Li Jin Chew

Summary

Publications

  1. doi request reprint Oligodendroglial alterations and the role of microglia in white matter injury: relevance to schizophrenia
    Li Jin Chew
    Center for Neuroscience Research, Children s Research Institute, Children s National Medical Center, Washington, DC 20010, USA
    Dev Neurosci 35:102-29. 2013
  2. pmc Modulation of the Wnt/beta-catenin pathway in human oligodendroglioma cells by Sox17 regulates proliferation and differentiation
    Hui Ling Chen
    Center for Neuroscience Research, Children s National Medical Center, Washington, DC 20010, USA
    Cancer Lett 335:361-71. 2013
  3. pmc Cellular changes underlying hyperoxia-induced delay of white matter development
    Thomas Schmitz
    Center for Neuroscience Research, Children s National Medical Center, Washington, DC 20010, USA
    J Neurosci 31:4327-44. 2011
  4. pmc Transgenic overexpression of Sox17 promotes oligodendrocyte development and attenuates demyelination
    Xiaotian Ming
    Center for Neuroscience Research, Children s Research Institute, Children s National Medical Center, Washington, DC 20010, USA
    J Neurosci 33:12528-42. 2013
  5. pmc Mechanisms of regulation of oligodendrocyte development by p38 mitogen-activated protein kinase
    Li Jin Chew
    Center for Neuroscience Research, Children s Research Institute, Children s National Medical Center, Washington, DC 20010, USA
    J Neurosci 30:11011-27. 2010
  6. pmc The Yin and Yang of Sox proteins: Activation and repression in development and disease
    Li Jin Chew
    Center for Neuroscience Research, Children s National Medical Center, Washington, DC, USA
    J Neurosci Res 87:3277-87. 2009
  7. pmc SRY-box containing gene 17 regulates the Wnt/β-catenin signaling pathway in oligodendrocyte progenitor cells
    Li Jin Chew
    Center for Neuroscience Research, and Center for Genetic Medicine Research, Children s Research Institute, Children s National Medical Center, Washington, DC 20010, USA
    J Neurosci 31:13921-35. 2011
  8. pmc Neonatal hyperoxia exposure disrupts axon-oligodendrocyte integrity in the subcortical white matter
    Jonathan Ritter
    Center for Neuroscience Research, Children s National Medical Center, Washington, District of Columbia 20010, USA
    J Neurosci 33:8990-9002. 2013
  9. ncbi request reprint Interferon-gamma inhibits cell cycle exit in differentiating oligodendrocyte progenitor cells
    Li Jin Chew
    Center for Neuroscience Research, Children s Research Institute, Children s National Medical Center, Washington, DC 20010, USA
    Glia 52:127-43. 2005
  10. pmc Cytokines and myelination in the central nervous system
    Thomas Schmitz
    Center for Neuroscience Research, Children s Research Institute, Washington, D C, USA
    ScientificWorldJournal 8:1119-47. 2008

Collaborators

Detail Information

Publications13

  1. doi request reprint Oligodendroglial alterations and the role of microglia in white matter injury: relevance to schizophrenia
    Li Jin Chew
    Center for Neuroscience Research, Children s Research Institute, Children s National Medical Center, Washington, DC 20010, USA
    Dev Neurosci 35:102-29. 2013
    ..By understanding the neurobiological basis of oligodendroglial abnormalities in schizophrenia, it is hoped that patients will benefit from the availability of targeted and more efficacious treatment options. ..
  2. pmc Modulation of the Wnt/beta-catenin pathway in human oligodendroglioma cells by Sox17 regulates proliferation and differentiation
    Hui Ling Chen
    Center for Neuroscience Research, Children s National Medical Center, Washington, DC 20010, USA
    Cancer Lett 335:361-71. 2013
    ..Our results thus identify Sox17 as a potential molecular target to include in HOG therapeutic strategies...
  3. pmc Cellular changes underlying hyperoxia-induced delay of white matter development
    Thomas Schmitz
    Center for Neuroscience Research, Children s National Medical Center, Washington, DC 20010, USA
    J Neurosci 31:4327-44. 2011
    ..Understanding the cellular dynamics and underlying mechanisms involved in hyperoxia-induced PWMI will allow for future targeted therapeutic intervention...
  4. pmc Transgenic overexpression of Sox17 promotes oligodendrocyte development and attenuates demyelination
    Xiaotian Ming
    Center for Neuroscience Research, Children s Research Institute, Children s National Medical Center, Washington, DC 20010, USA
    J Neurosci 33:12528-42. 2013
    ..This study demonstrates that overexpression of this transcription factor might be a viable protective strategy to mitigate the consequences of demyelination in the adult WM. ..
  5. pmc Mechanisms of regulation of oligodendrocyte development by p38 mitogen-activated protein kinase
    Li Jin Chew
    Center for Neuroscience Research, Children s Research Institute, Children s National Medical Center, Washington, DC 20010, USA
    J Neurosci 30:11011-27. 2010
    ..We show that oligodendrocyte differentiation involves p38-mediated Sox10 regulation and cross talk with parallel ERK and JNK pathways to repress c-Jun activity...
  6. pmc The Yin and Yang of Sox proteins: Activation and repression in development and disease
    Li Jin Chew
    Center for Neuroscience Research, Children s National Medical Center, Washington, DC, USA
    J Neurosci Res 87:3277-87. 2009
    ..Here we seek to provide an overview of the current knowledge of Sox gene functional mechanisms, in an effort to understand their roles in both development and pathology...
  7. pmc SRY-box containing gene 17 regulates the Wnt/β-catenin signaling pathway in oligodendrocyte progenitor cells
    Li Jin Chew
    Center for Neuroscience Research, and Center for Genetic Medicine Research, Children s Research Institute, Children s National Medical Center, Washington, DC 20010, USA
    J Neurosci 31:13921-35. 2011
    ..Our identification of downstream targets of Sox17 thus defines signaling pathways and molecular mechanisms in OPCs that are regulated by Sox17 during cell cycle exit and the onset of differentiation in oligodendrocyte development...
  8. pmc Neonatal hyperoxia exposure disrupts axon-oligodendrocyte integrity in the subcortical white matter
    Jonathan Ritter
    Center for Neuroscience Research, Children s National Medical Center, Washington, District of Columbia 20010, USA
    J Neurosci 33:8990-9002. 2013
    ..Understanding the pathology of premature PWMI injury will allow for the development of interventional strategies to preserve WM integrity and function...
  9. ncbi request reprint Interferon-gamma inhibits cell cycle exit in differentiating oligodendrocyte progenitor cells
    Li Jin Chew
    Center for Neuroscience Research, Children s Research Institute, Children s National Medical Center, Washington, DC 20010, USA
    Glia 52:127-43. 2005
    ....
  10. pmc Cytokines and myelination in the central nervous system
    Thomas Schmitz
    Center for Neuroscience Research, Children s Research Institute, Washington, D C, USA
    ScientificWorldJournal 8:1119-47. 2008
    ....
  11. ncbi request reprint Identification of Sox17 as a transcription factor that regulates oligodendrocyte development
    Jiho Sohn
    Center for Neuroscience Research, Children s National Medical Center, Washington, DC 20010, USA
    J Neurosci 26:9722-35. 2006
    ..These findings support important roles for Sox17 in controlling both oligodendrocyte progenitor cell cycle exit and differentiation...
  12. ncbi request reprint Microglia and inflammation: impact on developmental brain injuries
    Li Jin Chew
    Center for Neuroscience Research, Children s Research Institute, Children s National Medical Center, Washington, District of Columbia 20010, USA
    Ment Retard Dev Disabil Res Rev 12:105-12. 2006
    ..Understanding the processes of inflammation and microglial activation is critical for formulating effective preventative and therapeutic strategies for developmental brain injuries...
  13. ncbi request reprint A novel secreted splice variant of vascular endothelial cell growth inhibitor
    Li Jin Chew
    Department of Oncology, Lombardi Cancer Center, Georgetown University Medical Center, Washington, DC 20007, USA
    FASEB J 16:742-4. 2002
    ..These findings support the view that endothelial cell-secreted VEGI may function as an autocrine inhibitor of angiogenesis and a naturally existing modulator of vascular homeostasis...