Liang Cheng

Summary

Publications

  1. ncbi request reprint Soft tissue tumors of the prostate: a review
    David G Wagner
    Department of Pathology, University of Rochester Medical Center, 601 Elmwood Avenue, New York 14642, USA
    Anal Quant Cytol Histol 29:341-50. 2007
  2. ncbi request reprint The expression patterns of p53 and p16 and an analysis of a possible role of HPV in primary adenocarcinoma of the urinary bladder
    Riley E Alexander
    Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, Indiana, United States of America
    PLoS ONE 9:e95724. 2014
  3. ncbi request reprint Biomarkers in bladder cancer: translational and clinical implications
    Liang Cheng
    Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN, USA Department of Urology, Indiana University School of Medicine, Indianapolis, IN, USA Electronic address
    Crit Rev Oncol Hematol 89:73-111. 2014
  4. pmc Immunohistochemical analysis of chromatin remodeler DAXX in high grade urothelial carcinoma
    Antonio Zizzi
    Section of Pathological Anatomy, Polytechnic University of the Marche Region, School of Medicine, United Hospitals, Via Conca 71, 60126, Torrette Ancona, Italy
    Diagn Pathol 8:111. 2013
  5. doi request reprint Laser-assisted microdissection in translational research: theory, technical considerations, and future applications
    Liang Cheng
    Departments of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis 46202, USA
    Appl Immunohistochem Mol Morphol 21:31-47. 2013
  6. doi request reprint Histologic grading of urothelial carcinoma: a reappraisal
    Liang Cheng
    Department of Pathology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Hum Pathol 43:2097-108. 2012
  7. ncbi request reprint KRAS testing in clinical laboratory: optimizing targeted therapy
    Leticia Miravalle
    Department of Pathology, Indiana University School of Medicine, IN 46202, U S A
    Cancer Genomics Proteomics 9:337-41. 2012
  8. doi request reprint Molecular pathology of lung cancer: key to personalized medicine
    Liang Cheng
    Departments of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN, USA
    Mod Pathol 25:347-69. 2012
  9. doi request reprint Staging of prostate cancer
    Liang Cheng
    Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Histopathology 60:87-117. 2012
  10. pmc How much do you know about benign, preneoplastic, non-invasive and invasive neoplastic lesions of the urinary bladder classified according to the 2004 WHO scheme?
    Rodolfo Montironi
    Section of Pathological Anatomy, School of Medicine, Polytechnic University of the Marche Region Ancona, Ancona, Italy
    Diagn Pathol 6:31. 2011

Detail Information

Publications129 found, 100 shown here

  1. ncbi request reprint Soft tissue tumors of the prostate: a review
    David G Wagner
    Department of Pathology, University of Rochester Medical Center, 601 Elmwood Avenue, New York 14642, USA
    Anal Quant Cytol Histol 29:341-50. 2007
    ..Diagnostic immunohistochemistry is an important adjunct to histopathology for proper diagnosis and tumor subclassification...
  2. ncbi request reprint The expression patterns of p53 and p16 and an analysis of a possible role of HPV in primary adenocarcinoma of the urinary bladder
    Riley E Alexander
    Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, Indiana, United States of America
    PLoS ONE 9:e95724. 2014
    ..The goal of this study was to investigate p53 and p16 expression, as well as HPV status, in a relatively large series of primary bladder adenocarcinomas...
  3. ncbi request reprint Biomarkers in bladder cancer: translational and clinical implications
    Liang Cheng
    Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN, USA Department of Urology, Indiana University School of Medicine, Indianapolis, IN, USA Electronic address
    Crit Rev Oncol Hematol 89:73-111. 2014
    ..The scope of this review is to summarize the major biomarker findings that may have translational and clinical implications...
  4. pmc Immunohistochemical analysis of chromatin remodeler DAXX in high grade urothelial carcinoma
    Antonio Zizzi
    Section of Pathological Anatomy, Polytechnic University of the Marche Region, School of Medicine, United Hospitals, Via Conca 71, 60126, Torrette Ancona, Italy
    Diagn Pathol 8:111. 2013
    ..The aim of this exploratory immunohistochemical study was to evaluate DAXX protein expression in high grade invasive urothelial carcinoma (UC) of the bladder as a biological regulator of aggressiveness...
  5. doi request reprint Laser-assisted microdissection in translational research: theory, technical considerations, and future applications
    Liang Cheng
    Departments of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis 46202, USA
    Appl Immunohistochem Mol Morphol 21:31-47. 2013
    ..In this review, we also discuss the technical details of tissue preparation, analytical yields, tissue selection, and selected applications using LCM...
  6. doi request reprint Histologic grading of urothelial carcinoma: a reappraisal
    Liang Cheng
    Department of Pathology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Hum Pathol 43:2097-108. 2012
    ..Recent advances in the molecular grading of these tumors may eventually supplant traditional morphologic grading systems, allowing a more precise and objective assessment of the tumors' biologic potentials...
  7. ncbi request reprint KRAS testing in clinical laboratory: optimizing targeted therapy
    Leticia Miravalle
    Department of Pathology, Indiana University School of Medicine, IN 46202, U S A
    Cancer Genomics Proteomics 9:337-41. 2012
    ..Several methods for KRAS mutation detection have been described in the literature. Most of these are laboratory developed tests and only a few commercial assays are currently available...
  8. doi request reprint Molecular pathology of lung cancer: key to personalized medicine
    Liang Cheng
    Departments of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN, USA
    Mod Pathol 25:347-69. 2012
    ..Understanding these mechanisms may provide new treatment avenues and improve current treatment algorithms...
  9. doi request reprint Staging of prostate cancer
    Liang Cheng
    Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Histopathology 60:87-117. 2012
    ..We recommend that a future TNM staging system should consider subclassification of node-positive cancer on the basis of nodal cancer volume, using the diameter of the largest nodal metastasis and/or the number of positive nodes...
  10. pmc How much do you know about benign, preneoplastic, non-invasive and invasive neoplastic lesions of the urinary bladder classified according to the 2004 WHO scheme?
    Rodolfo Montironi
    Section of Pathological Anatomy, School of Medicine, Polytechnic University of the Marche Region Ancona, Ancona, Italy
    Diagn Pathol 6:31. 2011
    ..This paper is directed to all who are involved with the application of this classification at the anticancer research, diagnostic, prognostic and therapeutic levels, in particular to uropathologists, urologists and oncologists...
  11. ncbi request reprint Eosinophilic metaplasia of the prostate: a newly described lesion distinct from other eosinophilic changes in prostatic epithelium
    Liang Cheng
    Department of Pathology, Indiana University, Indianapolis, Indiana, USA
    Anal Quant Cytol Histol 30:226-30. 2008
    ..To describe the morphologic, immunohistochemical and ultrastructural features of large, intensely eosinophilic cytoplasmic granules in prostatic epithelial cells in the benign prostate, as well as the prevalence of this condition...
  12. doi request reprint Sarcomatoid carcinoma of the urinary bladder: the final common pathway of urothelial carcinoma dedifferentiation
    Liang Cheng
    Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN, USA
    Am J Surg Pathol 35:e34-46. 2011
    ..We emphasize the importance of molecular genetic studies in providing insight into the histogenesis of this neoplasm. Sarcomatoid carcinoma seems to represent the final common pathway of urothelial carcinoma dedifferentiation...
  13. doi request reprint Inflammatory myofibroblastic tumors of the genitourinary tract--single entity or continuum?
    Liang Cheng
    Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    J Urol 180:1235-40. 2008
    ....
  14. doi request reprint The clinical and therapeutic implications of cancer stem cell biology
    Liang Cheng
    Department of Pathology, Indiana University School of Medicine, 350 West 11th Street, Room 4010, Indianapolis, IN 4620, USA
    Expert Rev Anticancer Ther 11:1131-43. 2011
    ..It is noteworthy that CSCs are the only cells capable of sustaining tumorigenesis; however, the cell of origin of cancer, in which tumorigenesis is initiated, may be distinct from CSCs that propagate the tumor...
  15. doi request reprint Bladder cancer: translating molecular genetic insights into clinical practice
    Liang Cheng
    Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Hum Pathol 42:455-81. 2011
    ....
  16. doi request reprint Atypical sclerosing adenosis of the prostate: a rare mimic of adenocarcinoma
    Liang Cheng
    Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Histopathology 56:627-31. 2010
    ..It is incidentally found in about 2% of transurethral resection specimens. The aim was to describe cases with significant cytological atypia mimicking cancer, which have not been previously reported...
  17. doi request reprint Morphologic, immunohistochemical, and fluorescence in situ hybridization study of ovarian embryonal carcinoma with comparison to solid variant of yolk sac tumor and immature teratoma
    Liang Cheng
    Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Hum Pathol 41:716-23. 2010
    ..Chromosome 12p fluorescence in situ hybridization combined with OCT4, CD30, and glypican 3 immunostains is useful in confirming the diagnosis of ovarian embryonal carcinoma...
  18. ncbi request reprint Percentage of Gleason pattern 4 and 5 predicts survival after radical prostatectomy
    Liang Cheng
    Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Cancer 110:1967-72. 2007
    ..The objective of the current study was to determine whether the combined percentage of Gleason patterns 4 and 5 in radical prostatectomy specimens is an independent predictor of cancer-specific survival in prostate cancer patients...
  19. ncbi request reprint The origins of urothelial carcinoma
    Liang Cheng
    Departments of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN, USA
    Expert Rev Anticancer Ther 10:865-80. 2010
    ....
  20. doi request reprint Molecular determinants of tumor recurrence in the urinary bladder
    Liang Cheng
    Department of Pathology and Laboratory Medicine and Urology, Indiana University School of Medicine, 350 West 11th Street, Clarian Pathology Laboratory, Indianapolis, IN 46202, USA
    Future Oncol 5:843-57. 2009
    ..A unifying model of urothelial carcinogenesis, tumor recurrence and progression is proposed in this review...
  21. ncbi request reprint Overdiagnosis of bladder carcinoma
    Liang Cheng
    Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Anal Quant Cytol Histol 30:261-4. 2008
    ..To describe a group of archival patients who were overdiagnosed with bladder cancer according to contemporary criteria...
  22. doi request reprint Staging and reporting of urothelial carcinoma of the urinary bladder
    Liang Cheng
    Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, 350 West 11th Street, Clarian Pathology Laboratory Room 4010, Indianapolis, IN 46202, USA
    Mod Pathol 22:S70-95. 2009
    ..This review will discuss recent progress and controversial issues on the staging and substaging of bladder carcinomas. Essential elements for handling and reporting of bladder tumor specimens will also be discussed...
  23. doi request reprint Molecular and cytogenetic insights into the pathogenesis, classification, differential diagnosis, and prognosis of renal epithelial neoplasms
    Liang Cheng
    Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Hum Pathol 40:10-29. 2009
    ....
  24. ncbi request reprint Evidence for polyclonal origin of multifocal clear cell renal cell carcinoma
    Liang Cheng
    Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Clin Cancer Res 14:8087-93. 2008
    ..Renal cell carcinomas are often multifocal. We investigated the genomic signatures of multifocal clear cell renal cell carcinoma to determine whether multiple tumors in the same kidney bear a clonal relationship to one another...
  25. doi request reprint KIT gene mutation and amplification in dysgerminoma of the ovary
    Liang Cheng
    Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA
    Cancer 117:2096-103. 2011
    ..The purpose of this study was to analyze alterations of the KIT gene in a large series of dysgerminomas and correlate the findings with clinicopathological parameters...
  26. doi request reprint Molecular genetic evidence supporting the origin of somatic-type malignancy and teratoma from the same progenitor cell
    Jennifer B Kum
    Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Am J Surg Pathol 36:1849-56. 2012
    ....
  27. ncbi request reprint Amplifications of EGFR gene and protein expression of EGFR, Her-2/neu, c-kit, and androgen receptor in phyllodes tumor of the prostate
    Xiaoyan Wang
    Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Mod Pathol 20:175-82. 2007
    ..Anti-EGFR and/or antiandrogen agents may be potentially useful for management of patients with tumors expressing EGFR and/or androgen receptor...
  28. ncbi request reprint Preoperative prediction of small volume cancer (less than 0.5 ml) in radical prostatectomy specimens
    Liang Cheng
    Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, USA
    J Urol 174:898-902. 2005
    ..We examined various clinical parameters and prostate biopsy features to determine which variables are most predictive of small volume (less than 0.5 ml) cancer at prostatectomy...
  29. doi request reprint Evidence for common clonal origin of multifocal lung cancers
    Xiaoyan Wang
    Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, 350 West 11th Street, Clarian Pathology Laboratory, Indianapolis, IN 46202, USA
    J Natl Cancer Inst 101:560-70. 2009
    ..Lung cancer is the most common cause of cancer death in the United States. Multiple anatomically separate but histologically similar lung tumors are often found in the same patient. The clonal origin of multiple lung tumors is uncertain...
  30. doi request reprint Sarcomatoid carcinoma of the upper urinary tract: clinical outcome and molecular characterization
    Xiaoyan Wang
    Department of Pathology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Hum Pathol 40:211-7. 2009
    ..Gains of chromosome 3, 7, and 17 and loss of chromosome 9p21 were commonly observed in these tumors. Our findings suggest that targeted therapy may be a rational strategy in the management of these patients...
  31. ncbi request reprint Epidermal growth factor receptor protein expression and gene amplification in small cell carcinoma of the urinary bladder
    Xiaoyan Wang
    Department of Pathology, Indiana University, Indianapolis, Indiana 46202, USA, and United Hospitals, Ancona, Italy
    Clin Cancer Res 13:953-7. 2007
    ..This study was done to investigate EGFR protein expression and gene amplification in a large series of small cell carcinomas of the urinary bladder...
  32. ncbi request reprint Lymphovascular invasion is an independent prognostic factor in prostatic adenocarcinoma
    Liang Cheng
    Departments of Pathology and Laboratory Medicine, Indiana University School of Medicine, Medical Center, University Hospital 3465, 550 North University Boulevard, Indianapolis, IN 46202, USA
    J Urol 174:2181-5. 2005
    ..We retrospectively investigated lymphovascular invasion as a predictive factor for biochemical failure and cancer specific survival following radical prostatectomy...
  33. doi request reprint Renal cell neoplasms of oncocytosis have distinct morphologic, immunohistochemical, and cytogenetic profiles
    Stefano Gobbo
    Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN, USA
    Am J Surg Pathol 34:620-6. 2010
    ..In summary, the renal cell neoplasms of oncocytosis seem to have distinct morphologic, immunohistochemical, and cytogenetic profiles and likely are a distinct entity, not closely related to oncocytoma or chromophobe renal cell carcinoma...
  34. doi request reprint Clonal evidence for the progression of a testicular germ cell tumor to angiosarcoma
    Muhammad T Idrees
    Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Hum Pathol 41:139-44. 2010
    ..The results indicated a clonal origin of the tumors, which supports that angiosarcoma, as well as the teratomas, arose from the testicular germ cell tumors...
  35. ncbi request reprint Telomere shortening and chromosomal abnormalities in intestinal metaplasia of the urinary bladder
    Michael J Morton
    Department of Pathology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Clin Cancer Res 13:6232-6. 2007
    ..We used quantitative fluorescent in situ hybridization (FISH) to measure telomere length and UroVysion FISH to detect cytogenetic abnormalities in urinary bladder specimens with intestinal metaplasia...
  36. doi request reprint Epidermal growth factor receptor (EGFR) expression in prostatic adenocarcinoma after hormonal therapy: a fluorescence in situ hybridization and immunohistochemical analysis
    Rebecca A Marks
    Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA
    Prostate 68:919-23. 2008
    ..Activation of epidermal growth factor receptor (EGFR) has been implicated in prostate cancer cell growth...
  37. doi request reprint TP53 mutational analysis supports monoclonal origin of biphasic sarcomatoid urothelial carcinoma (carcinosarcoma) of the urinary bladder
    Andrew B Armstrong
    Department of Pathology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Mod Pathol 22:113-8. 2009
    ..Our results suggest that despite their conspicuous divergence at the phenotypic level, the sarcomatoid and carcinomatoid elements of this uncommon tumor share a common clonal origin...
  38. pmc Molecular genetic evidence for a common clonal origin of urinary bladder small cell carcinoma and coexisting urothelial carcinoma
    Liang Cheng
    Department of Pathology and Laboratory Medicine, Indiana University Medical Center, University Hospital 3465, 550 North University Boulevard, Indianapolis, Indiana 46202, USA
    Am J Pathol 166:1533-9. 2005
    ..Concordant genetic alterations and X chromosome inactivation between small-cell carcinoma and coexisting urothelial carcinoma suggest that both tumor components originate from the same cells in the urothelium...
  39. doi request reprint Mixed epithelial and stromal tumors of the kidney: evidence for a single cell of origin with capacity for epithelial and stromal differentiation
    Jennifer Bup Jong Kum
    Department of Pathology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Am J Surg Pathol 35:1114-22. 2011
    ..Our data support the theory that the stroma and epithelium arise from a common cell of origin...
  40. ncbi request reprint Urothelial carcinoma with an inverted growth pattern can be distinguished from inverted papilloma by fluorescence in situ hybridization, immunohistochemistry, and morphologic analysis
    Timothy D Jones
    Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Am J Surg Pathol 31:1861-7. 2007
    ..Morphologic features, as well as immunohistochemical stains (including stains for Ki-67, p53, and cytokeratin 20) and/or UroVysion FISH can help to distinguish inverted papilloma from urothelial carcinoma with an inverted growth pattern...
  41. ncbi request reprint Clonality and TP53 mutation analysis of focal nodular hyperplasia of the liver
    Suqin Zheng
    Dept of Pathology and Laboratory Medicine, Indiana University, Indianapolis, 46202, USA
    Am J Clin Pathol 134:65-70. 2010
    ..Our data indicate that a significant proportion of FNH lesions have a monoclonal origin, suggesting that they are neoplastic rather than reactive...
  42. doi request reprint Hypermethylation of tumor-suppressor gene CpG islands in small-cell carcinoma of the urinary bladder
    Phillip H Abbosh
    Department of Pathology, Indiana University, Indianapolis, IN, USA
    Mod Pathol 21:355-62. 2008
    ..These findings suggest that SCBC and TCC have common origins, establish DNA methylation of some tumor suppressors as frequent occurrences in both histopathologies, and suggest that MGMT methylation may be an SCBC-specific epimutation...
  43. ncbi request reprint Molecular genetic evidence for the independent origin of multifocal papillary tumors in patients with papillary renal cell carcinomas
    Timothy D Jones
    Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Clin Cancer Res 11:7226-33. 2005
    ..Molecular analysis of microsatellite and chromosome alterations and X-chromosome inactivation status in separate tumors in the same patient can be used to study the genetic relationships among the coexisting multiple tumors...
  44. ncbi request reprint Aberrant expression of CARM1, a transcriptional coactivator of androgen receptor, in the development of prostate carcinoma and androgen-independent status
    Heng Hong
    Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, University Hospital 3465, University Medical Center, 550 North University Boulevard, Indianapolis, IN 46202, USA
    Cancer 101:83-9. 2004
    ..It is involved in the regulation of the biologic functions of the AR. It remains to be determined whether CARM1 is involved in prostatic carcinogenesis...
  45. doi request reprint Clear cell papillary renal cell carcinoma-like tumors in patients with von Hippel-Lindau disease are unrelated to sporadic clear cell papillary renal cell carcinoma
    Sean R Williamson
    Department of Pathology and Laboratory Medicine, School of Medicine, Indiana University, Indianapolis, IN 46202, USA
    Am J Surg Pathol 37:1131-9. 2013
    ..In summary, tumors that histologically resemble CCPRCC sometimes occur in patients with VHL disease but usually lack the characteristic immunohistochemical and molecular profile, suggesting that they do not share the same pathogenesis. ..
  46. ncbi request reprint Clonal origin of metastatic testicular teratomas
    Timothy D Jones
    Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA, and Department of Pathology, Chang Gung Memorial Hospital Kaohsiung Medical Center, Kaohsiung, Taiwan
    Clin Cancer Res 12:5377-83. 2006
    ..Neither the genetic relationships among the different components in metastatic lesions nor the relationships between primary and metastatic GCT components have been elucidated...
  47. ncbi request reprint Fluorescence in situ hybridization analysis of chromosome 12p in paraffin-embedded tissue is useful for establishing germ cell origin of metastatic tumors
    Kevin M Kernek
    Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Mod Pathol 17:1309-13. 2004
    ....
  48. doi request reprint Is atypical adenomatous hyperplasia of the prostate a precursor lesion?
    Chen Zhang
    Department of Pathology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Prostate 71:1746-51. 2011
    ..Alpha-methylacyl-CoA racemase (AMACR) is highly expressed in prostatic adenocarcinoma. The precursor nature of atypical adenomatous hyperplasia (AAH) is uncertain...
  49. ncbi request reprint Radical prostatectomy as initial monotherapy for patients with pathologically confirmed high-grade prostate cancer
    Clint D Bahler
    Department of Urology, Indiana University Medical Center, Indianapolis, IN 46202, USA
    BJU Int 105:1372-6. 2010
    ..To report the long-term outcome of high-grade prostate cancer treated with radical prostatectomy (RP) as initial monotherapy, analyse the effect of clinical and pathological variables on survival, and report cancer-related symptoms...
  50. doi request reprint Human papillomavirus is not an etiologic agent of urothelial inverted papillomas
    Riley E Alexander
    Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Am J Surg Pathol 37:1223-8. 2013
    ..Our findings indicate the absence of HPV in urothelial inverted papillomas. HPV testing should not be used as a diagnostic adjunct for inverted papilloma cases. ..
  51. ncbi request reprint Radial distance of extraprostatic extension measured by ocular micrometer is an independent predictor of prostate-specific antigen recurrence: A new proposal for the substaging of pT3a prostate cancer
    Ming Tse Sung
    Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA
    Am J Surg Pathol 31:311-8. 2007
    ..The strength of its prognostic value for PSA recurrence makes it a potential criterion for incorporation into a future tumor, lymph node, metastasis staging system...
  52. ncbi request reprint Laser capture microdissection analysis reveals frequent allelic losses in papillary urothelial neoplasm of low malignant potential of the urinary bladder
    Liang Cheng
    Department of Pathology and Laboratory Medicine, School of Medicine, Indiana University Medical Center, University Hospital 3465, 550 North University Boulevard, Indianapolis, IN 46202, USA
    Cancer 101:183-8. 2004
    ..The biologic potential of PUNLMP of the urinary bladder is controversial. To the authors' knowledge, information regarding the genetic changes of PUNLMP tumors of the bladder is limited...
  53. doi request reprint Clear cell papillary renal cell carcinoma: a distinct histopathologic and molecular genetic entity
    Stefano Gobbo
    Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Am J Surg Pathol 32:1239-45. 2008
    ..This tumor has immunophenotypic and genetic profiles distinct from those of either classic papillary or clear cell renal cell carcinoma, and should be considered a distinct entity in the spectrum of renal cell neoplasia...
  54. ncbi request reprint The relationship between the extent of surgical margin positivity and prostate specific antigen recurrence in radical prostatectomy specimens
    Rebecca A Marks
    Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Hum Pathol 38:1207-11. 2007
    ....
  55. ncbi request reprint Does the presence of extranodal extension in pathological stage B1 nonseminomatous germ cell tumor necessitate adjuvant chemotherapy?
    Stephen D W Beck
    Department of Urology, Indiana University, Indianapolis, Indiana 46202, USA
    J Urol 177:944-6. 2007
    ..We decided to evaluate the significance of extranodal extension on disease-free survival in patients with pathological stage B nonseminomatous germ cell tumor who did not receive adjuvant chemotherapy...
  56. ncbi request reprint Genetically heterogeneous and clonally unrelated metastases may arise in patients with cutaneous melanoma
    Terrence M Katona
    Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Am J Surg Pathol 31:1029-37. 2007
    ....
  57. ncbi request reprint Down-regulation of fragile histidine triad expression in prostate carcinoma
    Rebecca L Fouts
    Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA
    Cancer 97:1447-52. 2003
    ..Numerous studies have indicated that the FHIT gene on chromosome 3p may play an important role in human neoplasia, although very few studies have investigated the FHIT gene in prostate carcinoma...
  58. pmc Elevated expression of cancer-associated proliferating cell nuclear antigen in high-grade prostatic intraepithelial neoplasia and prostate cancer
    Xiaoyan Wang
    Department of Pathology, Indiana University School of Medicine, Indianapolis, Indiana, USA
    Prostate 71:748-54. 2011
    ..The expression and potential utility of this marker in prostatic neoplasia is uncertain. With the development of this new caPCNA selective antibody, we explored the potential utility of this marker in prostate cancer...
  59. ncbi request reprint Small cell carcinoma of the urinary bladder: a clinicopathologic analysis of 64 patients
    Liang Cheng
    Department of Pathology and Laboratory Medicine, Indiana University, Indianapolis 46202, USA
    Cancer 101:957-62. 2004
    ..Small cell carcinoma of the urinary bladder is an uncommon tumor that has been described in case reports or small series. Herein, the authors report a series of 64 patients with small cell carcinoma of the urinary bladder...
  60. ncbi request reprint Chromosome 12p abnormalities in dysgerminoma of the ovary: a FISH analysis
    Paolo Cossu-Rocca
    Department of Pathology, Indiana University, Indianapolis, IN 46202, USA
    Mod Pathol 19:611-5. 2006
    ..FISH analyses for chromosome 12p abnormalities may be a useful diagnostic adjunct for confirming the diagnosis of dysgerminoma and for distinguishing it from nongerm cell malignancies that enter into the differential diagnosis...
  61. pmc Molecular genetic evidence for different clonal origins of epithelial and stromal components of phyllodes tumor of the prostate
    Ryan P McCarthy
    Department of Pathology and Laboratory Medicine, Indiana University Medical Center, University Hospital 3465, 550 North University Blvd, Indianapolis, IN 46202, USA
    Am J Pathol 165:1395-400. 2004
    ..While both epithelium and stroma are clonal proliferations, they appear to have different clonal origins...
  62. doi request reprint Does the size matter?: Prostate weight does not predict PSA recurrence after radical prostatectomy
    Darrell D Davidson
    Dept of Pathology, Indiana University School of Medicine, Indianapolis, 46202, USA
    Am J Clin Pathol 133:662-8. 2010
    ..Although increasing prostate weight correlates with increased patient age and higher preoperative PSA level, it does not independently predict postoperative cancer recurrence...
  63. doi request reprint Lymphoepithelioma-like carcinoma of the urinary bladder: clinicopathologic, immunohistochemical, and molecular features
    Sean R Williamson
    Department of Pathology, Indiana University School of Medicine, Indianapolis, IN, USA
    Am J Surg Pathol 35:474-83. 2011
    ..Investigation of immunohistochemical and molecular characteristics of bladder LELC is limited. The pathogenesis and biological behavior of these tumors are controversial...
  64. pmc A water soluble parthenolide analog suppresses in vivo tumor growth of two tobacco-associated cancers, lung and bladder cancer, by targeting NF-κB and generating reactive oxygen species
    Rajasubramaniam Shanmugam
    Department of Medicine, Indiana University, Indianapolis, IN, USA
    Int J Cancer 128:2481-94. 2011
    ..The data provides support for the conduct of clinical trials in TCC and NSCLC...
  65. ncbi request reprint Thyroid transcription factor 1 expression in small cell carcinoma of the urinary bladder: an immunohistochemical profile of 44 cases
    Timothy D Jones
    Department of Pathology and Laboratory Medicine, Indiana University, Indianapolis, IN 46202, USA
    Hum Pathol 36:718-23. 2005
    ..TTF-1 positivity is not a significant prognostic factor in small cell carcinoma of the urinary bladder...
  66. ncbi request reprint c-kit Expression in small cell carcinoma of the urinary bladder: prognostic and therapeutic implications
    Chong Xian Pan
    Department of Medicine, Indiana University, Indianapolis, IN 46202, USA
    Mod Pathol 18:320-3. 2005
    ..36). A significant proportion (27%) of small cell carcinomas of the urinary bladder expressed c-kit, suggesting that it may prove useful as a therapeutic target in small cell carcinoma of the urinary bladder...
  67. doi request reprint Incidence, histology and management of intraluminal thrombus at post-chemotherapy retroperitoneal lymph node dissection
    Paul Johnston
    Department of Urology, Indiana University Medical Center, Indianapolis, Indiana 46202, USA
    J Urol 190:874-7. 2013
    ..We determined the incidence, histology and management of intraluminal thrombus in a large group of patients treated with post-chemotherapy retroperitoneal lymph node dissection...
  68. ncbi request reprint The combined percentage of Gleason patterns 4 and 5 is the best predictor of cancer progression after radical prostatectomy
    Liang Cheng
    Department of Pathology and Laboratory Medicine, Indiana University Medical Center, University Hospital 3465, 550 N University Blvd, Indianapolis, IN 46202, USA
    J Clin Oncol 23:2911-7. 2005
    ..We evaluated the significance of the relative proportion of high-grade cancer (Gleason patterns 4 and/or 5) in predicting cancer progression in prostate cancer patients treated with radical prostatectomy...
  69. ncbi request reprint Maximum tumor diameter is an independent predictor of prostate-specific antigen recurrence in prostate cancer
    Lori E Eichelberger
    Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Mod Pathol 18:886-90. 2005
    ..13-2.56, P=0.01), controlling for risk factors, Gleason score, and surgical margin status. We conclude that maximum tumor diameter is a significant predictor of biochemical recurrence in patients with prostate cancer...
  70. ncbi request reprint Molecular genetic alterations in the laser-capture-microdissected stroma adjacent to bladder carcinoma
    Ryan F Paterson
    Department of Urology, Indiana University School of Medicine, Indianapolis, Indianapolis 46202, USA
    Cancer 98:1830-6. 2003
    ..In addition, the pattern of X-chromosome inactivation of the stromal cells was evaluated by analyzing the DNA methylation pattern at a polymorphic site on the androgen receptor gene...
  71. ncbi request reprint Interphase fluorescence in situ hybridization analysis of chromosome 12p abnormalities is useful for distinguishing epidermoid cysts of the testis from pure mature teratoma
    Liang Cheng
    Departments of Pathology and Laboratory Medicine, Indiana University School of Medicine, 350 West 11th Street, Indianapolis, IN 46202, USA
    Clin Cancer Res 12:5668-72. 2006
    ..In this study, we investigated the clinical utility of interphase fluorescence in situ hybridization (FISH) analysis of chromosome 12p abnormalities for distinguishing epidermoid cysts of the testis from pure mature teratoma...
  72. ncbi request reprint Expression of CD117 (c-kit) receptor in dysgerminoma of the ovary: diagnostic and therapeutic implications
    Michael Sever
    Department of Pathology and Laboratory Medicine, Indiana University, Indianapolis, IN 46202, USA
    Mod Pathol 18:1411-6. 2005
    ..Although the prognosis of patients with dysgerminoma is generally good, this receptor could potentially serve as a target for site-specific immunotherapy as an alternative and/or complement to conventional treatment options...
  73. doi request reprint Epidermal growth factor receptor protein expression and gene amplification in the chemorefractory metastatic embryonal carcinoma
    Xiaoyan Wang
    Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Mod Pathol 22:7-12. 2009
    ..EGFR chromosomal polysomy/amplification may be one of the mechanisms that cause increased EGFR protein expression, and could potentially be used as indication for anti-EGFR therapy...
  74. ncbi request reprint Divergent pathway of intestinal metaplasia and cystitis glandularis of the urinary bladder
    Ming Tse Sung
    Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Mod Pathol 19:1395-401. 2006
    ....
  75. ncbi request reprint Molecular genetic evidence of an independent origin of serous low malignant potential implants and lymph node inclusions
    Robert E Emerson
    Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Int J Gynecol Pathol 26:387-94. 2007
    ..However, in at least some cases, the implants and inclusions seem to arise independently from the associated ovarian serous LMP tumors...
  76. ncbi request reprint Molecular genetic evidence supporting the neoplastic nature of the Leydig cell component of ovarian Sertoli-Leydig cell tumors
    Robert E Emerson
    Department of Pathology, Indiana University, Indianapolis, Indiana, USA
    Int J Gynecol Pathol 26:368-74. 2007
    ..Similarly, the heterologous components, when present, appear to share clonal origin with the Sertoli cell components...
  77. ncbi request reprint Expression of KISS1 and MMP-9 in non-small cell lung cancer and their relations to metastasis and survival
    Suqin Zheng
    Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, 350 West 11th Street, Clarian Pathology Laboratory Room 4010, Indianapolis, IN 46202, USA
    Anticancer Res 30:713-8. 2010
    ..4.7%, p<0.05). Our data suggest that KISS1 and MMP-9 may serve as potential prognostic and therapeutic markers in lung cancer...
  78. ncbi request reprint Renal cell carcinomas with papillary architecture and clear cell components: the utility of immunohistochemical and cytogenetical analyses in differential diagnosis
    Stefano Gobbo
    Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Am J Surg Pathol 32:1780-6. 2008
    ..Despite these ancillary techniques, 2 cases remained unclassified. Our study establishes the utility of these procedures in accurately classifying the great majority of renal cell carcinomas with these findings...
  79. ncbi request reprint Prostate needle biopsies: multiple variables are predictive of final tumor volume in radical prostatectomy specimens
    Chistopher K Poulos
    Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Cancer 101:527-32. 2004
    ..The current study attempted to identify the biopsy variables that are most predictive of final tumor volume...
  80. ncbi request reprint Renal mucinous tubular and spindle carcinoma lacks the gains of chromosomes 7 and 17 and losses of chromosome Y that are prevalent in papillary renal cell carcinoma
    Paolo Cossu-Rocca
    Department of Pathology, Indiana University Medical Center, University Hospital, Indianapolis, IN 46202, USA
    Mod Pathol 19:488-93. 2006
    ..FISH analysis with centromeric probes for these chromosomes is potentially helpful in differentiating mucinous tubular and spindle cell carcinomas from papillary renal cell carcinomas...
  81. ncbi request reprint Classical pathology versus molecular pathology in renal cell carcinoma
    Peggy Soung Sullivan
    Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, 10833 Le Conte Avenue, CHS A7 149, Los Angeles, CA 90095, USA
    Curr Urol Rep 8:5-11. 2007
    ....
  82. ncbi request reprint Application of molecular diagnostic techniques to renal epithelial neoplasms
    Timothy D Jones
    Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indiana University Medical Center, University Hospital, Indianapolis, IN 46202, USA
    Clin Lab Med 25:279-303. 2005
    ....
  83. ncbi request reprint Elevated expression of angiogenin in prostate cancer and its precursors
    Terrence M Katona
    Department of Pathology and Laboratory Medicine, Indiana University School of Medicine and Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, Indiana 46202, USA
    Clin Cancer Res 11:8358-63. 2005
    ..In this study, we have investigated the expression of angiogenin in prostatic adenocarcinoma, high-grade prostatic intraepithelial neoplasia, and adjacent benign prostatic epithelium in a large cohort of prostatectomy specimens...
  84. ncbi request reprint Role of molecular markers in diagnosis and prognosis of renal cell carcinoma
    Guido Martignoni
    Department of Pathology, University of Verona, Verona, Italy
    Anal Quant Cytol Histol 29:41-9. 2007
    ..A wide variety of molecular markers have been examined, but further research is required to prove their value as prognostic tools...
  85. ncbi request reprint Invasion of fat justifies assignment of stage pT3a in prostatic adenocarcinoma
    Ming Tse Sung
    Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis 46202, USA
    Pathology 38:309-11. 2006
    ....
  86. ncbi request reprint OCT4 staining in testicular tumors: a sensitive and specific marker for seminoma and embryonal carcinoma
    Timothy D Jones
    Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN, USA
    Am J Surg Pathol 28:935-40. 2004
    ..OCT4 immunostaining has comparable sensitivity but greater consistency compared with CD30 in the diagnosis of embryonal carcinoma...
  87. ncbi request reprint Preoperative prediction of Gleason grade in radical prostatectomy specimens: the influence of different Gleason grades from multiple positive biopsy sites
    Chistopher K Poulos
    Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Mod Pathol 18:228-34. 2005
    ..We recommend that the highest Gleason score from all positive biopsy sites should be used when assigning an initial score using needle biopsies...
  88. ncbi request reprint Papillary renal cell carcinoma with oncocytic cells and nonoverlapping low grade nuclei: expanding the morphologic spectrum with emphasis on clinicopathologic, immunohistochemical and molecular features
    Lakshmi P Kunju
    Department of Pathology, University of Michigan School of Medicine, Ann Arbor, MI 48109, USA
    Hum Pathol 39:96-101. 2008
    ..Morphologic spectrum of these PRCCs emphasizes that the future prognostic model of PRCC may need to be based primarily on the nuclear characteristics, irrespective of the cytoplasmic features...
  89. doi request reprint Interobserver reproducibility in the diagnosis of invasive micropapillary carcinoma of the urinary tract among urologic pathologists
    Ankur R Sangoi
    Department of Pathology, Stanford University, Stanford, CA, USA
    Am J Surg Pathol 34:1367-76. 2010
    ..These findings suggest that more study of IMPC is needed to identify the individual pathologic features that might potentially correlate with an aggressive outcome and response to intravesical therapy...
  90. ncbi request reprint Evaluation of HER-2/neu expression in prostatic adenocarcinoma: a requested for a standardized, organ specific methodology
    Katya M Sanchez
    Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA
    Cancer 95:1650-5. 2002
    ..Some evidence suggests a role for HER-2/neu overexpression in prostate carcinoma progression. Reported rates of HER-2/neu overexpression in patients with prostate carcinoma vary greatly...
  91. ncbi request reprint Small cell carcinoma of the prostate: an immunohistochemical study
    Jorge L Yao
    Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, and Department of Pathology, Rochester General Hospital, Rochester, NY 14642, USA
    Am J Surg Pathol 30:705-12. 2006
    ..Immunohistochemical markers can help separate SCPC from HGPC and may be useful in histologically borderline cases. Potential therapeutic targets are identified immunohistochemically in SCPC (Bombesin/GRP, c-kit, bcl-2, and EGFR)...
  92. ncbi request reprint Clonal divergence and genetic heterogeneity in clear cell renal cell carcinomas with sarcomatoid transformation
    Timothy D Jones
    Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, 46202, USA
    Cancer 104:1195-203. 2005
    ..Analysis of the pattern of allelic loss and X-chromosome inactivation in both the clear cell and sarcomatoid components of the same tumor allows assessment of the genetic relationship of these tumor elements...
  93. ncbi request reprint Acquired cystic disease-associated renal tumors: an immunohistochemical and fluorescence in situ hybridization study
    Paolo Cossu-Rocca
    Department of Pathology and Laboratory Medicine, Indiana University, Indianapolis, IN 46202, USA
    Mod Pathol 19:780-7. 2006
    ....
  94. doi request reprint Schwannoma of the kidney
    Stefano Gobbo
    Department of Pathology and Laboratory Medicine, Indiana University, Indianapolis, IN 46202, USA
    Mod Pathol 21:779-83. 2008
    ..In conclusion, renal schwannoma is rare, usually arises centrally, impinging on the hilum or the pelvis, and is cured by resection. Sarcomatoid carcinoma and other spindle cell tumors should be considered in the differential diagnosis...
  95. doi request reprint Interphase cytogenetic analysis with centromeric probes for chromosomes 1, 2, 6, 10, and 17 in 11 tumors from a patient with bilateral renal oncocytosis
    Paolo Cossu-Rocca
    Department of Pathology and Laboratory Medicine, Indiana University, Indianapolis, IN, USA
    Mod Pathol 21:498-504. 2008
    ..These observations weigh against the concept that hybrid tumors of oncocytosis are closely related to chromophobe renal cell carcinoma...
  96. ncbi request reprint Anatomic distribution of periprostatic adipose tissue: a mapping study of 100 radical prostatectomy specimens
    Heng Hong
    Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA
    Cancer 97:1639-43. 2003
    ..However, the distribution of adipose tissue along the prostatic surfaces has not been studied extensively...
  97. ncbi request reprint Gains of chromosomes 7, 17, 12, 16, and 20 and loss of Y occur early in the evolution of papillary renal cell neoplasia: a fluorescent in situ hybridization study
    Matteo Brunelli
    Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202 5120, USA
    Mod Pathol 16:1053-9. 2003
    ..Progressive gains of these chromosomes do not appear to correlate with the transition from adenoma to carcinoma...
  98. ncbi request reprint Phase I/II trial of high intensity focused ultrasound for the treatment of previously untreated localized prostate cancer
    Michael O Koch
    Department of Urology, Indiana University School of Medicine and Focus Surgery, Inc, Indianapolis, Indiana 46202, USA
    J Urol 178:2366-70; discussion 2370-1. 2007
    ..We examined the safety and potential efficacy of transrectally delivered high intensity focused ultrasound for the full gland ablation of previously untreated localized prostate cancer...
  99. ncbi request reprint Metanephric adenoma lacks the gains of chromosomes 7 and 17 and loss of Y that are typical of papillary renal cell carcinoma and papillary adenoma
    Matteo Brunelli
    Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202 5120, USA
    Mod Pathol 16:1060-3. 2003
    ..Genetic analysis of chromosomes 7, 17, and Y may facilitate discrimination of metanephric adenoma from papillary renal cell carcinoma in difficult cases...
  100. ncbi request reprint Heterogeneity of Gleason grade in multifocal adenocarcinoma of the prostate
    Rebecca Arora
    Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Cancer 100:2362-6. 2004
    ..The current study was undertaken to compare the Gleason grades of individual adenocarcinoma foci in a given specimen with the overall Gleason grades (primary and secondary) of that specimen...
  101. doi request reprint CD44 expression is a feature of prostatic small cell carcinoma and distinguishes it from its mimickers
    Rochelle A Simon
    Department of Pathology, University of Rochester Medical Center, Rochester, NY 14642, USA
    Hum Pathol 40:252-8. 2009
    ....