Andrea V Leisewitz
- Regulation of ENT1 expression and ENT1-dependent nucleoside transport by c-Jun N-terminal kinaseAndrea V Leisewitz
Department of Pharmacology, School of Medicine, University of North Carolina at Chapel Hill, NC 27599 7365, USA
Biochem Biophys Res Commun 404:370-5. 2011..We propose that activation of JNK-cJun pathway negatively regulates mENT1 and suggest that this mechanism might contribute to the development of nucleoside analog-derived drug resistance...
- Identification of a novel point mutation in ENT1 that confers resistance to Ara-C in human T cell leukemia CCRF-CEM cellsEric I Zimmerman
Department of Pharmacology, 4009 Genetic Medicine Bldg, 120 Mason Farm Rd CB 7365, University of North Carolina Chapel Hill, Chapel Hill, NC 27599 7365, United States
FEBS Lett 583:425-9. 2009..These results define G24 as critical amino acid for ENT1 nucleoside uptake and suggest that mutations in TM1 may provide a mechanism for Ara-C resistance in CCRF-CEM Ara-C/8C cells...
- Imatinib-resistant CML cells have low ENT activity but maintain sensitivity to gemcitabineAndrea V Leisewitz
Department of Pharmacology, School of Medicine, University of North Carolina at Chapel Hill, North Carolina 27599, USA
Nucleosides Nucleotides Nucleic Acids 27:779-86. 2008..Although, imatinib-resistant cells showed decreased levels of both ENT1 and ENT2 activity and expression, these cells remained sensitive to gemcitabine, suggesting that nucleoside analogs can be used as adjunctive therapy...