Wenxing Chen

Summary

Publications

  1. pmc Molecular evidence of cryptotanshinone for treatment and prevention of human cancer
    Wenxing Chen
    College of Pharmacy and Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica, Nanjing University of Chinese Medicine, China
    Anticancer Agents Med Chem 13:979-87. 2013
  2. doi request reprint Beta-elemene inhibits melanoma growth and metastasis via suppressing vascular endothelial growth factor-mediated angiogenesis
    Wenxing Chen
    College of Pharmacy, Nanjing University of Chinese Medicine, 138 Xianlin Highway, 210046 Nanjing, China
    Cancer Chemother Pharmacol 67:799-808. 2011
  3. doi request reprint Anti-angiogenesis effect of essential oil from Curcuma zedoaria in vitro and in vivo
    Wenxing Chen
    College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, China
    J Ethnopharmacol 133:220-6. 2011
  4. pmc Holothurian glycosaminoglycan inhibits metastasis and thrombosis via targeting of nuclear factor-κB/tissue factor/Factor Xa pathway in melanoma B16F10 cells
    Yang Zhao
    Department of Clinical Pharmacy, College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, People s Republic of China
    PLoS ONE 8:e56557. 2013
  5. doi request reprint Inhibition of vascular endothelial growth factor-mediated angiogenesis involved in reproductive toxicity induced by sesquiterpenoids of Curcuma zedoaria in rats
    Liang Zhou
    College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210046, China
    Reprod Toxicol 37:62-9. 2013
  6. pmc Concerted suppression of STAT3 and GSK3β is involved in growth inhibition of non-small cell lung cancer by Xanthatin
    Li Tao
    Department of Pharmacology, College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, China
    PLoS ONE 8:e81945. 2013
  7. doi request reprint Saikosaponin D disrupts platelet-derived growth factor-β receptor/p38 pathway leading to mitochondrial apoptosis in human LO2 hepatocyte cells: a potential mechanism of hepatotoxicity
    Li Chen
    Department of Pharmacology, College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China
    Chem Biol Interact 206:76-82. 2013
  8. ncbi request reprint [Effect of danshensu on redox state and relevant nuclear transcription factors in non-small cell lung cancer A549 cells]
    Li Tao
    College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210046, China
    Zhongguo Zhong Yao Za Zhi 37:1265-8. 2012
  9. doi request reprint Inhibition of hypoxia-induced epithelial mesenchymal transition by luteolin in non-small cell lung cancer cells
    Junshan Ruan
    Department of Clinical Pharmacy, College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210029, PR China
    Mol Med Rep 6:232-8. 2012

Collaborators

Detail Information

Publications9

  1. pmc Molecular evidence of cryptotanshinone for treatment and prevention of human cancer
    Wenxing Chen
    College of Pharmacy and Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica, Nanjing University of Chinese Medicine, China
    Anticancer Agents Med Chem 13:979-87. 2013
    ..Here we briefly summarize the physical and chemical properties and the pharmacokinetic profiles of cryptotanshinone, and then comprehensively review its anticancer activities as well as the underlying mechanisms. ..
  2. doi request reprint Beta-elemene inhibits melanoma growth and metastasis via suppressing vascular endothelial growth factor-mediated angiogenesis
    Wenxing Chen
    College of Pharmacy, Nanjing University of Chinese Medicine, 138 Xianlin Highway, 210046 Nanjing, China
    Cancer Chemother Pharmacol 67:799-808. 2011
    ..It was to assess antiangiogenic effect of β-elemene in vitro and in vivo, and it was involved in inhibiting melanoma growth and metastasis, as well as to elucidate its intrinsic mechanism...
  3. doi request reprint Anti-angiogenesis effect of essential oil from Curcuma zedoaria in vitro and in vivo
    Wenxing Chen
    College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, China
    J Ethnopharmacol 133:220-6. 2011
    ....
  4. pmc Holothurian glycosaminoglycan inhibits metastasis and thrombosis via targeting of nuclear factor-κB/tissue factor/Factor Xa pathway in melanoma B16F10 cells
    Yang Zhao
    Department of Clinical Pharmacy, College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, People s Republic of China
    PLoS ONE 8:e56557. 2013
    ..Consequently, hGAG exerts a dual function in the inhibition of metastasis and coagulation activity in mouse melanoma B16F10 cells. Our studies suggest hGAG to be a promising therapeutic agent for metastatic cancer treatment...
  5. doi request reprint Inhibition of vascular endothelial growth factor-mediated angiogenesis involved in reproductive toxicity induced by sesquiterpenoids of Curcuma zedoaria in rats
    Liang Zhou
    College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210046, China
    Reprod Toxicol 37:62-9. 2013
    ..Our results suggest that the reproductive toxicity of C. zedoaria may be caused by sesquiterpenoids in the essential oil blocking VEGF-mediated angiogenesis...
  6. pmc Concerted suppression of STAT3 and GSK3β is involved in growth inhibition of non-small cell lung cancer by Xanthatin
    Li Tao
    Department of Pharmacology, College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, China
    PLoS ONE 8:e81945. 2013
    ..Thus, the discovery of xanthatin, which has ability to simultaneously orchestrate two independent signaling cascades, may have important implications for screening promising drugs in cancer therapies. ..
  7. doi request reprint Saikosaponin D disrupts platelet-derived growth factor-β receptor/p38 pathway leading to mitochondrial apoptosis in human LO2 hepatocyte cells: a potential mechanism of hepatotoxicity
    Li Chen
    Department of Pharmacology, College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China
    Chem Biol Interact 206:76-82. 2013
    ..These data collectively indicated that SSD induced apoptosis by interrupting PDGF-βR/p38 pathway in LO2 hepatocytes...
  8. ncbi request reprint [Effect of danshensu on redox state and relevant nuclear transcription factors in non-small cell lung cancer A549 cells]
    Li Tao
    College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210046, China
    Zhongguo Zhong Yao Za Zhi 37:1265-8. 2012
    ....
  9. doi request reprint Inhibition of hypoxia-induced epithelial mesenchymal transition by luteolin in non-small cell lung cancer cells
    Junshan Ruan
    Department of Clinical Pharmacy, College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210029, PR China
    Mol Med Rep 6:232-8. 2012
    ..Since integrin β1 and FAK signaling are closely related to EMT formation, these results suggest that luteolin inhibits hypoxia-induced EMT, at least in part, by inhibiting the expression of integrin β1 and FAK...