Alejandro Corvalan

Summary

Affiliation: Pontificia Universidad Catolica de Chile
Location: Santiago, Chile
URL: http://www.mpel.site88.net/
Summary:
Cancer Research, Epigenetics, Bioinformatics
Grants:
Fondecyt 1030130 (2003-2005), Fondecyt 1080563 (2008-2010), Fondecyt 1111014 (2011-2014), Fondef D09i1137 (2011-2013), Fonis SA06I20019(2006-2007)

Publications

  1. pmc Baseline assessment of prevalence and geographical distribution of HPV types in Chile using self-collected vaginal samples
    Catterina Ferreccio
    P Universidad Catolica de Chile, Escuela de Medicina, Santiago Chile
    BMC Public Health 8:78. 2008
  2. doi request reprint Serial analysis of gene expression identifies connective tissue growth factor expression as a prognostic biomarker in gallbladder cancer
    Hector Alvarez
    Department of Pathology, Pontificia Universidad Catolica de Chile, Santiago, Chile
    Clin Cancer Res 14:2631-8. 2008
  3. pmc Determinants of Epstein-Barr virus-positive gastric cancer: an international pooled analysis
    M C Camargo
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 6120 Executive Boulevard, Rockville, MD 20852, USA
    Br J Cancer 105:38-43. 2011
  4. doi request reprint Reprimo as a potential biomarker for early detection in gastric cancer
    Carolina Bernal
    Department of Anatomic Pathology, Centro Investigaciones Medicas, Pontificia Universidad Catolica de Chile, Santiago, Chile
    Clin Cancer Res 14:6264-9. 2008
  5. doi request reprint DNA methylation profile in diffuse type gastric cancer: evidence for hypermethylation of the BRCA1 promoter region in early-onset gastric carcinogenesis
    Carolina Bernal
    Departmento Anatomía Patológica, Pontificia Universidad Catolica de Chile, Santiago, Chile
    Biol Res 41:303-15. 2008
  6. doi request reprint [Risk factors associated with abnormal cervical cytology among Chilean women: a case control study]
    María Teresa Solis
    Departamento de Salud Publica, Escuela de Medicina, Pontificia Universidad Catolica de Chile, Chile
    Rev Med Chil 138:174-80. 2010
  7. doi request reprint Overexpression of p73 as a tissue marker for high-risk gastritis
    Gonzalo Carrasco
    Department of Anatomic Pathology, Pontificia Universidad Catolica de Chile, Santiago, Chile
    Clin Cancer Res 16:3253-9. 2010
  8. pmc Nrf2 and Keap1 abnormalities in non-small cell lung carcinoma and association with clinicopathologic features
    Luisa M Solis
    Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    Clin Cancer Res 16:3743-53. 2010
  9. doi request reprint Helicobacter pylori-induced loss of the inhibitor-of-apoptosis protein survivin is linked to gastritis and death of human gastric cells
    Manuel Valenzuela
    Laboratory of Cellular Communication, Fondo de Investigación Avanzada en Areas Prioritarias, Center for Molecular Studies of the Cell, Facultad de Medicina, Instituto de Ciencias Biomedicas, Universidad de Chile, Pontificia Universidad Catolica de Chile, Santiago, Chile
    J Infect Dis 202:1021-30. 2010
  10. ncbi request reprint Promoter hypermethylation of BRCA1 correlates with absence of expression in hereditary breast cancer tumors
    Teresa Tapia
    Department of Cell and Molecular Biology, Faculty of Biological Sciences, Pontificia Universidad Catolica de Chile, Santiago, Chile
    Epigenetics 3:157-63. 2008

Collaborators

Detail Information

Publications24

  1. pmc Baseline assessment of prevalence and geographical distribution of HPV types in Chile using self-collected vaginal samples
    Catterina Ferreccio
    P Universidad Catolica de Chile, Escuela de Medicina, Santiago Chile
    BMC Public Health 8:78. 2008
    ..A home-based self-collected vaginal sampling was nested in the 2003 Chilean population-based health survey in order to explore the possibility of a type-specific geographical variation for human papillomavirus..
  2. doi request reprint Serial analysis of gene expression identifies connective tissue growth factor expression as a prognostic biomarker in gallbladder cancer
    Hector Alvarez
    Department of Pathology, Pontificia Universidad Catolica de Chile, Santiago, Chile
    Clin Cancer Res 14:2631-8. 2008
    ..Gallbladder cancer (GBC) is an uncommon neoplasm in the United States, but one with high mortality rates. This malignancy remains largely understudied at the molecular level such that few targeted therapies or predictive biomarkers exist...
  3. pmc Determinants of Epstein-Barr virus-positive gastric cancer: an international pooled analysis
    M C Camargo
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 6120 Executive Boulevard, Rockville, MD 20852, USA
    Br J Cancer 105:38-43. 2011
    ..This study aimed to identify additional determinants of EBV positivity and their joint effects...
  4. doi request reprint Reprimo as a potential biomarker for early detection in gastric cancer
    Carolina Bernal
    Department of Anatomic Pathology, Centro Investigaciones Medicas, Pontificia Universidad Catolica de Chile, Santiago, Chile
    Clin Cancer Res 14:6264-9. 2008
    ..However, most cases are diagnosed at advanced stage because of the lack of screening programs. Therefore, the identification of plasma biomarkers for early detection is necessary...
  5. doi request reprint DNA methylation profile in diffuse type gastric cancer: evidence for hypermethylation of the BRCA1 promoter region in early-onset gastric carcinogenesis
    Carolina Bernal
    Departmento Anatomía Patológica, Pontificia Universidad Catolica de Chile, Santiago, Chile
    Biol Res 41:303-15. 2008
    ..DNA methylation identified subgroups of diffuse type gastric cancer. Hypermethylation of BRCA1 associated with young age suggests a role in early-onset gastric carcinoma...
  6. doi request reprint [Risk factors associated with abnormal cervical cytology among Chilean women: a case control study]
    María Teresa Solis
    Departamento de Salud Publica, Escuela de Medicina, Pontificia Universidad Catolica de Chile, Chile
    Rev Med Chil 138:174-80. 2010
    ..Cervical cancer is the third cause of cancer death among Chilean women, affecting mainly women from low socioeconomic status...
  7. doi request reprint Overexpression of p73 as a tissue marker for high-risk gastritis
    Gonzalo Carrasco
    Department of Anatomic Pathology, Pontificia Universidad Catolica de Chile, Santiago, Chile
    Clin Cancer Res 16:3253-9. 2010
    ..Histologic assessment of high-risk gastritis for the development of gastric cancer is not well defined. The identification of tissue markers together with the integration of histologic features will be required for this assessment...
  8. pmc Nrf2 and Keap1 abnormalities in non-small cell lung carcinoma and association with clinicopathologic features
    Luisa M Solis
    Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    Clin Cancer Res 16:3743-53. 2010
    ....
  9. doi request reprint Helicobacter pylori-induced loss of the inhibitor-of-apoptosis protein survivin is linked to gastritis and death of human gastric cells
    Manuel Valenzuela
    Laboratory of Cellular Communication, Fondo de Investigación Avanzada en Areas Prioritarias, Center for Molecular Studies of the Cell, Facultad de Medicina, Instituto de Ciencias Biomedicas, Universidad de Chile, Pontificia Universidad Catolica de Chile, Santiago, Chile
    J Infect Dis 202:1021-30. 2010
    ..Finally, overexpression of survivin in human gastric cells was sufficient to reduce cell death after infection. Taken together, these findings implicate survivin as an important survival factor in the gastric mucosa of humans...
  10. ncbi request reprint Promoter hypermethylation of BRCA1 correlates with absence of expression in hereditary breast cancer tumors
    Teresa Tapia
    Department of Cell and Molecular Biology, Faculty of Biological Sciences, Pontificia Universidad Catolica de Chile, Santiago, Chile
    Epigenetics 3:157-63. 2008
    ..Moreover, a number of biopsies with absence of expression on BRCA1 showed negative detection of estrogen and progesterone receptors, a similar phenotype to BRCA1 mutated breast tumors...
  11. doi request reprint High frequency of p16 promoter methylation in non-small cell lung carcinomas from Chile
    Leda M Guzman
    Escuela de Tecnología Médica, Facultad de Salud, Universidad Santo Tomás, Santiago, Chile
    Biol Res 40:365-72. 2007
    ..202, 0.202 and 0.147 respectively). Our results suggest that p16 promoter hypermethylation is a very frequent event in non-small cell lung carcinomas from Chile and could be smoking habit-independent...
  12. pmc In silico analysis of gastric carcinoma Serial Analysis of Gene Expression libraries reveals different profiles associated with ethnicity
    Francisco J Ossandon
    Laboratory of Molecular Pathology and Epidemiology, Centro Investigaciones Medicas, Pontificia Universidad Catolica de Chile, Santiago, Chile
    Mol Cancer 7:22. 2008
    ..These expression differences might contribute to explain the disparate outcome between the West and the East...
  13. ncbi request reprint Mismatch repair expression in testicular cancer predicts recurrence and survival
    Alfredo Velasco
    Department of Urology, Pontificia Universidad Catolica de Chile, Santiago, Chile
    Int J Cancer 122:1774-7. 2008
    ....
  14. ncbi request reprint E-cadherin and beta-catenin expression in Epstein-Barr virus-associated gastric carcinoma and their prognostic significance
    Chihaya Koriyama
    Department of Epidemiology and Preventive Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, 8 35 1 Sakuragaoka, Kagoshima, 890 8544, Japan
    World J Gastroenterol 13:3925-31. 2007
    ..To examine the role of E-cadherin and beta-catenin in carcinogenesis and to assess their prognostic implication in Epstein-Barr virus-associated gastric carcinomas (EBV-GCs)...
  15. pmc Analytical detection of immunoglobulin heavy chain gene rearrangements in gastric lymphoid infiltrates by peak area analysis of the melting curve in the LightCycler System
    Eduardo Retamales
    Departamento Laboratorio de Salud, Instituto Salud Publica de Chile, Santiago, Chile
    J Mol Diagn 9:351-7. 2007
    ....
  16. pmc Human papillomavirus-16 is integrated in lung carcinomas: a study in Chile
    F Aguayo
    Division of Oncogenic and Persistent Viruses, Center for Chronic Viral Diseases, Kagoshima University Graduate School of Medical and Dental Sciences, 8 35 1 Sakuragaoka, Kagoshima, 890 8544, Japan
    Br J Cancer 97:85-91. 2007
    ..Although the viral load was in general very low and HPV E6 expression is none or weak, further studies seem warranted to examine aetiological involvement of high-risk HPV in lung carcinogenesis...
  17. ncbi request reprint Epstein-Barr virus-associated primary lymphoepitheliomalike carcinoma of the esophagus
    José Rafael Valbuena
    Department of Anatomic Pathology, Pontificia Universidad Catolica de Chile, Santiago, Chile
    Diagn Mol Pathol 16:27-31. 2007
    ..To our knowledge, this is the first report that describes this recombinant type "i"/XhoI loss EBV strain in a primary LELC of the esophagus...
  18. ncbi request reprint [Gene expression profiles for therapeutic decisions in breast cancer]
    Alejandro Corvalan
    Laboratorio Biología Molecular, Departamento Anatomia Patologica, Pontificia Universidad Catolica de Chile, Santiago, Chile
    Rev Med Chil 135:257-63. 2007
    ..MINDACT is the first prospective effort to evaluate gene expression profiles in clinical practice. Our participation in this protocol, installs us in the first line of worldwide oncological investigation...
  19. ncbi request reprint Frequent epigenetic inactivation of chromosome 3p candidate tumor suppressor genes in gallbladder carcinoma
    Erick Riquelme
    Department of Anatomic Pathology, Pontificia Universidad Catolica de Chile, 85 Lira St Santiago 133202, Chile
    Cancer Lett 250:100-6. 2007
    ..We conclude that epigenetic inactivation by abnormal promoter methylation is a frequent event in chromosome 3p candidate TSGs in GBC pathogenesis, especially affecting genes SEMA3B (3p21.3) and FHIT (3p14.2)...
  20. ncbi request reprint Recent patents of DNA methylation biomarkers in gastrointestinal oncology
    Alejandro H Corvalan
    Department of Hematology Oncology, School of Medicine, Pontificia Universidad Catolica de Chile, Santiago 8330074 Chile
    Recent Pat DNA Gene Seq 4:202-9. 2010
    ..Thus the new field of DNA methylation biomarkers holds the promise of better methods for screening, early detection, disease progression and outcome predictor of therapy response in gastrointestinal oncology...
  21. pmc High-risk HPV infection after five years in a population-based cohort of Chilean women
    Catterina Ferreccio
    División de Salud Pública y Medicina Familiar, Escuela de Medicina Pontificia Universidad Católica de Chile, Marcoleta 434, Santiago 8330073, Chile
    Infect Agent Cancer 6:21. 2011
    ..abstract:..
  22. pmc Human papillomavirus and Epstein-Barr virus infections in breast cancer from chile
    Francisco Aguayo
    Virology Program, I, C, B, M, Faculty of Medicine, University of Chile, Independencia 1027, Santiago 838 9100, Chile
    Infect Agent Cancer 6:7. 2011
    ..abstract:..
  23. ncbi request reprint [Clinical and molecular features of cardial gastric cancer associated to Epstein Barr virus]
    Alejandro Corvalan
    Departamento de Anatomia Patologica, Pontificia Universidad Catolica de Chile, Santiago, Chile
    Rev Med Chil 133:753-60. 2005
    ..Mortality caused by cardial gastric cancer in Chile, is increasing. Previously we demonstrated an association between Epstein Barr virus and this specific location of gastric cancer...