Susan M Bueno

Summary

Country: Chile

Publications

  1. ncbi request reprint Chromosomal excision of a new pathogenicity island modulates Salmonella virulence in vivo
    Hugo E Tobar
    Departamento de Genetica Molecular y Microbiologia, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile Avenida Libertador Bernardo O Higgings Nº340, Santiago 8331010, Santiago, Chile
    Curr Gene Ther 13:240-9. 2013
  2. pmc Mechanisms used by virulent Salmonella to impair dendritic cell function and evade adaptive immunity
    Susan M Bueno
    Millennium Institute on Immunology and Immunotherapy, Departamento de Genetica Molecular y Microbiologia, Pontificia Universidad Catolica de Chile, Santiago, Chile
    Immunology 137:28-36. 2012
  3. pmc Salmonella pathogenicity island 1 differentially modulates bacterial entry to dendritic and non-phagocytic cells
    Susan M Bueno
    Millennium Nucleus on Immunology and Immunotherapy, Departamento de Genetica Molecular y Microbiologia, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, Santiago, Chile
    Immunology 130:273-87. 2010
  4. pmc The capacity of Salmonella to survive inside dendritic cells and prevent antigen presentation to T cells is host specific
    Susan M Bueno
    Millennium Nucleus on Immunology and Immunotherapy, Departamento de Genetica Molecular y Microbiologia, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, Santiago, Chile
    Immunology 124:522-33. 2008
  5. ncbi request reprint Evasion of host immunity by virulent Salmonella: implications for vaccine design
    S A Riquelme
    Millennium Institute on Immunology and Immunotherapy, Departamento de Genetica Molecular y Microbiologia, Pontificia Universidad Catolica de Chile, Santiago 8331010, Chile
    Curr Med Chem 18:5666-75. 2011
  6. pmc Virulent Salmonella enterica serovar typhimurium evades adaptive immunity by preventing dendritic cells from activating T cells
    Jaime A Tobar
    Departamento de Genetica Molecular y Microbiologia, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, Alameda 340, Santiago, Chile
    Infect Immun 74:6438-48. 2006
  7. pmc Excision of an unstable pathogenicity island in Salmonella enterica serovar Enteritidis is induced during infection of phagocytic cells
    Tania S Quiroz
    Departamento de Genetica Molecular y Microbiologia, Facultad de Ciencias Biologicas, Millennium Institute on Immunology and Immunotherapy, Pontificia Universidad Catolica de Chile, Santiago, Chile
    PLoS ONE 6:e26031. 2011
  8. doi request reprint Immunization with a recombinant bacillus Calmette-Guerin strain confers protective Th1 immunity against the human metapneumovirus
    Christian E Palavecino
    Instituto Milenio en Inmunología e Inmunoterapia, Departamento de Genetica Molecular y Microbiologia, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, Santiago 8330025, Chile
    J Immunol 192:214-23. 2014
  9. pmc IgG keeps virulent Salmonella from evading dendritic cell uptake
    Sebastián A Riquelme
    Millennium Institute of Immunology and Immunotherapy, Departamento de Genetica Molecular y Microbiologia, Facultad de Ciencias Biologicas, Pontificia Universidad Católica de Chile Departamento de Reumatología, Facultad de Medicina, Pontificia Universidad Catolica de Chile, Santiago, Chile
    Immunology 136:291-305. 2012
  10. doi request reprint Efficient lung recruitment of respiratory syncytial virus-specific Th1 cells induced by recombinant bacillus Calmette-Guérin promotes virus clearance and protects from infection
    Kelly M Cautivo
    Millennium Nucleus on Immunology and Immunotherapy, Departamento de Genetica Molecular y Microbiologia, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, Alameda 340, Santiago, Chile
    J Immunol 185:7633-45. 2010

Collaborators

  • Alexis M Kalergis
  • Carlos A Santiviago
  • Carolina Llanos
  • Guido C Mora
  • A Nicole Trombert
  • Juan A Fuentes
  • Michael L Dustin
  • Marcela Ferres
  • Wolf Dietrich Hardt
  • Orlando Diaz
  • Flavio Salazar-Onfray
  • Rodrigo Pacheco
  • Claudia A Riedel
  • Pablo A González
  • Leandro J Carreño
  • Sebastián A Riquelme
  • Roberto S Gómez
  • Pablo F Céspedes
  • Christian E Palavecino
  • Pamela A Nieto
  • Francisco J Salazar-Echegarai
  • Janyra A Espinoza
  • Karen Böhmwald
  • Hugo E Tobar
  • Juan P Mackern-Oberti
  • Margarita K Lay
  • Claudia M Cortes
  • Juan Pablo Mackern-Oberti
  • Manuel Alvarez-Lobos
  • Aniela Wozniak
  • Jorge E Mora
  • Kelly M Cautivo
  • Tania S Quiroz
  • Daniela V Araya
  • Hernán F Peñaloza
  • Sebasti n A Riquelme
  • Ignacio Anegon
  • Fabian Vega
  • Miguel A León
  • Eduardo A Albornoz
  • Javiera Torres
  • Claudia Cortes
  • S A Riquelme
  • Rodrigo J Lizana
  • Carolina P Quezada
  • Hernan E Gonzalez
  • Jaime A Tobar
  • Gonzalo P Mendez
  • Rodrigo A Díaz
  • Julien Pogu
  • María J Parga
  • Francisco J Salazar
  • Natalia Muñoz-Durango
  • Daniel B Aguirre
  • James B Dale
  • Camila B Schmidt
  • Evelyn Jara
  • Patricia Garcia
  • Andrea Vera
  • Isabelle Guisle-Marsollier
  • Victoria A Sarno
  • Thomas Simon
  • Enrique A Geoffroy
  • Tuan H Nguyen
  • Samantha A González
  • Bruno A Ramírez
  • Alison Creneguy
  • Michael Cammer
  • Catarina Sacristán
  • David Depoil
  • Tamara P Catalán
  • Franciso J Salazar-Echegarai
  • Joan W Berman
  • M Cecilia Opazo
  • Patricio Ibanez
  • Daniela P Pizarro
  • Carlos Quintana
  • Floria C Pancetti
  • Abner Espinoza
  • Vatenlina P Sebastian
  • Javier A Valenzuela
  • Pablo A Cisternas
  • Eliseo A Eugenin
  • Valentina P Sebastián
  • Juan C Alvarado
  • Rodrigo A Sandoval
  • David Naranjo
  • Felipe Court
  • Esteban Aliaga
  • Eliseo Eugenin

Detail Information

Publications46

  1. ncbi request reprint Chromosomal excision of a new pathogenicity island modulates Salmonella virulence in vivo
    Hugo E Tobar
    Departamento de Genetica Molecular y Microbiologia, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile Avenida Libertador Bernardo O Higgings Nº340, Santiago 8331010, Santiago, Chile
    Curr Gene Ther 13:240-9. 2013
    ..Our results suggest that the genetic excision of the pathogenicity island ROD21 in S. Enteritidis modulates the capacity of this bacterium to cause disease in mice due to a change in the expression of virulence genes. ..
  2. pmc Mechanisms used by virulent Salmonella to impair dendritic cell function and evade adaptive immunity
    Susan M Bueno
    Millennium Institute on Immunology and Immunotherapy, Departamento de Genetica Molecular y Microbiologia, Pontificia Universidad Catolica de Chile, Santiago, Chile
    Immunology 137:28-36. 2012
    ..Typhimurium. Here we discuss some of the recent data reported by the literature showing that several virulence proteins from Salmonella are required to modulate DC function and the activation of host adaptive immunity...
  3. pmc Salmonella pathogenicity island 1 differentially modulates bacterial entry to dendritic and non-phagocytic cells
    Susan M Bueno
    Millennium Nucleus on Immunology and Immunotherapy, Departamento de Genetica Molecular y Microbiologia, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, Santiago, Chile
    Immunology 130:273-87. 2010
    ..The SPI-1 could be considered not only as an inducer of epithelial cell invasion but as a controller of DC entry...
  4. pmc The capacity of Salmonella to survive inside dendritic cells and prevent antigen presentation to T cells is host specific
    Susan M Bueno
    Millennium Nucleus on Immunology and Immunotherapy, Departamento de Genetica Molecular y Microbiologia, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, Santiago, Chile
    Immunology 124:522-33. 2008
    ..Typhimurium or S. Enteritidis. Our data suggest that Salmonella host restriction is characterized by the ability of these bacteria to survive within DCs and avoid activation of the adaptive immune response in their specific hosts...
  5. ncbi request reprint Evasion of host immunity by virulent Salmonella: implications for vaccine design
    S A Riquelme
    Millennium Institute on Immunology and Immunotherapy, Departamento de Genetica Molecular y Microbiologia, Pontificia Universidad Catolica de Chile, Santiago 8331010, Chile
    Curr Med Chem 18:5666-75. 2011
    ..Here we describe recent data underscoring the virulence mechanisms used by Salmonella to exploit DC function and discuss strategies based on this new knowledge aimed at the design of new efficient and safe vaccines against this pathogen...
  6. pmc Virulent Salmonella enterica serovar typhimurium evades adaptive immunity by preventing dendritic cells from activating T cells
    Jaime A Tobar
    Departamento de Genetica Molecular y Microbiologia, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, Alameda 340, Santiago, Chile
    Infect Immun 74:6438-48. 2006
    ..Our data suggest that impairment of DC function by the activity of SPI-2 gene products is crucial for Salmonella pathogenesis...
  7. pmc Excision of an unstable pathogenicity island in Salmonella enterica serovar Enteritidis is induced during infection of phagocytic cells
    Tania S Quiroz
    Departamento de Genetica Molecular y Microbiologia, Facultad de Ciencias Biologicas, Millennium Institute on Immunology and Immunotherapy, Pontificia Universidad Catolica de Chile, Santiago, Chile
    PLoS ONE 6:e26031. 2011
    ..Enteritidis was residing inside murine phagocytic cells. These data suggest that ROD21 is an unstable pathogenicity island, whose frequency of excision depends on the environmental conditions found inside phagocytic cells...
  8. doi request reprint Immunization with a recombinant bacillus Calmette-Guerin strain confers protective Th1 immunity against the human metapneumovirus
    Christian E Palavecino
    Instituto Milenio en Inmunología e Inmunoterapia, Departamento de Genetica Molecular y Microbiologia, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, Santiago 8330025, Chile
    J Immunol 192:214-23. 2014
    ..These data strongly support the notion that rBCG induces protective Th1 immunity and could be considered as an efficient vaccine against hMPV. ..
  9. pmc IgG keeps virulent Salmonella from evading dendritic cell uptake
    Sebastián A Riquelme
    Millennium Institute of Immunology and Immunotherapy, Departamento de Genetica Molecular y Microbiologia, Facultad de Ciencias Biologicas, Pontificia Universidad Católica de Chile Departamento de Reumatología, Facultad de Medicina, Pontificia Universidad Catolica de Chile, Santiago, Chile
    Immunology 136:291-305. 2012
    ....
  10. doi request reprint Efficient lung recruitment of respiratory syncytial virus-specific Th1 cells induced by recombinant bacillus Calmette-Guérin promotes virus clearance and protects from infection
    Kelly M Cautivo
    Millennium Nucleus on Immunology and Immunotherapy, Departamento de Genetica Molecular y Microbiologia, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, Alameda 340, Santiago, Chile
    J Immunol 185:7633-45. 2010
    ..These results support the notion that an effective induction of Th1 T cell immunity against RSV during childhood could counteract the unbalanced Th2-like immune response triggered by the natural RSV infection...
  11. pmc Respiratory syncytial virus impairs T cell activation by preventing synapse assembly with dendritic cells
    Pablo A González
    Millennium Nucleus of Immunology and Immunotherapy, Departamento de Genetica Molecular y Microbiologia, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, Santiago 8331010, Chile
    Proc Natl Acad Sci U S A 105:14999-5004. 2008
    ..Our data suggest that impairment of immunological synapse could contribute to RSV pathogenesis by evading adaptive immunity and reducing T cell-mediated virus clearance...
  12. ncbi request reprint Gene elements that regulate Streptococcus pneumoniae virulence and immunity evasion
    Pamela A Nieto
    Millennium Institute on Immunology and Immunotherapy, Pontificia Universidad Catolica de Chile, Santiago, Chile
    Curr Gene Ther 13:51-64. 2013
    ..This knowledge could be relevant for generating new prophylactic and therapeutic tools and to prevent the severe infection caused by this pathogen...
  13. pmc Protective T cell immunity against respiratory syncytial virus is efficiently induced by recombinant BCG
    Susan M Bueno
    Millennium Nucleus on Immunology and Immunotherapy, Departamento de Genetica Molecular y Microbiologia, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, Santiago 8331010, Chile
    Proc Natl Acad Sci U S A 105:20822-7. 2008
    ..These data strongly support recombinant BCG as an efficient vaccine against RSV because of its capacity to promote protective Th1 immunity...
  14. pmc Modulation of tumor immunity by soluble and membrane-bound molecules at the immunological synapse
    Pablo A González
    Millennium Institute on Immunology and Immunotherapy, Departamento de Genetica Molecular y Microbiologia, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, Avenida Libertador Bernardo O Higgins no 340, Santiago 8331010, Chile
    Clin Dev Immunol 2013:450291. 2013
    ..Here, we discuss recent literature on the regulation and assembly of IS and the mechanisms evolved by tumors to modulate its function to escape T cell cytotoxicity, as well as novel strategies targeting the IS for therapy...
  15. doi request reprint Respiratory syncytial virus infection and immunity
    Pablo A González
    Millennium Institute on Immunology and Immunotherapy, Pontificia Universidad Catolica de Chile, Santiago, Chile
    Rev Med Virol 22:230-44. 2012
    ..Here, we discuss some of the most important advances made in this field that could lead to the development of new prophylactic tools...
  16. ncbi request reprint Impairment of T cell immunity by the respiratory syncytial virus: targeting virulence mechanisms for therapy and prophylaxis
    Pablo A González
    Departamento de Genetica Molecular y Microbiologia, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, Alameda 340, Santiago 8331010, Chile
    Curr Med Chem 16:4609-25. 2009
    ..Furthermore, novel strategies aimed to induce efficient T cell immunity against RSV are reviewed...
  17. pmc The half-life of the T-cell receptor/peptide-major histocompatibility complex interaction can modulate T-cell activation in response to bacterial challenge
    Leandro J Carreño
    Departamento de Genetica Molecular y Microbiologia, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, Santiago, Chile
    Immunology 121:227-37. 2007
    ..These observations underscore the importance of the TCR/pMHC half-life on the clearance of pathogens...
  18. ncbi request reprint T cell immunity evasion by virulent Salmonella enterica
    Susan M Bueno
    Millennium Nucleus on Immunology and Immunotherapy, Departamento de Genetica Molecular y Microbiologia, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, Chile
    Immunol Lett 111:14-20. 2007
    ..These new findings suggest a new pathogenesis model with DCs as key targets for Salmonella virulence factors...
  19. doi request reprint Deletion of a prophage-like element causes attenuation of Salmonella enterica serovar Enteritidis and promotes protective immunity
    Daniela V Araya
    Millennium Nucleus on Immunology and Immunotherapy, Departamento de Genetica Molecular y Microbiologia, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, Alameda 340, Santiago 8331010, Chile
    Vaccine 28:5458-66. 2010
    ..Enteritidis. These results suggest that strains lacking this prophage can induce a protective immunity in mice and be considered as potential attenuated vaccines against S. Enteritidis...
  20. doi request reprint Advances in understanding respiratory syncytial virus infection in airway epithelial cells and consequential effects on the immune response
    Margarita K Lay
    Millennium Institute on Immunology and Immunotherapy, Departamento de Genetica Molecular y Microbiologia, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, Alameda 340, Santiago E 8331010, Chile
    Microbes Infect 15:230-42. 2013
    ....
  21. pmc Impaired learning resulting from respiratory syncytial virus infection
    Janyra A Espinoza
    Millenium Institute on Immunology and Immunotherapy, Departamento de Genetica Molecular y Microbiologia, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, Santiago 8331010, Chile
    Proc Natl Acad Sci U S A 110:9112-7. 2013
    ..Our findings provide evidence that RSV can spread from the airways to the central nervous system and cause functional alterations to the brain, both of which can be prevented by proper immunization against RSV...
  22. ncbi request reprint Molecular interactions between dendritic cells and Salmonella: escape from adaptive immunity and implications on pathogenesis
    Susan M Bueno
    Departamento de Genetica Molecular y Microbiologia, Facultad de Ciencias Biologicas, Pontifica Universidad Catolica de Chile, Santiago
    Crit Rev Immunol 25:389-403. 2005
    ..Recent studies have demonstrated that impairment of DC function by the activity of SPI-2 gene products is crucial for Salmonella pathogenesis...
  23. pmc Modulation of nuclear factor-kappaB activity can influence the susceptibility to systemic lupus erythematosus
    Alexis M Kalergis
    Millennium Nucleus on Immunology and Immunotherapy, Departamento de Genetica Molecular y Microbiologia, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, Santiago, Chile
    Immunology 128:e306-14. 2009
    ..Our data suggest that the occurrence of SLE is significantly influenced by alterations of NF-kappaB function, which can be considered as a new therapeutic target for this disease...
  24. doi request reprint Local cytokine response upon respiratory syncytial virus infection
    Susan M Bueno
    Millennium Nucleus on Immunology and Immunotherapy, Departamento de Genetica Molecular y Microbiologia, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, Santiago, Chile
    Immunol Lett 136:122-9. 2011
    ..Here, we discuss recent research leading to the identification of RSV virulence factors that are responsible of promoting a pro-inflammatory environment at the airways and their implications on pathogenicity...
  25. pmc Precise excision of the large pathogenicity island, SPI7, in Salmonella enterica serovar Typhi
    Susan M Bueno
    Instituto de Ciencias Biomedicas, Universidad de Chile, Santiago, Chile
    J Bacteriol 186:3202-13. 2004
    ..SPI7 is an unstable genetic element, probably an intermediate in the pathway of lateral transfer of such pathogenicity islands among enteric gram-negative bacteria...
  26. doi request reprint Role of dendritic cells in the initiation, progress and modulation of systemic autoimmune diseases
    Juan Pablo Mackern-Oberti
    Millennium Institute on Immunology and Immunotherapy, Departamento de Genetica Molecular y Microbiologia, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, Chile
    Autoimmun Rev 14:127-39. 2015
    ..In this review, we discuss recent data relative to the role of DCs in systemic autoimmune pathogenesis and their use as a therapy to restore tolerance. ..
  27. pmc Interleukin-10 plays a key role in the modulation of neutrophils recruitment and lung inflammation during infection by Streptococcus pneumoniae
    Hernán F Peñaloza
    Millennium Institute on Immunology and Immunotherapy, Departamento de Genetica Molecular y Microbiologia, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, Santiago, Chile
    Immunology 146:100-12. 2015
    ..This feature of IL-10 is important to avoid excessive inflammation of tissues and to improve host survival, even though bacterial dissemination is less efficient in the absence of this cytokine...
  28. doi request reprint Modulation of the dendritic cell-T-cell synapse to promote pathogen immunity and prevent autoimmunity
    Leandro J Carreño
    Departamento de Genetica Molecular y Microbiologia, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, Alameda 340, Casilla 114 D, Santiago, Chile
    Immunotherapy 3:6-11. 2011
    ..In this article, we will discuss recent work relative to the molecular mechanisms controlling DC-T-cell synapse and their implications on immunoregulation to control autoimmunity and potentiate pathogen immunity...
  29. pmc Surface expression of the hRSV nucleoprotein impairs immunological synapse formation with T cells
    Pablo F Céspedes
    Millennium Institute on Immunology and Immunotherapy, Departamento de Genetica Molecular y Microbiologia, Facultad de Ciencias Biologicas, and
    Proc Natl Acad Sci U S A 111:E3214-23. 2014
    ..Our study defines this protein as a major virulence factor that contributes to impairing acquired immunity and enhances susceptibility to reinfection by hRSV...
  30. doi request reprint Central nervous system alterations caused by infection with the human respiratory syncytial virus
    Karen Böhmwald
    Millennium Institute on Immunology and Immunotherapy, Departamento de Genetica Molecular y Microbiologia, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, Santiago, Chile
    Rev Med Virol 24:407-19. 2014
    ..Here, we discuss recent findings linking the neurological, extrapulmonary effects of hRSV with infection and functional impairment of the CNS...
  31. doi request reprint Human metapneumovirus infection activates the TSLP pathway that drives excessive pulmonary inflammation and viral replication in mice
    Margarita K Lay
    Departamento de Genetica Molecular y Microbiologia, Facultad de Ciencias Biologicas, Millennium Institute on Immunology and Immunotherapy, Pontificia Universidad Catolica de Chile, Santiago, Chile
    Eur J Immunol 45:1680-95. 2015
    ..Altogether, these results suggest that activation of the TSLP pathway is pivotal in the development of pulmonary pathology and pulmonary hMPV replication. ..
  32. doi request reprint Respiratory syncytial virus detection in cells and clinical samples by using three new monoclonal antibodies
    Roberto S Gómez
    Millennium Institute on Immunology and Immunotherapy, Departamento de Genetica Molecular y Microbiologia, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, Santiago, Chile INSERM U1064, Nantes, France
    J Med Virol 86:1256-66. 2014
    ..These results suggest that these new anti-RSV mAbs can be considered for the rapid and reliable detection of RSV on infected cells and clinical specimens by multiple immunological approaches...
  33. doi request reprint Host immunity during RSV pathogenesis
    Susan M Bueno
    Millennium Nucleus on Immunology and Immunotherapy Departamento de Genética Molecular y Microbiología, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, Chile
    Int Immunopharmacol 8:1320-9. 2008
    ..Further, the virulence mechanisms used by RSV to avoid activation of protective immune responses are described...
  34. pmc Conjugal transfer of the pathogenicity island ROD21 in Salmonella enterica serovar Enteritidis depends on environmental conditions
    Francisco J Salazar-Echegarai
    Millennium Institute on Immunology and Immunotherapy, Departamento de Genetica Molecular y Microbiologia, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, Santiago, Chile
    PLoS ONE 9:e90626. 2014
    ..Further, ROD21 transfer frequency increases in response to environmental changes, such as pH and temperature. ..
  35. pmc Gestational hypothyroidism increases the severity of experimental autoimmune encephalomyelitis in adult offspring
    Eduardo A Albornoz
    1 Department of Biological Sciences, Faculty of Biological Sciences, Andrés Bello National University, Santiago, Chile
    Thyroid 23:1627-37. 2013
    ..Given that gestational hypothyroidism alters the immune cell ratio in offspring, it is possible that this condition could result in higher sensitivity for the development of autoimmune diseases...
  36. doi request reprint Respiratory Syncytial Virus: pathology, therapeutic drugs and prophylaxis
    Roberto S Gómez
    Millennium Institute of Immunology and Immunotherapy, Departamento de Genetica Molecular y Microbiologia, Facultad de Ciencias Biologicas, Chile INSERM U1064, Nantes, France
    Immunol Lett 162:237-47. 2014
    ..In this article, we discuss the most important advances in the development of drugs and vaccines, which could eventually lead to better strategies to treat or prevent the detrimental inflammation triggered by hRSV infection. ..
  37. pmc Induction of protective effector immunity to prevent pathogenesis caused by the respiratory syncytial virus. Implications on therapy and vaccine design
    Janyra A Espinoza
    Millennium Institute on Immunology, Departamento de Genetica Molecular y Microbiologia, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, Santiago, Chile
    Immunology 143:1-12. 2014
    ..Novel findings about the alterations that this virus causes in the central nervous system and potential therapies and vaccines designed to treat or prevent hRSV infection are discussed. ..
  38. ncbi request reprint Heme oxygenase-1 as a target for the design of gene and pharmaceutical therapies for autoimmune diseases
    Juan P Mackern-Oberti
    Millennium Institute on Immunology and Immunotherapy Departamento de Genética Molecular y Microbiologia, Facultad de Ciencias Biologicas, Departamento de Inmunologia Clinica y Reumatologia, Facultad de Medicina, Pontificia Universidad Católica de Chile Av Portugal 49, Santiago, Chile
    Curr Gene Ther 14:218-35. 2014
    ..In this article, recent data related to the immunoregulatory properties of HO-1/CO will be discussed, focusing on their potential therapeutic use to treat autoimmune diseases. ..
  39. pmc Targeting dendritic cell function during systemic autoimmunity to restore tolerance
    Juan P Mackern-Oberti
    Millennium Institute of Immunology and Immunotherapy, Departamento de Genetica Molecular y Microbiologia, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, Portugal 49, Santiago 8330025, Chile
    Int J Mol Sci 15:16381-417. 2014
    ..Herein, we review recent approaches evaluating the potential of tolDCs for the treatment of systemic autoimmune disorders. ..
  40. pmc Role of Salmonella enterica exposure in Chilean Crohn's disease patients
    Manuel Alvarez-Lobos
    Manuel Álvarez Lobos, Patricio Ibañez, Carlos Quintana, CAREI Group Active Cohort Registry of Inflammatory Bowel Disease, Department of Gastroenterology, Facultad de Medicina, Pontificia Universidad Catolica de Chile, Santiago 6510260, Chile
    World J Gastroenterol 19:5855-62. 2013
    ..To study the association between exposure to Salmonella enterica (SE) and Crohn's disease (CD) and its clinical implications in Chilean patients...
  41. pmc Carbon monoxide down-modulates Toll-like receptor 4/MD2 expression on innate immune cells and reduces endotoxic shock susceptibility
    Sebastián A Riquelme
    Millennium Institute on Immunology and Immunotherapy, Departamento de Genetica Molecular y Microbiologia, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, Santiago, Chile Inserm, UMR 1064, Nantes, France
    Immunology 144:321-32. 2015
    ..Our results suggest that CO treatment reduces the expression of the TLR4/MD2 complex on the surface of myeloid cells, which renders them resistant to LPS priming in vitro, as well as in vivo in a model of endotoxic shock. ..
  42. doi request reprint Carbon monoxide impairs mitochondria-dependent endosomal maturation and antigen presentation in dendritic cells
    Sebasti n A Riquelme
    Millennium Institute on Immunology and Immunotherapy, Departamento de Gen tica Molecular y Microbiolog a, Facultad de Ciencias Biol gicas, Pontificia Universidad Cat lica de Chile, Santiago, Chile
    Eur J Immunol . 2015
    ..In conclusion, CO produced by HO-1 impairs antigen-dependent inflammation by regulating DC immunogenicity by a mitochondria-dependent mechanism...
  43. pmc A novel live vector group A streptococcal emm type 9 vaccine delivered intranasally protects mice against challenge infection with emm type 9 group A streptococci
    Aniela Wozniak
    Laboratorio de Microbiologia, Departamento de Laboratorios Clínicos, Escuela de Medicina, Pontificia Universidad Catolica de Chile, Santiago, Chile
    Clin Vaccine Immunol 21:1343-9. 2014
    ..The design of this vaccine prototype may provide a lower cost alternative to vaccines comprised of purified recombinant proteins. ..
  44. pmc Hypothyroidism in the adult rat causes incremental changes in brain-derived neurotrophic factor, neuronal and astrocyte apoptosis, gliosis, and deterioration of postsynaptic density
    Claudia Cortes
    Millennium Institute on Immunology and Immunotherapy, Department of Biological Sciences, Faculty of Biological Sciences and Faculty of Medicine, Andres Bello University, Santiago, Chile
    Thyroid 22:951-63. 2012
    ..In this work, we analyzed the cellular and molecular changes in the adult brain occurring with the development of experimental hypothyroidism...
  45. ncbi request reprint The Salmonella enterica sv. Typhimurium smvA, yddG and ompD (porin) genes are required for the efficient efflux of methyl viologen
    Carlos A Santiviago
    Laboratorio de Microbiologia, Departamento de Genetica Molecular y Microbiologia, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, Alameda 340, Santiago, Chile
    Mol Microbiol 46:687-98. 2002
    ..TolC apparently facilitates the import of MV, and a subset of OMC proteins including the OmpD porin and TolC may facilitate both import and export of distinct subsets of toxic substrates...
  46. doi request reprint Altered chemokine receptor expression in papillary thyroid cancer
    Hernan E Gonzalez
    Millennium Nucleus on Immunology and Immunotherapy, Department of Molecular Genetics, Faculty of Biological Sciences, The Pontifical Catholic University of Chile, Santiago, Chile
    Thyroid 19:957-65. 2009
    ..Here we have evaluated whether PTC tissues express a different pattern of chemokine receptors and if the expression of these receptors correlates with LNM...