Ricardo Armisen

Summary

Affiliation: Universidad de Chile
Location: Santiago, Chile
URL: https://www.researchgate.net/profile/Ricardo_Armisen/?ev=hdr_xprf
Summary:
We are committed to understand cancer cell biology, from cell signaling to genomics, back and forward. Also, we want to contribute to medicine, looking for ways to move cancer cell biology knowledge from our labs to cancer patient care.
Grants:
Director "RED U-CANCER. UNA PLATAFORMA EN LINEA DE INVESTIGACION BASICO­ CLINICA DE CANCER EN CHILE", 2013, CONICYT

Investigador Principal “Física de Plasma, Potencia Pulsada y Biología Celular para Energía, Vida y Medio Ambiente", 2013, Anillo de Investigación en Ciencia y Tecnología


Director “Incorporación de la secuenciación de ultima generación en el cuidado de los pacientes con cáncer”, 2013, FONDEF

Director Centro de Investigación y Tratamiento del Cáncer, 2012, Facultad de Medicina Universidad de Chile

Co-Investigador"Ski-containing transcriptional co-repressor complexes on mitotic chromosomes repress the expression of selected target genes at early G1", 2012, FONDECYT 1120222

Co-Investigador “Protein kinase CK2 promotes colon cancer metastasis by increasing the expression of Endothelin-Converting Enzyme-1 isoform c (ECE-1c)”, 2012 , FONDECYT 1120132

Investigador Principal “The Transient Receptor Potential Melastatin 4 (TRPM4) channel stabilizes β-catenin and therefore enhances cell proliferation through a calcium-dependent negative regulation of GSK-3β activity”, 2012, FONDECYT 1120286

Director Domeyko II “U-CANCER: Red de Medicina Traslacional en Cáncer”, 2012, Vicerrectoría de Investigación Universidad de Chile

Co-Investigador “Centro de Estudios Moleculares de la Célula”, 2006, FONDAP 15010006

Publications

  1. doi request reprint TRPM4 enhances cell proliferation through up-regulation of the β-catenin signaling pathway
    Ricardo Armisen
    Centro de Estudios Moleculares de la Célula, Facultad de Medicina, Universidad de Chile, Santiago, Chile
    J Cell Physiol 226:103-9. 2011
  2. doi request reprint Phosphorylation of AKT/PKB by CK2 is necessary for the AKT-dependent up-regulation of β-catenin transcriptional activity
    Daniela P Ponce
    Program of Cellular and Molecular Biology, ICBM, Faculty of Medicine, University of Chile, Santiago, Chile
    J Cell Physiol 226:1953-9. 2011
  3. ncbi request reprint L-type calcium channel β subunit modulates angiotensin II responses in cardiomyocytes
    Tamara Hermosilla
    Centro de Estudios Moleculares de la Célula, Instituto de Ciencias Biomedicas, Universidad de Chile, Santiago, Chile
    Channels (Austin) 5:280-6. 2011
  4. doi request reprint Increased expression of the transient receptor potential melastatin 7 channel is critically involved in lipopolysaccharide-induced reactive oxygen species-mediated neuronal death
    Felipe Nuñez-Villena
    Departamento de Ciencias Biologicas, Facultad de Ciencias Biologicas, Universidad Andres Bello, Santiago, Chile
    Antioxid Redox Signal 15:2425-38. 2011
  5. ncbi request reprint Transient receptor potential melastatin 4 inhibition prevents lipopolysaccharide-induced endothelial cell death
    Alvaro Becerra
    Departamento de Ciencias Biologicas, Facultad de Ciencias Biologicas and Facultad de Medicina, Universidad Andres Bello, Av República 217, 8370146 Santiago, Chile
    Cardiovasc Res 91:677-84. 2011
  6. pmc Identification of Ski as a target for Aurora A kinase
    Jocelyn Mosquera
    Programa de Genética Humana, Instituto de Ciencias Biomedicas, Facultad de Medicina, Universidad de Chile, Santiago, Chile
    Biochem Biophys Res Commun 409:539-43. 2011
  7. doi request reprint Protein kinase CK2 promotes cancer cell viability via up-regulation of cyclooxygenase-2 expression and enhanced prostaglandin E2 production
    Roger Yefi
    Institute of Biomedical Sciences ICBM, Faculty of Medicine, University of Chile, Santiago, Chile
    J Cell Biochem 112:3167-75. 2011
  8. doi request reprint CK2 functionally interacts with AKT/PKB to promote the β-catenin-dependent expression of survivin and enhance cell survival
    Daniela P Ponce
    Institute of Biomedical Sciences, Cell Transformation Laboratory, Program of Cellular and Molecular Biology, ICBM, University of Chile, Av Independencia 1027, 8700664 Santiago, Chile
    Mol Cell Biochem 356:127-32. 2011
  9. pmc TMBIM3/GRINA is a novel unfolded protein response (UPR) target gene that controls apoptosis through the modulation of ER calcium homeostasis
    D Rojas-Rivera
    Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Santiago, Chile
    Cell Death Differ 19:1013-26. 2012
  10. pmc Chromosomal instability in mouse embryonic fibroblasts null for the transcriptional co-repressor Ski
    Katherine Marcelain
    Programa de Genética Humana, Instituto de Ciencias Biomedicas, Facultad de Medicina, Universidad de Chile, Santiago, Chile
    J Cell Physiol 227:278-87. 2012

Collaborators

Detail Information

Publications21

  1. doi request reprint TRPM4 enhances cell proliferation through up-regulation of the β-catenin signaling pathway
    Ricardo Armisen
    Centro de Estudios Moleculares de la Célula, Facultad de Medicina, Universidad de Chile, Santiago, Chile
    J Cell Physiol 226:103-9. 2011
    ..Our results identify TRPM4 as an important, unanticipated regulator of the β-catenin pathway, where aberrant signaling is frequently associated with cancer...
  2. doi request reprint Phosphorylation of AKT/PKB by CK2 is necessary for the AKT-dependent up-regulation of β-catenin transcriptional activity
    Daniela P Ponce
    Program of Cellular and Molecular Biology, ICBM, Faculty of Medicine, University of Chile, Santiago, Chile
    J Cell Physiol 226:1953-9. 2011
    ..Taken together, the data suggest that the CK2α-dependent up-regulation of β-catenin activity requires phosphorylation of AKT in human embryonic kidney cells...
  3. ncbi request reprint L-type calcium channel β subunit modulates angiotensin II responses in cardiomyocytes
    Tamara Hermosilla
    Centro de Estudios Moleculares de la Célula, Instituto de Ciencias Biomedicas, Universidad de Chile, Santiago, Chile
    Channels (Austin) 5:280-6. 2011
    ..These data demonstrate that Ca(v)β subunits alter the magnitude of inhibition of L-type current by Angiotensin II...
  4. doi request reprint Increased expression of the transient receptor potential melastatin 7 channel is critically involved in lipopolysaccharide-induced reactive oxygen species-mediated neuronal death
    Felipe Nuñez-Villena
    Departamento de Ciencias Biologicas, Facultad de Ciencias Biologicas, Universidad Andres Bello, Santiago, Chile
    Antioxid Redox Signal 15:2425-38. 2011
    ..To assess the mechanisms involved in lipopolysaccharide (LPS)-induced neuronal cell death, we examined the cellular consequences of LPS exposure in differentiated PC12 neurons and primary hippocampal neurons...
  5. ncbi request reprint Transient receptor potential melastatin 4 inhibition prevents lipopolysaccharide-induced endothelial cell death
    Alvaro Becerra
    Departamento de Ciencias Biologicas, Facultad de Ciencias Biologicas and Facultad de Medicina, Universidad Andres Bello, Av República 217, 8370146 Santiago, Chile
    Cardiovasc Res 91:677-84. 2011
    ..Here, we investigate the role of TRPM4 in LPS-induced endothelial cell death, testing whether suppression of the expression of TRPM4 confers endothelial cell resistance to LPS challenge...
  6. pmc Identification of Ski as a target for Aurora A kinase
    Jocelyn Mosquera
    Programa de Genética Humana, Instituto de Ciencias Biomedicas, Facultad de Medicina, Universidad de Chile, Santiago, Chile
    Biochem Biophys Res Commun 409:539-43. 2011
    ..These data identify Ski as a novel target of Aurora A and contribute to an understanding of the role of these proteins in the mitotic process...
  7. doi request reprint Protein kinase CK2 promotes cancer cell viability via up-regulation of cyclooxygenase-2 expression and enhanced prostaglandin E2 production
    Roger Yefi
    Institute of Biomedical Sciences ICBM, Faculty of Medicine, University of Chile, Santiago, Chile
    J Cell Biochem 112:3167-75. 2011
    ..Altogether, these findings provide new insight to the role of CK2 in cancer by up-regulating COX-2 expression and thereby PGE2 production...
  8. doi request reprint CK2 functionally interacts with AKT/PKB to promote the β-catenin-dependent expression of survivin and enhance cell survival
    Daniela P Ponce
    Institute of Biomedical Sciences, Cell Transformation Laboratory, Program of Cellular and Molecular Biology, ICBM, University of Chile, Av Independencia 1027, 8700664 Santiago, Chile
    Mol Cell Biochem 356:127-32. 2011
    ..Therefore, our results strongly suggest that CK2α-specific enhancement of β-catenin transcriptional activity as well as cell survival may depend on AKT hyperactivation by CK2...
  9. pmc TMBIM3/GRINA is a novel unfolded protein response (UPR) target gene that controls apoptosis through the modulation of ER calcium homeostasis
    D Rojas-Rivera
    Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Santiago, Chile
    Cell Death Differ 19:1013-26. 2012
    ..These findings suggest the existence of a conserved group of functionally related cell death regulators across species beyond the BCL-2 family of proteins operating at the ER membrane...
  10. pmc Chromosomal instability in mouse embryonic fibroblasts null for the transcriptional co-repressor Ski
    Katherine Marcelain
    Programa de Genética Humana, Instituto de Ciencias Biomedicas, Facultad de Medicina, Universidad de Chile, Santiago, Chile
    J Cell Physiol 227:278-87. 2012
    ..The presented data support a new role for Ski in the mitotic process and in maintenance of genetic stability, providing insights into the mechanism of tumor suppression mediated by this protein...
  11. pmc Prion protein misfolding affects calcium homeostasis and sensitizes cells to endoplasmic reticulum stress
    Mauricio Torres
    Center for Molecular Studies of the Cell, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Santiago, Chile
    PLoS ONE 5:e15658. 2010
    ..Our results suggest that alterations in calcium homeostasis and increased susceptibility to ER stress are common pathological features of both infectious and familial PrD models...
  12. ncbi request reprint Repressor element-1 silencing transcription/neuron-restrictive silencer factor is required for neural sodium channel expression during development of Xenopus
    Ricardo Armisen
    Programa de Fisiologia y Biofisica, Instituto de Ciencias Biomedicas, Facultad de Medicina, Universidad de Chile, Independencia 1027, Santiago, Chile
    J Neurosci 22:8347-51. 2002
    ..Furthermore, they suggest that REST/NRSF may be used to activate or repress transcription of neuronal genes in distinct cellular and developmental contexts...
  13. ncbi request reprint A mutation in serca underlies motility dysfunction in accordion zebrafish
    Michelle R Gleason
    Department of Neurobiology and Behavior, State University of New York at Stony Brook, 550 CMM, Stony Brook, NY 11794, USA
    Dev Biol 276:441-51. 2004
    ..We conclude that the motility dysfunction in embryonic and larval accordion zebrafish stems directly from defective calcium transport in skeletal muscle rather than defective CNS drive...
  14. ncbi request reprint Developmental regulation of the expression of sodium currents in Xenopus primary neurons
    Patricio Olguin
    Programa de Fisiologia y Biofisica, Instituto de Ciencias Biomedicas, Facultad de Medicina, Universidad de Chile, Chile
    Biol Res 39:483-91. 2006
    ....
  15. ncbi request reprint Activation of H2O2-induced VSOR Cl- currents in HTC cells require phospholipase Cgamma1 phosphorylation and Ca2+ mobilisation
    Diego Varela
    Centro de Estudios Moleculares de la Célula and Instituto de Ciencias Biomédicas, Facultad de Medicina, Universidad de Chile, Santiago, Chile
    Cell Physiol Biochem 20:773-80. 2007
    ....
  16. ncbi request reprint Cell death by necrosis, a regulated way to go
    Mauricio Henriquez
    Centro FONDAP de Estudios Moleculares de la Célula CEMC, Instituto de Ciencias Biomedicas, Facultad de Medicina, Universidad de Chile, Santiago, Chile
    Curr Mol Med 8:187-206. 2008
    ..Emphasis is laid on summarizing our understanding of events that permit switching between cell death modes and how they connect to necrosis. Finally, potential implications for the treatment of some disease states are mentioned...
  17. doi request reprint Endovenous laser and echo-guided foam ablation in great saphenous vein reflux: one-year follow-up results
    Rodrigo Gonzalez-Zeh
    Clínica de Várices Doctor González Folch, Santiago, Chile
    J Vasc Surg 48:940-6. 2008
    ....
  18. pmc Hydrogen peroxide removes TRPM4 current desensitization conferring increased vulnerability to necrotic cell death
    Felipe Simon
    Centro de Estudios Moleculares de la Célula and Instituto de Ciencias Biomédicas, Facultad de Medicina, Universidad de Chile, Av Independencia 1027, Independencia 838 0543, Santiago, Chile
    J Biol Chem 285:37150-8. 2010
    ..In addition, HeLa cells exposed to H(2)O(2) displayed an irreversible loss of membrane potential, which was prevented by TRPM4 knockdown...
  19. pmc BH3-only proteins are part of a regulatory network that control the sustained signalling of the unfolded protein response sensor IRE1α
    Diego A Rodriguez
    Institute of Biomedical Sciences, Center for Molecular Studies of the Cell, Santiago, Chile
    EMBO J 31:2322-35. 2012
    ..We conclude that a subset of BCL-2 family members participates in a new UPR-regulatory network, thus assuming apoptosis-unrelated functions...