Juan C Saez

Summary

Country: Chile

Publications

  1. ncbi request reprint Hunting for connexin hemichannels
    Juan C Saez
    Departamento de Fisiologia, Pontificia Universidad Catolica de Chile, Santiago and Instituto Milenio, Centro Interdisciplinario de Neurociencias de Valparaíso, Valparaiso, Chile Electronic address
    FEBS Lett 588:1205-11. 2014
  2. doi request reprint Boldine prevents renal alterations in diabetic rats
    Romina Hernández-Salinas
    Departamento de Fisiologia, Pontificia Universidad Catolica de Chile, Alameda Bernardo O Higgins, No 340, 6513677 Santiago, Chile
    J Diabetes Res 2013:593672. 2013
  3. doi request reprint Cell membrane permeabilization via connexin hemichannels in living and dying cells
    Juan C Saez
    Departamento de Ciencias Fisiologicas, Pontificia Universidad Catolica de Chile, Santiago, Chile
    Exp Cell Res 316:2377-89. 2010
  4. pmc Connexin-based gap junction hemichannels: gating mechanisms
    Juan C Saez
    Departamento de Ciencias Fisiologicas, Pontificia Universidad Catolica de Chile, Santiago, Chile
    Biochim Biophys Acta 1711:215-24. 2005
  5. pmc ATP and glutamate released via astroglial connexin 43 hemichannels mediate neuronal death through activation of pannexin 1 hemichannels
    Juan A Orellana
    Departamento de Fisiologia, Pontificia Universidad Catolica de Chile, Santiago, Chile
    J Neurochem 118:826-40. 2011
  6. pmc Hypoxia in high glucose followed by reoxygenation in normal glucose reduces the viability of cortical astrocytes through increased permeability of connexin 43 hemichannels
    Juan A Orellana
    Departamento de Ciencias Fisiologicas, Pontificia Universidad Catolica de Chile, Alameda 340, Santiago, Chile
    Glia 58:329-43. 2010
  7. doi request reprint Linoleic acid induces opening of connexin26 hemichannels through a PI3K/Akt/Ca(2+)-dependent pathway
    Vania Figueroa
    Departamento de Fisiologia, Pontificia Universidad Catolica de Chile, Santiago, Chile
    Biochim Biophys Acta 1828:1169-79. 2013
  8. ncbi request reprint Histamine reduces gap junctional communication of human tonsil high endothelial cells in culture
    Xavier F Figueroa
    Departamento de Ciencias Fisiologicas, Facultad de Ciencias Biologicas, Pontificia Universidad, Catolica de Chile, Chile
    Microvasc Res 68:247-57. 2004
  9. pmc Glucose increases intracellular free Ca(2+) in tanycytes via ATP released through connexin 43 hemichannels
    Juan A Orellana
    Departamento de Fisiologia, Pontificia Universidad Catolica de Chile, Santiago, Chile
    Glia 60:53-68. 2012
  10. pmc Opening of connexin 43 hemichannels is increased by lowering intracellular redox potential
    Mauricio A Retamal
    Núcleo Milenio Inmunología e Inmunoterapia, Departamento de Ciencias Fisiologicas, Pontificia Universidad Catolica de Chile, Santiago 4860, Chile
    Proc Natl Acad Sci U S A 104:8322-7. 2007

Collaborators

Detail Information

Publications50

  1. ncbi request reprint Hunting for connexin hemichannels
    Juan C Saez
    Departamento de Fisiologia, Pontificia Universidad Catolica de Chile, Santiago and Instituto Milenio, Centro Interdisciplinario de Neurociencias de Valparaíso, Valparaiso, Chile Electronic address
    FEBS Lett 588:1205-11. 2014
    ..We here present a brief overview of connexin hemichannels as functional channels and itemize a list of aspects to consider when concluding on their involvement. ..
  2. doi request reprint Boldine prevents renal alterations in diabetic rats
    Romina Hernández-Salinas
    Departamento de Fisiologia, Pontificia Universidad Catolica de Chile, Alameda Bernardo O Higgins, No 340, 6513677 Santiago, Chile
    J Diabetes Res 2013:593672. 2013
    ..Thus boldine prevented both renal and cellular alterations and could be useful for preventing tissue damage in diabetic subjects. ..
  3. doi request reprint Cell membrane permeabilization via connexin hemichannels in living and dying cells
    Juan C Saez
    Departamento de Ciencias Fisiologicas, Pontificia Universidad Catolica de Chile, Santiago, Chile
    Exp Cell Res 316:2377-89. 2010
    ....
  4. pmc Connexin-based gap junction hemichannels: gating mechanisms
    Juan C Saez
    Departamento de Ciencias Fisiologicas, Pontificia Universidad Catolica de Chile, Santiago, Chile
    Biochim Biophys Acta 1711:215-24. 2005
    ..Taken together, the data indicate that hemichannels are gated by multiple mechanisms that independently or cooperatively affect their open probability under physiological as well as pathological conditions...
  5. pmc ATP and glutamate released via astroglial connexin 43 hemichannels mediate neuronal death through activation of pannexin 1 hemichannels
    Juan A Orellana
    Departamento de Fisiologia, Pontificia Universidad Catolica de Chile, Santiago, Chile
    J Neurochem 118:826-40. 2011
    ....
  6. pmc Hypoxia in high glucose followed by reoxygenation in normal glucose reduces the viability of cortical astrocytes through increased permeability of connexin 43 hemichannels
    Juan A Orellana
    Departamento de Ciencias Fisiologicas, Pontificia Universidad Catolica de Chile, Alameda 340, Santiago, Chile
    Glia 58:329-43. 2010
    ..Cx43 hemichannels may be a novel therapeutic target to reduce cell death following stroke, particularly in hyperglycemic conditions...
  7. doi request reprint Linoleic acid induces opening of connexin26 hemichannels through a PI3K/Akt/Ca(2+)-dependent pathway
    Vania Figueroa
    Departamento de Fisiologia, Pontificia Universidad Catolica de Chile, Santiago, Chile
    Biochim Biophys Acta 1828:1169-79. 2013
    ..Since LA is an essential polyunsaturated fatty acid, its effect on HCs might be relevant to cell growth as well as to cellular functions of differentiated cells such as audition...
  8. ncbi request reprint Histamine reduces gap junctional communication of human tonsil high endothelial cells in culture
    Xavier F Figueroa
    Departamento de Ciencias Fisiologicas, Facultad de Ciencias Biologicas, Pontificia Universidad, Catolica de Chile, Chile
    Microvasc Res 68:247-57. 2004
    ..Hence, the histamine-induced reduction in gap junctional communication between HUTEC is mediated by cytoskeleton-dependent and -independent mechanisms and might contribute to modulate endothelial function in lymphoid tissue...
  9. pmc Glucose increases intracellular free Ca(2+) in tanycytes via ATP released through connexin 43 hemichannels
    Juan A Orellana
    Departamento de Fisiologia, Pontificia Universidad Catolica de Chile, Santiago, Chile
    Glia 60:53-68. 2012
    ..It also establishes that Cx43 hemichannels can be rapidly activated under physiological conditions by the sequential activation of glucosensing proteins in normal tanycytes...
  10. pmc Opening of connexin 43 hemichannels is increased by lowering intracellular redox potential
    Mauricio A Retamal
    Núcleo Milenio Inmunología e Inmunoterapia, Departamento de Ciencias Fisiologicas, Pontificia Universidad Catolica de Chile, Santiago 4860, Chile
    Proc Natl Acad Sci U S A 104:8322-7. 2007
    ..These findings suggest that lowering intracellular redox potential increases the opening of Cx43 and Cx43-EGFP hemichannels, possibly by action on cytoplasmic cysteine residues in the connexin C terminus...
  11. ncbi request reprint Injury of skeletal muscle and specific cytokines induce the expression of gap junction channels in mouse dendritic cells
    Liliana A Corvalán
    Departamento de Ciencias Fisiologicas, Pontificia Universidad Catolica de Chile, Santiago, Chile
    J Cell Physiol 211:649-60. 2007
    ..Increased levels of connexin43 and connexin45 protein and mRNA accompanied the appearance of cellular coupling. These studies provide demonstration of connexin expression and regulation by specific danger signals in DCs...
  12. pmc Disruption in connexin-based communication is associated with intracellular Ca²⁺ signal alterations in astrocytes from Niemann-Pick type C mice
    Pablo J Sáez
    Departamento de Fisiologia, Pontificia Universidad Catolica de Chile, Santiago, Chile
    PLoS ONE 8:e71361. 2013
    ..Therefore, Npc1⁻/⁻ astrocytes present features of connexin based channels compatible with those of reactive astrocytes and hemichannels might be a novel therapeutic target to reduce neuroinflammation in NPC disease...
  13. doi request reprint Glial hemichannels and their involvement in aging and neurodegenerative diseases
    Juan A Orellana
    Facultad de Medicina, Departamento de Neurologia, Pontificia Universidad Catolica de Chile, Santiago, Chile
    Rev Neurosci 23:163-77. 2012
    ..Therefore, blockade of hemichannels expressed by glial cells and/or neurons during neuroinflammation might prevent neurodegeneration...
  14. pmc Functional role of gap junctions in cytokine-induced leukocyte adhesion to endothelium in vivo
    Loreto P Véliz
    Departamento de Ciencias Fisiologicas, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, Av B O Higgins 340, P O Box Casilla 114 D, Santiago, Chile
    Am J Physiol Heart Circ Physiol 295:H1056-H1066. 2008
    ..These results demonstrate an important role for GJ communication in leukocyte adhesion and transmigration during acute inflammation in vivo and further suggest that endothelial Cx43 is key in these processes...
  15. ncbi request reprint Identification of second messengers that induce expression of functional gap junctions in microglia cultured from newborn rats
    Agustin D Martinez
    Departamento de Ciencias Fisiologicas, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, Alameda 340, Santiago, Chile
    Brain Res 943:191-201. 2002
    ....
  16. ncbi request reprint Cx43 hemichannels and gap junction channels in astrocytes are regulated oppositely by proinflammatory cytokines released from activated microglia
    Mauricio A Retamal
    Departamento de Ciencias Fisiologicas, Pontificia Universidad Catolica de Chile, Santiago 6513492, Chile
    J Neurosci 27:13781-92. 2007
    ..Accordingly, this opposite regulation may affect glucose trafficking and certainly will modify the metabolic status of astrocytes involved in brain inflammation...
  17. pmc Possible involvement of TLRs and hemichannels in stress-induced CNS dysfunction via mastocytes, and glia activation
    Adam Aguirre
    Departamento de Fisiologia, Pontificia Universidad Catolica de Chile, Santiago, Chile
    Mediators Inflamm 2013:893521. 2013
    ..Such disorders could eventually be potentiated by stress and might be part of the etiopathogenesis of CNS dysfunctions including autism spectrum disorders and schizophrenia. ..
  18. pmc De novo expression of connexin hemichannels in denervated fast skeletal muscles leads to atrophy
    Luis A Cea
    Departamento de Fisiologia, Pontificia Universidad Catolica de Chile, Santiago 6513677, Chile
    Proc Natl Acad Sci U S A 110:16229-34. 2013
    ..Consequently, Cx hemichannels are potential targets for new therapeutic agents to prevent or reduce muscle atrophy induced by denervation of diverse etiologies. ..
  19. doi request reprint Modulation of gap junction channels and hemichannels by growth factors
    Kurt A Schalper
    Clinica Alemana de Santiago, Universidad del Desarrollo, Santiago, Chile
    Mol Biosyst 8:685-98. 2012
    ..The functional consequence of variation in cell-cell communication via these membrane channels is implicated in disease as well as normal cellular responses...
  20. pmc Connexin hemichannel composition determines the FGF-1-induced membrane permeability and free [Ca2+]i responses
    Kurt A Schalper
    Departamento de Ciencias Fisiologicas, Pontificia Universidad Catolica de Chile, Santiago, Chile
    Mol Biol Cell 19:3501-13. 2008
    ..The cell density of Cx26 and Cx43 HeLa transfectants cultured in serum-free medium was differentially affected by FGF-1. Thus, the FGF-1-induced cell permeabilization and derived consequences depend on the Cx composition of HCs...
  21. ncbi request reprint Expression of connexins during differentiation and regeneration of skeletal muscle: functional relevance of connexin43
    Roberto Araya
    Departamento de Fisiologia, Pontificia Universidad Catolica de Chile, Santiago, Chile
    J Cell Sci 118:27-37. 2005
    ..Thus, the expression of Cx45 and Cx43 is upregulated during skeletal muscle regeneration and Cx43 is required for normal myogenesis in vitro and adult muscle regeneration in vivo...
  22. pmc Role of connexin-based gap junction channels and hemichannels in ischemia-induced cell death in nervous tissue
    Jorge E Contreras
    Departamento de Ciencias Fisiologicas, Pontificia Universidad Catolica de Chile, Chile
    Brain Res Brain Res Rev 47:290-303. 2004
    ..In addition to the cell specific features of an ischemic insult, propagation of cell damage and death within affected tissues may be affected by expression and regulation of gap junction channels and hemichannels formed by connexins...
  23. doi request reprint Regulation of intercellular calcium signaling through calcium interactions with connexin-based channels
    Juan A Orellana
    Departamento de Neurologia, Facultad de Medicina, Pontificia Universidad Catolica de Chile, Marcoleta 391, 8330024, Santiago, Chile
    Adv Exp Med Biol 740:777-94. 2012
    ..Here, we review evidence supporting the role of Ca(2+) in the regulation of GJCs and HCs formed by connexins. Also it is speculated how these connexin-based channels could contribute to the propagation of intercellular Ca(2+) signals...
  24. pmc Cation permeation through connexin 43 hemichannels is cooperative, competitive and saturable with parameters depending on the permeant species
    Juan A Orellana
    Departamento de Fisiologia, Pontificia Universidad Catolica de Chile, Santiago, Chile
    Biochem Biophys Res Commun 409:603-9. 2011
    ..Thus, competitive inhibition of permeation through hemichannels might contribute to cellular retention of essential molecules and/or uptake inhibition of toxic compounds...
  25. doi request reprint Gap junctions at the dendritic cell-T cell interface are key elements for antigen-dependent T cell activation
    Raul Elgueta
    Universidad de Chile, Santiago, Chile
    J Immunol 183:277-84. 2009
    ..These results strongly suggest that functional gap junctions assemble at the interface between DCs and T cells during Ag presentation and that they play an essential role in T cell activation...
  26. pmc Modulation of brain hemichannels and gap junction channels by pro-inflammatory agents and their possible role in neurodegeneration
    Juan A Orellana
    Departamento de Ciencias Fisiologicas, Pontificia Universidad Catolica de Chile, Santiago, Chile
    Antioxid Redox Signal 11:369-99. 2009
    ..These changes are likely to occur in diverse cell types of the CNS and contribute to neurodegeneration during inflammatory process...
  27. pmc ATP is required and advances cytokine-induced gap junction formation in microglia in vitro
    Pablo J Sáez
    Departamento de Fisiologia, Pontificia Universidad Catolica de Chile, Alameda 340, 6513677 Santiago, Chile
    Mediators Inflamm 2013:216402. 2013
    ..Our data support the notion that extracellular ATP affects the cellular communication between microglia through autocrine and paracrine mechanisms, which might affect the timing of immune response under neuroinflammatory conditions...
  28. ncbi request reprint Regulation of hepatic connexins in cholestasis: possible involvement of Kupffer cells and inflammatory mediators
    Hernan E Gonzalez
    Departamento de Ciencias Fisiologicas, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, Santiago, Chile
    Am J Physiol Gastrointest Liver Physiol 282:G991-G1001. 2002
    ..Thus hepatocyte gap junctions are downregulated in forms of cholestasis associated with inflammation, and reduced intercellular communication might be induced in part by proinflammatory mediators...
  29. ncbi request reprint Possible involvement of different connexin43 domains in plasma membrane permeabilization induced by ischemia-reperfusion
    Mauricio A Retamal
    Departamento de Ciencias Fisiologicas, Pontificia Universidad Catolica de Chile, Alameda 340, Santiago, Chile
    J Membr Biol 218:49-63. 2007
    ....
  30. ncbi request reprint The formation of skeletal muscle myotubes requires functional membrane receptors activated by extracellular ATP
    Roberto Araya
    Departamento de Ciencias Fisiologicas, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, Alameda 340, Region Metropolitana, Santiago 114D, Chile
    Brain Res Brain Res Rev 47:174-88. 2004
    ....
  31. ncbi request reprint Functional gap junctions facilitate melanoma antigen transfer and cross-presentation between human dendritic cells
    Ariadna Mendoza-Naranjo
    Disciplinary Program of Immunology, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Santiago, Chile
    J Immunol 178:6949-57. 2007
    ..These results suggest that GJs formed between hDCs used in cancer vaccination protocols could be essentials for the establishment of a more efficient antitumor response...
  32. ncbi request reprint Chlorpromazine reduces the intercellular communication via gap junctions in mammalian cells
    Juan A Orellana
    Departamento de Ciencias Fisiologicas, Pontificia Universidad Catolica de Chile, Alameda 340, Santiago, Chile
    Toxicol Appl Pharmacol 213:187-97. 2006
    ..If Cx43 were the only connexin expressed, MAPK-dependent phosphorylation of this connexin would induce closure of gap junction channels...
  33. pmc S-nitrosylation and permeation through connexin 43 hemichannels in astrocytes: induction by oxidant stress and reversal by reducing agents
    Mauricio A Retamal
    Departamento de Ciencias Fisiologicas, Pontificia Universidad Catolica de Chile, Santiago 6513492, Chile
    Proc Natl Acad Sci U S A 103:4475-80. 2006
    ....
  34. doi request reprint Amyloid β-induced death in neurons involves glial and neuronal hemichannels
    Juan A Orellana
    Departamento de Fisiologia, Pontificia Universidad Catolica de Chile, Santiago 6513677, Chile
    J Neurosci 31:4962-77. 2011
    ..Consequently, this work opens novel avenues for alternative treatments that target glial cells and neurons to maintain neuronal survival in the presence of Aβ...
  35. ncbi request reprint TNF-alpha plus IFN-gamma induce connexin43 expression and formation of gap junctions between human monocytes/macrophages that enhance physiological responses
    Eliseo A Eugenin
    Departamento de Ciencias Fisiologicas, Pontificia Universidad Catolica de Chile, Santiago, Chile
    J Immunol 170:1320-8. 2003
    ..We propose that some monocyte/macrophage responses are coordinated by connexin-formed membrane channels expressed transiently at inflammatory sites in which these cells form aggregates...
  36. doi request reprint The ATP required for potentiation of skeletal muscle contraction is released via pannexin hemichannels
    Manuel A Riquelme
    Departamento de Fisiologia, Pontificia Universidad Catolica de Chile, Santiago 8, Chile
    Neuropharmacology 75:594-603. 2013
    ..This article is part of the Special Issue Section entitled 'Current Pharmacology of Gap Junction Channels and Hemichannels'...
  37. pmc Connexin 43 hemichannels mediate the Ca2+ influx induced by extracellular alkalinization
    Kurt A Schalper
    Departamento de Fisiologia, Pontificia Universidad Catolica de Chile, Alameda 340, 4 to Piso, Santiago, 8331150 Chile
    Am J Physiol Cell Physiol 299:C1504-15. 2010
    ..These studies identify a membrane pathway for Ca(2+) influx and provide a potential explanation for the activation of cellular events induced by extracellular alkalinization...
  38. pmc Critical role of the first transmembrane domain of Cx26 in regulating oligomerization and function
    Oscar Jara
    Centro Interdisciplinario de Neurociencias de Valparaíso, Universidad de Valparaiso, Valparaiso, Chile
    Mol Biol Cell 23:3299-311. 2012
    ..Moreover, Cx26 oligomerization appears dependent on transient TM1 dimerization as an intermediate step...
  39. doi request reprint Currently used methods for identification and characterization of hemichannels
    Kurt A Schalper
    Departamento de Ciencias Fisiologicas, Núcleo de Immunología e inmuroterapía, Pontificia Universidad Catolica de Chile, Santiago, Chile
    Cell Commun Adhes 15:207-18. 2008
    ..Although the available in vitro evidence is substantial, further studies and possibly new experimental approaches are required to understand the role and properties of connexin and pannexin hemichannels in vivo...
  40. ncbi request reprint Hemichannels in the neurovascular unit and white matter under normal and inflamed conditions
    Juan A Orellana
    Departamento de Fisiologia, Pontificia Universidad Catolica de Chile, Santiago, Chile
    CNS Neurol Disord Drug Targets 10:404-14. 2011
    ..Therefore, blocking hemichannels expressed by glial cells and/or neurons of the inflamed central nervous system might prevent neurovascular unit dysfunction and neurodegeneration...
  41. ncbi request reprint Dysfunctions of the diffusional membrane pathways mediated by hemichannels in inherited and acquired human diseases
    Kurt A Schalper
    Departamento de Fisiologia, Pontificia Universidad Catolica de Chile, P O Box 114 D, Santiago, Chile
    Curr Vasc Pharmacol 7:486-505. 2009
    ....
  42. ncbi request reprint Presence and importance of connexin43 during myogenesis
    Roberto Araya
    Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, Santiago, Chile
    Cell Commun Adhes 10:451-6. 2003
    ..Our results indicate that Cx43-containing gap junctions are required for normal skeletal muscle terminal differentiation. These channels might provide a pathway for the intercellular transfer of signals involved in myogenesis...
  43. doi request reprint Release of gliotransmitters through astroglial connexin 43 hemichannels is necessary for fear memory consolidation in the basolateral amygdala
    Jimmy Stehberg
    Laboratorio de Neurobiologia, Departamento de Ciencias Biologicas, Facultad de Ciencias Biologicas and Facultad de Medicina, Universidad Andres Bello, Santiago, Chile
    FASEB J 26:3649-57. 2012
    ....
  44. doi request reprint FasL-triggered death of Jurkat cells requires caspase 8-induced, ATP-dependent cross-talk between Fas and the purinergic receptor P2X(7)
    Adam Aguirre
    Centro de Estudios Moleculares de la Célula, Universidad de Chile, Santiago, Chile
    J Cell Physiol 228:485-93. 2013
    ..Thus, a hitherto unsuspected route was uncovered connecting the extrinsic to the intrinsic pathway to amplify death signals emanating from the Fas receptor in type II cells...
  45. ncbi request reprint Connexin- and pannexin-based channels in normal skeletal muscles and their possible role in muscle atrophy
    Luis A Cea
    Departamento de Fisiologia, Pontificia Universidad Catolica de Chile, Alameda 340, Santiago, Chile
    J Membr Biol 245:423-36. 2012
    ..Consequently, inhibition of connexin hemichannels expressed by injured or denervated skeletal muscles might reduce or prevent deleterious changes triggered by conditions that promote muscle atrophy...
  46. pmc Metabolic inhibition induces opening of unapposed connexin 43 gap junction hemichannels and reduces gap junctional communication in cortical astrocytes in culture
    Jorge E Contreras
    Departamento de Ciencias Fisiologicas, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, Santiago 340, Chile
    Proc Natl Acad Sci U S A 99:495-500. 2002
    ..Alternatively, dying astrocytes might compromise the health of neighboring cells via Cx43 gap junctions, thereby promoting the propagation of cell death...
  47. pmc Metabolic inhibition increases activity of connexin-32 hemichannels permeable to Ca2+ in transfected HeLa cells
    Helmuth A Sánchez
    Departamento de Ciencias Fisiologicas, Pontificia Universidad Catolica de Chile, Alameda 340, Santiago, Chile
    Am J Physiol Cell Physiol 297:C665-78. 2009
    ..Thus HC blockade could reduce the increase in free [Ca(2+)](i) and cell death induced by ischemia-like conditions in cells expressing Cx32 HCs...
  48. ncbi request reprint Plasma membrane channels formed by connexins: their regulation and functions
    Juan C Saez
    Departamento de Ciencias Fisiologicas, Pontificia Universidad Catolica de Chile, Alameda 340, Santiago, Chile
    Physiol Rev 83:1359-400. 2003
    ..The observed phenotypes range from specific tissue dysfunction to embryonic lethality...
  49. ncbi request reprint Activation of human polymorphonuclear cells induces formation of functional gap junctions and expression of connexins
    Maria C Branes
    Departamento de Ciencias Fisiologicas, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, Santiago, Chile
    Med Sci Monit 8:BR313-23. 2002
    ..We hypothesized that conditions that partially mimic the chemical environment of inflammatory foci induce the expression of functional gap junctions (GJs) between cultured PMNs...
  50. doi request reprint Diffusion of nitric oxide across cell membranes of the vascular wall requires specific connexin-based channels
    Xavier F Figueroa
    Departamento de Fisiologia, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, Alameda 340, Casilla 114 D, Santiago, Chile Electronic address
    Neuropharmacology 75:471-8. 2013
    ..This article is part of the Special Issue Section entitled 'Current Pharmacology of Gap Junction Channels and Hemichannels'...