Sophie Chen

Summary

Publications

  1. ncbi Natural products triggering biological targets--a review of the anti-inflammatory phytochemicals targeting the arachidonic acid pathway in allergy asthma and rheumatoid arthritis
    Sophie Chen
    Ovarian and Prostate Cancer Research Trust Laboratory, University of Surrey Technology Centre, 10 Nugent Road, Guildford, Surrey, UK
    Curr Drug Targets 12:288-301. 2011
  2. ncbi Advances in the treatment of ovarian cancer: a potential role of antiinflammatory phytochemicals
    Sophie S Chen
    Department of Research and Development, Ovarian and Prostate Cancer Research Trust Laboratory, Guildford, Surrey, United Kingdom
    Discov Med 13:7-17. 2012
  3. ncbi Polyphenols inhibit indoleamine 3,5-dioxygenase-1 enzymatic activity--a role of immunomodulation in chemoprevention
    Sophie S Chen
    Department of Research and Development, Ovarian and Prostate Cancer Research Trust Laboratory, Guildford, Surrey GU2 7YG, United Kingdom
    Discov Med 14:327-33. 2012
  4. doi Natural inhibitors of indoleamine 3,5-dioxygenase induced by interferon-gamma in human neural stem cells
    S Chen
    Ovarian and Prostate Cancer Research Trust Laboratory, Surrey Research Park, Guildford, Surrey GU2 7AF, United Kingdom
    Biochem Biophys Res Commun 429:117-23. 2012
  5. pmc Down-regulation of androgen-receptor and PSA by phytochemicals
    Sophie Chen
    Department of Medicine, New York Medical College, Valhalla, NY 10595, USA
    Int J Oncol 32:405-11. 2008
  6. doi Combined activity of oridonin and wogonin in advanced-stage ovarian cancer cells: sensitivity of ovarian cancer cells to phyto-active chemicals
    Sophie Chen
    Ovarian and Prostate Cancer Research Trust Laboratory, Guildford, Surrey GU2 7AF, UK
    Cell Biol Toxicol 27:133-47. 2011
  7. ncbi PC-SPES: herbal formulation for prostate cancer
    Leonard S Marks
    Urological Sciences Research Foundation, Culver City, California 90232, USA
    Urology 60:369-75; discussion 376-7. 2002
  8. ncbi The cytostatic and cytotoxic effects of oridonin (Rubescenin), a diterpenoid from Rabdosia rubescens, on tumor cells of different lineage
    Sophie Chen
    NovaSpes Research Lab, Hawthorne, NY 10532, USA
    Int J Oncol 26:579-88. 2005
  9. ncbi PC-SPES decreases proliferation and induces differentiation and apoptosis of human acute myeloid leukemia cells
    Takayuki Ikezoe
    Department of Medicine, Kochi Medical School, Nankoku, Kochi 783 8505, Japan
    Int J Oncol 23:1203-11. 2003

Detail Information

Publications9

  1. ncbi Natural products triggering biological targets--a review of the anti-inflammatory phytochemicals targeting the arachidonic acid pathway in allergy asthma and rheumatoid arthritis
    Sophie Chen
    Ovarian and Prostate Cancer Research Trust Laboratory, University of Surrey Technology Centre, 10 Nugent Road, Guildford, Surrey, UK
    Curr Drug Targets 12:288-301. 2011
    ..Modulation of Th1/Th2 cytokines and histamine/mucus release by some of these enzyme inhibitors are also briefly discussed...
  2. ncbi Advances in the treatment of ovarian cancer: a potential role of antiinflammatory phytochemicals
    Sophie S Chen
    Department of Research and Development, Ovarian and Prostate Cancer Research Trust Laboratory, Guildford, Surrey, United Kingdom
    Discov Med 13:7-17. 2012
    ..In order to evaluate objectively the potential benefit of these compounds in the treatment of ovarian cancer, strategically designed, large scale studies are warranted...
  3. ncbi Polyphenols inhibit indoleamine 3,5-dioxygenase-1 enzymatic activity--a role of immunomodulation in chemoprevention
    Sophie S Chen
    Department of Research and Development, Ovarian and Prostate Cancer Research Trust Laboratory, Guildford, Surrey GU2 7YG, United Kingdom
    Discov Med 14:327-33. 2012
    ..These results suggest that attenuation of immune suppression via inhibition of IDO-1 enzyme activity may be one of the important mechanisms of polyphenols in chemoprevention or combinatorial cancer therapy...
  4. doi Natural inhibitors of indoleamine 3,5-dioxygenase induced by interferon-gamma in human neural stem cells
    S Chen
    Ovarian and Prostate Cancer Research Trust Laboratory, Surrey Research Park, Guildford, Surrey GU2 7AF, United Kingdom
    Biochem Biophys Res Commun 429:117-23. 2012
    ..The inhibitory activity might have partially contributed to the anti-cancer and neuro-protective property of the compounds...
  5. pmc Down-regulation of androgen-receptor and PSA by phytochemicals
    Sophie Chen
    Department of Medicine, New York Medical College, Valhalla, NY 10595, USA
    Int J Oncol 32:405-11. 2008
    ..In each case, these compounds have independent activities which may partly contribute to the biological activity of PC-SPES...
  6. doi Combined activity of oridonin and wogonin in advanced-stage ovarian cancer cells: sensitivity of ovarian cancer cells to phyto-active chemicals
    Sophie Chen
    Ovarian and Prostate Cancer Research Trust Laboratory, Guildford, Surrey GU2 7AF, UK
    Cell Biol Toxicol 27:133-47. 2011
    ..These findings suggest that oridonin and wogonin may have activity in ovarian cancer following its development of resistance to carboplatin and paclitaxel...
  7. ncbi PC-SPES: herbal formulation for prostate cancer
    Leonard S Marks
    Urological Sciences Research Foundation, Culver City, California 90232, USA
    Urology 60:369-75; discussion 376-7. 2002
    ..PC-SPES is of great interest in men with androgen-independent CaP, an area in which future research should be primarily directed...
  8. ncbi The cytostatic and cytotoxic effects of oridonin (Rubescenin), a diterpenoid from Rabdosia rubescens, on tumor cells of different lineage
    Sophie Chen
    NovaSpes Research Lab, Hawthorne, NY 10532, USA
    Int J Oncol 26:579-88. 2005
    ..The present data suggest that further studies are warranted to assess the potential of oridonin in cancer prevention and/or treatment...
  9. ncbi PC-SPES decreases proliferation and induces differentiation and apoptosis of human acute myeloid leukemia cells
    Takayuki Ikezoe
    Department of Medicine, Kochi Medical School, Nankoku, Kochi 783 8505, Japan
    Int J Oncol 23:1203-11. 2003
    ..PC-SPES might be useful with ATRA for treatment of patients with acute promyelocytic leukemia (APL), and it could have a role in other types of cancers including MDS...