publisher
..This study identifies the guanine exchange factor responsible for Rap1b activation during neuronal polarization and provides an alternate explanation for cAMP-dependent acquisition of neuronal polarity. ..
Villarroel Campos D, Bronfman F, Gonzalez Billault C. Rab GTPase signaling in neurite outgrowth and axon specification. Cytoskeleton (Hoboken). 2016;73:498-507 pubmed publisher
..Finally, discussion will be provided on how specific effector-mediated Rab activation modifies several molecules essential to neuronal differentiation. © 2016 Wiley Periodicals, Inc. ..
Wilson C, Terman J, Gonzalez Billault C, Ahmed G. Actin filaments-A target for redox regulation. Cytoskeleton (Hoboken). 2016;73:577-595 pubmed publisher
..Finally, we discuss the role of these enzymes and redox signaling in regulating the actin cytoskeleton in vivo and highlight their importance for neuronal form and function in health and disease. © 2016 Wiley Periodicals, Inc. ..
Villarroel Campos D, Henríquez D, Bodaleo F, Oguchi M, Bronfman F, Fukuda M, et al
. Rab35 Functions in Axon Elongation Are Regulated by P53-Related Protein Kinase in a Mechanism That Involves Rab35 Protein Degradation and the Microtubule-Associated Protein 1B. J Neurosci. 2016;36:7298-313 pubmed publisher
..We demonstrate that Rab35 regulates Cdc42 activity in neurons. This is the first evidence showing that a Rab protein is regulated by degradation dependent on the ubiquitin-proteasome system. ..
Wilson C, Muñoz Palma E, Gonzalez Billault C. From birth to death: A role for reactive oxygen species in neuronal development. Semin Cell Dev Biol. 2018;80:43-49 pubmed publisher