Andrea V Leisewitz

Summary

Country: Chile

Publications

  1. pmc Regulation of ENT1 expression and ENT1-dependent nucleoside transport by c-Jun N-terminal kinase
    Andrea V Leisewitz
    Department of Pharmacology, School of Medicine, University of North Carolina at Chapel Hill, NC 27599 7365, USA
    Biochem Biophys Res Commun 404:370-5. 2011
  2. pmc Identification of a novel point mutation in ENT1 that confers resistance to Ara-C in human T cell leukemia CCRF-CEM cells
    Eric I Zimmerman
    Department of Pharmacology, 4009 Genetic Medicine Bldg, 120 Mason Farm Rd CB 7365, University of North Carolina Chapel Hill, Chapel Hill, NC 27599 7365, United States
    FEBS Lett 583:425-9. 2009
  3. pmc Imatinib-resistant CML cells have low ENT activity but maintain sensitivity to gemcitabine
    Andrea V Leisewitz
    Department of Pharmacology, School of Medicine, University of North Carolina at Chapel Hill, North Carolina 27599, USA
    Nucleosides Nucleotides Nucleic Acids 27:779-86. 2008

Collaborators

  • Eric I Zimmerman
  • Min Huang
  • Lee M Graves
  • Jing Yang
  • Yanhong Wang

Detail Information

Publications3

  1. pmc Regulation of ENT1 expression and ENT1-dependent nucleoside transport by c-Jun N-terminal kinase
    Andrea V Leisewitz
    Department of Pharmacology, School of Medicine, University of North Carolina at Chapel Hill, NC 27599 7365, USA
    Biochem Biophys Res Commun 404:370-5. 2011
    ..We propose that activation of JNK-cJun pathway negatively regulates mENT1 and suggest that this mechanism might contribute to the development of nucleoside analog-derived drug resistance...
  2. pmc Identification of a novel point mutation in ENT1 that confers resistance to Ara-C in human T cell leukemia CCRF-CEM cells
    Eric I Zimmerman
    Department of Pharmacology, 4009 Genetic Medicine Bldg, 120 Mason Farm Rd CB 7365, University of North Carolina Chapel Hill, Chapel Hill, NC 27599 7365, United States
    FEBS Lett 583:425-9. 2009
    ..These results define G24 as critical amino acid for ENT1 nucleoside uptake and suggest that mutations in TM1 may provide a mechanism for Ara-C resistance in CCRF-CEM Ara-C/8C cells...
  3. pmc Imatinib-resistant CML cells have low ENT activity but maintain sensitivity to gemcitabine
    Andrea V Leisewitz
    Department of Pharmacology, School of Medicine, University of North Carolina at Chapel Hill, North Carolina 27599, USA
    Nucleosides Nucleotides Nucleic Acids 27:779-86. 2008
    ..Although, imatinib-resistant cells showed decreased levels of both ENT1 and ENT2 activity and expression, these cells remained sensitive to gemcitabine, suggesting that nucleoside analogs can be used as adjunctive therapy...