Differential Regulation of TauT by Calcitriol and Retinoic Acid via VDR/RXR in LLC-PK1 and MCF-7 CellsRussell W Chesney
Division of Nephrology, Department of Pediatrics, University of Tennessee Health Science Center, Le Bonheur Children s Hospital, Children s Foundation Research Tower, Rm 476R, 50 North Dunlap, 38103, Memphis, TN, USA
Adv Exp Med Biol 776:291-305. 2013
..Our results show that expression of TauT is differentially regulated by VD(3) and RA via formation of VDR and RXR complexes in the nuclei in a cell type-dependent manner...
- Early animal models of rickets and proof of a nutritional deficiency hypothesis
Russell W Chesney
Department of Pediatrics, The University of Tennessee Health Science Center, Memphis, TN, USA
J Pediatr Gastroenterol Nutr 54:322-7. 2012
..Nonetheless, at the end of these studies, a nutritional deficiency of vitamin D resulting from a poor diet or lack of adequate sunshine was firmly established as a cause of rickets...
- Environmental factors in Tiny Tim's near-fatal illness
Russell W Chesney
Department of Pediatrics, Le Bonheur Children s Hospital, The University of Tennessee Health Science Center, Memphis, TN, USA
Arch Pediatr Adolesc Med 166:271-5. 2012
..This component of the innate immune system has strong killing properties for Mycobacterium tuberculosis. The combination of rickets and TB represent a crippling condition that could be reversed by improved vitamin D status...
Theobald palm and his remarkable observation: how the sunshine vitamin came to be recognizedRussell W Chesney
The Department of Pediatrics, Le Bonheur Children s Hospital, Children s Foundation Research Center, The University of Tennessee Health Science Center, Memphis, TN 38103, USA
Nutrients 4:42-51. 2012
..This opened a new era of appreciation for the curative powers of the sun and "the sunshine vitamin". While Palm's observations were in some ways obscure, they had a potent effect on the development of photobiology...
- Metabolic bone disease in lion cubs at the London Zoo in 1889: the original animal model of rickets
Russell W Chesney
Department of Pediatrics, The University of Tennessee Health Science Center, Memphis, Tennesee 38103, USA
J Biomed Sci 17:S36. 2010
..Taurine-conjugated bile salts undoubtedly permitted absorption of vitamins A and D, thus preventing the occurrence of metabolic bone disease and rickets...
New thoughts concerning the epidemic of rickets: was the role of alum overlooked?Russell W Chesney
Pediatr Nephrol 27:3-6. 2012
..Namely, alum used as an adulterant in bread in certain locations may have contributed to metabolic bone disease during the great epidemic of rickets...
- Taurine and the renal system
Russell W Chesney
Department of Pediatrics, University of Tennessee Health Science Center, and the Children s Foundation Research Center at Le Bonheur Children s Medical Center, 50 N, Dunlap, Memphis, Tennessee 38103, USA
J Biomed Sci 17:S4. 2010
..The role of the kidney in adaptation to variations in dietary taurine intake and the regulation of taurine body pool size are described. Finally, the protective function of taurine against several kidney diseases is reviewed...
- Randomized Intervention for Children With Vesicoureteral Reflux (RIVUR): background commentary of RIVUR investigators
Russell W Chesney
University of Tennessee Health Science Center, Department of Pediatrics, Memphis, TN 38103, USA
Pediatrics 122:S233-9. 2008
..Such recommendations should be evidence-based...
- Mechanisms of regulation of taurine transporter activity: a complex interplay of regulatory systems
Xiaobin Han
Department of Pediatrics, University of Tennessee Health Science Center, Memphis, TN, USA
Adv Exp Med Biol 583:79-90. 2006
- Functional TauT protects against acute kidney injury
Xiaobin Han
Department of Pediatrics, University of Tennessee Health Science Center, 50 North Dunlap, Room 301 WPT, Memphis, TN 38103, USA
J Am Soc Nephrol 20:1323-32. 2009
..These data suggest that functional TauT plays a critical role in protecting against cisplatin-induced nephrotoxicity, possibly by attenuating a p53-dependent pathway...
- Mechanism of TauT in protecting against cisplatin-induced kidney injury (AKI)
Xiaobin Han
Department of Pediatrics, University of Tennessee Health Science Center, Memphis, TN, USA
Adv Exp Med Biol 643:105-12. 2009
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- Is TauT an anti-apoptotic gene?
Xiaobin Han
Department of Pediatrics, University of Tennessee Health Science Center, Memphis, TN, USA
Adv Exp Med Biol 583:59-67. 2006
- Stress-responsive gene TauT and acute kidney injury
Xiaobin Han
Department of Pediatrics, University of Tennessee Health Science Center, and the Children s Foundation Research Center at Le Bonheur Children s Medical Center, Memphis, Tennessee, USA
J Biomed Sci 17:S28. 2010
..In the present study, we have investigated how TauT is regulated by p53 and c-Jun and its role during acute kidney injury (AKI)...
- TauT protects against cisplatin-induced acute kidney injury (AKI) established in a TauT transgenic mice model
Xiaobin Han
Department of Pediatrics, University of Tennessee Health Science Center and the Children s Memphis, TN, USA
Adv Exp Med Biol 643:113-22. 2009
..06 mg/dl). However, over-expression of hTauT effectively prevented the progression of cisplatin-induced AKI in hTauT transgenic mice, as measured by the levels of BUN and serum creatininelevels (23 +/- 3.5 mg/dl and 0.6 +/- 0.05 mg/dl)...
- Regulation of taurine transporter gene (TauT) by WT1
Xiaobin Han
Department of Pediatrics, University of Tennessee Health Science Center, and the Children s Foundation Research Center at Le Bonheur Children s Medical Center, 50 North Dunlap, Memphis, TN 38103 4909, USA
FEBS Lett 540:71-6. 2003
..Mutation of this WT1 consensus sequence abolished binding of WT1. These results demonstrate that TauT may represent a downstream target gene of WT1 during renal development...
- Transactivation of TauT by p53 in MCF-7 cells: the role of estrogen receptors
Xiaobin Han
Department of Pediatrics, University of Tennessee Health Science Center, Memphis, TN, USA
Adv Exp Med Biol 526:139-47. 2003
- Rickets in lion cubs at the London Zoo in 1889: some new insights
Russell W Chesney
University of Tennessee Health Science Center, Department of Pediatrics, Children s Foundation Research Center, Le Bonheur Children s Medical Center, Memphis, TN 38103, USA
Pediatrics 123:e948-50. 2009
..However, gum health and the presence of taurine-conjugated bile salts undoubtedly permitted absorption of vitamin A and D, the latter promoting the cure of rickets...
- The future of pediatric nephrology
Russell W Chesney
Department of Pediatrics, University of Tennessee Health Science Center, 50 N Dunlap, Room 306, Memphis, TN 38103, USA
Pediatr Nephrol 20:867-71. 2005
..The International Pediatric Nephrology Association (IPNA), its journal, and pediatric advocates will need to use their energies to take on these challenges...
- Gating of taurine transport: role of the fourth segment of the taurine transporter
Xiaobin Han
Department of Pediatrics, University of Tennessee Health Science Center, Memphis, TN, USA
Adv Exp Med Biol 526:149-57. 2003
- Who was John Howland and why was an award named after him 50 years ago?
Russell W Chesney
Department of Pediatrics, University of Tennessee Health Science Center, LeBonheur Children s Medical Center, Memphis, Tennessee 38103, USA
Pediatr Res 53:523-5. 2003
- Rickets: an old form for a new century
Russell W Chesney
Department of Pediatrics, The University of Tennessee Health Science Center, Le Bonheur Children's Medical Center, Memphis, Tennessee 38103-4909, USA
Pediatr Int 45:509-11. 2003
- American Pediatric Society Presidential Address 2003: the failure of Ockham's razor in 21st century pediatrics
Russell W Chesney
University of Tennessee Health Science Center, Department of Pediatrics, Le Bonheur Children's Medical Center, 50 N. Dunlap, Room 306-307, Memphis, TN 38103, USA
Pediatr Res 55:903-7. 2004
- Does taurine deficiency cause metabolic bone disease and rickets in polar bear cubs raised in captivity?
Russell W Chesney
The University of Tennessee Health Science Center, USA
Adv Exp Med Biol 643:325-31. 2009
..Higher dietary intake of TAU by free-ranging cubs may influence bile acid conjugation and improve vitamin D absorption...
- Changing requirements for evaluation of pharmacologic agents
Russell W Chesney
Department of Pediatrics, Center for Pediatric Pharmacokinetics and Therapeutics, University of Tennessee, Memphis, USA
Pediatrics 113:1128-32. 2004
..This article reviews new laws that govern drug testing in children and the use of children in therapeutic research...
- Transcriptional repression of taurine transporter gene (TauT) by p53 in renal cells
Xiaobin Han
Department of Pediatrics, University of Tennessee Health Science Center and the Children s Foundation Research Center at Le Bonheur Children s Medical Center, Memphis, Tennessee 38103, USA
J Biol Chem 277:39266-73. 2002
..Mutation of this p53 consensus sequence abolished binding of p53. These results demonstrate that TauT may represent a downstream target gene of p53 that could link the roles of p53 in renal development and apoptosis...
- Knockdown of TauT Expression Impairs Human Embryonic Kidney 293 Cell Development
Xiaobin Han
Department of Pediatrics, University of Tennessee Health Science Center, and the Children s Foundation Research Institute at Le Bonheur Children s Hospital, Rm 307R, 50 North Dunlap, 38103, Memphis, TN, USA
Adv Exp Med Biol 776:307-20. 2013
..In conclusion, the results from this study suggest that TauT plays a role in the development of renal cells. Knockdown of TauT impairs kidney development, possibly through regulation of cell cycle-related genes...
- The role of taurine in renal disorders
Xiaobin Han
Department of Pediatrics, The University of Tennessee Health Science Center, and the Children s Foundation Research Institute at Le Bonheur Children s Hospital, Memphis, TN, 38103, USA
Amino Acids 43:2249-63. 2012
..The studies evaluated will be mainly recent ones, recognizing that older reviews of the role of this taurine in the kidney are available...
- Report of an NIH task force on research priorities in chronic kidney disease in children
Russell W Chesney
Department of Pediatrics, University of Tennessee Health Science Center, 50 North Dunlap, 38103-4909, USA
Pediatr Nephrol 21:14-25. 2006
- Children as clinical research subjects
Russell W Chesney
Department of Pediatrics, University of Tennessee Health Science Center, Le Bonheur Children's Medical Center, St. Jude Children's Research Hospital, 50 North Dunlap Street, Memphis, TN 38103, USA
J Pediatr 146:579-80. 2005
- Women pediatricians: can facts shed light on prejudices and myths?
Russell W Chesney
Department of Pediatrics, University of Tennessee Health Science Center, LeBonheur Children s Medical Center, Memphis, Tennessee, USA
J Pediatr 144:413-4. 2004
- The development of pediatric nephrology
Russell W Chesney
Department of Pediatrics, University of Tennessee College of Medicine, LeBonheur Children s Medical Center, Memphis, Tennessee 38103, USA
Pediatr Res 52:770-8. 2002
..The scientific basis of pediatric nephrology, ongoing patient care needs, and its technical aspects - renal biopsy, dialysis and transplantation - assure its continuing future as a major pediatric discipline on all continents...
- Rationale and design issues of the Randomized Intervention for Children With Vesicoureteral Reflux (RIVUR) study
Ron Keren
Department of Pediatrics, Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
Pediatrics 122:S240-50. 2008
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