Nibaldo C Inestrosa

Summary

Country: Chile

Publications

  1. ncbi request reprint Acetylcholinesterase (AChE)--amyloid-beta-peptide complexes in Alzheimer's disease. the Wnt signaling pathway
    Nibaldo C Inestrosa
    Centro FONDAP de Regulación Celular y Patología Joaquín V Luco, MIFAB, Facultad de Ciencias Biológicas Pontificia Universidad Católica de Chile, Santiago, Chile
    Curr Alzheimer Res 1:249-54. 2004
  2. pmc On cognitive ecology and the environmental factors that promote Alzheimer disease: lessons from Octodon degus (Rodentia: Octodontidae)
    Daniela S Rivera
    Departamento de Ecología and Center of Applied Ecology and Sustainability CAPES, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, 6513677, Santiago, Chile
    Biol Res 49:10. 2016
  3. pmc Wnt-5a-regulated miR-101b controls COX2 expression in hippocampal neurons
    Juan Francisco Codocedo
    Departamento de Biologia Celular y Molecular, Facultad de Ciencias Biologicas, Centro de Envejecimiento y Regeneración CARE, Pontificia Universidad Catolica de Chile, Santiago, Chile
    Biol Res 49:9. 2016
  4. ncbi request reprint Rhein-Huprine Derivatives Reduce Cognitive Impairment, Synaptic Failure and Amyloid Pathology in AβPPswe/PS-1 Mice of Different Ages
    Felipe G Serrano
    CARE Biomedical Center, P Catholic University of Chile, Postal Code 8331150, PO Box 114 D, Santiago, Chile
    Curr Alzheimer Res 13:1017-29. 2016
  5. ncbi request reprint Recent Advances in Neuroinflammation Therapeutics: PPARs/LXR as Neuroinflammatory Modulators
    Sussy Bastías-Candia
    CARE Biomedical Center, Pontificia Universidad Catolica de Chile, Postal Code 8331150, Santiago, Chile
    Curr Pharm Des 22:1312-23. 2016
  6. doi request reprint Wnt signalling in neuronal differentiation and development
    Nibaldo C Inestrosa
    Centro de Envejecimiento y Regeneración CARE, Departamento de Biologia Celular y Molecular, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, 340, P O Box 114 D, Santiago, Chile
    Cell Tissue Res 359:215-23. 2015
  7. ncbi request reprint Effects of tetrahydrohyperforin in mouse hippocampal slices: neuroprotection, long-term potentiation and TRPC channels
    C Montecinos-Oliva
    CARE Biomedical Center, Pontificia Universidad Catolica de Chile, Av Alameda 340, Santiago, Chile
    Curr Med Chem 21:3494-506. 2014
  8. ncbi request reprint Role of Wnt signaling in tissue fibrosis, lessons from skeletal muscle and kidney
    P Cisternas
    CARE Biomedical Center, Faculty of Biological Sciences, P Catholic University of Chile, Alameda 340, P O Box 114 D, Santiago, Chile
    Curr Mol Med 14:510-22. 2014
  9. pmc SIRT1 regulates dendritic development in hippocampal neurons
    Juan F Codocedo
    Departamento de Biologia Celular y Molecular, Centro de Envejecimiento y Regeneración, Facultad de Ciencias Biologicas, P Universidad Catolica de Chile, Santiago, Chile
    PLoS ONE 7:e47073. 2012
  10. pmc Interactions of AChE with Aβ Aggregates in Alzheimer's Brain: Therapeutic Relevance of IDN 5706
    Francisco J Carvajal
    Centro de Envejecimiento y Regeneración CARE, Departamento de Biologia Celular y Molecular, Facultad de Ciencias Biologicas, Pontificia Universidad Católica de Chile Santiago, Chile
    Front Mol Neurosci 4:19. 2011

Detail Information

Publications107 found, 100 shown here

  1. ncbi request reprint Acetylcholinesterase (AChE)--amyloid-beta-peptide complexes in Alzheimer's disease. the Wnt signaling pathway
    Nibaldo C Inestrosa
    Centro FONDAP de Regulación Celular y Patología Joaquín V Luco, MIFAB, Facultad de Ciencias Biológicas Pontificia Universidad Católica de Chile, Santiago, Chile
    Curr Alzheimer Res 1:249-54. 2004
    ..Compounds that mimic the Wnt signaling or modulate the cross-talking with this pathway could be used as neuroprotective agents for therapeutic strategies in AD patients...
  2. pmc On cognitive ecology and the environmental factors that promote Alzheimer disease: lessons from Octodon degus (Rodentia: Octodontidae)
    Daniela S Rivera
    Departamento de Ecología and Center of Applied Ecology and Sustainability CAPES, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, 6513677, Santiago, Chile
    Biol Res 49:10. 2016
    ....
  3. pmc Wnt-5a-regulated miR-101b controls COX2 expression in hippocampal neurons
    Juan Francisco Codocedo
    Departamento de Biologia Celular y Molecular, Facultad de Ciencias Biologicas, Centro de Envejecimiento y Regeneración CARE, Pontificia Universidad Catolica de Chile, Santiago, Chile
    Biol Res 49:9. 2016
    ..Several evidences indicate that the miRNAs are actively involved in the regulation of neuronal function...
  4. ncbi request reprint Rhein-Huprine Derivatives Reduce Cognitive Impairment, Synaptic Failure and Amyloid Pathology in AβPPswe/PS-1 Mice of Different Ages
    Felipe G Serrano
    CARE Biomedical Center, P Catholic University of Chile, Postal Code 8331150, PO Box 114 D, Santiago, Chile
    Curr Alzheimer Res 13:1017-29. 2016
    ..These studies indicated that rhein-huprine derivatives with multiple properties might have interesting therapeutic potential for AD. ..
  5. ncbi request reprint Recent Advances in Neuroinflammation Therapeutics: PPARs/LXR as Neuroinflammatory Modulators
    Sussy Bastías-Candia
    CARE Biomedical Center, Pontificia Universidad Catolica de Chile, Postal Code 8331150, Santiago, Chile
    Curr Pharm Des 22:1312-23. 2016
    ....
  6. doi request reprint Wnt signalling in neuronal differentiation and development
    Nibaldo C Inestrosa
    Centro de Envejecimiento y Regeneración CARE, Departamento de Biologia Celular y Molecular, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, 340, P O Box 114 D, Santiago, Chile
    Cell Tissue Res 359:215-23. 2015
    ..In this review, we summarize the reported roles of Wnt signalling cascades in these processes with a particular emphasis on the role of Wnts in neuronal differentiation and development. ..
  7. ncbi request reprint Effects of tetrahydrohyperforin in mouse hippocampal slices: neuroprotection, long-term potentiation and TRPC channels
    C Montecinos-Oliva
    CARE Biomedical Center, Pontificia Universidad Catolica de Chile, Av Alameda 340, Santiago, Chile
    Curr Med Chem 21:3494-506. 2014
    ..We propose that the effect of IDN5706 is mediated through activation of the TRPC3/6/7 channel subfamily. The unveiling of the drug's mechanism of action is a necessary step toward the clinical use of IDN5706 in Alzheimer's disease. ..
  8. ncbi request reprint Role of Wnt signaling in tissue fibrosis, lessons from skeletal muscle and kidney
    P Cisternas
    CARE Biomedical Center, Faculty of Biological Sciences, P Catholic University of Chile, Alameda 340, P O Box 114 D, Santiago, Chile
    Curr Mol Med 14:510-22. 2014
    ..The aim of this review is to discuss the pro-fibrotic effect of Wnt signaling in both skeletal muscle and kidney, and to try to understand how this pathway is associated with the TGF-β, CTGF and angiotensin II pro-fibrotic pathway. ..
  9. pmc SIRT1 regulates dendritic development in hippocampal neurons
    Juan F Codocedo
    Departamento de Biologia Celular y Molecular, Centro de Envejecimiento y Regeneración, Facultad de Ciencias Biologicas, P Universidad Catolica de Chile, Santiago, Chile
    PLoS ONE 7:e47073. 2012
    ..Our findings indicate that SIRT1 plays a role in the development and maintenance of dendritic branching in hippocampal neurons, and suggest that these effects are mediated by the ROCK signaling pathway...
  10. pmc Interactions of AChE with Aβ Aggregates in Alzheimer's Brain: Therapeutic Relevance of IDN 5706
    Francisco J Carvajal
    Centro de Envejecimiento y Regeneración CARE, Departamento de Biologia Celular y Molecular, Facultad de Ciencias Biologicas, Pontificia Universidad Católica de Chile Santiago, Chile
    Front Mol Neurosci 4:19. 2011
    ..We concluded that early treatment with IDN 5706 decreases AChE-Aβ interaction and this effect might be of therapeutic interest in the treatment of AD...
  11. pmc Postsynaptic Receptors for Amyloid-β Oligomers as Mediators of Neuronal Damage in Alzheimer's Disease
    Margarita C Dinamarca
    Centro de Envejecimiento y Regeneración, Departamento de Biologia Celular y Molecular, Facultad de Ciencias Biologicas, Pontificia Universidad Católica de Chile Santiago, Chile
    Front Physiol 3:464. 2012
    ..The characterization of the interaction between Aβ receptors and Aβ oligomers could help to understand the source of the neurologic damage observed in the brain of the Alzheimer's disease patients...
  12. pmc Peroxisome proliferator-activated receptor (PPAR) γ and PPARα agonists modulate mitochondrial fusion-fission dynamics: relevance to reactive oxygen species (ROS)-related neurodegenerative disorders?
    Juan M Zolezzi
    Departamento de Biologia, Facultad de Ciencias, Universidad de Tarapaca, Arica, Chile
    PLoS ONE 8:e64019. 2013
    ..Additionally, our results suggest that PGC-1α and mitochondrial dynamics should be further studied in future therapy research oriented to ameliorate neurodegenerative disorders, such as AD...
  13. pmc Canonical Wnt signaling protects hippocampal neurons from Aβ oligomers: role of non-canonical Wnt-5a/Ca(2+) in mitochondrial dynamics
    Carmen Silva-Alvarez
    Departamento de Biologia Celular y Molecular, Centro de Envejecimiento y Regeneración, Facultad de Ciencias Biologicas, Pontificia Universidad Católica de Chile Santiago, Chile
    Front Cell Neurosci 7:97. 2013
    ..Since mitochondrial dysfunction is present in neurodegenerative diseases, the therapeutic possibilities of the activation of Wnt signaling are evident. ..
  14. doi request reprint Wnts in adult brain: from synaptic plasticity to cognitive deficiencies.
    Carolina A Oliva
    Centro de Envejecimiento y Regeneraci n, Facultad de Ciencias Biol gicas, Pontificia Universidad Cat lica de Chile Santiago, Chile Departamento de Biolog a Celular y Molecular, Facultad de Ciencias Biol gicas, Pontificia Universidad Cat lica de Chile Santiago, Chile
    Front Cell Neurosci 7:224. 2013
    ....
  15. doi request reprint Chronic hypoxia induces the activation of the Wnt/β-catenin signaling pathway and stimulates hippocampal neurogenesis in wild-type and APPswe-PS1ΔE9 transgenic mice in vivo.
    Lorena Varela Nallar
    Centro de Envejecimiento y Regeneraci n CARE, Departamento de Biolog a Celular y Molecular, Pontificia Universidad Cat lica de Chile Santiago, Chile Centro de Investigaciones Biom dicas, Facultad de Ciencias Biol gicas y Facultad de Medicina, Universidad Andr s Bello Santiago, Chile
    Front Cell Neurosci 8:17. 2014
    ....
  16. pmc Signaling pathway cross talk in Alzheimer's disease
    Juan A Godoy
    Centro de Envejecimiento y Regeneración CARE Departamento de Biología Celular y Molecular Facultad de Ciencias Biológicas, Pontificia Universidad Catolica de Chile, Av, Alameda 340, Santiago, Chile
    Cell Commun Signal 12:23. 2014
    ....
  17. doi request reprint Nicotine prevents synaptic impairment induced by amyloid-β oligomers through α7-nicotinic acetylcholine receptor activation
    Nibaldo C Inestrosa
    Centro de Envejecimiento y Regeneración CARE, Pontificia Universidad Catolica de Chile, PO Box 114 D, Santiago, Chile
    Neuromolecular Med 15:549-69. 2013
    ..Activation of the α7-nAChR/PI3K signaling pathway and its cross-talk with the Wnt signaling pathway might well be therapeutic targets for potential AD treatments. ..
  18. doi request reprint Peroxisome proliferators reduce spatial memory impairment, synaptic failure, and neurodegeneration in brains of a double transgenic mice model of Alzheimer's disease
    Nibaldo C Inestrosa
    Centro de Envejecimiento y Regeneración CARE, Santiago, Chile Departamento de Biología Celular y Molecular, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, Santiago, Chile
    J Alzheimers Dis 33:941-59. 2013
    ..We concluded that peroxisomal proliferation reduces various AD neuropathological markers and peroxisome proliferators may be considered as potential therapeutic agents against the disease...
  19. doi request reprint Wnt signaling: role in Alzheimer disease and schizophrenia
    Nibaldo C Inestrosa
    Centro de Envejecimiento y Regeneración CARE, Departamento de Biologia Celular y Molecular, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, Alameda 340, 8331150, Santiago, Chile
    J Neuroimmune Pharmacol 7:788-807. 2012
    ..This review focuses on the relationship between Wnt signaling and its potential relevance for the treatment of neurodegenerative and neuropsychiatric diseases including AD and Schizophrenia...
  20. pmc Tetrahydrohyperforin prevents cognitive deficit, Aβ deposition, tau phosphorylation and synaptotoxicity in the APPswe/PSEN1ΔE9 model of Alzheimer's disease: a possible effect on APP processing
    N C Inestrosa
    Centro de Envejecimiento y Regeneración CARE, Santiago, Chile
    Transl Psychiatry 1:e20. 2011
    ..These findings indicate that IDN5706 ameliorates AD neuropathology and could be considered of therapeutic relevance in AD treatment...
  21. pmc Intracellular amyloid formation in muscle cells of Abeta-transgenic Caenorhabditis elegans: determinants and physiological role in copper detoxification
    Alicia N Minniti
    Centro de Regulación Celular y Patología Joaquín V, Luco CRCP, MIFAB, Centro de Envejecimiento y Regeneración CARE, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, Alameda 340, 8331010 Santiago, Chile
    Mol Neurodegener 4:2. 2009
    ..In addition, it is also known that Abeta is involved in Inclusion Body Myositis, a common myopathy of the elderly in which the peptide accumulates intracellularly...
  22. pmc Axotomy-induced neurotrophic withdrawal causes the loss of phenotypic differentiation and downregulation of NGF signalling, but not death of septal cholinergic neurons
    Oscar M Lazo
    Department of Physiology, Neurobiology Unit, Center of Ageing and Regeneration CARE, Nucleus Millennium in Regenerative Biology MINREB, Faculty of Biological Sciences, Pontificia Universidad Catolica de Chile, Alameda 340, CP 8331010, Santiago, Chile
    Mol Neurodegener 5:5. 2010
    ..The principal aim of this study was to evaluate, using modern quantitative confocal microscopy, neurodegenerative changes in septal cholinergic neurons after axotomy and to assess their response to delayed infusion of NGF in rats...
  23. doi request reprint Amyloid-cholinesterase interactions. Implications for Alzheimer's disease
    Nibaldo C Inestrosa
    CRCP Biomedical Center, Pontificia Universidad Catolica de Chile, Santiago, Chile
    FEBS J 275:625-32. 2008
    ..Recent studies also indicate that acetylcholinesterase induces the aggregation of prion protein with a similar dependence on the peripherical anionic site...
  24. pmc The role of Wnt signaling in neuronal dysfunction in Alzheimer's Disease
    Nibaldo C Inestrosa
    Centro de Envejecimiento y Regeneración CARE, Centro de Regulación Celular y Patología Joaquín V, Luco CRCP, MIFAB, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, Alameda 340, Santiago, Chile
    Mol Neurodegener 3:9. 2008
    ..In conclusion the activation of the Wnt signaling pathway could be proposed as a therapeutic target for the treatment of AD...
  25. doi request reprint Emerging roles of Wnts in the adult nervous system
    Nibaldo C Inestrosa
    Centro de Envejecimiento y Regeneración CARE, Centro de Regulacion Celular y Patologia Joaquin V Luco CRCP, MIFAB, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, Santiago, Chile
    Nat Rev Neurosci 11:77-86. 2010
    ..Here, the latest insights into the function of Wnt signalling in the adult nervous system and therapeutic opportunities for neurodegenerative diseases such as Alzheimer's and Parkinson's disease are discussed...
  26. pmc Wnt-5a occludes Abeta oligomer-induced depression of glutamatergic transmission in hippocampal neurons
    Waldo Cerpa
    Centro de Envejecimiento y Regeneración CARE, Centro de Regulación Celular y Patología Joaquín V, Luco CRCP, MIFAB, Departamento de Biologia Celular y Molecular, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, Santiago, Chile
    Mol Neurodegener 5:3. 2010
    ..Abeta oligomers block hippocampal long-term potentiation (LTP) and impair rodent spatial memory. Wnt signaling plays an important role in neural development, including synaptic differentiation...
  27. pmc Amyloid-beta-Acetylcholinesterase complexes potentiate neurodegenerative changes induced by the Abeta peptide. Implications for the pathogenesis of Alzheimer's disease
    Margarita C Dinamarca
    Centro de Regulación Celular y Patología Joaquín V, Luco CRCP, Instituto Milenio MIFAB, Centro de Envejecimiento y Regeneración CARE, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, Alameda 340, 8331010 Santiago, Chile
    Mol Neurodegener 5:4. 2010
    ..From a therapeutic point of view, activation of the Wnt signaling pathway, as well as NMDAR inhibition may be important factors to protect neurons under Abeta-AChE attack...
  28. doi request reprint c-Abl modulates AICD dependent cellular responses: transcriptional induction and apoptosis
    Mary C Vázquez
    Department of Cellular and Molecular Biology, Faculty of Biological Sciences, Pontifical Catholic University of Chile, Santiago, Chile
    J Cell Physiol 220:136-43. 2009
    ....
  29. ncbi request reprint Peroxisomal proliferation protects from beta-amyloid neurodegeneration
    Manuel J Santos
    Unidad de Bioquímica Celular y Genética, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, Casilla 114 D, Santiago, Chile
    J Biol Chem 280:41057-68. 2005
    ..Our data suggest, for the first time, a direct link between peroxisomal proliferation and neuroprotection from Abeta-induced degenerative changes...
  30. pmc Acetylcholinesterase-Abeta complexes are more toxic than Abeta fibrils in rat hippocampus: effect on rat beta-amyloid aggregation, laminin expression, reactive astrocytosis, and neuronal cell loss
    Ariel E Reyes
    Centro de Regulación Celular y Patología Joaquín V Luco, Millennium Institute of Fundamental and Applied Biology, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, Santiago, Chile
    Am J Pathol 164:2163-74. 2004
    ..Our studies are consistent with the notion that Abeta-AChE complexes are more toxic than Abeta fibrils and that AChE triggered some of the neurodegenerative changes observed in Alzheimer's disease brains...
  31. ncbi request reprint Wnt-3a overcomes beta-amyloid toxicity in rat hippocampal neurons
    Alejandra R Alvarez
    Centro FONDAP de Regulación Celular y Patología Joaquín V Luco, MIFAB, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, Santiago, Chile
    Exp Cell Res 297:186-96. 2004
    ..Our results support the hypothesis that a loss of function of Wnt signaling may play a role in the progression of neurodegenerative diseases such as Alzheimer's disease...
  32. ncbi request reprint The anti-inflammatory and cholinesterase inhibitor bifunctional compound IBU-PO protects from beta-amyloid neurotoxicity by acting on Wnt signaling components
    Ginny G Farías
    Centro FONDAP de Regulación Celular y Patología Joaquín V Luco, MIFAB, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, Santiago, Chile
    Neurobiol Dis 18:176-83. 2005
    ..In addition, IBU-PO enhances, dose-dependently, the non-amyloidogenic amyloid precursor protein (APP) cleavage by increasing secreted APP and decreasing endogenous Abeta1-40 in rat hippocampal neurons...
  33. ncbi request reprint Peroxisome proliferator-activated receptor gamma up-regulates the Bcl-2 anti-apoptotic protein in neurons and induces mitochondrial stabilization and protection against oxidative stress and apoptosis
    Karen Fuenzalida
    Centro de Regulación Celular y Patologia Joaquín V Luco and Millennium Institute for Fundamental and Applied Biology, Department of Cellular and Molecular Biology, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, Santiago, Chile
    J Biol Chem 282:37006-15. 2007
    ..Altogether, these data suggest that PPARgamma supports survival in neurons in part through a mechanism involving increased expression of Bcl-2...
  34. doi request reprint Calcium/calmodulin-dependent protein kinase type IV is a target gene of the Wnt/beta-catenin signaling pathway
    Macarena S Arrázola
    Centro Basal de Excelencia para el Envejecimiento y Regeneración CARE, Centro de Regulación Celular y Patología Joaquín V Luco CRCP and MIFAB, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, Santiago, Chile
    J Cell Physiol 221:658-67. 2009
    ..We conclude that CaMKIV is regulated by the Wnt signaling pathway and that its expression could play a role in the neuroprotective function of the Wnt signaling against the Alzheimer's amyloid peptide...
  35. ncbi request reprint Human-like rodent amyloid-beta-peptide determines Alzheimer pathology in aged wild-type Octodon degu
    Nibaldo C Inestrosa
    Centro FONDAP de Regulación Celular y Patología Joaquín V Luco, MIFAB, Facultad de Ciencias Biologicas, P Universidad Catolica de Chile, Alameda 340, Santiago, Chile
    Neurobiol Aging 26:1023-8. 2005
    ..Our results indicate that aged O. degu constitutes the first wild-type rodent model for neurodegenerative processes associated to AD...
  36. pmc Role of the Wnt receptor Frizzled-1 in presynaptic differentiation and function
    Lorena Varela-Nallar
    Centro de Envejecimiento y Regeneración, Centro de Regulación Celular y Patología Joaquín V Luco and MIFAB, Chile
    Neural Dev 4:41. 2009
    ..Some Wnt signaling components are localized at central synapses, and it is thus possible that this pathway could be activated at the synapse...
  37. ncbi request reprint The hyperforin derivative IDN5706 occludes spatial memory impairments and neuropathological changes in a double transgenic Alzheimer's mouse model
    W Cerpa
    Centro de Envejecimiento y Regeneración, Departamento de Biologia Celular y Molecular, Pontificia Universidad Catolica de Chile, Santiago, Chile
    Curr Alzheimer Res 7:126-33. 2010
    ..We conclude that the hyperforin derivative, IDN5706, has therapeutic potential for prevention and treatment of AD...
  38. doi request reprint Wnt-5a modulates recycling of functional GABAA receptors on hippocampal neurons
    Loreto Cuitino
    Centro de Envejecimiento y Regeneración, Centro de Regulación Celular y Patología Joaquín V Luco, Instituto Milenio, Departamento de Biologia Celular y Molecular, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, 8331010 Santiago, Chile
    J Neurosci 30:8411-20. 2010
    ..Therefore, we postulate that Wnt-5a, by activation of CaMKII, induces the recycling of functional GABA(A)-Rs on the mature hippocampal neurons...
  39. doi request reprint Wnt-5a increases NO and modulates NMDA receptor in rat hippocampal neurons
    Francisco J Muñoz
    Centro de Envejecimiento y Regeneración CARE, Departamento de Biologia Celular y Molecular, Facultad de Ciencias Biologicas, P Universidad Catolica de Chile, Santiago de Chile, Chile Laboratory of Molecular Physiology and Channelopathies, Department of Experimental and Health Sciences, Universitat Pompeu Fabra, Parc de Recerca Biomedica de Barcelona, Spain
    Biochem Biophys Res Commun 444:189-94. 2014
    ..To the best of our knowledge, this is the first time that Wnt-5a signaling is related to NO production, which in turn increases NMDARs trafficking to the cell surface. ..
  40. doi request reprint Tetrahydrohyperforin induces mitochondrial dynamics and prevents mitochondrial Ca2+ overload after Aβ and Aβ-AChE complex challenge in rat hippocampal neurons
    Juan M Zolezzi
    Centro de Envejecimiento y Regeneración CARE, Santiago, Chile
    J Alzheimers Dis 37:735-46. 2013
    ..Our results offer further explanation for the effects observed for THH and the beneficial effects of this ethno-botanical drug in AD. ..
  41. doi request reprint Beta-amyloid oligomers affect the structure and function of the postsynaptic region: role of the Wnt signaling pathway
    Margarita C Dinamarca
    Centro de Regulación Celular y Patología Joaquín V Luco, MIFAB, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, Santiago, Chile
    Neurodegener Dis 5:149-52. 2008
    ..The cellular mechanism by which beta-amyloid peptide (Abeta) affects synapses remains unclear. Abeta oligomers target synapses in cultured rat hippocampal neurons suggesting that they play a key role in the regulation of synapses...
  42. doi request reprint STI571 prevents apoptosis, tau phosphorylation and behavioural impairments induced by Alzheimer's beta-amyloid deposits
    Gonzalo I Cancino
    Departamento de Biologia Celular y Molecular, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, Santiago, Chile
    Brain 131:2425-42. 2008
    ..These results are consistent with the role of the c-Abl/p73 signalling pathway in Abeta neurodegeneration, and suggest that STI571-like compounds would be effective in therapeutic treatments of Alzheimer disease...
  43. pmc Synaptic clustering of PSD-95 is regulated by c-Abl through tyrosine phosphorylation
    Karen Perez de Arce
    Laboratorio de Señalización Celular, Departmento de Biologia Celular y Molecular, Pontificia Universidad Catolica de Chile, 8331010 Santiago, Chile
    J Neurosci 30:3728-38. 2010
    ..Our results indicate that c-Abl regulates synapse formation by mediating tyrosine phosphorylation and clustering of PSD-95...
  44. ncbi request reprint Wnt-7a modulates the synaptic vesicle cycle and synaptic transmission in hippocampal neurons
    Waldo Cerpa
    Centro de Regulación Celular y Patología Joaquín V Luco, Instituto Milenio MIFAB, Departamento de Biologia Celular y Molecular, Facultad de Ciencias Biologicas, P Universidad Catolica de Chile, Alameda 340, 8331010 Santiago, Chile
    J Biol Chem 283:5918-27. 2008
    ..These results indicate that the presynaptic function of rat hippocampal neurons is modulated by the canonical Wnt signaling...
  45. pmc Thiazolidinediones promote axonal growth through the activation of the JNK pathway
    Rodrigo A Quintanilla
    Centro de Envejecimiento y Regeneración CARE, Departamento de Biologia Celular y Molecular, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, Santiago, Chile
    PLoS ONE 8:e65140. 2013
    ..These novel findings may contribute to the understanding of the effects of PPARγ on neuronal differentiation and validate the use of PPARγ activators as therapeutic agents in neurodegenerative diseases...
  46. doi request reprint Inclusion body myositis: a view from the Caenorhabditis elegans muscle
    Daniela L Rebolledo
    Centro de Envejecimiento y Regeneración CARE, Centro de Regulación Celular y Patología Joaquín V Luco, MIFAB, Facultad de Ciencias Biologicas, P Universidad Catolica de Chile, Alameda 340, Santiago, Chile
    Mol Neurobiol 38:178-98. 2008
    ..as well as anatomical, physiological, and behavioral characteristics add to the value of this model. In the present work, we review evidence that supports the use of Caenorhabditis elegans as a biological model for IBM...
  47. ncbi request reprint Trolox and 17beta-estradiol protect against amyloid beta-peptide neurotoxicity by a mechanism that involves modulation of the Wnt signaling pathway
    Rodrigo A Quintanilla
    Centro de Regulación Celular y Patología Joaquín V Luco, Millennium Institute of Fundamental and Applied Biology, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, Casilla 114 D, Santiago, Chile
    J Biol Chem 280:11615-25. 2005
    ..Our results suggest that control of oxidative stress, regulation of cytoplasmic calcium, and activation of Wnt signaling may prevent A beta neurotoxicity...
  48. ncbi request reprint Induction of cellular prion protein gene expression by copper in neurons
    Lorena Varela-Nallar
    CRCP, Biomedical Center, P Catholic Univ of Chile, Alameda 340, Santiago, Chile
    Am J Physiol Cell Physiol 290:C271-81. 2006
    ..These findings demonstrate that Prnp expression is upregulated by copper in neuronal cells by an MTF-1-independent mechanism, and suggest a metal-specific modulation of Prnp in neurons...
  49. ncbi request reprint Copper brain homeostasis: role of amyloid precursor protein and prion protein
    Nibaldo C Inestrosa
    Centro de Regulacion Celular y Patologia Joaquin V Luco CRCP, MIFAB, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, Santiago, Chile
    IUBMB Life 57:645-50. 2005
    ..Results with transgenic and other animal models have established the relation between these pathogenic proteins and copper. In particular, APP transgenic models, suggest a beneficial effect for copper in AD...
  50. doi request reprint Voluntary Running Attenuates Memory Loss, Decreases Neuropathological Changes and Induces Neurogenesis in a Mouse Model of Alzheimer's Disease
    Cheril Tapia-Rojas
    Centro de Envejecimiento y Regeneración CARE, Departamento de Biologia Celular y Molecular, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, Santiago, Chile
    Brain Pathol 26:62-74. 2016
    ..These findings support that voluntary exercise might have therapeutic value on AD. ..
  51. ncbi request reprint The N-terminal copper-binding domain of the amyloid precursor protein protects against Cu2+ neurotoxicity in vivo
    Waldo F Cerpa
    Centro FONDAP de Regulación Celular y Patología Joaquín V Luco, MIFAB, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, Santiago, Chile
    FASEB J 18:1701-3. 2004
    ..We also found that Cu2+ neurotoxicity is associated with an increase in nitrotyrosine immunofluorescence as well as with a decrease in Cu2+ uptake. The CuBD of APP therefore may play a role in the detoxification of brain Cu...
  52. pmc Frizzled-5 receptor is involved in neuronal polarity and morphogenesis of hippocampal neurons
    Paula G Slater
    Centro de Envejecimiento y Regeneración CARE, Departamento de Biologia Celular y Molecular, Facultad de Ciencias Biologicas, P Universidad Catolica de Chile, Santiago, Chile
    PLoS ONE 8:e78892. 2013
    ..Our results suggest that, Fzd5 has a role in the establishment of neuronal polarity, and in the morphogenesis of neuronal processes, in part through the activation of the non-canonical Wnt mechanism involving JNK. ..
  53. pmc Postsynaptic dysfunction is associated with spatial and object recognition memory loss in a natural model of Alzheimer's disease
    Alvaro O Ardiles
    Centro Interdisciplinario de Neurociencia de Valparaíso, Facultad de Ciencias, Universidad de Valparaiso, 2360102 Valparaíso, Chile
    Proc Natl Acad Sci U S A 109:13835-40. 2012
    ..These findings validate O. degus as a suitable natural model for studying how sporadic AD may be initiated...
  54. doi request reprint Overexpression of amyloid precursor protein increases copper content in HEK293 cells
    Miriam Suazo
    INTA, Laboratorio de Bioinformatica y Expresion Genica, Universidad de Chile, Macul, Santiago, Chile
    Biochem Biophys Res Commun 382:740-4. 2009
    ..We conclude that Cu(2+) reduction activity of APP facilitates copper uptake and may represent an early step in cellular copper homeostasis...
  55. doi request reprint Tetrahydrohyperforin decreases cholinergic markers associated with amyloid-β plaques, 4-hydroxynonenal formation, and caspase-3 activation in AβPP/PS1 mice
    Francisco J Carvajal
    Centro de Envejecimiento y Regeneración CARE, Departamento de Biologia Celular y Molecular, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, Santiago, Chile
    J Alzheimers Dis 36:99-118. 2013
    ..Our data support a therapeutic potential of THH for the treatment of AD...
  56. doi request reprint Tetrahydrohyperforin increases adult hippocampal neurogenesis in wild-type and APPswe/PS1ΔE9 mice
    Ana C Abbott
    Centro de Envejecimiento y Regeneración CARE, Departamento de Biologia Celular y Molecular, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, Santiago, Chile
    J Alzheimers Dis 34:873-85. 2013
    ..These results indicate that IDN5706 increases adult hippocampal neurogenesis and may have therapeutic value in neurological disorders in which adult neurogenesis is impaired...
  57. doi request reprint Wnt-5a is a synaptogenic factor with neuroprotective properties against Aβ toxicity
    Lorena Varela-Nallar
    Centro de Envejecimiento y Regeneración, Departamento de Biologia Celular y Molecular, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, Santiago, Chile
    Neurodegener Dis 10:23-6. 2012
    ..This ligand is expressed in the hippocampus, stimulates dendritic spine morphogenesis and increases glutamatergic neurotransmission. Moreover, we have also shown that Wnt-5a induces the clustering of PSD-95...
  58. ncbi request reprint PPAR gamma activators induce growth arrest and process extension in B12 oligodendrocyte-like cells and terminal differentiation of cultured oligodendrocytes
    Alejandro D Roth
    Centro de Regulación Celular y Patología, Departamento de Biologia Celular y Molecular, Facultad de Ciencias Biologicas, P Universidad Catolica de Chile, Santiago, Chile
    J Neurosci Res 72:425-35. 2003
    ..Our data suggest a relevant role for PPARgamma in oligodendrocyte lipid metabolism and differentiation...
  59. ncbi request reprint M1 muscarinic receptor activation protects neurons from beta-amyloid toxicity. A role for Wnt signaling pathway
    Ginny G Farías
    Centro FONDAP de Regulación Celular y Patología Joaquín V Luco, MIFAB, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, Santiago, Chile
    Neurobiol Dis 17:337-48. 2004
    ..We conclude that the cross-talk between the muscarinic signaling and Wnt components underlie the neuroprotective effect of the M1 mAChR activation...
  60. doi request reprint Frizzled-1 is involved in the neuroprotective effect of Wnt3a against Abeta oligomers
    Marcelo A Chacón
    Centro de Regulacion Celular y Patologia Joaquin V Luco CRCP, Instituto Milenio MIFAB, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, Santiago, Chile
    J Cell Physiol 217:215-27. 2008
    ....
  61. pmc Wnt-5a/JNK signaling promotes the clustering of PSD-95 in hippocampal neurons
    Ginny G Farías
    Centro de Envejecimiento y Regeneración, Centro de Regulación Celular y Patología Joaquín V Luco, Instituto Milenio, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, Alameda 340, P O Box 8331150, Santiago, Chile
    J Biol Chem 284:15857-66. 2009
    ..Our studies indicate that the Wnt-5a/JNK pathway modulates the postsynaptic region of mammalian synapse directing the clustering and distribution of the physiologically relevant scaffold protein, PSD-95...
  62. pmc The Gαo Activator Mastoparan-7 Promotes Dendritic Spine Formation in Hippocampal Neurons
    Valerie T Ramirez
    Centro de Envejecimiento y Regeneración CARE, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, 8331150 Santiago, Chile
    Neural Plast 2016:4258171. 2016
    ..Our results demonstrate a critical role for Gα(o) subunit signaling in the regulation of synapse formation...
  63. doi request reprint Wnt5a inhibits K(+) currents in hippocampal synapses through nitric oxide production
    Jorge Parodi
    Centro de Envejecimiento y Regeneración CARE, Departamento de Biologia Celular y Molecular, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, Santiago, Chile
    Mol Cell Neurosci 68:314-22. 2015
    ..Together, our results show that Wnt5a increases NO production by acting on ROR2 receptors, which in turn inhibit Kv currents. These results reveal a novel mechanism by which Wnt5a may regulate the excitability of hippocampal neurons. ..
  64. ncbi request reprint Wnt-7a induces presynaptic colocalization of alpha 7-nicotinic acetylcholine receptors and adenomatous polyposis coli in hippocampal neurons
    Ginny G Farías
    Centro de Regulación Celular y Patología Joaquín V Luco, Millennium Institute for Fundamental and Applied Biology, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, 8331010 Santiago, Chile
    J Neurosci 27:5313-25. 2007
    ..Modulation by Wnt signaling may be essential for alpha7-nAChR expression and function in synapses...
  65. ncbi request reprint Is there a role for copper in neurodegenerative diseases?
    Waldo Cerpa
    Centro de Regulacion Celular y Patologia Joaquin V Luco CRCP, MIFAB, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, Alameda 340, Santiago, Chile
    Mol Aspects Med 26:405-20. 2005
    ..Here, we review the evidence that supports both, the role of beta-APP and PrP(C), in copper metabolism and the putative role of copper in neurodegenerative diseases...
  66. doi request reprint Wnt signaling modulates pre- and postsynaptic maturation: therapeutic considerations
    Ginny G Farías
    Centro de Envejecimiento y Regeneración CARE, Instituto Milenio MIFAB, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, Santiago, Chile
    Dev Dyn 239:94-101. 2010
    ..We also elaborate on the idea that Wnt signaling pathways are a target for the treatment of neurodegenerative diseases that affect synaptic integrity, such as Alzheimer's disease...
  67. pmc Wingless-type family member 5A (Wnt-5a) stimulates synaptic differentiation and function of glutamatergic synapses
    Lorena Varela-Nallar
    Centro de Envejecimiento y Regeneración, Departamento de Biologia Celular y Molecular, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, Santiago 8331150, Chile
    Proc Natl Acad Sci U S A 107:21164-9. 2010
    ..We conclude that Wnt-5a stimulates different aspects of synaptic differentiation and plasticity in the mammalian central nervous system...
  68. pmc Genome-wide identification of new Wnt/beta-catenin target genes in the human genome using CART method
    Christian Hodar
    Laboratorio de Bioinformatica y Expresion Genica, INTA, Universidad de Chile, Santiago, Chile
    BMC Genomics 11:348. 2010
    ..In this article, we construct a classification tool that uses the transcription factor binding site motifs composition of some gene promoters to identify new Wnt/beta-catenin pathway target genes potentially involved in brain diseases...
  69. pmc Frizzled-1 receptor regulates adult hippocampal neurogenesis
    Muriel D Mardones
    Center for Biomedical Research, Faculty of Biological Sciences and Faculty of Medicine, Universidad Andres Bello, Santiago, Chile
    Mol Brain 9:29. 2016
    ..Here we studied the potential role of Frizzled-1 (FZD1) receptor in adult hippocampal neurogenesis...
  70. ncbi request reprint Peroxisome proliferator-activated receptor gamma is expressed in hippocampal neurons and its activation prevents beta-amyloid neurodegeneration: role of Wnt signaling
    Nibaldo C Inestrosa
    Centro FONDAP de Regulación Celular y Patología Joaquín V Luco, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, Santiago, Chile
    Exp Cell Res 304:91-104. 2005
    ..More important, the fact that the activation of PPAR gamma attenuated A beta-dependent neurodegeneration opens the possibility to fight AD from a new therapeutic perspective...
  71. doi request reprint Heparin activates Wnt signaling for neuronal morphogenesis
    Marcela Colombres
    Centro de Regulación Celular y Patología Joaquín V Luco, MIFAB, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, Santiago, Chile
    J Cell Physiol 216:805-15. 2008
    ..Changes in the expression of specific HSPGs were observed upon differentiation of N2a cells. Taken together, our findings suggest that HSPGs may modulate canonical Wnt signaling for neuronal morphogenesis...
  72. ncbi request reprint Protein kinase C inhibits amyloid beta peptide neurotoxicity by acting on members of the Wnt pathway
    Jose L Garrido
    Centro de Regulación Celular y Patología, MIFAB, Facultad de Ciencias Biologicas, P Universidad Catolica de Chile, Santiago
    FASEB J 16:1982-4. 2002
    ..Our results suggest that regulation of members of the Wnt signaling pathway by Ca2+-dependent PKC isoforms may be important in controlling the neurotoxic process induced by Ab...
  73. ncbi request reprint Structural and functional organization of synaptic acetylcholinesterase
    Rebeca Aldunate
    Centro FONDAP de Regulación Celular y Patología Joaquín V Luco, MIFAB, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, 114 D Santiago, Chile
    Brain Res Brain Res Rev 47:96-104. 2004
    ..These mutations determine end-plate acetylcholinesterase deficiency and induce one type of synaptic functional disorders observed in Congenital Myasthenic Syndromes (CMSs)...
  74. ncbi request reprint Signal transduction during amyloid-beta-peptide neurotoxicity: role in Alzheimer disease
    Rodrigo A Fuentealba
    Centro FONDAP de Regulación Celular y Patología Joaquín Luco, MIFAB, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, Santiago, Chile
    Brain Res Brain Res Rev 47:275-89. 2004
    ....
  75. doi request reprint Methionine sulfoxide reductase A expression is regulated by the DAF-16/FOXO pathway in Caenorhabditis elegans
    Alicia N Minniti
    Centro de Envejecimiento y Regeneración, Centro de Regulación Celular y Patología Joaquín V Luco, Santiago, Chile
    Aging Cell 8:690-705. 2009
    ..This repair mechanism, rather than the general decreased of radical oxygen species levels, could be one of the main determinants of organisms' lifespan...
  76. doi request reprint Age Progression of Neuropathological Markers in the Brain of the Chilean Rodent Octodon degus, a Natural Model of Alzheimer's Disease
    Nibaldo C Inestrosa
    Centro de Envejecimiento y Regeneración CARE, Departamento de Biologia Celular y Molecular, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, Santiago, Chile
    Brain Pathol 25:679-91. 2015
    ..With these results, we suggest that the O. degus could represent a new model for AD research and a powerful tool in the search for therapeutic strategies against AD. ..
  77. doi request reprint Frizzled receptors in neurons: from growth cones to the synapse
    Lorena Varela-Nallar
    Centro de Envejecimiento y Regeneración, Departamento de Biologia Celular y Molecular, Facultad de Ciencias Biologicas, P Universidad Catolica de Chile, Santiago, Chile
    Cytoskeleton (Hoboken) 69:528-34. 2012
    ..These findings suggest that the Wnt signaling pathway might be temporally and spatially fine tuned during the development of neuronal circuits through specific Frizzled receptors...
  78. doi request reprint Adult hippocampal neurogenesis in aging and Alzheimer's disease
    Lorena Varela-Nallar
    Centro de Envejecimiento y Regeneración CARE, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, Santiago, Chile
    Birth Defects Res C Embryo Today 90:284-96. 2010
    ..Finally, we focus on hippocampal neurogenesis in Alzheimer's disease, reviewing animal models of the disease used for the study of this process and the conclusions that have been drawn in this context...
  79. doi request reprint Release of acetylcholinesterase (AChE) from beta-amyloid plaques assemblies improves the spatial memory impairments in APP-transgenic mice
    Margarita C Dinamarca
    Centro de Regulación Celular y Patología Joaquín V Luco, Centro de Envejecimiento y Regeneración CARE, MIFAB, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, Chile
    Chem Biol Interact 175:142-9. 2008
    ..Altogether this gathered evidence indicates the important role of AChE in the neurotoxicity of Abeta plaques and finding new compounds which decrease the AChE-Abeta interaction may be a putative therapeutic agent to fight the disease...
  80. ncbi request reprint Structure-function implications in Alzheimer's disease: effect of Abeta oligomers at central synapses
    Waldo Cerpa
    Centro de Regulacion Celular y Patologia Joaquin V Luco CRCP, Millennium Institute MIFAB, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, Santiago, Chile
    Curr Alzheimer Res 5:233-43. 2008
    ..Here we review recent progress about Abeta structure and function, from the formation of amyloid fibrils and some molecular chaperones which modulate the amyloidogenesic process to synaptic damage induce by Abeta oligomers...
  81. doi request reprint The role of Wnt signaling in neuroprotection
    Waldo Cerpa
    Departamento de Biologia Celular y Molecular, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, Santiago, Chile
    Drug News Perspect 22:579-91. 2009
    ..The study of the Wnt pathway is a promising approach in the search for possible targets to fight the deleterious effects of neurodegenerative conditions such as AD...
  82. doi request reprint Copper reduces Aβ oligomeric species and ameliorates neuromuscular synaptic defects in a C. elegans model of inclusion body myositis
    Daniela L Rebolledo
    Centro de Regulación Celular y Patología Joaquín V Luco, Millennium Institute of Fundamental and Applied Biology, Centro de Envejecimiento y Regeneración, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, 8331010 Santiago, Chile
    J Neurosci 31:10149-58. 2011
    ..Our findings emphasize the importance of neuromuscular synaptic dysfunction and the relevance of modulating the amyloidogenic component as an alternative therapeutic approach for this debilitating disease...
  83. ncbi request reprint The human prion octarepeat fragment prevents and reverses the inhibitory action of copper in the P2X4 receptor without modifying the zinc action
    Ramón A Lorca
    Centro de Regulación Celular y Patología, J V Luco Instituto MIFAB, Departamento de Fisiologia, Facultad de Ciencias Biologicas, P Universidad Catolica de Chile, Santiago, Chile
    J Neurochem 85:709-16. 2003
    ..Our findings highlight the role of PrP in copper homeostasis and hint at its possible role as a modulator of synapses regulated by this trace metal...
  84. ncbi request reprint Synaptotoxicity in Alzheimer's disease: the Wnt signaling pathway as a molecular target
    Nibaldo C Inestrosa
    Centro de Regulacion Celular y Patologia Joaquin V Luco CRCP, MIFAB, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, Santiago, Chile
    IUBMB Life 59:316-21. 2007
    ....
  85. pmc ATP induces NO production in hippocampal neurons by P2X(7) receptor activation independent of glutamate signaling
    Juan Francisco Codocedo
    Centro de Envejecimiento y Regeneración, Departamento de Biologia Celular y Molecular, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, Santiago, Chile
    PLoS ONE 8:e57626. 2013
    ..In sum, exogenous ATP elicited NO production in hippocampal neurons independently of NMDA receptor activity...
  86. doi request reprint The synaptic protein neuroligin-1 interacts with the amyloid β-peptide. Is there a role in Alzheimer's disease?
    Margarita C Dinamarca
    Centro de Envejecimiento y Regeneración CARE, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Santiago, Chile
    Biochemistry 50:8127-37. 2011
    ..In conclusion, our results show that NL-1 interacts with Aβ increasing the formation of Aβ oligomers, suggesting that this interaction could triggers the targeting of Aβ oligomer to the postsynaptic regions of excitatory synapses...
  87. ncbi request reprint Acetylcholinesterase interaction with Alzheimer amyloid beta
    Nibaldo C Inestrosa
    FONDA Biomedical Center, P Catholic University of Chile, Santiago, Chile
    Subcell Biochem 38:299-317. 2005
    ....
  88. ncbi request reprint Acetylcholinesterase-amyloid-beta-peptide interaction: effect of Congo Red and the role of the Wnt pathway
    Nibaldo C Inestrosa
    FONDAP Biomedical Center, P Catholic University of Chile, P O Box 114 D, Santiago, Chile
    Curr Alzheimer Res 2:301-6. 2005
    ....
  89. ncbi request reprint The functional links between prion protein and copper
    Lorena Varela-Nallar
    Centro de Regulacion Celular y Patologia Joaquin V Luco CRCP, MIFAB, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, Santiago, Chile
    Biol Res 39:39-44. 2006
    ..Here we address some of the evidence that support a physiological link between PrPC and copper. Also, in vivo experiments suggesting the physiological relevance of PrPC interaction with heparan sulfate proteoglycans are discussed...
  90. doi request reprint Wnt signaling in neuroprotection and stem cell differentiation
    Enrique M Toledo
    Centro de Envejecimiento y Regeneración CARE, Instituto Milenio MIFAB, Departamento de Biologia Celular y Molecular, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, Chile
    Prog Neurobiol 86:281-96. 2008
    ....
  91. pmc Cholinergic abnormalities, endosomal alterations and up-regulation of nerve growth factor signaling in Niemann-Pick type C disease
    Carolina Cabeza
    Physiology Department, Millennium Nucleus in Regenerative Biology, Faculty of Biological Sciences, Pontificia Universidad Catolica de Chile, Santiago, Chile
    Mol Neurodegener 7:11. 2012
    ....
  92. ncbi request reprint Acetylcholinesterase induces the expression of the beta-amyloid precursor protein in glia and activates glial cells in culture
    Rommy von Bernhardi
    Departamento de Neurologia, Facultad de Medicina, Pontificia Universidad Catolica de Chile, Santiago, Chile
    Neurobiol Dis 14:447-57. 2003
    ..As a whole, we found that AChE has additional effects that could result in an increased synthesis of Abeta, both by increasing beta-APP expression of astrocytes and by further activating glial cells...
  93. ncbi request reprint Structure and function of amyloid in Alzheimer's disease
    Carlos Morgan
    Centro FONDAP de Regulación Celular y Patología Joaquín V Luco, MIFAB, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, P O Box 114 D, Santiago, Chile
    Prog Neurobiol 74:323-49. 2004
    ..This review is focused on Alzheimer's amyloid fibrils in general and has been divided into two parts dealing with the structure and function of amyloid...
  94. ncbi request reprint Copper reduction by copper binding proteins and its relation to neurodegenerative diseases
    Carlos Opazo
    Centro de Regulación Celular y Patología, MIFAB, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, Santiago, Chile
    Biometals 16:91-8. 2003
    ..Moreover, protein-metal complexes could be the catalytic centers for the formation of reactive oxygen species involved in the oxidative damage present both in Alzheimer's and Prion disease...
  95. ncbi request reprint Heparan sulfate proteoglycans are increased during skeletal muscle regeneration: requirement of syndecan-3 for successful fiber formation
    Juan Carlos Casar
    Centro de Regulación Celular y Patología, Facultad de Ciencias Biologicas, MIFAB, P Universidad Catolica de Chile, Santiago, Chile
    J Cell Sci 117:73-84. 2004
    ..These data constitute the first in vivo evidence suggesting the requirement of a specific heparan sulfate proteoglycan for successful skeletal muscle regeneration...
  96. ncbi request reprint Acetylcholinesterase induces neuronal cell loss, astrocyte hypertrophy and behavioral deficits in mammalian hippocampus
    Marcelo A Chacón
    Centro de Regulación Celular y Patología Dr Joaquín V Luco, MIFAB, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, Santiago, Chile
    J Neurochem 87:195-204. 2003
    ....
  97. ncbi request reprint Blood cells cholinesterase activity in early stage Alzheimer's disease and vascular dementia
    Rommy von Bernhardi
    Department of Neurology, Faculty of Medicine, Pontificia Universidad Catolica de Chile, Marcoleta 391, Santiago, Chile
    Dement Geriatr Cogn Disord 19:204-12. 2005
    ....
  98. pmc The Cellular Prion Protein Prevents Copper-Induced Inhibition of P2X(4) Receptors
    Ramón A Lorca
    Departamento de Fisiologia, Centro de Envejecimiento y Regeneración CARE, Facultad de Ciencias Biologicas, P Universidad Catolica de Chile, Santiago 8331150, Chile
    Int J Alzheimers Dis 2011:706576. 2011
    ..Thus, our observations suggest a role for PrP(C) in modulating synaptic activity through binding of extracellular Cu(2+)...
  99. ncbi request reprint Metalloenzyme-like activity of Alzheimer's disease beta-amyloid. Cu-dependent catalytic conversion of dopamine, cholesterol, and biological reducing agents to neurotoxic H(2)O(2)
    Carlos Opazo
    Centro de Regulación Celular y Patología, Departamento de Biologia Celular y Molecular, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, Santiago 114 D, Chile
    J Biol Chem 277:40302-8. 2002
    ..Cu. Therefore, microregional catalytic H(2)O(2) production, combined with the exhaustion of reducing agents, may mediate the neurotoxicity of Abeta in Alzheimer's disease, and inhibitors of this novel activity may be of therapeutic value...
  100. ncbi request reprint Ethanol specifically decreases peroxisome proliferator activated receptor beta in B12 oligodendrocyte-like cells
    Andrea V Leisewitz
    Centro de Regulación Celular y Patología, Departamento de Biologia Celular y Molecular, Facultad de Ciencias Biologicas, Millenium Institute for Fundamental and Applied Biology, Pontificia Universidad Catolica de Chile, Santiago, Chile
    J Neurochem 85:135-41. 2003
    ..Our results suggest a possible link between PPARbeta function and ethanol-induced abnormal myelination in oligodendrocytes...
  101. ncbi request reprint An overview of the current and novel drugs for Alzheimer's disease with particular reference to anti-cholinesterase compounds
    Marcela Colombres
    Centro FONDAP de Regulación Celular y Patología, Joaquín V Luco, MIFAB, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, Santiago, Chile
    Curr Pharm Des 10:3121-30. 2004
    ....