Mauricio A Retamal
Affiliation: Facultad de Medicina
Retamal M, Orellana V, Arévalo N, Rojas C, Arjona R, Alcaíno C, et al
. Cx46 hemichannel modulation by nitric oxide: Role of the fourth transmembrane helix cysteine and its possible involvement in cataract formation. Nitric Oxide. 2019;: pubmed publisher
..We propose that increased hemichannel opening and/or changes in their electrophysiological properties due to S-nitrosation of the human Cx46 cysteine in TM4 could be an important factor in cataract formation. ..
LeÃ³n Paravic C, Figueroa V, GuzmÃ¡n D, Valderrama C, Vallejos A, Fiori M, et al
. Carbon monoxide (CO) is a novel inhibitor of connexin hemichannels. J Biol Chem. 2014;289:36150-7 pubmed publisher
..The inhibition of HCs could help to understand some of the biological actions of CO in physiological and pathological conditions. ..
Dalamon V, Fiori M, Figueroa V, Oliva C, Del Rio R, Gonzalez W, et al
. Gap-junctional channel and hemichannel activity of two recently identified connexin 26 mutants associated with deafness. Pflugers Arch. 2016;468:909-18 pubmed publisher
..Deafness associated with G109V could result from decreased GJCs activity, whereas deafness associated to L10P may have a more complex mechanism that involves changes in HC permeability. ..
Retamal M, Yin S, Altenberg G, Reuss L. Modulation of Cx46 hemichannels by nitric oxide. Am J Physiol Cell Physiol. 2009;296:C1356-63 pubmed publisher
..However, it is unlikely that NO induces cataract formation due to the hemichannel activation, because at normal resting potential, NO had no major effects on Cx46 hemichannel permeability. ..
García I, Sánchez H, Martinez A, Retamal M. Redox-mediated regulation of connexin proteins; focus on nitric oxide. Biochim Biophys Acta Biomembr. 2018;1860:91-95 pubmed publisher
..In this mini-review, we summarize the current knowledge about the effects of redox potential focused in NO on the trafficking, formation and functional properties of hemichannels and gap junction channels. ..