Federico Leighton

Summary

Country: Chile

Publications

  1. ncbi request reprint Endothelial nitric oxide synthase as a mediator of the positive health effects of Mediterranean diets and wine against metabolic syndrome
    Federico Leighton
    Laboratorio de Nutrición Molecular, Facultad de Ciencias Biologicas, Universidad Catolica de Chile, Santiago, Chile
    World Rev Nutr Diet 97:33-51. 2007
  2. doi request reprint Health impact of Mediterranean diets in food at work
    Federico Leighton
    Center for Molecular Nutrition and Chronic Diseases, Pontificia Universidad Catolica de Chile, Casilla 114 D, Santiago, Chile
    Public Health Nutr 12:1635-43. 2009
  3. doi request reprint Mediterranean diet and red wine protect against oxidative damage in young volunteers
    Inés Urquiaga
    Center of Molecular Nutrition and Chronic Diseases, Faculty of Biological Sciences, Catholic University of Chile, Marcoleta 49, Santiago, Chile
    Atherosclerosis 211:694-9. 2010
  4. doi request reprint Mediterranean food and diets, global resource for the control of metabolic syndrome and chronic diseases
    Inés Urquiaga
    Center for Molecular Nutrition and Chronic Diseases, Pontificia Universidad Catolica de Chile, Casilla 114 D, Santiago, Chile
    World Rev Nutr Diet 98:150-73. 2008
  5. ncbi request reprint A central role of eNOS in the protective effect of wine against metabolic syndrome
    Federico Leighton
    Laboratorio de Nutrición Molecular, Facultad de Ciencias Biologicas, Universidad Catolica de Chile, Chile
    Cell Biochem Funct 24:291-8. 2006
  6. pmc Lipoperoxidation and protein oxidative damage exhibit different kinetics during septic shock
    Max Andresen
    Departamento de Medicina Intensiva, Facultad de Medicina, Pontificia Universidad Catolica de Chile, Alameda, 340 Santiago, Chile
    Mediators Inflamm 2008:168652. 2008
  7. ncbi request reprint Effect of Mediterranean and Occidental diets, and red wine, on plasma fatty acids in humans. An intervention study
    Inés Urquiaga
    Molecular Nutrition Laboratory, Faculty of Biological Sciences, Catholic University of Chile, Santiago, Chile
    Biol Res 37:253-61. 2004
  8. ncbi request reprint Wine and health: evidence and mechanisms
    Inés Urquiaga
    Molecular Nutrition Laboratory, Faculty of Biological Sciences, Catholic University of Chile, Santiago, Chile
    World Rev Nutr Diet 95:122-39. 2005
  9. ncbi request reprint Red wine reduces oxidative stress in patients with acute coronary syndrome
    Eduardo Guarda
    Facultad de Medicina, Pontificia, Universidad Catolica de Chile, Santiago, Chile
    Int J Cardiol 104:35-8. 2005
  10. ncbi request reprint Juice and phenolic fractions of the berry Aristotelia chilensis inhibit LDL oxidation in vitro and protect human endothelial cells against oxidative stress
    Soledad Miranda-Rottmann
    Programa Bases Moleculares de las Enfermedades Crónicas, Facultad de Ciencias Biologicas, Pontifica Universidad Catolica de Chile, Santiago, Chile
    J Agric Food Chem 50:7542-7. 2002

Collaborators

Detail Information

Publications24

  1. ncbi request reprint Endothelial nitric oxide synthase as a mediator of the positive health effects of Mediterranean diets and wine against metabolic syndrome
    Federico Leighton
    Laboratorio de Nutrición Molecular, Facultad de Ciencias Biologicas, Universidad Catolica de Chile, Santiago, Chile
    World Rev Nutr Diet 97:33-51. 2007
  2. doi request reprint Health impact of Mediterranean diets in food at work
    Federico Leighton
    Center for Molecular Nutrition and Chronic Diseases, Pontificia Universidad Catolica de Chile, Casilla 114 D, Santiago, Chile
    Public Health Nutr 12:1635-43. 2009
    ..To evaluate the feasibility of diet mediterranisation, in a food-at-work context, and its consequence on metabolic syndrome in a mid-age unselected healthy male population group...
  3. doi request reprint Mediterranean diet and red wine protect against oxidative damage in young volunteers
    Inés Urquiaga
    Center of Molecular Nutrition and Chronic Diseases, Faculty of Biological Sciences, Catholic University of Chile, Marcoleta 49, Santiago, Chile
    Atherosclerosis 211:694-9. 2010
    ..To assess the effect on oxidative damage of the administration of a Mediterranean diet (MD) compared with an Occidental diet (OD), in young adult volunteers, with or without the concomitant intake of red wine...
  4. doi request reprint Mediterranean food and diets, global resource for the control of metabolic syndrome and chronic diseases
    Inés Urquiaga
    Center for Molecular Nutrition and Chronic Diseases, Pontificia Universidad Catolica de Chile, Casilla 114 D, Santiago, Chile
    World Rev Nutr Diet 98:150-73. 2008
  5. ncbi request reprint A central role of eNOS in the protective effect of wine against metabolic syndrome
    Federico Leighton
    Laboratorio de Nutrición Molecular, Facultad de Ciencias Biologicas, Universidad Catolica de Chile, Chile
    Cell Biochem Funct 24:291-8. 2006
    ..This hypothesis is supported by epidemiological observations and needs experimental validation in human intervention studies...
  6. pmc Lipoperoxidation and protein oxidative damage exhibit different kinetics during septic shock
    Max Andresen
    Departamento de Medicina Intensiva, Facultad de Medicina, Pontificia Universidad Catolica de Chile, Alameda, 340 Santiago, Chile
    Mediators Inflamm 2008:168652. 2008
    ..Our results suggest early and persistent oxidative stress during septic shock and a correlation between increasing levels of lipoperoxidation and sepsis severity...
  7. ncbi request reprint Effect of Mediterranean and Occidental diets, and red wine, on plasma fatty acids in humans. An intervention study
    Inés Urquiaga
    Molecular Nutrition Laboratory, Faculty of Biological Sciences, Catholic University of Chile, Santiago, Chile
    Biol Res 37:253-61. 2004
    ..Volunteers on MD showed a better fatty acid profile than those on OD, suggesting a lower cardiovascular risk. Moderate consumption of wine improves this profile in the MD group...
  8. ncbi request reprint Wine and health: evidence and mechanisms
    Inés Urquiaga
    Molecular Nutrition Laboratory, Faculty of Biological Sciences, Catholic University of Chile, Santiago, Chile
    World Rev Nutr Diet 95:122-39. 2005
  9. ncbi request reprint Red wine reduces oxidative stress in patients with acute coronary syndrome
    Eduardo Guarda
    Facultad de Medicina, Pontificia, Universidad Catolica de Chile, Santiago, Chile
    Int J Cardiol 104:35-8. 2005
    ..Moderate red wine consumption improved endothelial function in normal volunteers. Herein we explored the effects of moderate red wine consumption in endothelial function and in oxidative stress in patients with an acute coronary syndrome...
  10. ncbi request reprint Juice and phenolic fractions of the berry Aristotelia chilensis inhibit LDL oxidation in vitro and protect human endothelial cells against oxidative stress
    Soledad Miranda-Rottmann
    Programa Bases Moleculares de las Enfermedades Crónicas, Facultad de Ciencias Biologicas, Pontifica Universidad Catolica de Chile, Santiago, Chile
    J Agric Food Chem 50:7542-7. 2002
    ..These results show that ach is a rich source of phenolics with high antioxidant capacity and suggest that it may have antiatherogenic properties...
  11. ncbi request reprint Wine, diet, antioxidant defenses, and oxidative damage
    Druso D Pérez
    Department of Cellular and Molecular Biology, Catholic University of Chile, Santiago, Chile
    Ann N Y Acad Sci 957:136-45. 2002
    ..In conclusion, the results identify 8OHdG as a very promising general marker of oxidative stress in nutrition intervention studies in humans, and red wine shows a remarkable protective effect...
  12. ncbi request reprint [Oxidative stress in critically ill patients]
    Max Andresen H
    Unidad de Tratamiento Intensivo, Programa Medicina Intensiva, Facultad de Medicina, Pontificia Universidad Catolica de Chile, Santiago, Chile
    Rev Med Chil 134:649-56. 2006
    ..Nevertheless, there are few studies in humans that only show improvements in hemodynamic variables, reduction in inflammatory mediators levels, decreases in oxidized compounds and that suggest a lower incidence of multiple organ failure...
  13. doi request reprint Lysosomal vitamin E accumulation in Niemann-Pick type C disease
    Luz Fernanda Yévenes
    Departamento de Biologia Celular y Molecular, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, Santiago, Chile
    Biochim Biophys Acta 1822:150-60. 2012
    ..This may result in a decreased bioavailability and impaired antioxidant function of vitamin E in NPC, contributing to the disease pathogenesis...
  14. ncbi request reprint Reactive oxygen species mediates homocysteine-induced mitochondrial biogenesis in human endothelial cells: modulation by antioxidants
    Karen Perez-de-Arce
    Departamento de Nutricion, Diabetes y Metabolismo, Facultad de Medicina, Pontificia Universidad Catolica de Chile, Santiago, Chile
    Biochem Biophys Res Commun 338:1103-9. 2005
    ..Taken together, our results suggest that ROS is an important mediator of mitochondrial biogenesis induced by Hcy, and that modulation of oxidative stress by antioxidants may protect against the adverse vascular effects of Hcy...
  15. ncbi request reprint Haemostatic cardiovascular risk factors: differential effects of red wine and diet on healthy young
    Diego Mezzano
    Department of Hematology Oncology, School of Medicine, and Department of Cell and Molecular Biology, Faculty of Biological Sciences, P Catholic University of Chile, Santiago, Chile
    Pathophysiol Haemost Thromb 33:472-8. 2003
    ..However,the increased platelet aggregation/secretion after wine intake, possibly a "rebound" phenomenon, would be a risk factor for thrombosis...
  16. doi request reprint Methionine sulfoxide reductase A expression is regulated by the DAF-16/FOXO pathway in Caenorhabditis elegans
    Alicia N Minniti
    Centro de Envejecimiento y Regeneración, Centro de Regulación Celular y Patología Joaquín V Luco, Santiago, Chile
    Aging Cell 8:690-705. 2009
    ..This repair mechanism, rather than the general decreased of radical oxygen species levels, could be one of the main determinants of organisms' lifespan...
  17. ncbi request reprint [Nutrients intake in elderly people living in Providence, Santiago de Chile]
    Oscar Castillo
    Departamento de Nutricion, Escuela de Medicina, Laboratorio de Citología, Programa Bases Moleculares de las Enfermedades Crónicas, Facultad de Ciencias Biologicas, Universidad Catolica de Chile, Lira 40, Santiago
    Rev Med Chil 130:1335-42. 2002
    ..The information available on food intake in the elderly in Chile is restricted to individuals of low socioeconomic groups, but there is no data available on food intake in elderly of higher income groups...
  18. pmc Myricetin, quercetin and catechin-gallate inhibit glucose uptake in isolated rat adipocytes
    Pablo Strobel
    Molecular Nutrition Laboratory, Faculty of Biological Sciences, Universidad Catolica de Chile, Casilla 114 D, Santiago, Chile
    Biochem J 386:471-8. 2005
    ..Furthermore, the results suggest that GLUT transporters are involved in flavonoid incorporation into cells...
  19. doi request reprint Diagnosis of mild platelet function disorders. Reliability and usefulness of light transmission platelet aggregation and serotonin secretion assays
    Teresa Quiroga
    Department of Clinical Laboratory, School of Medicine, Pontificia Universidad Catolica de Chile, Santiago, Chile
    Br J Haematol 147:729-36. 2009
    ..Normal PA with adrenaline and low ADP concentration robustly predict a normal PA. Simultaneous PA/PS assays enable the diagnosis of isolated PS defects. This study confirmed that hereditary PA-PS defects are highly prevalent...
  20. ncbi request reprint Alpha-tocopherol metabolism is abnormal in scavenger receptor class B type I (SR-BI)-deficient mice
    Pablo Mardones
    Departamento de Gastroenterologia, Facultad de Medicina, Pontificia Universidad Catolica, Santiago, Chile
    J Nutr 132:443-9. 2002
    ..Defective tissue uptake of lipoprotein alpha-T in SR-BI-deficient mice may contribute to the reproductive and cardiovascular pathologies exhibited by these animals...
  21. ncbi request reprint Cytoprotection by neutral fraction of tannat red wine against oxidative stress-induced cell death
    Carolina Echeverry
    Neurochemistry Department, Instituto de Investigaciones Biologicas Clemente Estable, Avda Italia 3318, 11610 Montevideo, Uruguay
    J Agric Food Chem 52:7395-9. 2004
    ..This is the first paper to reveal the active fraction of total wine responsible of its cytoprotection...
  22. ncbi request reprint [Ultrasound assessment of endothelial function in Chilean children and adults]
    Alfredo M Germain
    Departamento de Obstetricia y Ginecologia, Facultad de Medicina, Pontificia Universidad Catolica de Chile
    Rev Med Chil 132:437-44. 2004
    ..Endothelial dysfunction is an important pathogenetic mechanism in the development of atherosclerosis...
  23. ncbi request reprint Nox1-based NADPH oxidase-derived superoxide is required for VSMC activation by advanced glycation end-products
    Alejandra San Martin
    Division of Cardiology, Department of Medicine, Emory University, Atlanta, GA 30322, USA
    Free Radic Biol Med 42:1671-9. 2007
    ..This study establishes that AGE activate iNOS in VSMC through a ROS-sensitive, NF-kappaB-dependent mechanism involving ROS generation by a Nox1-based oxidase...
  24. ncbi request reprint Antioxidant and pro-oxidant effects of red wine and its fractions on Cu(II) induced LDL oxidation evaluated by absorbance and chemiluminescence measurements
    Karsten A Hötzer
    Faculty of Chemistry and Biology, Department of Chemistry, University of Santiago, Chile
    Free Radic Res 39:175-83. 2005
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