Carmen Chifiriuc



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    Chifiriuc M, Bleotu C, Pîrcălăbioru G, Israil A, Dinu S, Ruta S, et al. Cytokine profiles of HeLa and human diploid cells induced by different fractions of Vibrio parahaemolyticus cultures exposed to stress conditions. Roum Arch Microbiol Immunol. 2010;69:164-72 pubmed
  2. Vlaicu I, Borodi G, Scăețeanu G, Chifiriuc M, Măruţescu L, Popa M, et al. X-ray Crystal Structure, Geometric Isomerism, and Antimicrobial Activity of New Copper(II) Carboxylate Complexes with Imidazole Derivatives. Molecules. 2018;23: pubmed publisher
  3. Marc G, Araniciu C, Oniga S, Vlase L, Pîrnău A, Duma M, et al. New N-(oxazolylmethyl)-thiazolidinedione Active against Candida albicans Biofilm: Potential Als Proteins Inhibitors. Molecules. 2018;23: pubmed publisher
    ..Considering the well documented role of Als1 and Als3 in biofilm formation, our new class of compounds that target these proteins could represent a new approach in C. albicans infection prevention and management. ..
  4. Zarafu I, Turcu I, Culita D, Petrescu S, Popa M, Chifiriuc M, et al. Antimicrobial Features of Organic Functionalized Graphene-Oxide with Selected Amines. Materials (Basel). 2018;11: pubmed publisher
    ..In exchange, the amines alone proved generally more efficient against biofilm-embedded cells. (4) Conclusions: Such hybrid materials may have a wide range of potential use in biomedical applications. ..
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    Bertesteanu S, Chifiriuc M, Grumezescu A, Printza A, Marie Paule T, Grumezescu V, et al. Biomedical applications of synthetic, biodegradable polymers for the development of anti-infective strategies. Curr Med Chem. 2014;21:3383-90 pubmed
    ..e., antimicrobial and anti-inflammatory agents and vaccines) activity, as well as for the design of biomaterials with increased biocompatibility and resistance to microbial colonization. ..
  6. Limban C, Missir A, Grumezescu A, Oprea A, Grumezescu V, Vasile B, et al. Bioevaluation of novel anti-biofilm coatings based on PVP/Fe3O4 nanostructures and 2-((4-ethylphenoxy)methyl)-N- (arylcarbamothioyl)benzamides. Molecules. 2014;19:12011-30 pubmed publisher
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    Saviuc C, Drumea V, Olariu L, Chifiriuc M, Bezirtzoglou E, Lazăr V. Essential oils with microbicidal and antibiofilm activity. Curr Pharm Biotechnol. 2015;16:137-51 pubmed
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    Mihai M, Holban A, Giurcăneanu C, Popa L, Buzea M, Filipov M, et al. Identification and phenotypic characterization of the most frequent bacterial etiologies in chronic skin ulcers. Rom J Morphol Embryol. 2014;55:1401-8 pubmed
    ..However, in order to establish a statistical relevant correlation, larger studies are needed. ..
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    Pop C, Hussien M, Popa M, Mares A, Grumezescu A, Grigore R, et al. Metallic-based micro and nanostructures with antimicrobial activity. Curr Top Med Chem. 2015;15:1577-82 pubmed
    ..The purpose of this review was to present the antimicrobial activity of metal cations in micro- and nanoparticulate forms and the dependence of this biological activity on shape, size and physico-chemical conditions. ..

More Information


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    Chifiriuc M, Ditu L, Banu O, Bleotu C, Drăcea O, Bucur M, et al. Subinhibitory concentrations of phenyl lactic acid interfere with the expression of virulence factors in Staphylococcus aureus and Pseudomonas aeruginosa clinical strains. Roum Arch Microbiol Immunol. 2009;68:27-33 pubmed
  2. Bilcu M, Grumezescu A, Oprea A, Popescu R, Mogoşanu G, Hristu R, et al. Efficiency of vanilla, patchouli and ylang ylang essential oils stabilized by iron oxide@C14 nanostructures against bacterial adherence and biofilms formed by Staphylococcus aureus and Klebsiella pneumoniae clinical strains. Molecules. 2014;19:17943-56 pubmed publisher
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    Holban A, Chifiriuc M, Lazar V. Recognition and Impact of Host-derived Molecules on Bacterial Cell-to-cell Signalling Pathways. Med Chem. 2015;11:610-7 pubmed
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    Mihai M, Holban A, Giurcaneanu C, Popa L, Oanea R, Lazar V, et al. Microbial biofilms: impact on the pathogenesis of periodontitis, cystic fibrosis, chronic wounds and medical device-related infections. Curr Top Med Chem. 2015;15:1552-76 pubmed
  5. Oprea A, Pandel L, Dumitrescu A, Andronescu E, Grumezescu V, Chifiriuc M, et al. Bioactive ZnO Coatings Deposited by MAPLE-An Appropriate Strategy to Produce Efficient Anti-Biofilm Surfaces. Molecules. 2016;21: pubmed publisher
  6. Vasile Scăețeanu G, Chifiriuc M, Bleotu C, Kamerzan C, Măruţescu L, Daniliuc C, et al. Synthesis, Structural Characterization, Antimicrobial Activity, and In Vitro Biocompatibility of New Unsaturated Carboxylate Complexes with 2,2'-Bipyridine. Molecules. 2018;23: pubmed publisher
    ..Taken together, these results demonstrate the potential of zinc and copper complexes for use in the development of novel antimicrobial and anti-proliferative agents. ..
  7. Radulescu M, Holban A, Mogoanta L, Bălşeanu T, Mogoşanu G, Savu D, et al. Fabrication, Characterization, and Evaluation of Bionanocomposites Based on Natural Polymers and Antibiotics for Wound Healing Applications. Molecules. 2016;21: pubmed publisher
    ..The evaluation of antimicrobial potential was evaluated by the viable cell count assay on strains belonging to two clinically relevant bacterial species (i.e., Escherichia coli and Staphylococcus aureus). ..
  8. Chifiriuc M, Ratiu A, Popa M, Ecovoiu A. Drosophotoxicology: An Emerging Research Area for Assessing Nanoparticles Interaction with Living Organisms. Int J Mol Sci. 2016;17:36 pubmed publisher
  9. Saviuc C, Ciubucă B, Dincă G, Bleotu C, Drumea V, Chifiriuc M, et al. Development and Sequential Analysis of a New Multi-Agent, Anti-Acne Formulation Based on Plant-Derived Antimicrobial and Anti-Inflammatory Compounds. Int J Mol Sci. 2017;18: pubmed publisher
  10. Floroian L, Ristoscu C, Mihailescu N, Negut I, Badea M, Ursutiu D, et al. Functionalized Antimicrobial Composite Thin Films Printing for Stainless Steel Implant Coatings. Molecules. 2016;21: pubmed publisher
    ..The results proved that the applied method allows for the fabrication of implantable biomaterials which shield metal ion release and possess increased biocompatibility and resistance to microbial colonization and biofilm growth. ..
  11. Ion A, Andronescu E, Rădulescu D, Radulescu M, Iordache F, Vasile B, et al. Biocompatible 3D Matrix with Antimicrobial Properties. Molecules. 2016;21:E115 pubmed publisher
    ..Our data strongly recommend the obtained 3D matrix to be used as a successful alternative for the fabrication of three dimensional (3D) anti-infective regeneration matrix for bone tissue engineering. ..
  12. Turcu I, Zarafu I, Popa M, Chifiriuc M, Bleotu C, Culita D, et al. Lipoic Acid Gold Nanoparticles Functionalized with Organic Compounds as Bioactive Materials. Nanomaterials (Basel). 2017;7: pubmed publisher
  13. Delcaru C, Podgoreanu P, Alexandru I, Popescu N, Măruţescu L, Bleotu C, et al. Antibiotic Resistance and Virulence Phenotypes of Recent Bacterial Strains Isolated from Urinary Tract Infections in Elderly Patients with Prostatic Disease. Pathogens. 2017;6: pubmed publisher
  14. Măruţescu L, Calu L, Chifiriuc M, Bleotu C, Daniliuc C, Fălcescu D, et al. Synthesis, Physico-chemical Characterization, Crystal Structure and Influence on Microbial and Tumor Cells of Some Co(II) Complexes with 5,7-Dimethyl-1,2,4-triazolo[1,5-a]pyrimidine. Molecules. 2017;22: pubmed publisher
    ..All species were evaluated for antimicrobial activity towards planktonic and biofilm-embedded microbial cells and influence on HEp-2 cell viability, cellular cycle and gene expression. ..
  15. Radulescu M, Andronescu E, Dolete G, Popescu R, Fufă O, Chifiriuc M, et al. Silver Nanocoatings for Reducing the Exogenous Microbial Colonization of Wound Dressings. Materials (Basel). 2016;9: pubmed publisher
    ..The reported data recommend this type of coatings to obtain modified WDs with antibacterial properties, able to prevent the exogenous microbial contamination of the wound tissue, colonization and further biofilm development. ..
  16. Oniga S, Araniciu C, Palage M, Popa M, Chifiriuc M, Marc G, et al. New 2-Phenylthiazoles as Potential Sortase A Inhibitors: Synthesis, Biological Evaluation and Molecular Docking. Molecules. 2017;22: pubmed publisher
    ..The new compounds could be used as add-on therapies together with known antibacterial agents in order to combat multidrug-resistance enterococcal infections. ..
  17. Limban C, Măruţescu L, Chifiriuc M. Synthesis, spectroscopic properties and antipathogenic activity of new thiourea derivatives. Molecules. 2011;16:7593-607 pubmed publisher
    ..Our results demonstrate the potential of these derivatives for further development of novel anti-microbial agents with antibiofilm properties. ..