Research Topics
Species | C E FardellaSummaryCountry: Chile Publications
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Publications
Refractory depression in a patient with peripheral resistance to thyroid hormone (RTH) and the effect of triiodothyronine treatmentCarlos E Fardella
Departamento de Endocrinologia, Pontificia Universidad Catolica de Chile, Santiago, Chile
Endocrine 31:272-8. 2007..Screening for RTH in refractory chronic depression may provide an alternative treatment for this psychiatric condition...- Primary hyperaldosteronism in essential hypertensives: prevalence, biochemical profile, and molecular biologyC E Fardella
Department of Endocrinology, Faculty of Medicine, Catholic University of Chile, Santiago
J Clin Endocrinol Metab 85:1863-7. 2000..A high proportion of PA suppressed SA with dexamethasone, but only a few had a chimeric gene or high levels of 18-hydroxycortisol. These results emphasize the need to further investigate EH patients... - Genetic study of patients with dexamethasone-suppressible aldosteronism without the chimeric CYP11B1/CYP11B2 geneC E Fardella
Department of Endocrinology, Faculty of Medicine, Catholic University of Chile, Marcoleta 391, Santiago, Chile
J Clin Endocrinol Metab 86:4805-7. 2001..We suggest that the dexamethasone suppression test could lead to an incorrect diagnosis of glucocorticoid-remediable aldosteronism... - Primary aldosteronismCarlos E Fardella
Department of Endocrinology, Faculty of Medicine, Catholic University of Chile, Santiago
Clin Lab 48:181-90. 2002..We also discuss the treatment, and the differential diagnosis with other hyper-mineralocorticoid states... - Primary aldosteronism and hypertensive diseaseLorena Mosso
Department of Endocrinology, Faculty of Medicine, Pontificia Universidad Catolica de Chile, Lira 85, 5 piso, Santiago, Chile
Hypertension 42:161-5. 2003..The low frequency of computed tomography scan abnormalities and hypokalemia suggests that the diagnosis for most PA patients corresponds to attenuated forms of the disease... 
[Primary aldosteronism]Carlos E Fardella
Departamento de Endocrinologia, Facultad de Medicina, Pontificia Universidad Catolica de Chile, Santiago, Chile
Rev Med Chil 136:905-14. 2008..This article reviews the prevalence, diagnosis and treatment of PA and also the clinical, biochemical and genetic characteristics of its different subtypes...- [Pathological characteristics of thyroid microcarcinoma. A review of 402 biopsies]Carlos Fardella
Departamento de Endocrinologia, Escuela de Medicina, Pontificia Universidad Catolica de Chile, Santiago de Chile
Rev Med Chil 133:1305-10. 2005..Thyroid microcarcinoma is a tumor of 10 mm or less, that should have a low risk of mortality. However, a subgroup of these carcinomas is as aggressive as bigger tumors... - A new presentation of the chimeric CYP11B1/CYP11B2 gene with low prevalence of primary aldosteronism and atypical gene segregation patternCristian A Carvajal
Department of Endocrinology, Pontificia Universidad Catolica de Chile, Santiago, Chile
Hypertension 59:85-91. 2012..Most adults have normal aldosterone and renin levels, which could mask them as essential hypertensives... - [Hypertension and mineralocorticoids. Usefulness of renin and aldosterone measurements]C E Fardella
Departamentos de Endocrinología y Medicina Interna, Facultad de Medicina, Pontificia Universidad Catolica de Chile, Santiago de Chile
Rev Med Chil 127:604-10. 1999..This article reviews these forms of hypertension, their clinical workup and their relevance in the usual hypertensive patients... - Primary aldosteronism can alter peripheral levels of transforming growth factor beta and tumor necrosis factor alphaC A Carvajal
Department of Endocrinology, Faculty of Medicine, Pontificia Universidad Catolica de Chile, Santiago, Chile
J Endocrinol Invest 32:759-65. 2009..Primary aldosteronism (PA) is the most common secondary cause of hypertension that has recently been implicated in alterations of the immune system and progression of cardiovascular disease... - A de novo unequal cross-over mutation between CYP11B1 and CYP11B2 genes causes familial hyperaldosteronism type IC A Carvajal
Endocrinology Department, Faculty of Medicine, Pontificia Universidad Catolica de Chile, Santiago, Chile
J Endocrinol Invest 34:140-4. 2011.... - A possible association between primary aldosteronism and a lower beta-cell functionLorena M Mosso
Department of Nutrition and Diabetes, Faculty of Medicine, Pontificia Universidad Catolica de Chile, Santiago, Chile
J Hypertens 25:2125-30. 2007..We investigated the glucose insulin sensitivity and insulin secretion in patients with idiopathic primary aldosteronism... - [Possible pathogenetic role of 11 beta-hydroxysteroid dehydrogenase type 1 (11betaHSD1) gene polymorphisms in arterial hypertension]Mauricio A Morales
Departamento de Endocrinologia, Pontificia Universidad Catolica de Chile, Lira 85, Santiago, Chile
Rev Med Chil 136:701-10. 2008..Several polymorphisms have been reported in HSDl IB 1 gene (CAI5, CAI9 and InsA83557), which could modify HSDl IB 1 gene expression or activity... - A polymorphic GT short tandem repeat affecting beta-ENaC mRNA expression is associated with low renin essential hypertensionAlexis A Gonzalez
Department of Endocrinology, Faculty of Medicine, Pontificia Universidad Catolica de Chile, Santiago, Chile
Am J Hypertens 20:800-6. 2007.... - Aldosterone, plasma Renin activity, and aldosterone/renin ratio in a normotensive healthy pediatric populationAlejandro Martinez-Aguayo
Department of Endocrinology, School of Medicine, Pontificia Universidad Catolica de Chile, Lira 85, Piso 5, Santiago 8330074, Chile
Hypertension 56:391-6. 2010..We demonstrated that normal aldosterone/renin ratio values in a healthy pediatric population without NH were lower than those reported for an adult normotensive population... - [Microsatellite marker AGAT of the mineralocorticoid receptor gene is associated with plasma renin activity in patients with essential hypertension]Carlos R Muñoz-Brauning
Departamento de Endocrinologia, Facultad de Medicina, Pontificia Universidad Catolica de Chile
Rev Med Chil 133:1415-23. 2005..Moreover, microsatellite regions can be associated to the regulation of the gene expression, producing subtle pathologies... - [Subclinical endothelial inflammation markers in a family with type I familial hyperaldosteronism caused by a de novo mutation]Carlos B Stehr
Departamento de Endocrinologia, Facultad de Medicina, Pontificia Universidad Catolica de Chile, Santiago, Chile
Rev Med Chil 136:1134-40. 2008..Recently it has been shown that aldosterone plays a role in the production of endothelial oxidative stress and subclinical inflammation... - Primary aldosteronism and its impact on the generation of arterial hypertension, endothelial injury and oxidative stressAlejandro Martinez-Aguayo
Endocrinology Unit, Department of Paediatrics, Faculty of Medicine, Pontificia Universidad Catolica de Chile, Santiago, Chile
J Pediatr Endocrinol Metab 23:323-30. 2010..In this review, we discuss some of the cardiovascular actions of aldosterone and the most frequent causes of PA... - Frequency of familial hyperaldosteronism type 1 in a hypertensive pediatric population: clinical and biochemical presentationMarlene Aglony
Division of Pediatrics, Pontificia Universidad Catolica de Chile, Santiago, Chile
Hypertension 57:1117-21. 2011.... - Biochemical and genetic characterization of 11 beta-hydroxysteroid dehydrogenase type 2 in low-renin essential hypertensivesCristian A Carvajal
Department of Endocrinology and Metabolism, Faculty of Medicine, Pontificia Universidad Catolica de Chile, Santiago, Chile
J Hypertens 23:71-7. 2005..If it fails, cortisol will stimulate sodium and water reabsorption, increasing the intravascular volume that suppresses renin and secondarily increase the blood pressure... - Aldosterone promotes autoimmune damage by enhancing Th17-mediated immunityAndres A Herrada
Millennium Nucleus on Immunology and Immunotherapy, Departamento de Genetica Molecular y Microbiologia, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, Santiago, Chile
J Immunol 184:191-202. 2010.... - Increased diagnosis of primary aldosteronism, including surgically correctable forms, in centers from five continentsPaolo Mulatero
Hypertension Unit, Department of Medicine and Experimental Oncology, University of Torino, 10133 Turin, Italy
J Clin Endocrinol Metab 89:1045-50. 2004..In conclusion, the wide use of the ARR as a screening test in hypertensive patients led to a marked increase in the detection rate of PA...