C E Fardella

Summary

Country: Chile

Publications

  1. ncbi request reprint Refractory depression in a patient with peripheral resistance to thyroid hormone (RTH) and the effect of triiodothyronine treatment
    Carlos E Fardella
    Departamento de Endocrinologia, Pontificia Universidad Catolica de Chile, Santiago, Chile
    Endocrine 31:272-8. 2007
  2. pmc Different effects of progesterone and estradiol on chimeric and wild type aldosterone synthase in vitro
    Andrea Vecchiola
    Molecular Endocrinology Laboratory, Department of Endocrinology, School of Medicine, Pontificia Universidad Catolica de Chile, Lira 85, 5th Floor, Santiago, Chile
    Reprod Biol Endocrinol 11:76. 2013
  3. ncbi request reprint [Pathological characteristics of thyroid microcarcinoma. A review of 402 biopsies]
    Carlos Fardella
    Departamento de Endocrinologia, Escuela de Medicina, Pontificia Universidad Catolica de Chile, Santiago de Chile
    Rev Med Chil 133:1305-10. 2005
  4. doi request reprint [Primary aldosteronism]
    Carlos E Fardella
    Departamento de Endocrinologia, Facultad de Medicina, Pontificia Universidad Catolica de Chile, Santiago, Chile
    Rev Med Chil 136:905-14. 2008
  5. ncbi request reprint Primary aldosteronism and hypertensive disease
    Lorena Mosso
    Department of Endocrinology, Faculty of Medicine, Pontificia Universidad Catolica de Chile, Lira 85, 5 piso, Santiago, Chile
    Hypertension 42:161-5. 2003
  6. ncbi request reprint Primary aldosteronism
    Carlos E Fardella
    Department of Endocrinology, Faculty of Medicine, Catholic University of Chile, Santiago
    Clin Lab 48:181-90. 2002
  7. ncbi request reprint Genetic study of patients with dexamethasone-suppressible aldosteronism without the chimeric CYP11B1/CYP11B2 gene
    C E Fardella
    Department of Endocrinology, Faculty of Medicine, Catholic University of Chile, Marcoleta 391, Santiago, Chile
    J Clin Endocrinol Metab 86:4805-7. 2001
  8. ncbi request reprint Primary hyperaldosteronism in essential hypertensives: prevalence, biochemical profile, and molecular biology
    C E Fardella
    Department of Endocrinology, Faculty of Medicine, Catholic University of Chile, Santiago
    J Clin Endocrinol Metab 85:1863-7. 2000
  9. doi request reprint A new presentation of the chimeric CYP11B1/CYP11B2 gene with low prevalence of primary aldosteronism and atypical gene segregation pattern
    Cristian A Carvajal
    Department of Endocrinology, Pontificia Universidad Catolica de Chile, Santiago, Chile
    Hypertension 59:85-91. 2012
  10. ncbi request reprint [Hypertension and mineralocorticoids. Usefulness of renin and aldosterone measurements]
    C E Fardella
    Departamentos de Endocrinología y Medicina Interna, Facultad de Medicina, Pontificia Universidad Catolica de Chile, Santiago de Chile
    Rev Med Chil 127:604-10. 1999

Collaborators

  • J Montero
  • Lorena Mosso
  • C Campino
  • Alexis A Gonzalez
  • GILBERTO GONZALEZ
  • Damian G Romero
  • G Valdivia
  • William F Young
  • Michael Stowasser
  • P Mulatero
  • Richard D Gordon
  • Kuniaki Mukai
  • Cristian A Carvajal
  • Alejandro Martinez-Aguayo
  • C A Carvajal
  • Marlene Aglony
  • A M Kalergis
  • Hernan Garcia
  • Rodrigo Bancalari
  • Lillian Bolte
  • R Baudrand
  • N Muñoz-Durango
  • Andrea Vecchiola
  • Carolina Valdivia
  • Carlos F Lagos
  • Pamela Trejo
  • Carolina Loureiro
  • Andrea Inostroza
  • Alejandra Avila
  • Carolina Avalos
  • Viviana Perez
  • C B Stehr
  • Andres A Herrada
  • Carlos B Stehr
  • Mauricio A Morales
  • Carlos R Muñoz-Brauning
  • P A Vöhringer
  • O Olivieri
  • G Faccini
  • G Guidi
  • J Cerda
  • G Owen
  • Fidel Allende
  • Alejandra Tapia-Castillo
  • N A Letelier
  • Sandra Solari
  • Tadashi Ogishima
  • Cristóbal A Fuentes
  • M F Barake
  • Gareth Owen
  • Juan E Tichauer
  • Rene Baudrand
  • Cecilia Mellado
  • Karin Brinkmann
  • E M Riquelme
  • Veronica Mericq
  • T Montero
  • Vinka Giadrosich
  • M J Santos
  • P A Gonzalez
  • Ana Rocha
  • Claudia A Riedel
  • Claudia M Cortes
  • Pablo A González
  • Cristian A Amador
  • Francisco J Contreras
  • Luis F Michea
  • Alexis M Kalergis
  • Natacha P Marini
  • Fernando Figueroa
  • A A Herrada
  • F J Contreras
  • C R Castillo
  • Rosemarie Mellado
  • Hernan Alcaino
  • Andreina Cattani
  • Rocío A Artigas
  • Eugenia Ortiz
  • Sergio Lavandera
  • Patricia Lacourt
  • Gareth I Owen

Detail Information

Publications25

  1. ncbi request reprint Refractory depression in a patient with peripheral resistance to thyroid hormone (RTH) and the effect of triiodothyronine treatment
    Carlos E Fardella
    Departamento de Endocrinologia, Pontificia Universidad Catolica de Chile, Santiago, Chile
    Endocrine 31:272-8. 2007
    ..Screening for RTH in refractory chronic depression may provide an alternative treatment for this psychiatric condition...
  2. pmc Different effects of progesterone and estradiol on chimeric and wild type aldosterone synthase in vitro
    Andrea Vecchiola
    Molecular Endocrinology Laboratory, Department of Endocrinology, School of Medicine, Pontificia Universidad Catolica de Chile, Lira 85, 5th Floor, Santiago, Chile
    Reprod Biol Endocrinol 11:76. 2013
    ..The purpose of this study was to investigate in vitro whether female sex steroids modulate the activity of chimeric (ASCE) or wild type (ASWT) aldosterone synthase enzymes...
  3. ncbi request reprint [Pathological characteristics of thyroid microcarcinoma. A review of 402 biopsies]
    Carlos Fardella
    Departamento de Endocrinologia, Escuela de Medicina, Pontificia Universidad Catolica de Chile, Santiago de Chile
    Rev Med Chil 133:1305-10. 2005
    ..Thyroid microcarcinoma is a tumor of 10 mm or less, that should have a low risk of mortality. However, a subgroup of these carcinomas is as aggressive as bigger tumors...
  4. doi request reprint [Primary aldosteronism]
    Carlos E Fardella
    Departamento de Endocrinologia, Facultad de Medicina, Pontificia Universidad Catolica de Chile, Santiago, Chile
    Rev Med Chil 136:905-14. 2008
    ..This article reviews the prevalence, diagnosis and treatment of PA and also the clinical, biochemical and genetic characteristics of its different subtypes...
  5. ncbi request reprint Primary aldosteronism and hypertensive disease
    Lorena Mosso
    Department of Endocrinology, Faculty of Medicine, Pontificia Universidad Catolica de Chile, Lira 85, 5 piso, Santiago, Chile
    Hypertension 42:161-5. 2003
    ..The low frequency of computed tomography scan abnormalities and hypokalemia suggests that the diagnosis for most PA patients corresponds to attenuated forms of the disease...
  6. ncbi request reprint Primary aldosteronism
    Carlos E Fardella
    Department of Endocrinology, Faculty of Medicine, Catholic University of Chile, Santiago
    Clin Lab 48:181-90. 2002
    ..We also discuss the treatment, and the differential diagnosis with other hyper-mineralocorticoid states...
  7. ncbi request reprint Genetic study of patients with dexamethasone-suppressible aldosteronism without the chimeric CYP11B1/CYP11B2 gene
    C E Fardella
    Department of Endocrinology, Faculty of Medicine, Catholic University of Chile, Marcoleta 391, Santiago, Chile
    J Clin Endocrinol Metab 86:4805-7. 2001
    ..We suggest that the dexamethasone suppression test could lead to an incorrect diagnosis of glucocorticoid-remediable aldosteronism...
  8. ncbi request reprint Primary hyperaldosteronism in essential hypertensives: prevalence, biochemical profile, and molecular biology
    C E Fardella
    Department of Endocrinology, Faculty of Medicine, Catholic University of Chile, Santiago
    J Clin Endocrinol Metab 85:1863-7. 2000
    ..A high proportion of PA suppressed SA with dexamethasone, but only a few had a chimeric gene or high levels of 18-hydroxycortisol. These results emphasize the need to further investigate EH patients...
  9. doi request reprint A new presentation of the chimeric CYP11B1/CYP11B2 gene with low prevalence of primary aldosteronism and atypical gene segregation pattern
    Cristian A Carvajal
    Department of Endocrinology, Pontificia Universidad Catolica de Chile, Santiago, Chile
    Hypertension 59:85-91. 2012
    ..Most adults have normal aldosterone and renin levels, which could mask them as essential hypertensives...
  10. ncbi request reprint [Hypertension and mineralocorticoids. Usefulness of renin and aldosterone measurements]
    C E Fardella
    Departamentos de Endocrinología y Medicina Interna, Facultad de Medicina, Pontificia Universidad Catolica de Chile, Santiago de Chile
    Rev Med Chil 127:604-10. 1999
    ..This article reviews these forms of hypertension, their clinical workup and their relevance in the usual hypertensive patients...
  11. doi request reprint Primary aldosteronism can alter peripheral levels of transforming growth factor beta and tumor necrosis factor alpha
    C A Carvajal
    Department of Endocrinology, Faculty of Medicine, Pontificia Universidad Catolica de Chile, Santiago, Chile
    J Endocrinol Invest 32:759-65. 2009
    ..Primary aldosteronism (PA) is the most common secondary cause of hypertension that has recently been implicated in alterations of the immune system and progression of cardiovascular disease...
  12. doi request reprint A de novo unequal cross-over mutation between CYP11B1 and CYP11B2 genes causes familial hyperaldosteronism type I
    C A Carvajal
    Endocrinology Department, Faculty of Medicine, Pontificia Universidad Catolica de Chile, Santiago, Chile
    J Endocrinol Invest 34:140-4. 2011
    ....
  13. ncbi request reprint Immune system alterations by aldosterone during hypertension: from clinical observations to genomic and non-genomic mechanisms leading to vascular damage
    N Muñoz-Durango
    Millennium Institute on Immunology and Immunotherapy, Departamento de Genetica Molecular y Microbiologia, Pontificia Universidad Catolica de Chile, Chile
    Curr Mol Med 13:1035-46. 2013
    ..In addition, regulatory T cells diminish the inflammatory damage caused by aldosterone during hypertension. This is a very active area of research that could lead to new therapeutic targets for treating hypertension...
  14. ncbi request reprint A possible association between primary aldosteronism and a lower beta-cell function
    Lorena M Mosso
    Department of Nutrition and Diabetes, Faculty of Medicine, Pontificia Universidad Catolica de Chile, Santiago, Chile
    J Hypertens 25:2125-30. 2007
    ..We investigated the glucose insulin sensitivity and insulin secretion in patients with idiopathic primary aldosteronism...
  15. doi request reprint [Possible pathogenetic role of 11 beta-hydroxysteroid dehydrogenase type 1 (11betaHSD1) gene polymorphisms in arterial hypertension]
    Mauricio A Morales
    Departamento de Endocrinologia, Pontificia Universidad Catolica de Chile, Lira 85, Santiago, Chile
    Rev Med Chil 136:701-10. 2008
    ..Several polymorphisms have been reported in HSDl IB 1 gene (CAI5, CAI9 and InsA83557), which could modify HSDl IB 1 gene expression or activity...
  16. ncbi request reprint A polymorphic GT short tandem repeat affecting beta-ENaC mRNA expression is associated with low renin essential hypertension
    Alexis A Gonzalez
    Department of Endocrinology, Faculty of Medicine, Pontificia Universidad Catolica de Chile, Santiago, Chile
    Am J Hypertens 20:800-6. 2007
    ....
  17. doi request reprint High sodium intake is associated with increased glucocorticoid production, insulin resistance and metabolic syndrome
    R Baudrand
    Department of Endocrinology, School of Medicine, Pontificia Universidad Catolica de Chile, Santiago, Chile Millennium Institute of Immunology and Immunotherapy, Pontificia Universidad Catolica de Chile, Santiago, Chile
    Clin Endocrinol (Oxf) 80:677-84. 2014
    ..High sodium (HS) diet is associated with hypertension (HT) and insulin resistance (IR). We evaluated whether HS diet was associated with a dysregulation of cortisol production and metabolic syndrome (MetS)...
  18. ncbi request reprint [Microsatellite marker AGAT of the mineralocorticoid receptor gene is associated with plasma renin activity in patients with essential hypertension]
    Carlos R Muñoz-Brauning
    Departamento de Endocrinologia, Facultad de Medicina, Pontificia Universidad Catolica de Chile
    Rev Med Chil 133:1415-23. 2005
    ..Moreover, microsatellite regions can be associated to the regulation of the gene expression, producing subtle pathologies...
  19. doi request reprint Aldosterone, plasma Renin activity, and aldosterone/renin ratio in a normotensive healthy pediatric population
    Alejandro Martinez-Aguayo
    Department of Endocrinology, School of Medicine, Pontificia Universidad Catolica de Chile, Lira 85, Piso 5, Santiago 8330074, Chile
    Hypertension 56:391-6. 2010
    ..We demonstrated that normal aldosterone/renin ratio values in a healthy pediatric population without NH were lower than those reported for an adult normotensive population...
  20. doi request reprint [Subclinical endothelial inflammation markers in a family with type I familial hyperaldosteronism caused by a de novo mutation]
    Carlos B Stehr
    Departamento de Endocrinologia, Facultad de Medicina, Pontificia Universidad Catolica de Chile, Santiago, Chile
    Rev Med Chil 136:1134-40. 2008
    ..Recently it has been shown that aldosterone plays a role in the production of endothelial oxidative stress and subclinical inflammation...
  21. ncbi request reprint Primary aldosteronism and its impact on the generation of arterial hypertension, endothelial injury and oxidative stress
    Alejandro Martinez-Aguayo
    Endocrinology Unit, Department of Paediatrics, Faculty of Medicine, Pontificia Universidad Catolica de Chile, Santiago, Chile
    J Pediatr Endocrinol Metab 23:323-30. 2010
    ..In this review, we discuss some of the cardiovascular actions of aldosterone and the most frequent causes of PA...
  22. doi request reprint Frequency of familial hyperaldosteronism type 1 in a hypertensive pediatric population: clinical and biochemical presentation
    Marlene Aglony
    Division of Pediatrics, Pontificia Universidad Catolica de Chile, Santiago, Chile
    Hypertension 57:1117-21. 2011
    ....
  23. ncbi request reprint Biochemical and genetic characterization of 11 beta-hydroxysteroid dehydrogenase type 2 in low-renin essential hypertensives
    Cristian A Carvajal
    Department of Endocrinology and Metabolism, Faculty of Medicine, Pontificia Universidad Catolica de Chile, Santiago, Chile
    J Hypertens 23:71-7. 2005
    ..If it fails, cortisol will stimulate sodium and water reabsorption, increasing the intravascular volume that suppresses renin and secondarily increase the blood pressure...
  24. doi request reprint Aldosterone promotes autoimmune damage by enhancing Th17-mediated immunity
    Andres A Herrada
    Millennium Nucleus on Immunology and Immunotherapy, Departamento de Genetica Molecular y Microbiologia, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, Santiago, Chile
    J Immunol 184:191-202. 2010
    ....
  25. ncbi request reprint Increased diagnosis of primary aldosteronism, including surgically correctable forms, in centers from five continents
    Paolo Mulatero
    Hypertension Unit, Department of Medicine and Experimental Oncology, University of Torino, 10133 Turin, Italy
    J Clin Endocrinol Metab 89:1045-50. 2004
    ..In conclusion, the wide use of the ARR as a screening test in hypertensive patients led to a marked increase in the detection rate of PA...