Soft tissue tumors of the prostate: a reviewDavid G Wagner
Department of Pathology, University of Rochester Medical Center, 601 Elmwood Avenue, New York 14642, USA
Anal Quant Cytol Histol 29:341-50. 2007
..Diagnostic immunohistochemistry is an important adjunct to histopathology for proper diagnosis and tumor subclassification...
Laser-assisted microdissection in translational research: theory, technical considerations, and future applicationsLiang Cheng
Departments of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis 46202, USA
Appl Immunohistochem Mol Morphol 21:31-47. 2013
..In this review, we also discuss the technical details of tissue preparation, analytical yields, tissue selection, and selected applications using LCM...
- Histologic grading of urothelial carcinoma: a reappraisal
Liang Cheng
Department of Pathology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
Hum Pathol 43:2097-108. 2012
..Recent advances in the molecular grading of these tumors may eventually supplant traditional morphologic grading systems, allowing a more precise and objective assessment of the tumors' biologic potentials...
- KRAS testing in clinical laboratory: optimizing targeted therapy
Leticia Miravalle
Department of Pathology, Indiana University School of Medicine, IN 46202, U S A
Cancer Genomics Proteomics 9:337-41. 2012
..Several methods for KRAS mutation detection have been described in the literature. Most of these are laboratory developed tests and only a few commercial assays are currently available...
- Molecular pathology of lung cancer: key to personalized medicine
Liang Cheng
Departments of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN, USA
Mod Pathol 25:347-69. 2012
..Understanding these mechanisms may provide new treatment avenues and improve current treatment algorithms...
- Staging of prostate cancer
Liang Cheng
Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
Histopathology 60:87-117. 2012
..We recommend that a future TNM staging system should consider subclassification of node-positive cancer on the basis of nodal cancer volume, using the diameter of the largest nodal metastasis and/or the number of positive nodes...
How much do you know about benign, preneoplastic, non-invasive and invasive neoplastic lesions of the urinary bladder classified according to the 2004 WHO scheme?Rodolfo Montironi
Section of Pathological Anatomy, School of Medicine, Polytechnic University of the Marche Region Ancona, Ancona, Italy
Diagn Pathol 6:31. 2011
..This paper is directed to all who are involved with the application of this classification at the anticancer research, diagnostic, prognostic and therapeutic levels, in particular to uropathologists, urologists and oncologists...
- The origins of urothelial carcinoma
Liang Cheng
Departments of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN, USA
Expert Rev Anticancer Ther 10:865-80. 2010
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- Eosinophilic metaplasia of the prostate: a newly described lesion distinct from other eosinophilic changes in prostatic epithelium
Liang Cheng
Department of Pathology, Indiana University, Indianapolis, Indiana, USA
Anal Quant Cytol Histol 30:226-30. 2008
..To describe the morphologic, immunohistochemical and ultrastructural features of large, intensely eosinophilic cytoplasmic granules in prostatic epithelial cells in the benign prostate, as well as the prevalence of this condition...
- Overdiagnosis of bladder carcinoma
Liang Cheng
Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
Anal Quant Cytol Histol 30:261-4. 2008
..To describe a group of archival patients who were overdiagnosed with bladder cancer according to contemporary criteria...
- Molecular determinants of tumor recurrence in the urinary bladder
Liang Cheng
Department of Pathology and Laboratory Medicine and Urology, Indiana University School of Medicine, 350 West 11th Street, Clarian Pathology Laboratory, Indianapolis, IN 46202, USA
Future Oncol 5:843-57. 2009
..A unifying model of urothelial carcinogenesis, tumor recurrence and progression is proposed in this review...
- Molecular and cytogenetic insights into the pathogenesis, classification, differential diagnosis, and prognosis of renal epithelial neoplasms
Liang Cheng
Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
Hum Pathol 40:10-29. 2009
....
- Evidence for polyclonal origin of multifocal clear cell renal cell carcinoma
Liang Cheng
Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
Clin Cancer Res 14:8087-93. 2008
..Renal cell carcinomas are often multifocal. We investigated the genomic signatures of multifocal clear cell renal cell carcinoma to determine whether multiple tumors in the same kidney bear a clonal relationship to one another...
- Bladder cancer: translating molecular genetic insights into clinical practice
Liang Cheng
Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
Hum Pathol 42:455-81. 2011
....
- Morphologic, immunohistochemical, and fluorescence in situ hybridization study of ovarian embryonal carcinoma with comparison to solid variant of yolk sac tumor and immature teratoma
Liang Cheng
Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
Hum Pathol 41:716-23. 2010
..Chromosome 12p fluorescence in situ hybridization combined with OCT4, CD30, and glypican 3 immunostains is useful in confirming the diagnosis of ovarian embryonal carcinoma...
- Staging and reporting of urothelial carcinoma of the urinary bladder
Liang Cheng
Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, 350 West 11th Street, Clarian Pathology Laboratory Room 4010, Indianapolis, IN 46202, USA
Mod Pathol 22:S70-95. 2009
..This review will discuss recent progress and controversial issues on the staging and substaging of bladder carcinomas. Essential elements for handling and reporting of bladder tumor specimens will also be discussed...
- Atypical sclerosing adenosis of the prostate: a rare mimic of adenocarcinoma
Liang Cheng
Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
Histopathology 56:627-31. 2010
..It is incidentally found in about 2% of transurethral resection specimens. The aim was to describe cases with significant cytological atypia mimicking cancer, which have not been previously reported...
- Percentage of Gleason pattern 4 and 5 predicts survival after radical prostatectomy
Liang Cheng
Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
Cancer 110:1967-72. 2007
..The objective of the current study was to determine whether the combined percentage of Gleason patterns 4 and 5 in radical prostatectomy specimens is an independent predictor of cancer-specific survival in prostate cancer patients...
- Inflammatory myofibroblastic tumors of the genitourinary tract--single entity or continuum?
Liang Cheng
Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
J Urol 180:1235-40. 2008
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- Sarcomatoid carcinoma of the urinary bladder: the final common pathway of urothelial carcinoma dedifferentiation
Liang Cheng
Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN, USA
Am J Surg Pathol 35:e34-46. 2011
..We emphasize the importance of molecular genetic studies in providing insight into the histogenesis of this neoplasm. Sarcomatoid carcinoma seems to represent the final common pathway of urothelial carcinoma dedifferentiation...
- The clinical and therapeutic implications of cancer stem cell biology
Liang Cheng
Department of Pathology, Indiana University School of Medicine, 350 West 11th Street, Room 4010, Indianapolis, IN 4620, USA
Expert Rev Anticancer Ther 11:1131-43. 2011
..It is noteworthy that CSCs are the only cells capable of sustaining tumorigenesis; however, the cell of origin of cancer, in which tumorigenesis is initiated, may be distinct from CSCs that propagate the tumor...
- KIT gene mutation and amplification in dysgerminoma of the ovary
Liang Cheng
Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA
Cancer 117:2096-103. 2011
..The purpose of this study was to analyze alterations of the KIT gene in a large series of dysgerminomas and correlate the findings with clinicopathological parameters...
- Molecular genetic evidence supporting the origin of somatic-type malignancy and teratoma from the same progenitor cell
Jennifer B Kum
Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
Am J Surg Pathol 36:1849-56. 2012
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- Preoperative prediction of small volume cancer (less than 0.5 ml) in radical prostatectomy specimens
Liang Cheng
Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, USA
J Urol 174:898-902. 2005
..We examined various clinical parameters and prostate biopsy features to determine which variables are most predictive of small volume (less than 0.5 ml) cancer at prostatectomy...
- Amplifications of EGFR gene and protein expression of EGFR, Her-2/neu, c-kit, and androgen receptor in phyllodes tumor of the prostate
Xiaoyan Wang
Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
Mod Pathol 20:175-82. 2007
..Anti-EGFR and/or antiandrogen agents may be potentially useful for management of patients with tumors expressing EGFR and/or androgen receptor...
- Telomere shortening and chromosomal abnormalities in intestinal metaplasia of the urinary bladder
Michael J Morton
Department of Pathology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
Clin Cancer Res 13:6232-6. 2007
..We used quantitative fluorescent in situ hybridization (FISH) to measure telomere length and UroVysion FISH to detect cytogenetic abnormalities in urinary bladder specimens with intestinal metaplasia...
- Renal cell neoplasms of oncocytosis have distinct morphologic, immunohistochemical, and cytogenetic profiles
Stefano Gobbo
Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN, USA
Am J Surg Pathol 34:620-6. 2010
..In summary, the renal cell neoplasms of oncocytosis seem to have distinct morphologic, immunohistochemical, and cytogenetic profiles and likely are a distinct entity, not closely related to oncocytoma or chromophobe renal cell carcinoma...
- Sarcomatoid carcinoma of the upper urinary tract: clinical outcome and molecular characterization
Xiaoyan Wang
Department of Pathology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
Hum Pathol 40:211-7. 2009
..Gains of chromosome 3, 7, and 17 and loss of chromosome 9p21 were commonly observed in these tumors. Our findings suggest that targeted therapy may be a rational strategy in the management of these patients...
- Lymphovascular invasion is an independent prognostic factor in prostatic adenocarcinoma
Liang Cheng
Departments of Pathology and Laboratory Medicine, Indiana University School of Medicine, Medical Center, University Hospital 3465, 550 North University Boulevard, Indianapolis, IN 46202, USA
J Urol 174:2181-5. 2005
..We retrospectively investigated lymphovascular invasion as a predictive factor for biochemical failure and cancer specific survival following radical prostatectomy...
- Evidence for common clonal origin of multifocal lung cancers
Xiaoyan Wang
Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, 350 West 11th Street, Clarian Pathology Laboratory, Indianapolis, IN 46202, USA
J Natl Cancer Inst 101:560-70. 2009
..Lung cancer is the most common cause of cancer death in the United States. Multiple anatomically separate but histologically similar lung tumors are often found in the same patient. The clonal origin of multiple lung tumors is uncertain...
- Epidermal growth factor receptor protein expression and gene amplification in small cell carcinoma of the urinary bladder
Xiaoyan Wang
Department of Pathology, Indiana University, Indianapolis, Indiana 46202, USA, and United Hospitals, Ancona, Italy
Clin Cancer Res 13:953-7. 2007
..This study was done to investigate EGFR protein expression and gene amplification in a large series of small cell carcinomas of the urinary bladder...
- Clonal evidence for the progression of a testicular germ cell tumor to angiosarcoma
Muhammad T Idrees
Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
Hum Pathol 41:139-44. 2010
..The results indicated a clonal origin of the tumors, which supports that angiosarcoma, as well as the teratomas, arose from the testicular germ cell tumors...
- TP53 mutational analysis supports monoclonal origin of biphasic sarcomatoid urothelial carcinoma (carcinosarcoma) of the urinary bladder
Andrew B Armstrong
Department of Pathology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
Mod Pathol 22:113-8. 2009
..Our results suggest that despite their conspicuous divergence at the phenotypic level, the sarcomatoid and carcinomatoid elements of this uncommon tumor share a common clonal origin...
- Epidermal growth factor receptor (EGFR) expression in prostatic adenocarcinoma after hormonal therapy: a fluorescence in situ hybridization and immunohistochemical analysis
Rebecca A Marks
Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA
Prostate 68:919-23. 2008
..Activation of epidermal growth factor receptor (EGFR) has been implicated in prostate cancer cell growth...
- Mixed epithelial and stromal tumors of the kidney: evidence for a single cell of origin with capacity for epithelial and stromal differentiation
Jennifer Bup Jong Kum
Department of Pathology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
Am J Surg Pathol 35:1114-22. 2011
..Our data support the theory that the stroma and epithelium arise from a common cell of origin...
- Molecular genetic evidence for a common clonal origin of urinary bladder small cell carcinoma and coexisting urothelial carcinoma
Liang Cheng
Department of Pathology and Laboratory Medicine, Indiana University Medical Center, University Hospital 3465, 550 North University Boulevard, Indianapolis, Indiana 46202, USA
Am J Pathol 166:1533-9. 2005
..Concordant genetic alterations and X chromosome inactivation between small-cell carcinoma and coexisting urothelial carcinoma suggest that both tumor components originate from the same cells in the urothelium...
- Clonal origin of metastatic testicular teratomas
Timothy D Jones
Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA, and Department of Pathology, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Kaohsiung, Taiwan
Clin Cancer Res 12:5377-83. 2006
..CONCLUSION: Our data support the common clonal origin of metastatic mature teratomas with other components of metastatic testicular GCTs and with each component of the primary tumor...
- Molecular genetic evidence for the independent origin of multifocal papillary tumors in patients with papillary renal cell carcinomas
Timothy D Jones
Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
Clin Cancer Res 11:7226-33. 2005
..Thus, intrarenal metastasis does not seem to play an important role in the spread of papillary renal cell carcinoma, a finding that has surgical, therapeutic, and prognostic implications...
- Clonality and TP53 mutation analysis of focal nodular hyperplasia of the liver
Suqin Zheng
Dept of Pathology and Laboratory Medicine, Indiana University, Indianapolis, 46202, USA
Am J Clin Pathol 134:65-70. 2010
..Our data indicate that a significant proportion of FNH lesions have a monoclonal origin, suggesting that they are neoplastic rather than reactive...
- Urothelial carcinoma with an inverted growth pattern can be distinguished from inverted papilloma by fluorescence in situ hybridization, immunohistochemistry, and morphologic analysis
Timothy D Jones
Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
Am J Surg Pathol 31:1861-7. 2007
..Morphologic features, as well as immunohistochemical stains (including stains for Ki-67, p53, and cytokeratin 20) and/or UroVysion FISH can help to distinguish inverted papilloma from urothelial carcinoma with an inverted growth pattern...
- Radical prostatectomy as initial monotherapy for patients with pathologically confirmed high-grade prostate cancer
Clint D Bahler
Department of Urology, Indiana University Medical Center, Indianapolis, IN 46202, USA
BJU Int 105:1372-6. 2010
..To report the long-term outcome of high-grade prostate cancer treated with radical prostatectomy (RP) as initial monotherapy, analyse the effect of clinical and pathological variables on survival, and report cancer-related symptoms...
- Radial distance of extraprostatic extension measured by ocular micrometer is an independent predictor of prostate-specific antigen recurrence: A new proposal for the substaging of pT3a prostate cancer
Ming Tse Sung
Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA
Am J Surg Pathol 31:311-8. 2007
..The strength of its prognostic value for PSA recurrence makes it a potential criterion for incorporation into a future tumor, lymph node, metastasis staging system...
- Is atypical adenomatous hyperplasia of the prostate a precursor lesion?
Chen Zhang
Department of Pathology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
Prostate 71:1746-51. 2011
..Alpha-methylacyl-CoA racemase (AMACR) is highly expressed in prostatic adenocarcinoma. The precursor nature of atypical adenomatous hyperplasia (AAH) is uncertain...
- Laser capture microdissection analysis reveals frequent allelic losses in papillary urothelial neoplasm of low malignant potential of the urinary bladder
Liang Cheng
Department of Pathology and Laboratory Medicine, School of Medicine, Indiana University Medical Center, University Hospital 3465, 550 North University Boulevard, Indianapolis, IN 46202, USA
Cancer 101:183-8. 2004
..The biologic potential of PUNLMP of the urinary bladder is controversial. To the authors' knowledge, information regarding the genetic changes of PUNLMP tumors of the bladder is limited...
- Clear cell papillary renal cell carcinoma: a distinct histopathologic and molecular genetic entity
Stefano Gobbo
Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
Am J Surg Pathol 32:1239-45. 2008
..This tumor has immunophenotypic and genetic profiles distinct from those of either classic papillary or clear cell renal cell carcinoma, and should be considered a distinct entity in the spectrum of renal cell neoplasia...
- Hypermethylation of tumor-suppressor gene CpG islands in small-cell carcinoma of the urinary bladder
Phillip H Abbosh
Department of Pathology, Indiana University, Indianapolis, IN, USA
Mod Pathol 21:355-62. 2008
..These findings suggest that SCBC and TCC have common origins, establish DNA methylation of some tumor suppressors as frequent occurrences in both histopathologies, and suggest that MGMT methylation may be an SCBC-specific epimutation...
- Genetically heterogeneous and clonally unrelated metastases may arise in patients with cutaneous melanoma
Terrence M Katona
Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
Am J Surg Pathol 31:1029-37. 2007
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- The relationship between the extent of surgical margin positivity and prostate specific antigen recurrence in radical prostatectomy specimens
Rebecca A Marks
Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
Hum Pathol 38:1207-11. 2007
....
- Lymphoepithelioma-like carcinoma of the urinary bladder: clinicopathologic, immunohistochemical, and molecular features
Sean R Williamson
Department of Pathology, Indiana University School of Medicine, Indianapolis, IN, USA
Am J Surg Pathol 35:474-83. 2011
..Investigation of immunohistochemical and molecular characteristics of bladder LELC is limited. The pathogenesis and biological behavior of these tumors are controversial...
- Small cell carcinoma of the urinary bladder: a clinicopathologic analysis of 64 patients
Liang Cheng
Department of Pathology and Laboratory Medicine, Indiana University, Indianapolis 46202, USA
Cancer 101:957-62. 2004
..Small cell carcinoma of the urinary bladder is an uncommon tumor that has been described in case reports or small series. Herein, the authors report a series of 64 patients with small cell carcinoma of the urinary bladder...
- Molecular genetic evidence for different clonal origins of epithelial and stromal components of phyllodes tumor of the prostate
Ryan P McCarthy
Department of Pathology and Laboratory Medicine, Indiana University Medical Center, University Hospital 3465, 550 North University Blvd, Indianapolis, IN 46202, USA
Am J Pathol 165:1395-400. 2004
..While both epithelium and stroma are clonal proliferations, they appear to have different clonal origins...
- Elevated expression of cancer-associated proliferating cell nuclear antigen in high-grade prostatic intraepithelial neoplasia and prostate cancer
Xiaoyan Wang
Department of Pathology, Indiana University School of Medicine, Indianapolis, Indiana, USA
Prostate 71:748-54. 2011
..The expression and potential utility of this marker in prostatic neoplasia is uncertain. With the development of this new caPCNA selective antibody, we explored the potential utility of this marker in prostate cancer...
- Thyroid transcription factor 1 expression in small cell carcinoma of the urinary bladder: an immunohistochemical profile of 44 cases
Timothy D Jones
Department of Pathology and Laboratory Medicine, Indiana University, Indianapolis, IN 46202, USA
Hum Pathol 36:718-23. 2005
..TTF-1 positivity is not a significant prognostic factor in small cell carcinoma of the urinary bladder...
- Aberrant expression of CARM1, a transcriptional coactivator of androgen receptor, in the development of prostate carcinoma and androgen-independent status
Heng Hong
Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, University Hospital 3465, University Medical Center, 550 North University Boulevard, Indianapolis, IN 46202, USA
Cancer 101:83-9. 2004
..It is involved in the regulation of the biologic functions of the AR. It remains to be determined whether CARM1 is involved in prostatic carcinogenesis...
- A water soluble parthenolide analog suppresses in vivo tumor growth of two tobacco-associated cancers, lung and bladder cancer, by targeting NF-κB and generating reactive oxygen species
Rajasubramaniam Shanmugam
Department of Medicine, Indiana University, Indianapolis, IN, USA
Int J Cancer 128:2481-94. 2011
..The data provides support for the conduct of clinical trials in TCC and NSCLC...
- Does the presence of extranodal extension in pathological stage B1 nonseminomatous germ cell tumor necessitate adjuvant chemotherapy?
Stephen D W Beck
Department of Urology, Indiana University, Indianapolis, Indiana 46202, USA
J Urol 177:944-6. 2007
..We decided to evaluate the significance of extranodal extension on disease-free survival in patients with pathological stage B nonseminomatous germ cell tumor who did not receive adjuvant chemotherapy...
- Does the size matter?: Prostate weight does not predict PSA recurrence after radical prostatectomy
Darrell D Davidson
Dept of Pathology, Indiana University School of Medicine, Indianapolis, 46202, USA
Am J Clin Pathol 133:662-8. 2010
..Although increasing prostate weight correlates with increased patient age and higher preoperative PSA level, it does not independently predict postoperative cancer recurrence...
- Down-regulation of fragile histidine triad expression in prostate carcinoma
Rebecca L Fouts
Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA
Cancer 97:1447-52. 2003
..Numerous studies have indicated that the FHIT gene on chromosome 3p may play an important role in human neoplasia, although very few studies have investigated the FHIT gene in prostate carcinoma...
- Chromosome 12p abnormalities in dysgerminoma of the ovary: a FISH analysis
Paolo Cossu-Rocca
Department of Pathology, Indiana University, Indianapolis, IN 46202, USA
Mod Pathol 19:611-5. 2006
..FISH analyses for chromosome 12p abnormalities may be a useful diagnostic adjunct for confirming the diagnosis of dysgerminoma and for distinguishing it from nongerm cell malignancies that enter into the differential diagnosis...
- The combined percentage of Gleason patterns 4 and 5 is the best predictor of cancer progression after radical prostatectomy
Liang Cheng
Department of Pathology and Laboratory Medicine, Indiana University Medical Center, University Hospital 3465, 550 N University Blvd, Indianapolis, IN 46202, USA
J Clin Oncol 23:2911-7. 2005
..We evaluated the significance of the relative proportion of high-grade cancer (Gleason patterns 4 and/or 5) in predicting cancer progression in prostate cancer patients treated with radical prostatectomy...
- Expression of KISS1 and MMP-9 in non-small cell lung cancer and their relations to metastasis and survival
Suqin Zheng
Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, 350 West 11th Street, Clarian Pathology Laboratory Room 4010, Indianapolis, IN 46202, USA
Anticancer Res 30:713-8. 2010
..4.7%, p<0.05). Our data suggest that KISS1 and MMP-9 may serve as potential prognostic and therapeutic markers in lung cancer...
- Molecular genetic evidence supporting the neoplastic nature of the Leydig cell component of ovarian Sertoli-Leydig cell tumors
Robert E Emerson
Department of Pathology, Indiana University, Indianapolis, Indiana, USA
Int J Gynecol Pathol 26:368-74. 2007
..Similarly, the heterologous components, when present, appear to share clonal origin with the Sertoli cell components...
- Molecular genetic evidence of an independent origin of serous low malignant potential implants and lymph node inclusions
Robert E Emerson
Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
Int J Gynecol Pathol 26:387-94. 2007
..However, in at least some cases, the implants and inclusions seem to arise independently from the associated ovarian serous LMP tumors...
- Molecular genetic alterations in the laser-capture-microdissected stroma adjacent to bladder carcinoma
Ryan F Paterson
Department of Urology, Indiana University School of Medicine, Indianapolis, Indianapolis 46202, USA
Cancer 98:1830-6. 2003
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- Fluorescence in situ hybridization analysis of chromosome 12p in paraffin-embedded tissue is useful for establishing germ cell origin of metastatic tumors
Kevin M Kernek
Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
Mod Pathol 17:1309-13. 2004
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- Epidermal growth factor receptor protein expression and gene amplification in the chemorefractory metastatic embryonal carcinoma
Xiaoyan Wang
Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
Mod Pathol 22:7-12. 2009
..EGFR chromosomal polysomy/amplification may be one of the mechanisms that cause increased EGFR protein expression, and could potentially be used as indication for anti-EGFR therapy...
- Renal cell carcinomas with papillary architecture and clear cell components: the utility of immunohistochemical and cytogenetical analyses in differential diagnosis
Stefano Gobbo
Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
Am J Surg Pathol 32:1780-6. 2008
..Despite these ancillary techniques, 2 cases remained unclassified. Our study establishes the utility of these procedures in accurately classifying the great majority of renal cell carcinomas with these findings...
- Interphase fluorescence in situ hybridization analysis of chromosome 12p abnormalities is useful for distinguishing epidermoid cysts of the testis from pure mature teratoma
Liang Cheng
Departments of Pathology and Laboratory Medicine, Indiana University School of Medicine, 350 West 11th Street, Indianapolis, IN 46202, USA
Clin Cancer Res 12:5668-72. 2006
..In this study, we investigated the clinical utility of interphase fluorescence in situ hybridization (FISH) analysis of chromosome 12p abnormalities for distinguishing epidermoid cysts of the testis from pure mature teratoma...
- Expression of CD117 (c-kit) receptor in dysgerminoma of the ovary: diagnostic and therapeutic implications
Michael Sever
Department of Pathology and Laboratory Medicine, Indiana University, Indianapolis, IN 46202, USA
Mod Pathol 18:1411-6. 2005
..Although the prognosis of patients with dysgerminoma is generally good, this receptor could potentially serve as a target for site-specific immunotherapy as an alternative and/or complement to conventional treatment options...
- Maximum tumor diameter is an independent predictor of prostate-specific antigen recurrence in prostate cancer
Lori E Eichelberger
Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
Mod Pathol 18:886-90. 2005
..13-2.56, P=0.01), controlling for risk factors, Gleason score, and surgical margin status. We conclude that maximum tumor diameter is a significant predictor of biochemical recurrence in patients with prostate cancer...
- Divergent pathway of intestinal metaplasia and cystitis glandularis of the urinary bladder
Ming-Tse Sung
Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
Mod Pathol 19:1395-401. 2006
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- Prostate needle biopsies: multiple variables are predictive of final tumor volume in radical prostatectomy specimens
Chistopher K Poulos
Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
Cancer 101:527-32. 2004
..Although these preoperative biopsy parameters were significant in linear regression models, none was sufficient as a single predictor of tumor volume...
- Application of molecular diagnostic techniques to renal epithelial neoplasms
Timothy D Jones
Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indiana University Medical Center, University Hospital, Indianapolis, IN 46202, USA
Clin Lab Med 25:279-303. 2005
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- Classical pathology versus molecular pathology in renal cell carcinoma
Peggy Soung Sullivan
Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, 10833 Le Conte Avenue, CHS A7 149, Los Angeles, CA 90095, USA
Curr Urol Rep 8:5-11. 2007
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- Renal mucinous tubular and spindle carcinoma lacks the gains of chromosomes 7 and 17 and losses of chromosome Y that are prevalent in papillary renal cell carcinoma
Paolo Cossu-Rocca
Department of Pathology, Indiana University Medical Center, University Hospital, Indianapolis, IN 46202, USA
Mod Pathol 19:488-93. 2006
..FISH analysis with centromeric probes for these chromosomes is potentially helpful in differentiating mucinous tubular and spindle cell carcinomas from papillary renal cell carcinomas...
- OCT4 staining in testicular tumors: a sensitive and specific marker for seminoma and embryonal carcinoma
Timothy D Jones
Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN, USA
Am J Surg Pathol 28:935-40. 2004
..OCT4 immunostaining has comparable sensitivity but greater consistency compared with CD30 in the diagnosis of embryonal carcinoma...
- Interobserver reproducibility in the diagnosis of invasive micropapillary carcinoma of the urinary tract among urologic pathologists
Ankur R Sangoi
Department of Pathology, Stanford University, Stanford, CA, USA
Am J Surg Pathol 34:1367-76. 2010
..These findings suggest that more study of IMPC is needed to identify the individual pathologic features that might potentially correlate with an aggressive outcome and response to intravesical therapy...
- Papillary renal cell carcinoma with oncocytic cells and nonoverlapping low grade nuclei: expanding the morphologic spectrum with emphasis on clinicopathologic, immunohistochemical and molecular features
Lakshmi P Kunju
Department of Pathology, University of Michigan School of Medicine, Ann Arbor, MI 48109, USA
Hum Pathol 39:96-101. 2008
..Morphologic spectrum of these PRCCs emphasizes that the future prognostic model of PRCC may need to be based primarily on the nuclear characteristics, irrespective of the cytoplasmic features...
- Role of molecular markers in diagnosis and prognosis of renal cell carcinoma
Guido Martignoni
Department of Pathology, University of Verona, Verona, Italy
Anal Quant Cytol Histol 29:41-9. 2007
..A wide variety of molecular markers have been examined, but further research is required to prove their value as prognostic tools...
- Invasion of fat justifies assignment of stage pT3a in prostatic adenocarcinoma
Ming-Tse Sung
Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis 46202, USA
Pathology 38:309-11. 2006
..Accordingly, the finding of carcinoma invading adipose tissue in needle biopsies should continue to be considered as extraprostatic extension and stage pT3a assigned...
- Evaluation of HER-2/neu expression in prostatic adenocarcinoma: a requested for a standardized, organ specific methodology
Katya M Sanchez
Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA
Cancer 95:1650-5. 2002
..The findings suggest that adenocarcinoma of the prostate should be evaluated for HER-2/neu expression with a prostate specific immunohistochemical procedure that differs from the FDA-approved standard procedure...
- Elevated expression of angiogenin in prostate cancer and its precursors
Terrence M Katona
Department of Pathology and Laboratory Medicine, Indiana University School of Medicine and Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, Indiana 46202, USA
Clin Cancer Res 11:8358-63. 2005
..In this study, we have investigated the expression of angiogenin in prostatic adenocarcinoma, high-grade prostatic intraepithelial neoplasia, and adjacent benign prostatic epithelium in a large cohort of prostatectomy specimens...
- Preoperative prediction of Gleason grade in radical prostatectomy specimens: the influence of different Gleason grades from multiple positive biopsy sites
Chistopher K Poulos
Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
Mod Pathol 18:228-34. 2005
..We recommend that the highest Gleason score from all positive biopsy sites should be used when assigning an initial score using needle biopsies...
- OCT4: a novel biomarker for dysgerminoma of the ovary
Liang Cheng
Departments of Pathology and Laboratory Medicine, Indiana University Medical Center, University Hospital 3465, 550 North University Boulevard, Indianapolis, IN 46202, USA
Am J Surg Pathol 28:1341-6. 2004
..OCT4 may aid in the detection of small foci of metastatic dygerminoma in extraovarian sites and may also help distinguish dysgerminoma from other primary and metastatic tumors of the ovary...
- Small cell carcinoma of the prostate: an immunohistochemical study
Jorge L Yao
Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, and Department of Pathology, Rochester General Hospital, Rochester, NY 14642, USA
Am J Surg Pathol 30:705-12. 2006
..Immunohistochemical markers can help separate SCPC from HGPC and may be useful in histologically borderline cases. Potential therapeutic targets are identified immunohistochemically in SCPC (Bombesin/GRP, c-kit, bcl-2, and EGFR)...
- Heterogeneity of Gleason grade in multifocal adenocarcinoma of the prostate
Rebecca Arora
Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
Cancer 100:2362-6. 2004
..These findings may have implications with respect to future biomarker and tissue array studies...
- Carcinomas of ovary and lung with clear cell features: can immunohistochemistry help in differential diagnosis?
Nicole R Howell
Department of Pathology, Stony Brook University Hospital, New York, NY, USA
Int J Gynecol Pathol 26:134-40. 2007
..Our results suggest that an immunohistochemical panel consisting of TTF-1, CEA, CA-125, and OCT-4 is helpful in distinguishing most pulmonary and ovarian carcinomas with clear cell features...
- Acquired cystic disease-associated renal tumors: an immunohistochemical and fluorescence in situ hybridization study
Paolo Cossu-Rocca
Department of Pathology and Laboratory Medicine, Indiana University, Indianapolis, IN 46202, USA
Mod Pathol 19:780-7. 2006
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- CD44 expression is a feature of prostatic small cell carcinoma and distinguishes it from its mimickers
Rochelle A Simon
Department of Pathology, University of Rochester Medical Center, Rochester, NY 14642, USA
Hum Pathol 40:252-8. 2009
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- Clonal divergence and genetic heterogeneity in clear cell renal cell carcinomas with sarcomatoid transformation
Timothy D Jones
Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, 46202, USA
Cancer 104:1195-203. 2005
..This genetic heterogeneity indicates genetic divergence during the clonal evolution of renal cell carcinoma...
- Interphase cytogenetic analysis with centromeric probes for chromosomes 1, 2, 6, 10, and 17 in 11 tumors from a patient with bilateral renal oncocytosis
Paolo Cossu-Rocca
Department of Pathology and Laboratory Medicine, Indiana University, Indianapolis, IN, USA
Mod Pathol 21:498-504. 2008
..These observations weigh against the concept that hybrid tumors of oncocytosis are closely related to chromophobe renal cell carcinoma...
- Schwannoma of the kidney
Stefano Gobbo
Department of Pathology and Laboratory Medicine, Indiana University, Indianapolis, IN 46202, USA
Mod Pathol 21:779-83. 2008
..In conclusion, renal schwannoma is rare, usually arises centrally, impinging on the hilum or the pelvis, and is cured by resection. Sarcomatoid carcinoma and other spindle cell tumors should be considered in the differential diagnosis...
- Phase I/II trial of high intensity focused ultrasound for the treatment of previously untreated localized prostate cancer
Michael O Koch
Department of Urology, Indiana University School of Medicine and Focus Surgery, Inc, Indianapolis, Indiana 46202, USA
J Urol 178:2366-70; discussion 2370-1. 2007
..We examined the safety and potential efficacy of transrectally delivered high intensity focused ultrasound for the full gland ablation of previously untreated localized prostate cancer...
- Gains of chromosomes 7, 17, 12, 16, and 20 and loss of Y occur early in the evolution of papillary renal cell neoplasia: a fluorescent in situ hybridization study
Matteo Brunelli
Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202-5120, USA
Mod Pathol 16:1053-9. 2003
..Progressive gains of these chromosomes do not appear to correlate with the transition from adenoma to carcinoma...
- Metanephric adenoma lacks the gains of chromosomes 7 and 17 and loss of Y that are typical of papillary renal cell carcinoma and papillary adenoma
Matteo Brunelli
Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202-5120, USA
Mod Pathol 16:1060-3. 2003
..Genetic analysis of chromosomes 7, 17, and Y may facilitate discrimination of metanephric adenoma from papillary renal cell carcinoma in difficult cases...
- Anatomic distribution of periprostatic adipose tissue: a mapping study of 100 radical prostatectomy specimens
Heng Hong
Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA
Cancer 97:1639-43. 2003
..Further refinement of the prostate carcinoma staging system is needed...
- Perineural invasion in radical prostatectomy specimens: lack of prognostic significance
James C Ng
Department of Urology, Indiana University School of Medicine, Indianapolis, Indiana, USA
J Urol 172:2249-51. 2004
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- Analysis of ovarian teratomas for isochromosome 12p: evidence supporting a dual histogenetic pathway for teratomatous elements
Christopher Poulos
Department of Pathology, Indiana University School of Medicine, Indianapolis, IN 46202-5280, USA
Mod Pathol 19:766-71. 2006
..Furthermore, the findings of i(12p) in both the teratomatous and nonteratomatous components of ovarian mixed GCTs supports that the teratoma derives from other components, similar to the situation in the testis...
- Tertiary Gleason pattern 5 is a powerful predictor of biochemical relapse in patients with Gleason score 7 prostatic adenocarcinoma
Eyas M Hattab
Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
J Urol 175:1695-9; discussion 1699. 2006
..Therefore, tertiary pattern 5 should be reported in radical prostatectomy specimens...
- OCT4 is superior to CD30 in the diagnosis of metastatic embryonal carcinomas after chemotherapy
Ming-Tse Sung
Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
Hum Pathol 37:662-7. 2006
..OCT4 is a useful diagnostic marker to identify metastatic embryonal carcinomas after chemotherapy, with a better sensitivity than CD30...
- Understanding the molecular genetics of renal cell neoplasia: implications for diagnosis, prognosis and therapy
Liang Cheng
Indiana University School of Medicine, Clarian Pathology Laboratory, 350 West 11th Street, Indianapolis, IN 46202, USA
Expert Rev Anticancer Ther 10:843-64. 2010
..We review the molecular and genetic characteristics of renal neoplasms, with emphasis on markers that demonstrate utility in differentiating morphologically similar neoplasms and in predicting clinical outcome...
