Álvaro Glavic

Summary

Affiliation: Universidad de Chile
Country: Chile

Publications

  1. Edwards S, Delgado M, Nader G, Piel M, Bellaiche Y, Lennon Dumenil A, et al. An in vitro method for studying subcellular rearrangements during cell polarization in Drosophila melanogaster hemocytes. Mech Dev. 2018;: pubmed publisher
  2. Glavic A, López Varea A, de Celis J. The balance between GMD and OFUT1 regulates Notch signaling pathway activity by modulating Notch stability. Biol Res. 2011;44:25-34 pubmed publisher
    ..We propose that the GDP-fucose/OFUT1 balance determines the ability of OFUT1 to endocytose and degrade Notch in a manner that is independent of the residues affected by Abruptex mutations in Notch EGF domains. ..
  3. Rojas Benítez D, Thiaville P, de Crécy Lagard V, Glavic A. The Levels of a Universally Conserved tRNA Modification Regulate Cell Growth. J Biol Chem. 2015;290:18699-707 pubmed publisher
    ..These findings reveal an unprecedented relationship between the translation machinery and TOR, where translation efficiency, limited by the availability of t(6)A-modified tRNA, determines growth potential in eukaryotic cells. ..
  4. Ibar C, Glavic A. Drosophila p115 is required for Cdk1 activation and G2/M cell cycle transition. Mech Dev. 2017;144:191-200 pubmed publisher
  5. Rojas Benítez D, Eggers C, Glavic A. Modulation of the Proteostasis Machinery to  Overcome Stress Caused by Diminished Levels of  t6A-Modified tRNAs in Drosophila. Biomolecules. 2017;7: pubmed publisher
    ..Our results suggest that t6A-modified tRNAs, synthetized by the threonyl-carbamoyl transferase complex (TCTC), are required for organismal growth and imaginal cell survival, and is most likely to support proper protein synthesis. ..