R A Burgos

Summary

Affiliation: Universidad Austral de Chile
Country: Chile

Publications

  1. ncbi Andrographolide inhibits IFN-gamma and IL-2 cytokine production and protects against cell apoptosis
    Rafael A Burgos
    Laboratory of Molecular Pharmacology, Institute of Pharmacology, Faculty of Veterinary Science, Universidad Austral de Chile, Valdivia, Chile
    Planta Med 71:429-34. 2005
  2. ncbi Andrographis paniculata (Nees) selectively blocks voltage-operated calcium channels in rat vas deferens
    R A Burgos
    Institute of Pharmacology, Faculty of Veterinary Science, Universidad Austral de Chile, P O Box 567, Valdivia, Chile
    J Ethnopharmacol 71:115-21. 2000
  3. ncbi 14-deoxyandrographolide as a platelet activating factor antagonist in bovine neutrophils
    Rafael A Burgos
    Laboratory of Molecular Pharmacology, Institute of Pharmacology, Facultad de Ciencias Veterinarias, Universidad Austral de Chile, Valdivia, Chile
    Planta Med 71:604-8. 2005
  4. ncbi New potential targets to modulate neutrophil function in inflammation
    R A Burgos
    Laboratory of Molecular Pharmacology, Institute of Pharmacology, Faculty of Veterinary Sciences, Universidad Austral de Chile, Casilla 567, Valdivia, Chile
    Mini Rev Med Chem 9:153-68. 2009
  5. ncbi Efficacy of an Andrographis paniculata composition for the relief of rheumatoid arthritis symptoms: a prospective randomized placebo-controlled trial
    R A Burgos
    Institute of Pharmacology and Morphophysiology, Universidad Austral de Chile, P O Box 567, Valdivia, Chile
    Clin Rheumatol 28:931-46. 2009
  6. ncbi Calcium influx, a new potential therapeutic target in the control of neutrophil-dependent inflammatory diseases in bovines
    R A Burgos
    Laboratory of Molecular Pharmacology, Institute of Pharmacology and Morphophysiology, Faculty of Veterinary Science, Universidad Austral de Chile, Valdivia, Chile
    Vet Immunol Immunopathol 143:1-10. 2011
  7. ncbi Effect of 14-deoxyandrographolide on calcium-mediated rat uterine smooth muscle contractility
    Rafael A Burgos
    Institute of Pharmacology, Facultad de Ciencias Veterinarias, Universidad Austral de Chile, Valdivia, Chile
    Phytother Res 17:1011-5. 2003
  8. ncbi Andrographis paniculata (Ness) induces relaxation of uterus by blocking voltage operated calcium channels and inhibits Ca(+2) influx
    R A Burgos
    Institute of Pharmacology, Faculty of Veterinary Science, Universidad Austral de Chile, P O Box 567, Valdivia, Chile
    Phytother Res 15:235-9. 2001
  9. ncbi 2-Aminoethoxydiphenyl borate (2-APB) reduces respiratory burst, MMP-9 release and CD11b expression, and increases l-selectin shedding in bovine neutrophils
    I Conejeros
    Universidad Austral de Chile, Valdivia, Chile
    Res Vet Sci 92:103-10. 2012
  10. ncbi 2-Aminoethoxydiphenyl borate (2-APB) reduces alkaline phosphatase release, CD63 expression, F-actin polymerization and chemotaxis without affecting the phagocytosis activity in bovine neutrophils
    I Conejeros
    Laboratory of Inflammation Pharmacology, Institute of Pharmacology and Morphophysiology, Faculty of Veterinary Science, Universidad Austral de Chile, P O Box 567, Valdivia, Chile
    Vet Immunol Immunopathol 145:540-5. 2012

Collaborators

  • C D Figueroa
  • Timothy P LaBranche
  • M Calvo
  • I Conejeros
  • María A Hidalgo
  • P Alarcon
  • M A Hidalgo
  • Juan L Hancke
  • M D Carretta
  • María D Carretta
  • E Jara
  • Pamela Ehrenfeld
  • A Sandoval
  • Alvaro J Sandoval
  • Ilona I Concha
  • P Ehrenfeld
  • Mirentxu I Iruretagoyena
  • Z D Velásquez
  • N Tadich
  • R Patterson
  • C Hermosilla
  • C Concha
  • D Werling
  • Francisca Pavicic
  • Evelyn Jara
  • Kanti D Bhoola
  • Cesar Toledo
  • Pablo Alarcon
  • Carlos B Gonzalez
  • Francisco Nualart
  • Carola E Matus
  • Loreto Solis
  • Jeanette P Riquelme
  • A Sanhueza
  • F Triviños
  • J L Hancke
  • D Carretta
  • F Nualart
  • K D Bhoola
  • C E Matus
  • C Millan
  • J E Figueroa
  • Jaime Figueroa
  • Patricia Cortes
  • Alex Romero
  • Alexis M Kalergis
  • Jaime A Tobar
  • Carlos Smith
  • Peter Eyre
  • Flavio Ojeda

Detail Information

Publications21

  1. ncbi Andrographolide inhibits IFN-gamma and IL-2 cytokine production and protects against cell apoptosis
    Rafael A Burgos
    Laboratory of Molecular Pharmacology, Institute of Pharmacology, Faculty of Veterinary Science, Universidad Austral de Chile, Valdivia, Chile
    Planta Med 71:429-34. 2005
    ..We conclude that both diterpenic labdanes isolated from A. paniculata can exert potent immunosuppressant effects without affecting the viability of the cells...
  2. ncbi Andrographis paniculata (Nees) selectively blocks voltage-operated calcium channels in rat vas deferens
    R A Burgos
    Institute of Pharmacology, Faculty of Veterinary Science, Universidad Austral de Chile, P O Box 567, Valdivia, Chile
    J Ethnopharmacol 71:115-21. 2000
    ..The influx was completely blockaded with 0.4 mg/ml A. paniculata. These results suggest that A. paniculata selectively blockades VOCs, hence inhibiting the 45Ca(2+) influx...
  3. ncbi 14-deoxyandrographolide as a platelet activating factor antagonist in bovine neutrophils
    Rafael A Burgos
    Laboratory of Molecular Pharmacology, Institute of Pharmacology, Facultad de Ciencias Veterinarias, Universidad Austral de Chile, Valdivia, Chile
    Planta Med 71:604-8. 2005
    ..63, suggesting that there is more than one binding site for 14-DAP. We concluded that 14-DAP is an effective antagonist of PAF-mediated processes in bovine neutrophils, probably by virtue of its calcium channel blocking property...
  4. ncbi New potential targets to modulate neutrophil function in inflammation
    R A Burgos
    Laboratory of Molecular Pharmacology, Institute of Pharmacology, Faculty of Veterinary Sciences, Universidad Austral de Chile, Casilla 567, Valdivia, Chile
    Mini Rev Med Chem 9:153-68. 2009
    ..In this review, we summarize new potential drugs targets against neutrophils mediated inflammatory responses...
  5. ncbi Efficacy of an Andrographis paniculata composition for the relief of rheumatoid arthritis symptoms: a prospective randomized placebo-controlled trial
    R A Burgos
    Institute of Pharmacology and Morphophysiology, Universidad Austral de Chile, P O Box 567, Valdivia, Chile
    Clin Rheumatol 28:931-46. 2009
    ..These findings suggest that A. paniculata could be a useful "natural complement" in the treatment of AR; however, a larger trial and a more extended period of treatment is necessary in order to corroborate these results...
  6. ncbi Calcium influx, a new potential therapeutic target in the control of neutrophil-dependent inflammatory diseases in bovines
    R A Burgos
    Laboratory of Molecular Pharmacology, Institute of Pharmacology and Morphophysiology, Faculty of Veterinary Science, Universidad Austral de Chile, Valdivia, Chile
    Vet Immunol Immunopathol 143:1-10. 2011
    ..In this paper, we will review the role of calcium influx as a potential anti-inflammatory target and summarize the most recent evidences for this in bovine neutrophils...
  7. ncbi Effect of 14-deoxyandrographolide on calcium-mediated rat uterine smooth muscle contractility
    Rafael A Burgos
    Institute of Pharmacology, Facultad de Ciencias Veterinarias, Universidad Austral de Chile, Valdivia, Chile
    Phytother Res 17:1011-5. 2003
    ..Based on these data, it appears that 14-DAP is an uterine smooth muscle relaxant which produces a selective blockade of voltage operated calcium channels...
  8. ncbi Andrographis paniculata (Ness) induces relaxation of uterus by blocking voltage operated calcium channels and inhibits Ca(+2) influx
    R A Burgos
    Institute of Pharmacology, Faculty of Veterinary Science, Universidad Austral de Chile, P O Box 567, Valdivia, Chile
    Phytother Res 15:235-9. 2001
    ..The influx was completely blockaded with 0.4 mg/mL of A. paniculata. These results strongly suggest that A. paniculata blockades voltage operated calcium channels inhibiting the entry of Ca(+2) from the external medium...
  9. ncbi 2-Aminoethoxydiphenyl borate (2-APB) reduces respiratory burst, MMP-9 release and CD11b expression, and increases l-selectin shedding in bovine neutrophils
    I Conejeros
    Universidad Austral de Chile, Valdivia, Chile
    Res Vet Sci 92:103-10. 2012
    ....
  10. ncbi 2-Aminoethoxydiphenyl borate (2-APB) reduces alkaline phosphatase release, CD63 expression, F-actin polymerization and chemotaxis without affecting the phagocytosis activity in bovine neutrophils
    I Conejeros
    Laboratory of Inflammation Pharmacology, Institute of Pharmacology and Morphophysiology, Faculty of Veterinary Science, Universidad Austral de Chile, P O Box 567, Valdivia, Chile
    Vet Immunol Immunopathol 145:540-5. 2012
    ..coli and S. aureus bioparticles. We concluded that inhibition of Ca(2+) influx could be a useful strategy to reduce inflammatory process in cattle...
  11. ncbi D-lactic acid interferes with the effects of platelet activating factor on bovine neutrophils
    P Alarcon
    Laboratory of Inflammation Pharmacology, Institute of Pharmacology and Morphophysiology, Faculty of Veterinary Science, Universidad Austral de Chile, P O Box 567, Valdivia, Chile
    Vet Immunol Immunopathol 144:68-78. 2011
    ..Moreover, the increase of MMP-9 release and CD11b expression induced by 10mM D-lactic acid could promote an nonspecific neutrophil-dependent inflammatory reaction in cattle with acute ruminal acidosis...
  12. ncbi Induction of reactive oxygen species in bovine neutrophils is CD11b, but not dectin-1-dependent
    I Conejeros
    Laboratory of Inflammation Pharmacology, Institute of Pharmacology and Morphophysiology, Faculty of Veterinary Science, Universidad Austral de Chile, P O Box 567, Valdivia, Chile
    Vet Immunol Immunopathol 139:308-12. 2011
    ..Taken together, our data describe the presence of specific PRRs transcripts in the mRNA isolated from bovine neutrophil and show a CD11b-/Ca(2+) dependent ROS production by these cells...
  13. ncbi Propionate induces pH(i) changes through calcium flux, ERK1/2, p38, and PKC in bovine neutrophils
    A Sandoval
    Institute of Pharmacology, Faculty of Veterinary Science, Universidad Austral de Chile, P O Box 567, Valdivia, Chile
    Vet Immunol Immunopathol 115:286-98. 2007
    ....
  14. ncbi Store-operated calcium entry mediates intracellular alkalinization, ERK1/2, and Akt/PKB phosphorylation in bovine neutrophils
    Alvaro J Sandoval
    Laboratory of Molecular Pharmacology, Institute of Pharmacology, Faculty of Veterinary Science, Universidad Austral de Chile, Valdivia, Chile
    J Leukoc Biol 82:1266-77. 2007
    ..Finally, 2-APB could be an important tool to characterize Ca(2+) signaling in neutrophils...
  15. ncbi Andrographolide reduces IL-2 production in T-cells by interfering with NFAT and MAPK activation
    María D Carretta
    Faculty of Veterinary Science, Laboratory of Molecular Pharmacology, Institute of Pharmacology, Universidad Austral de Chile, Valdivia, Chile
    Eur J Pharmacol 602:413-21. 2009
    ..We concluded that andrographolide can exert immunomodulatory effects by interfering with NFAT activation and ERK1 and ERK5 phosphorylation in T-cells...
  16. ncbi Andrographolide interferes with binding of nuclear factor-kappaB to DNA in HL-60-derived neutrophilic cells
    María A Hidalgo
    Laboratory of Molecular Pharmacology, Institute of Pharmacology, Universidad Austral de Chile, PO Box 567, Isla Teja s n, Valdivia, Chile
    Br J Pharmacol 144:680-6. 2005
    ..7. It is concluded that andrographolide exerts its anti-inflammatory effects by inhibiting NF-kappaB binding to DNA, and thus reducing the expression of proinflammatory proteins, such as COX-2...
  17. ncbi Platelet-activating factor increases pH(i) in bovine neutrophils through the PI3K-ERK1/2 pathway
    María A Hidalgo
    Laboratory of Molecular Pharmacology, Institute of Pharmacology, Faculty of Veterinary Science, Universidad Austral de Chile, PO Box 567, Isla Teja s n, Valdivia, Chile
    Br J Pharmacol 141:311-21. 2004
    ..6. Our results suggest that PAF induces intracellular alkalinization via PI3K-MAPK activation. This effect is upstream regulated by PAF receptor, PTX-sensitive G protein, tyrosine kinase, PI3K and MEK1/2 in bovine neutrophils...
  18. ncbi Determination of specific receptor sites for platelet activating factor in bovine neutrophils
    Rafael A Burgos
    Laboratory of Molecular Pharmacology, Institute of Pharmacology, Faculty of Veterinary Sciences, Universidad Austral de Chile, PO Box 567, Valdivia, Chile
    Am J Vet Res 65:628-36. 2004
    ..The most effective PAF antagonists were 14-deoxyandrographolide and WEB 2086; these PAF antagonists may be potentially useful in the treatment of inflammatory processes in cattle...
  19. ncbi Kinin B1 receptor activation turns on exocytosis of matrix metalloprotease-9 and myeloperoxidase in human neutrophils: involvement of mitogen-activated protein kinase family
    Pamela Ehrenfeld
    Laboratorio de Patologia Celular, Instituto de Anatomia, Histología and Patología, Universidad Austral de Chile, Valdivia, Chile
    J Leukoc Biol 86:1179-89. 2009
    ....
  20. ncbi Activation of kinin B1 receptors induces chemotaxis of human neutrophils
    P Ehrenfeld
    Instituto de Histologia y Patologia, Universidad Austral de Chile, Casilla 567, Valdivia, Chile
    J Leukoc Biol 80:117-24. 2006
    ..A generation of kinin B(1) receptor agonists during the early phase of acute inflammation may favor the recruitment of neutrophils to the inflammatory site...
  21. ncbi Andrographolide interferes with T cell activation and reduces experimental autoimmune encephalomyelitis in the mouse
    Mirentxu I Iruretagoyena
    , , , Alameda 340, Santiago, Chile
    J Pharmacol Exp Ther 312:366-72. 2005
    ..Our data suggest that andrographolide is able to efficiently block T cell activation in vitro, as well as in vivo, a feature that could be useful for interfering with detrimental T cell responses...