Sanjay Chhibber

Summary

Publications

  1. pmc Depolymerase improves gentamicin efficacy during Klebsiella pneumoniae induced murine infection
    Shruti Bansal
    Department of Microbiology, Panjab University, Sector 14, Chandigarh 160014, India
    BMC Infect Dis 14:456. 2014
  2. pmc Co-therapy using lytic bacteriophage and linezolid: effective treatment in eliminating methicillin resistant Staphylococcus aureus (MRSA) from diabetic foot infections
    Sanjay Chhibber
    Department of Microbiology, Panjab University, Chandigarh, India
    PLoS ONE 8:e56022. 2013
  3. pmc Inhibiting biofilm formation by Klebsiella pneumoniae B5055 using an iron antagonizing molecule and a bacteriophage
    Sanjay Chhibber
    Department of Microbiology, Basic Medical Sciences BMS Block, Panjab University, 160014 Chandigarh, India
    BMC Microbiol 13:174. 2013
  4. doi request reprint Curcumin alone and in combination with augmentin protects against pulmonary inflammation and acute lung injury generated during Klebsiella pneumoniae B5055-induced lung infection in BALB/c mice
    Shruti Bansal
    Department of Microbiology, Panjab University, Chandigarh 160014, India
    J Med Microbiol 59:429-37. 2010
  5. doi request reprint 2-Chloroadenosine (2-CADO) treatment modulates the pro-inflammatory immune response to prevent acute lung inflammation in BALB/c mice suffering from Klebsiella pneumoniae B5055-induced pneumonia
    Vijay Kumar
    Department of Microbiology, Panjab University, Chandigarh 160014, India
    Int J Antimicrob Agents 35:599-602. 2010
  6. doi request reprint Thalidomide treatment modulates macrophage pro-inflammatory function and cytokine levels in Klebsiella pneumoniae B5055 induced pneumonia in BALB/c mice
    Vijay Kumar
    Department of Microbiology, Panjab University, Chandigarh 160014, India
    Int Immunopharmacol 10:777-83. 2010
  7. ncbi request reprint Evidence to support the therapeutic potential of bacteriophage Kpn5 in burn wound infection caused by Klebsiella pneumoniae in BALB/c mice
    Seema Kumari
    Basic Medical Sciences Building, Department of Microbiology, Panjab University, Chandigarh, India
    J Microbiol Biotechnol 20:935-41. 2010
  8. doi request reprint Quorum sensing signal molecules cause renal tissue inflammation through local cytokine responses in experimental UTI caused by Pseudomonas aeruginosa
    Ravi Kumar Gupta
    Department of Microbiology, BMS Block, Panjab University, Chandigarh 160014, India
    Immunobiology 218:181-5. 2013
  9. doi request reprint Restricting ciprofloxacin-induced resistant variant formation in biofilm of Klebsiella pneumoniae B5055 by complementary bacteriophage treatment
    Vivek Verma
    Department of Microbiology, Basic Medical Sciences BMS Block, Panjab University, Chandigarh, India
    J Antimicrob Chemother 64:1212-8. 2009
  10. ncbi request reprint Topical treatment of Klebsiella pneumoniae B5055 induced burn wound infection in mice using natural products
    Seema Kumari
    Basic Medical Sciences Building, Department of Microbiology, Panjab University, Chandigarh 160014, India
    J Infect Dev Ctries 4:367-77. 2010

Collaborators

Detail Information

Publications64

  1. pmc Depolymerase improves gentamicin efficacy during Klebsiella pneumoniae induced murine infection
    Shruti Bansal
    Department of Microbiology, Panjab University, Sector 14, Chandigarh 160014, India
    BMC Infect Dis 14:456. 2014
    ..In the present study, use of an Aeromonas punctata derived capsule depolymerase against K. pneumoniae, to reinstate the efficacy of gentamicin during pneumonia and septicemia was investigated...
  2. pmc Co-therapy using lytic bacteriophage and linezolid: effective treatment in eliminating methicillin resistant Staphylococcus aureus (MRSA) from diabetic foot infections
    Sanjay Chhibber
    Department of Microbiology, Panjab University, Chandigarh, India
    PLoS ONE 8:e56022. 2013
    ..The present study focuses on the use of lytic bacteriophage in combination with linezolid as an effective treatment strategy against foot infection in diabetic population...
  3. pmc Inhibiting biofilm formation by Klebsiella pneumoniae B5055 using an iron antagonizing molecule and a bacteriophage
    Sanjay Chhibber
    Department of Microbiology, Basic Medical Sciences BMS Block, Panjab University, 160014 Chandigarh, India
    BMC Microbiol 13:174. 2013
    ..Therefore in the present study, the effect of limiting iron levels by addition of divalent Co[II] ions in combination with a bacteriophage was used for preventing/disrupting Klebsiella pneumoniae biofilms...
  4. doi request reprint Curcumin alone and in combination with augmentin protects against pulmonary inflammation and acute lung injury generated during Klebsiella pneumoniae B5055-induced lung infection in BALB/c mice
    Shruti Bansal
    Department of Microbiology, Panjab University, Chandigarh 160014, India
    J Med Microbiol 59:429-37. 2010
    ..Hence, curcumin can be used as an adjunct therapy along with antibiotics as an anti-inflammatory or an immunomodulatory agent in the case of acute lung infection...
  5. doi request reprint 2-Chloroadenosine (2-CADO) treatment modulates the pro-inflammatory immune response to prevent acute lung inflammation in BALB/c mice suffering from Klebsiella pneumoniae B5055-induced pneumonia
    Vijay Kumar
    Department of Microbiology, Panjab University, Chandigarh 160014, India
    Int J Antimicrob Agents 35:599-602. 2010
    ..Moreover, in combination with AMC, 2-CADO exhibited its immunomodulatory action in acute lung infection and prevented ALI, whilst an antibacterial action was exhibited by AMC...
  6. doi request reprint Thalidomide treatment modulates macrophage pro-inflammatory function and cytokine levels in Klebsiella pneumoniae B5055 induced pneumonia in BALB/c mice
    Vijay Kumar
    Department of Microbiology, Panjab University, Chandigarh 160014, India
    Int Immunopharmacol 10:777-83. 2010
    ..05) elevated. Thus thalidomide proved a promising immunomodulatory agent in acute lung inflammation associated with pneumonia caused by gram negative bacterial infection...
  7. ncbi request reprint Evidence to support the therapeutic potential of bacteriophage Kpn5 in burn wound infection caused by Klebsiella pneumoniae in BALB/c mice
    Seema Kumari
    Basic Medical Sciences Building, Department of Microbiology, Panjab University, Chandigarh, India
    J Microbiol Biotechnol 20:935-41. 2010
    ..This approach not only helps in the clearance of bacteria from the host but also protects against the ensuing inflammatory damage due to the exaggerated response seen in any infectious process...
  8. doi request reprint Quorum sensing signal molecules cause renal tissue inflammation through local cytokine responses in experimental UTI caused by Pseudomonas aeruginosa
    Ravi Kumar Gupta
    Department of Microbiology, BMS Block, Panjab University, Chandigarh 160014, India
    Immunobiology 218:181-5. 2013
    ..These results provide first evidence regarding the role of QS signal molecules and point towards the importance of AHLs in induction of renal cytokines and tissue inflammatory responses...
  9. doi request reprint Restricting ciprofloxacin-induced resistant variant formation in biofilm of Klebsiella pneumoniae B5055 by complementary bacteriophage treatment
    Vivek Verma
    Department of Microbiology, Basic Medical Sciences BMS Block, Panjab University, Chandigarh, India
    J Antimicrob Chemother 64:1212-8. 2009
    ..The pathogenic potential of the resistant variants formed during the treatment was evaluated...
  10. ncbi request reprint Topical treatment of Klebsiella pneumoniae B5055 induced burn wound infection in mice using natural products
    Seema Kumari
    Basic Medical Sciences Building, Department of Microbiology, Panjab University, Chandigarh 160014, India
    J Infect Dev Ctries 4:367-77. 2010
    ..Efficacy of honey and aloe vera gel was evaluated in the treatment of burn wound infection induced with Klebsiella pneumoniae B5055 and their efficacy was compared with an isolated and well-characterized Klebsiella specific phage Kpn5...
  11. doi request reprint A comparative study of induction of pneumonia in mice with planktonic and biofilm cells of Klebsiella pneumoniae
    Sonica Sharma
    Department of Microbiology, Panjab University Department of Pathology, Government Medical College, Chandigarh, India
    Microbiol Immunol 55:295-303. 2011
    ..pneumoniae to induce acute pneumonia in mice in terms of bacterial counts and histopathological changes. However, biofilm cell-induced infection showed delayed clearance as compared to infection induced with the planktonic form...
  12. ncbi request reprint Protection with bacteriophage KØ1 against fatal Klebsiella pneumoniae-induced burn wound infection in mice
    Rohit Malik
    Department of Microbiology, Panjab University, Chandigarh, India
    J Microbiol Immunol Infect 42:134-40. 2009
    ..This study investigated the protective effect of K. pneumoniae-specific bacteriophage KØ1 isolated from the environment in a mouse model of burn wound infection induced by K. pneumoniae...
  13. doi request reprint Dietary supplementation with omega-3 polyunsaturated fatty acids ameliorates acute pneumonia induced by Klebsiella pneumoniae in BALB/c mice
    Sonica Sharma
    Department of Microbiology, Panjab University, Chandigarh, India
    Can J Microbiol 59:503-10. 2013
    ..This mechanism is operative through upregulation of nonspecific and specific immune defenses of the host. ..
  14. doi request reprint Long-term flaxseed oil supplementation diet protects BALB/c mice against Streptococcus pneumoniae infection
    Archana Saini
    Department of Microbiology, BAMS Block, Panjab University, Chandigarh, India
    Med Microbiol Immunol 199:27-34. 2010
    ..On the contrary, short-term supplementation did not show such an effect on lung colonization...
  15. doi request reprint Therapeutic potential of bacteriophage in treating Klebsiella pneumoniae B5055-mediated lobar pneumonia in mice
    Sanjay Chhibber
    Department of Microbiology, Panjab University, Chandigarh 160014, India
    J Med Microbiol 57:1508-13. 2008
    ..The results of this study therefore suggest that the timing of starting the phage therapy after initiation of infection significantly contributes towards the success of the treatment...
  16. ncbi request reprint Contribution of Tamm-Horsfall protein to virulence of Pseudomonas aeruginosa in urinary tract infection
    Kusum Harjai
    Department of Microbiology, Biomedical Sciences Block, Panjab University, Chandigarh 160014, India
    Microbes Infect 7:132-7. 2005
    ..aeruginosa was used to cause infection. This study shows that THP may not necessarily act as a host defense component; rather, it may help in renal colonization of P. aeruginosa in vivo...
  17. ncbi request reprint Protective efficacy and immunogenicity of Escherichia coli K13 diphtheria toxoid conjugate against experimental ascending pyelonephritis
    Varinder Kumar
    Department of Microbiology, Panjab University, Basic Medical Sciences Building, Sector 14, Chandigarh, 160014, India
    Med Microbiol Immunol 194:211-7. 2005
    ..Suitability of K13-DT conjugate as an effective vaccine candidate against urinary tract infections caused by E. coli has been discussed...
  18. ncbi request reprint Effect of macrophage secretory products on elaboration of virulence factors by planktonic and biofilm cells of Pseudomonas aeruginosa
    Rahul Mittal
    Department of Microbiology, Panjab University, BAMS Block, Chandigarh 160014, India
    Comp Immunol Microbiol Infect Dis 29:12-26. 2006
    ..aeruginosa was grown in presence of supernatants with macrophage secretory products. Implications of these findings in relation to urinary tract infections induced by P. aeruginosa have been discussed...
  19. doi request reprint Bacteriophage versus antimicrobial agents for the treatment of murine burn wound infection caused by Klebsiella pneumoniae B5055
    Seema Kumari
    Basic Medical Sciences Building, Department of Microbiology, Panjab University, Chandigarh 160014, India
    J Med Microbiol 60:205-10. 2011
    ..pneumoniae B5055 in comparison to multiple applications of silver nitrate and gentamicin...
  20. doi request reprint Acute lung inflammation in Klebsiella pneumoniae B5055-induced pneumonia and sepsis in BALB/c mice: a comparative study
    Vijay Kumar
    Department of Microbiology, Panjab University, Chandigarh, 160014, India
    Inflammation 34:452-62. 2011
    ..Hence, during pneumonia, controlled activation of macrophages may lead to resolution of inflammation...
  21. doi request reprint Structural changes induced by a lytic bacteriophage make ciprofloxacin effective against older biofilm of Klebsiella pneumoniae
    Vivek Verma
    Department of Microbiology, Basic Medical Sciences BMS Block, Panjab University, Chandigarh, India
    Biofouling 26:729-37. 2010
    ..However, application of phage and antibiotic in combination resulted in slightly increased biofilm eradication confirming the speculation that antibiotic efficacy can be augmented by bacteriophage...
  22. ncbi request reprint Induction of resistance to respiratory tract infection with Klebsiella pneumoniae in mice fed on a diet supplemented with tulsi (Ocimum sanctum) and clove (Syzgium aromaticum) oils
    Archana Saini
    Department of Microbiology, Panjab University, Chandigarh, India
    J Microbiol Immunol Infect 42:107-13. 2009
    ..This study was conducted to study the effect of tulsi (Ocimum sanctum) oil and clove (Syzgium aromaticum) oil on the susceptibility of experimental mice to respiratory tract infection...
  23. doi request reprint Stenotrophomonas maltophilia flagellin induces a compartmentalized innate immune response in mouse lung
    Ayaid Khadem Zgair
    Department of Microbiology, BMS Block, Panjab University, Chandigarh 160014, India
    J Med Microbiol 59:913-9. 2010
    ..n. instillation of 5 microg flagellin resulted in the generation of an effective innate immunity compared to other flagellin doses. Our data provide strong evidence that S. maltophilia flagellin stimulates innate immunity in mouse lung...
  24. doi request reprint Susceptibility of different phases of biofilm of Klebsiella pneumoniae to three different antibiotics
    Saloni Singla
    Department of Microbiology, Panjab University, Chandigarh, India
    J Antibiot (Tokyo) 66:61-6. 2013
    ..Calcofluor staining suggested increased production of exopolysaccharide in older biofilm compared with younger biofim that might be responsible for the increased resistance of older biofilm of K. pneumoniae to antibiotics...
  25. pmc Inhibitory effect of polyunsaturated fatty acids on apoptosis induced by Streptococcus pneumoniae in alveolar macrophages
    Archana Saini
    Department of Microbiology, Panjab University, Chandigarh, India
    Indian J Med Res 137:1193-8. 2013
    ..In this study, we tried to evaluate the role of n-3 polyunsaturated fatty acids on the process of macrophage phagocytic activity and apoptosis in mice...
  26. ncbi request reprint Contribution of quorum-sensing systems to virulence of Pseudomonas aeruginosa in an experimental pyelonephritis model
    Rahul Mittal
    Department of Microbiology, Panjab University, Chandigarh, India
    J Microbiol Immunol Infect 39:302-9. 2006
    ..In the present investigation, we studied the contribution of quorum-sensing signals during the course of P. aeruginosa-induced pyelonephritis in mice...
  27. ncbi request reprint Efficacy of bacteriophage treatment in murine burn wound infection induced by klebsiella pneumoniae
    Seema Kumari
    Department of Microbiology, Panjab University, Chandigarh 160014, India
    J Microbiol Biotechnol 19:622-8. 2009
    ..pneumoniae induces burn wound infection, especially in situations where multiple antibiotic-resistant organisms are encountered...
  28. doi request reprint Quorum sensing is necessary for the virulence of Pseudomonas aeruginosa during urinary tract infection
    Ravi Kumar
    Department of Microbiology, BMS Block, Panjab University, Chandigarh, India
    Kidney Int 76:286-92. 2009
    ..Our results suggests that quorum-sensing signals may act as virulence factors and are essential for P. aeruginosa multiplication and virulence during the course of urinary tract infection...
  29. doi request reprint Anti-inflammatory effect of thalidomide alone or in combination with augmentin in Klebsiella pneumoniae B5055 induced acute lung infection in BALB/c mice
    Vijay Kumar
    Department of Microbiology, Panjab University, Chandigarh 160014, India
    Eur J Pharmacol 592:146-50. 2008
    ..Hence, it can be used as an adjunct therapy along with antibiotics as an anti-inflammatory or an immunomodulatory agent in case of acute lung infection...
  30. pmc Screening & profiling of quorum sensing signal molecules in Pseudomonas aeruginosa isolates from catheterized urinary tract infection patients
    Ravi Kumar
    Department of Microbiology, Panjab University, Chandigarh, India
    Indian J Med Res 134:208-13. 2011
    ..In this study P. aeruginosa isolates from catheterized urinary tract infection patients were screened and profiled for the presence of different type of quorum sensing (QS) signal molecules...
  31. doi request reprint Artificial Klebsiella pneumoniae biofilm model mimicking in vivo system: altered morphological characteristics and antibiotic resistance
    Saloni Singla
    Department of Microbiology, Panjab University, Chandigarh, India
    J Antibiot (Tokyo) 67:305-9. 2014
    ..The present model holds considerable clinical relevance and may be useful for evaluating the efficacy of antimicrobial agent on bacterial biofilms in vitro...
  32. ncbi request reprint Immunological and biological relationship among flagellin of Pseudomonas aeruginosa, Burkholderia cepacia and Stenotrophomonas maltophilia
    Ayaid Khadem Zgair
    Department of Microbiology, BMS Block, Panjab University, Chandigarh, 160014, India
    Mikrobiologiia 81:371-6. 2012
    ..maltophilia. The results of the present study prove that no specific relationship existed among all the studied flagellar proteins obtained from closely related bacteria...
  33. doi request reprint Zingerone inhibit biofilm formation and improve antibiofilm efficacy of ciprofloxacin against Pseudomonas aeruginosa PAO1
    Lokender Kumar
    Department of Microbiology, BMS Block, Panjab University, Chandigarh 160014, India
    Fitoterapia 90:73-8. 2013
    ..These findings prove zingerone as potential phytotherapeutic agent which in future can be employed to formulate preventive strategies against biofilm associated infections caused by P.aeruginosa...
  34. ncbi request reprint Adhering ability of Stenotrophomonas maltophilia is dependent on growth conditions
    Ayaid K Zgair
    Department of Microbiology, BMS Block, Panjab University, Chandigarh, 160014, India
    Mikrobiologiia 80:459-64. 2011
    ..A negative correlation was observed between glucose concentrations and pH of media, the latter declined faster under microaerophilic conditions as compared to aerobic condition...
  35. ncbi request reprint Protective role of liposome incorporated lipopolysaccharide antigen of Klebsiella pneumoniae in a rat model of lobar pneumonia
    Sanjay Chhibber
    Department of Microbiology, Panjab University, Chandigarh 160014, India
    Jpn J Infect Dis 57:150-5. 2004
    ..It is concluded that a non-toxic and immunogenic form of K. pneumoniae LPS can be obtained by incorporation of the native preparation into liposomes...
  36. doi request reprint Characterization of a T7-like lytic bacteriophage of Klebsiella pneumoniae B5055: a potential therapeutic agent
    Vivek Verma
    Department of Microbiology, Panjab University, Chandigarh, 160014, India
    Curr Microbiol 59:274-81. 2009
    ..We propose the use of this characterized phage, KPO1K2, as a prophylactic/therapeutic agent especially for the treatment of catheter associated UTI caused by Klebsiella pneumoniae...
  37. doi request reprint Inactivation and injury of Escherichia coli in a copper water storage vessel: effects of temperature and pH
    Riti Sharan
    Department of Microbiology, Panjab University, Chandigarh, India
    Antonie Van Leeuwenhoek 97:91-7. 2010
    ..These findings have important implications for the practical application of copper-based water disinfection methods, in terms of their likely efficacy under environmental conditions...
  38. doi request reprint Adhesion of Stenotrophomonas maltophilia to mouse tracheal mucus is mediated through flagella
    Ayaid Khadem Zgair
    Department of Microbiology, BMS Block, Panjab University, Chandigarh 160014, India
    J Med Microbiol 60:1032-7. 2011
    ..maltophilia has the ability to adhere to mouse tracheal mucus and that flagella play an important role in this process. However, further studies using genetically defined mutants lacking flagella are needed to support this observation...
  39. ncbi request reprint Immunological and pathological aspects of respiratory tract infection with Stenotrophomonas maltophilia in BALB/c mice
    Ayaid Khadem Zgair
    Department of Microbiology, BMS Block, Panjab University, Chandigarh, 160014, India
    J Microbiol Biotechnol 20:1585-91. 2010
    ..No mortality was observed among the infected animals and infection was resolved by 5th post infection day. No drastic changes in the lung tissue were observed on histopathological examination...
  40. doi request reprint Augmentation of virulence related traits of pqs mutants by Pseudomonas quinolone signal through membrane vesicles
    Anju Bala
    Department of Microbiology, BMS Block, Panjab University, Chandigarh, India
    J Basic Microbiol 55:566-78. 2015
    ..This augmentation of the virulence traits may be associated with the efficient delivery of PQS among bacterial cells, which could be one possible mechanism of pqs system contributing to the overall virulence of P. aeruginosa. ..
  41. doi request reprint Thermal treatment of the bacteriophage lysate of Klebsiella pneumoniae B5055 as a step for the purification of capsular depolymerase enzyme
    Tesfaye Kassa
    Department of Microbiology, Basic Medical Sciences BMS Block, Panjab University, Chandigarh 160014, India
    J Virol Methods 179:135-41. 2012
    ..Both thermal and mild acid treatment resulted in comparable enzyme levels, however; mild acid treatment appeared to be cumbersome and cause chemical contamination...
  42. doi request reprint Detection and quantification of quinolone signalling molecule: a third quorum sensing molecule of Pseudomonas aeruginosa by high performance-thin layer chromatography
    Anju Bala
    Department of Microbiology, BMS Block, Panjab University, Chandigarh 160014, India
    J Chromatogr B Analyt Technol Biomed Life Sci 930:30-5. 2013
    ..aeruginosa isolates. Further, PQS production was also dependent on growth phase of P. aeruginosa with maximum production in late stationary phase...
  43. doi request reprint Essential role of calcium in the infection process of broad-spectrum methicillin-resistant Staphylococcus aureus bacteriophage
    Sanjay Chhibber
    Department of Microbiology, Panjab University, Chandigarh, India
    J Basic Microbiol 54:775-80. 2014
    ..This will contribute towards more effective phage preparations for use in treatments against MRSA infections. ..
  44. doi request reprint Zingerone silences quorum sensing and attenuates virulence of Pseudomonas aeruginosa
    Lokender Kumar
    Department of Microbiology, Panjab University, Chandigarh 160014, India
    Fitoterapia 102:84-95. 2015
    ..The results of the present study revealed the anti-quorum sensing activity of zingerone targeting ligand-receptor interaction, hence proposing zingerone as a suitable anti-virulent drug candidate against P. aeruginosa infections...
  45. doi request reprint Structural alterations in Pseudomonas aeruginosa by zingerone contribute to enhanced susceptibility to antibiotics, serum and phagocytes
    Lokender Kumar
    Department of Microbiology, BMS Block, Panjab University, Chandigarh 160014, India
    Life Sci 117:24-32. 2014
    ..The aim of the present study was oriented towards exploiting zingerone (active component of ginger) in making P. aeruginosa more susceptible to killing with antibiotics, humoral/cellular defences and studying its underlying mechanism...
  46. doi request reprint Pseudomonas quinolone signalling system: a component of quorum sensing cascade is a crucial player in the acute urinary tract infection caused by Pseudomonas aeruginosa
    Anju Bala
    Department of Microbiology, BMS Block, Panjab University, Sector 14, Chandigarh 160014, India
    Int J Med Microbiol 304:1199-208. 2014
    ..aeruginosa. This system can be a potential target for futuristic anti-infective approach against this organism. ..
  47. pmc Zingerone suppresses liver inflammation induced by antibiotic mediated endotoxemia through down regulating hepatic mRNA expression of inflammatory markers in Pseudomonas aeruginosa peritonitis mouse model
    Lokender Kumar
    Department of Microbiology, BMS Block, Panjab University, Chandigarh, India
    PLoS ONE 9:e106536. 2014
    ..These results thus suggest that zingerone treatment can be used as a co-therapy with antibiotics to reduced endotoxin induced inflammation during treatment of severe P.aeruginosa infections. ..
  48. doi request reprint Potential of sequential treatment with minocycline and S. aureus specific phage lysin in eradication of MRSA biofilms: an in vitro study
    Shivani Chopra
    Department of Microbiology, Panjab University, Chandigarh, 160014, India
    Appl Microbiol Biotechnol 99:3201-10. 2015
    ..Hence, our results showed that using minocycline sequentially with endolysin, MR-10 can effectively eradicate both young as well as older biofilm formed by ica-positive and ica-negative MRSA...
  49. pmc Bacteriophage mediated killing of Staphylococcus aureus in vitro on orthopaedic K wires in presence of linezolid prevents implant colonization
    Sandeep Kaur
    Department of Microbiology, Panjab University, Chandigarh, India
    PLoS ONE 9:e90411. 2014
    ..Combination therapy using linezolid and bacteriophage impregnated in biopolymer was investigated in the present study as an alternative strategy to prevent MRSA colonisation on the orthopaedic implant surface...
  50. doi request reprint Aeromonas punctata derived depolymerase that disrupts the integrity of Klebsiella pneumoniae capsule: optimization of depolymerase production
    Shruti Bansal
    Department of Microbiology, Panjab University, Chandigarh, India
    J Basic Microbiol 54:711-20. 2014
    ..Further improvements in the enzyme can lead to its successful development as prophylactic and/or a therapeutic agent...
  51. doi request reprint Bacteriophage-aided intracellular killing of engulfed methicillin-resistant Staphylococcus aureus (MRSA) by murine macrophages
    Sandeep Kaur
    Department of Microbiology, Panjab University, Chandigarh, 160014, India
    Appl Microbiol Biotechnol 98:4653-61. 2014
    ..aureus inside macrophages. This approach shall not only restrict intracellular proliferation of staphylococci within the myeloid cells but also protect the host from further relapse of infection and treatment failures...
  52. doi request reprint Local delivery of linezolid from poly-D,L-lactide (PDLLA)-linezolid-coated orthopaedic implants to prevent MRSA mediated post-arthroplasty infections
    Sandeep Kaur
    Department of Microbiology, Panjab University, Chandigarh 160014, India
    Diagn Microbiol Infect Dis 79:387-92. 2014
    ..With the rise in MRSA mediated orthopaedic device related infections, the use of linezolid loaded polymer coated implants is definitely an attractive strategy against drug resistant strains of S. aureus. ..
  53. ncbi request reprint Macrophage inflammatory protein-2, neutrophil recruitment and bacterial persistence in an experimental mouse model of urinary tract infection
    Rahul Mittal
    Department of Microbiology, Biomedical Sciences Block, Panjab University, Chandigarh 160014, India
    Microbes Infect 6:1326-32. 2004
    ..The role of MIP-2 and neutrophils in relation to the persistence of P. aeruginosa in the urinary tract of mice is discussed...
  54. doi request reprint Nanocolloidal carriers of isotretinoin: antimicrobial activity against Propionibacterium acnes and dermatokinetic modeling
    Kaisar Raza
    UGC Centre of Excellence in Applications of Nanomaterials, Nanoparticles and Nanocomposites, Panjab University, Chandigarh, India
    Mol Pharm 10:1958-63. 2013
    ..Besides establishing ITR as an antimicrobial agent against acne-causing bacteria, the current work ratifies immense potential of nanocolloidal carriers like SLNs and NLCs to treat acne in a more efficient manner...
  55. pmc Methicillin-resistant Staphylococcus aureus phage plaque size enhancement using sublethal concentrations of antibiotics
    Sandeep Kaur
    Department of Microbiology, Panjab University, Chandigarh, India
    Appl Environ Microbiol 78:8227-33. 2012
    ..Significant enhancements in the plaque size of these phages were observed. These results indicate that this modification can therefore safely be incorporated in the traditional DLA overlay method to search for new MRSA-virulent phages...
  56. pmc Acyl homoserine lactones from culture supernatants of Pseudomonas aeruginosa accelerate host immunomodulation
    Ravi Kumar Gupta
    Department of Microbiology, Bio Medical Sciences Block, Panjab University, Chandigarh, India
    PLoS ONE 6:e20860. 2011
    ..The inhibition of T-cells was stronger with natural AHLs compared to synthetic AHLs. Moreover, the natural AHLs were also able to shift immune responses away from host protective Th1 responses to pathogen protective Th2 responses...
  57. ncbi request reprint Immunoassay method to check the flagellin mediated binding of stenotrophomonas maltophilia to polystyrene
    Ayaid K Zgair
    Department of Microbiology, Panjab University, Chandigarh, 160014, India
    Mikrobiologiia 80:136-8. 2011
    ..860155). These evidences conclusively prove the involvement of flagella in the adhesion ofS. maltophilia to polystyrene surface and enzyme immunoassay, a quick and reliable method to check this phenomenon...
  58. doi request reprint Antibiotic susceptibility of ica-positive and ica-negative MRSA in different phases of biofilm growth
    Shivani Chopra
    Department of Microbiology, Panjab University, Chandigarh, India
    J Antibiot (Tokyo) 68:15-22. 2015
    ..However, none of the antibiotics used in this study was effective in eradicating the mature biofilms. ..
  59. doi request reprint Phytochemical-induced reduction of pulmonary inflammation during Klebsiella pneumoniae lung infection in mice
    Shruti Bansal
    Panjab University, Chandigarh, India
    J Infect Dev Ctries 8:838-44. 2014
    ..Its anti-inflammatory property was here studied alone and in combination with clarithromycin in a mouse model of acute inflammation...
  60. doi request reprint Applications of thin-layer chromatography in extraction and characterisation of ajoene from garlic bulbs
    Anitha Vadekeetil
    A Department of Microbiology, Panjab University, Chandigarh 160014, India
    Nat Prod Res 29:768-71. 2015
    ..HPTLC profiling showed that ajoene exhibits QSI effect by inhibiting the production of both long-chain acyl homoserine lactones and Pseudomonas quinolone signal (PQS) by P. aeruginosa and also by inactivating PQS molecules...
  61. doi request reprint New possibility for providing protection against urinary tract infection caused by Pseudomonas aeruginosa by non-adjuvanted flagellin 'b' induced immunity
    Neha Sabharwal
    Department of Microbiology, Basic Medical Sciences Block I, South Campus, Panjab University, Chandigarh 160014, India
    Immunol Lett 162:229-38. 2014
    ..In conclusion, this is the first report that describes flagellin as a potential prophylactic agent which downregulates inflammation and curbs UTIs...
  62. doi request reprint Azithromycin and ciprofloxacin: A possible synergistic combination against Pseudomonas aeruginosa biofilm-associated urinary tract infections
    Hina Saini
    Department of Microbiology, Basic Medical Sciences Block I, South Campus, Panjab University, Chandigarh 160014, India
    Int J Antimicrob Agents 45:359-67. 2015
    ..0001). We conclude that AZM+CIP therapy holds promise against biofilm-associated UTIs as it confers antibacterial, immunomodulatory and anti-inflammatory effects. ..
  63. doi request reprint Efficacy of purified lactonase and ciprofloxacin in preventing systemic spread of Pseudomonas aeruginosa in murine burn wound model
    Parul Gupta
    Department of Microbiology, BMS Block, Panjab University, Chandigarh 160014, India
    Burns 41:153-62. 2015
    ..aeruginosa. This is the first report of topical administration of lactonase along with antibiotic for the efficient control of burn wound infection. ..
  64. ncbi request reprint Induction & resolution of lobar pneumonia following intranasal instillation with Klebsiella pneumoniae in mice
    Vanashree Yadav
    Department of Microbiology, Panjab University, Chandigarh, India
    Indian J Med Res 118:47-52. 2003
    ..In the present study, we successfully attempted to establish an acute respiratory tract infection model in BALB/c strain of mice with K. pneumoniae employing a simple, reproducible intranasal instillation method...