D Mezzano

Summary

Country: Chile

Publications

  1. ncbi request reprint Inflammation, not hyperhomocysteinemia, is related to oxidative stress and hemostatic and endothelial dysfunction in uremia
    D Mezzano
    Departments of Hematology Oncology and Nephrology, School of Medicine, Catholic University of Chile, P O Box 114 D, Santiago, Chile
    Kidney Int 60:1844-50. 2001
  2. ncbi request reprint Endothelial cell markers in chronic uremia: relationship with hemostatic defects and severity of renal failure
    D Mezzano
    Department of Hematology Oncology, School of Medicine, Catholic University of Chile, Santiago
    Thromb Res 88:465-72. 1997
  3. doi request reprint The level of laboratory testing required for diagnosis or exclusion of a platelet function disorder using platelet aggregation and secretion assays
    Diego Mezzano
    Department of Hematology Oncology, School of Medicine, Pontificia Universidad Catolica de Chile, Santiago, Chile
    Semin Thromb Hemost 35:242-54. 2009
  4. doi request reprint Tissue factor storage, synthesis and function in normal and activated human platelets
    Diego Mezzano
    Department of Hematology Oncology, School of Medicine, Pontificia Universidad Catolica de Chile, Santiago, Chile
    Thromb Res 122:S31-6. 2008
  5. ncbi request reprint Haemostatic cardiovascular risk factors: differential effects of red wine and diet on healthy young
    Diego Mezzano
    Department of Hematology Oncology, School of Medicine, and Department of Cell and Molecular Biology, Faculty of Biological Sciences, P Catholic University of Chile, Santiago, Chile
    Pathophysiol Haemost Thromb 33:472-8. 2003
  6. ncbi request reprint Distinctive effects of red wine and diet on haemostatic cardiovascular risk factors
    Diego Mezzano
    Department of Hematology Oncology, Faculty of Medicine, Catholic University of Chile, Santiago, Chile
    Biol Res 37:217-24. 2004
  7. ncbi request reprint Mediterranean diet, but not red wine, is associated with beneficial changes in primary haemostasis
    D Mezzano
    Department of Haematology Oncology, Faculty of Biological Sciences, Pontificia Universidad Catolica de Chile, Santiago, Chile
    Eur J Clin Nutr 57:439-46. 2003
  8. ncbi request reprint Increased activation of protein C, but lower plasma levels of free, activated protein C in uraemic patients: relationship with systemic inflammation and haemostatic activation
    D Mezzano
    Department of Haematology Oncology, School of Medicine, Catholic University of Chile, Chile
    Br J Haematol 113:905-10. 2001
  9. ncbi request reprint Complementary effects of Mediterranean diet and moderate red wine intake on haemostatic cardiovascular risk factors
    D Mezzano
    Department of Hematology Oncology, School of Medicine, Catholic University of Chile, Santiago, Chile
    Eur J Clin Nutr 55:444-51. 2001
  10. ncbi request reprint Vegetarians and cardiovascular risk factors: hemostasis, inflammatory markers and plasma homocysteine
    D Mezzano
    Department of Hematology Oncology and Nutrition, School of Medicine, Catholic University of Chile, Santiago de Chile
    Thromb Haemost 81:913-7. 1999

Collaborators

Detail Information

Publications31

  1. ncbi request reprint Inflammation, not hyperhomocysteinemia, is related to oxidative stress and hemostatic and endothelial dysfunction in uremia
    D Mezzano
    Departments of Hematology Oncology and Nephrology, School of Medicine, Catholic University of Chile, P O Box 114 D, Santiago, Chile
    Kidney Int 60:1844-50. 2001
    ..Using correlation analysis, we assessed the relative contributions of inflammation and hyperhomocysteinemia in the abnormal oxidative stress, endothelial activation/dysfunction, and hemostasis activation in patients with CRF...
  2. ncbi request reprint Endothelial cell markers in chronic uremia: relationship with hemostatic defects and severity of renal failure
    D Mezzano
    Department of Hematology Oncology, School of Medicine, Catholic University of Chile, Santiago
    Thromb Res 88:465-72. 1997
    ..The progression of chronic renal failure, through endothelial cell damage, would lead to aggravation of the platelet functional defect potentiating the hemorrhagic risk...
  3. doi request reprint The level of laboratory testing required for diagnosis or exclusion of a platelet function disorder using platelet aggregation and secretion assays
    Diego Mezzano
    Department of Hematology Oncology, School of Medicine, Pontificia Universidad Catolica de Chile, Santiago, Chile
    Semin Thromb Hemost 35:242-54. 2009
    ..Special emphasis will be given to LTA and platelet secretion tests, as well as to the reasons why sensitive tests are needed to explore the lesser known participation of platelets in blood clotting and fibrinolytic processes...
  4. doi request reprint Tissue factor storage, synthesis and function in normal and activated human platelets
    Diego Mezzano
    Department of Hematology Oncology, School of Medicine, Pontificia Universidad Catolica de Chile, Santiago, Chile
    Thromb Res 122:S31-6. 2008
    ..Much research is needed to validate this platelet-based hemostasis model...
  5. ncbi request reprint Haemostatic cardiovascular risk factors: differential effects of red wine and diet on healthy young
    Diego Mezzano
    Department of Hematology Oncology, School of Medicine, and Department of Cell and Molecular Biology, Faculty of Biological Sciences, P Catholic University of Chile, Santiago, Chile
    Pathophysiol Haemost Thromb 33:472-8. 2003
    ..However,the increased platelet aggregation/secretion after wine intake, possibly a "rebound" phenomenon, would be a risk factor for thrombosis...
  6. ncbi request reprint Distinctive effects of red wine and diet on haemostatic cardiovascular risk factors
    Diego Mezzano
    Department of Hematology Oncology, Faculty of Medicine, Catholic University of Chile, Santiago, Chile
    Biol Res 37:217-24. 2004
    ..The longer BT in individuals on MD, obtained independently of red wine, denotes less interaction of platelets with the vascular wall, which could be beneficial from the point of view of CV risk...
  7. ncbi request reprint Mediterranean diet, but not red wine, is associated with beneficial changes in primary haemostasis
    D Mezzano
    Department of Haematology Oncology, Faculty of Biological Sciences, Pontificia Universidad Catolica de Chile, Santiago, Chile
    Eur J Clin Nutr 57:439-46. 2003
    ..2) To test whether red wine supplementation modified these variables, independently of the diet...
  8. ncbi request reprint Increased activation of protein C, but lower plasma levels of free, activated protein C in uraemic patients: relationship with systemic inflammation and haemostatic activation
    D Mezzano
    Department of Haematology Oncology, School of Medicine, Catholic University of Chile, Chile
    Br J Haematol 113:905-10. 2001
    ..Lower free plasma APC in CRF may be pathogenically associated with atherothrombosis, a major cause of death in this disease...
  9. ncbi request reprint Complementary effects of Mediterranean diet and moderate red wine intake on haemostatic cardiovascular risk factors
    D Mezzano
    Department of Hematology Oncology, School of Medicine, Catholic University of Chile, Santiago, Chile
    Eur J Clin Nutr 55:444-51. 2001
    ..Also, to test if red wine supplementation modifies HCVRF, independent of diet...
  10. ncbi request reprint Vegetarians and cardiovascular risk factors: hemostasis, inflammatory markers and plasma homocysteine
    D Mezzano
    Department of Hematology Oncology and Nutrition, School of Medicine, Catholic University of Chile, Santiago de Chile
    Thromb Haemost 81:913-7. 1999
    ..tHcy was significantly increased in vegetarians, and correlated only with cobalamin levels. The increased platelet function and tHcy found in vegetarians may counteract the known cardiovascular health benefits of vegetarian diet (VD)...
  11. ncbi request reprint Tranexamic acid inhibits fibrinolysis, shortens the bleeding time and improves platelet function in patients with chronic renal failure
    D Mezzano
    Department of Hematology Oncology, School of Medicine, Catholic University of Chile, Santiago
    Thromb Haemost 82:1250-4. 1999
    ..Our aim was to explore the effect of inhibiting both plasmin action with tranexamic acid (TA) and thrombin production with low molecular weight heparin (LMWH), on the bleeding time (BT) and platelet function in patients with CRF...
  12. ncbi request reprint Cardiovascular risk factors in vegetarians. Normalization of hyperhomocysteinemia with vitamin B(12) and reduction of platelet aggregation with n-3 fatty acids
    D Mezzano
    Departments of Hematology Oncology, Catholic University of Chile, Santiago, Chile
    Thromb Res 100:153-60. 2000
    ..Whether this supplementation improves the already reduced cardiovascular morbidity and mortality associated with vegetarian diet has yet to be demonstrated...
  13. ncbi request reprint High prevalence of bleeders of unknown cause among patients with inherited mucocutaneous bleeding. A prospective study of 280 patients and 299 controls
    Teresa Quiroga
    Department of Clinical Laboratory, School of Medicine, Pontificia Universidad Catolica de Chile, Santiago, Chile
    Haematologica 92:357-65. 2007
    ..However, the relative prevalence of these disorders, their clinical differential diagnosis, and the proportion of patients with MCB of unknown cause (BUC) after an initial comprehensive laboratory testing are unknown...
  14. ncbi request reprint Template bleeding time and PFA-100 have low sensitivity to screen patients with hereditary mucocutaneous hemorrhages: comparative study in 148 patients
    T Quiroga
    Clinical Laboratory and Department of Hematology Oncology, School of Medicine, P Catholic University of Chile, Santiago, Chile
    J Thromb Haemost 2:892-8. 2004
    ..Exclusion criteria: drug intake, concomitant diseases including minor infections, low platelet count, diseases of secondary hemostasis...
  15. doi request reprint Laboratory assessment of familial, nonthrombocytopenic mucocutaneous bleeding: a definitive diagnosis is often not possible
    Jaime Pereira
    Department of Hematology Oncology, School of Medicine, Pontificia Universidad Catolica de Chile, Santiago, Chile
    Semin Thromb Hemost 34:654-62. 2008
    ....
  16. doi request reprint An adenine insertion in exon 6 of human GP6 generates a truncated protein associated with a bleeding disorder in four Chilean families
    V Matus
    Departments of Hematology Oncology, School of Medicine, Pontificia Universidad Catolica de Chile, Santiago, Chile
    J Thromb Haemost 11:1751-9. 2013
    ..The defect in most of the reported patients is acquired and associated with other diseases. To date, only two patients have been characterized at the molecular level who carry different compound heterozygous mutations in the GP6 gene...
  17. ncbi request reprint Platelet aging in vivo is associated with loss of membrane phospholipid asymmetry
    J Pereira
    Department of Hematology Oncology, School of Medicine, Catholic University of Chile, Santiago
    Thromb Haemost 82:1318-21. 1999
    ....
  18. ncbi request reprint Platelet aging in vivo is associated with activation of apoptotic pathways: studies in a model of suppressed thrombopoiesis in dogs
    Jaime Pereira
    Department of Haematology Oncology, School of Medicine, Catholic University of Chile, Santiago
    Thromb Haemost 87:905-9. 2002
    ..In conclusion, our data provide for the first time, evidence that platelet senescence is associated with changes characteristics of apoptosis, which may promote their removal from circulation...
  19. ncbi request reprint Pregnant rats treated with a serotonin precursor have reduced fetal weight and lower plasma volume and kallikrein levels
    Sofia P Salas
    Department of Obstetrics and Gynecology, Center for Medical Research, Pontificia Universidad Catolica de Chile, Santiago, Chile
    Hypertension 50:773-9. 2007
    ..We postulate that an increased vascular resistance, both at the placental and renal levels, mediates these effects...
  20. ncbi request reprint Human platelets synthesize and express functional tissue factor
    Olga Panes
    Department of Hematology Oncology, School of Medicine, Pontificia Universidad Catolica de Chile, Santiago, Chile
    Blood 109:5242-50. 2007
    ..These observations simplify, unify, and provide a more coherent formulation of the current cell-based model of hemostasis...
  21. ncbi request reprint Thrombin generation in platelet-poor plasma is normal in patients with hereditary mucocutaneous haemorrhages
    Teresa Quiroga
    Department of Clinical Laboratory, School of Medicine, Catholic University of Chile, Santiago, Chile
    Pathophysiol Haemost Thromb 33:30-5. 2003
    ..As a next step we plan to investigate thrombin generation in PRP...
  22. ncbi request reprint Blood cells cholinesterase activity in early stage Alzheimer's disease and vascular dementia
    Rommy von Bernhardi
    Department of Neurology, Faculty of Medicine, Pontificia Universidad Catolica de Chile, Marcoleta 391, Santiago, Chile
    Dement Geriatr Cogn Disord 19:204-12. 2005
    ....
  23. ncbi request reprint Platelet membrane glycoprotein polymorphisms do not influence the clinical expressivity of von Willebrand disease type 1
    Jaime Pereira
    Department of Haematology Oncology, School of Medicine, Catholic University of Chile, P O Box 114 D, Santiago Chile
    Thromb Haemost 90:1135-40. 2003
    ..The wide variation in GPVI content was not associated with the severity of bleeding in the patients. Other genetic factors that may contribute to the variable expressivity of VWD type 1 should be investigated...
  24. ncbi request reprint Circulating platelet-derived microparticles in systemic lupus erythematosus. Association with increased thrombin generation and procoagulant state
    Jaime Pereira
    Department of Hematology Oncology, Catholic University of Chile, Santiago, Chile
    Thromb Haemost 95:94-9. 2006
    ....
  25. doi request reprint Procarboxypeptidase U (TAFI) and the Thr325Ile proCPU polymorphism in patients with hereditary mucocutaneous hemorrhages
    Valeria Matus
    Department of Haematology Oncology, School of Medicine, Pontificia Universidad Catolica de Chile, Santiago, Chile
    Clin Chim Acta 401:158-61. 2009
    ..Theoretically, decreased plasma procarboxypeptidase U (proCPU) levels or lower carboxypeptidase U (CPU) stability would result in higher fibrinolytic activity and bleeding tendency...
  26. ncbi request reprint Glycoprotein Ib/IX complex is the target in rifampicin-induced immune thrombocytopenia
    J Pereira
    Department of Haematology Oncology, School of Medicine, Catholic University of Chile, Santiago, Chile
    Br J Haematol 110:907-10. 2000
    ..The binding site of the rifampicin-dependent antibody, located in the GPIb/IX complex, seems to be a favoured target for antibodies induced by different drugs...
  27. doi request reprint Diagnosis of mild platelet function disorders. Reliability and usefulness of light transmission platelet aggregation and serotonin secretion assays
    Teresa Quiroga
    Department of Clinical Laboratory, School of Medicine, Pontificia Universidad Catolica de Chile, Santiago, Chile
    Br J Haematol 147:729-36. 2009
    ..Normal PA with adrenaline and low ADP concentration robustly predict a normal PA. Simultaneous PA/PS assays enable the diagnosis of isolated PS defects. This study confirmed that hereditary PA-PS defects are highly prevalent...
  28. doi request reprint Mediterranean food and diets, global resource for the control of metabolic syndrome and chronic diseases
    Inés Urquiaga
    Center for Molecular Nutrition and Chronic Diseases, Pontificia Universidad Catolica de Chile, Casilla 114 D, Santiago, Chile
    World Rev Nutr Diet 98:150-73. 2008
  29. doi request reprint Health impact of Mediterranean diets in food at work
    Federico Leighton
    Center for Molecular Nutrition and Chronic Diseases, Pontificia Universidad Catolica de Chile, Casilla 114 D, Santiago, Chile
    Public Health Nutr 12:1635-43. 2009
    ..To evaluate the feasibility of diet mediterranisation, in a food-at-work context, and its consequence on metabolic syndrome in a mid-age unselected healthy male population group...
  30. ncbi request reprint High plasma levels of lipoprotein(a) in uremic patients are related to markers of inflammation, and to activated, not impaired, fibrinolysis
    Antonio Gatica
    Thromb Haemost 88:688-9. 2002
  31. ncbi request reprint Tranexamic acid and uremic bleeding: evidence-based treatment recommendations
    Patricio Downey
    Nat Clin Pract Nephrol 3:E2; author reply E3. 2007