Maite A Castro
Affiliation: Universidad Austral de Chile
Covarrubias Pinto A, Moll P, SolÃs Maldonado M, AcuÃ±a A, Riveros A, MirÃ³ M, et al
. Beyond the redox imbalance: Oxidative stress contributes to an impaired GLUT3 modulation in Huntington's disease. Free Radic Biol Med. 2015;89:1085-96 pubmed publisher
Covarrubias Pinto A, AcuÃ±a A, Boncompain G, Papic E, Burgos P, Perez F, et al
. Ascorbic acid increases SVCT2 localization at the plasma membrane by accelerating its trafficking from early secretory compartments and through the endocytic-recycling pathway. Free Radic Biol Med. 2018;120:181-191 pubmed publisher
..We propose that these two mechanisms have key protective implications in the homeostasis of metabolically active and specialized tissues. ..
Covarrubias Pinto A, AcuÃ±a A, BeltrÃ¡n F, Torres DÃaz L, Castro M. Old Things New View: Ascorbic Acid Protects the Brain in Neurodegenerative Disorders. Int J Mol Sci. 2015;16:28194-217 pubmed publisher
..In this review, we focus on ascorbic acid homeostasis, its functions, how it is used by neurons and recycled to ensure antioxidant supply during synaptic activity and how this antioxidant is dysregulated in neurodegenerative disorders. ..
Rosas Arellano A, Villalobos González J, Palma Tirado L, Beltrán F, Cárabez Trejo A, Missirlis F, et al
. A simple solution for antibody signal enhancement in immunofluorescence and triple immunogold assays. Histochem Cell Biol. 2016;146:421-30 pubmed publisher
..The addition of glycine, Triton X-100, Tween20 and hydrogen peroxide during antibody incubation steps is recommended in immunohistochemistry methods. ..
Rosas Arellano A, Tejeda Guzmán C, Lorca Ponce E, Palma Tirado L, Mantellero C, Rojas P, et al
. Huntington's disease leads to decrease of GABA-A tonic subunits in the D2 neostriatal pathway and their relocalization into the synaptic cleft. Neurobiol Dis. 2018;110:142-153 pubmed publisher
..Finally, the association of GABA-A tonic receptors with the D2 pathway in 6-month-old mice was largely lost at 12 months of age. ..