Properties and dissemination of H5N1 viruses isolated during an influenza outbreak in migratory waterfowl in western ChinaHualan Chen
Harbin Veterinary Research Institute, Harbin 150001, People s Republic of China
J Virol 80:5976-83. 2006
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Development and application of avian influenza vaccines in ChinaHualan Chen
Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, 427 Maduan Street, Harbin, 150001, People s Republic of China
Curr Top Microbiol Immunol 333:153-62. 2009
..Over 30 billion doses of these vaccines have been used in China and other countries, including Vietnam, Mongolia, and Egypt, and have played an important role in H5N1 avian influenza control in these countries...
- The evolution of H5N1 influenza viruses in ducks in southern China
H Chen
Animal Influenza Laboratory of the Ministry of Agriculture, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, 427 Maduan Street, Harbin 150001, People s Republic of China
Proc Natl Acad Sci U S A 101:10452-7. 2004
..Our findings suggest that immediate action is needed to prevent the transmission of highly pathogenic avian influenza viruses from the apparently healthy ducks into chickens or mammalian hosts...
- H5N1 avian influenza in China
Hualan Chen
Animal Influenza Laboratory of the Ministry of Agriculture and National Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, 150001, China
Sci China C Life Sci 52:419-27. 2009
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Avian influenza vaccination: the experience in ChinaH Chen
Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, 427 Maduan Street, Harbin 150001, People s Republic of China
Rev Sci Tech 28:267-74. 2009
..Despite the successes obtained with the vaccination strategy, China still faces challenges in its efforts to eliminate H5N1 virus circulation in poultry...
- H5N1 influenza marker vaccine for serological differentiation between vaccinated and infected chickens
Chengjun Li
Harbin Veterinary Research Institute, CAAS, 427 Maduan Street, Harbin, Heilongjiang 150001, People s Republic of China
Biochem Biophys Res Commun 372:293-7. 2008
..H5N1/PR8-5B19 is therefore an attractive marker vaccine candidate, eliciting a strong, protective antibody response and enabling serological discrimination between vaccinated and wild-type virus-infected chickens...
- Continued evolution of H5N1 influenza viruses in wild birds, domestic poultry, and humans in China from 2004 to 2009
Yanbing Li
Animal Influenza Laboratory of the Ministry of Agriculture and National Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, CAAS, 427 Maduan Street, Harbin 150001, People s Republic of China
J Virol 84:8389-97. 2010
..Our results demonstrate that the H5N1 AIVs circulating in nature have complex biological characteristics and pose a continued challenge for disease control and pandemic preparedness...
- Newcastle disease virus-vectored rabies vaccine is safe, highly immunogenic, and provides long-lasting protection in dogs and cats
Jinying Ge
Harbin Veterinary Research Institute, CAAS, 427 Maduan Street, Harbin 150001, People s Republic of China
J Virol 85:8241-52. 2011
..This is the first study to demonstrate that immunization with an NDV-vectored vaccine can induce long-lasting, systemic protective immunity against rabies...
- Two amino acid residues in the matrix protein M1 contribute to the virulence difference of H5N1 avian influenza viruses in mice
Shufang Fan
Animal Influenza Laboratory of the Ministry of Agriculture and National Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, CAAS, Harbin, PR China
Virology 384:28-32. 2009
..We thus firstly prove the M1 protein contributes to the virulence of H5N1 viruses in mice, and the amino acid residues shown to attenuate the virulence could be targeted in influenza virus candidates for live vaccine development...
- A protein chip designed to differentiate visually antibodies in chickens which were infected by four different viruses
Xiurong Wang
Animal Influenza Laboratory of Ministry of Agriculture and State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, CAAS, Harbin, China
J Virol Methods 167:119-24. 2010
..In conclusion, this protein chip can be used to differentiate the antibodies induced by the four avian viruses...
- Immunogenicity and protective efficacy of a live attenuated H5N1 vaccine in nonhuman primates
Shufang Fan
Animal Influenza Laboratory of the Ministry of Agriculture and National Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, PR China
PLoS Pathog 5:e1000409. 2009
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- Vaccines developed for H5 highly pathogenic avian influenza in China
Chuanling Qiao
Animal Influenza Laboratory of the Ministry of Agriculture, Harbin 150001, People's Republic of China
Ann N Y Acad Sci 1081:182-92. 2006
..Laboratory tests indicated that after one dose of immunization of this vaccine, chickens could develop an over than 40 weeks protective immune response against H5N1 virus challenge...
- Key molecular factors in hemagglutinin and PB2 contribute to efficient transmission of the 2009 H1N1 pandemic influenza virus
Ying Zhang
State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, People s Republic of China
J Virol 86:9666-74. 2012
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- Newcastle disease virus-vectored Nipah encephalitis vaccines induce B and T cell responses in mice and long-lasting neutralizing antibodies in pigs
Dongni Kong
State Key Laboratory of Veterinary Biotechnology and Animal Influenza Laboratory of the Ministry of Agriculture, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin 150001, People s Republic of China
Virology 432:327-35. 2012
..Recombinant rLa-NiVG/F thus appear to be promising NiV vaccine candidates for pigs and potentially humans...
- Recombinant fowlpox virus vector-based vaccine completely protects chickens from H5N1 avian influenza virus
Chuanling Qiao
Animal Influenza Laboratory of the Ministry of Agriculture, State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, 427 Maduan Street, Harbin 150001, PR China
Antiviral Res 81:234-8. 2009
..These results demonstrate that the rFPV-HA-NA vaccine is effective in the prevention of infection of H5N1 AI virus...
- Enhanced protective efficacy of H5 subtype avian influenza DNA vaccine with codon optimized HA gene in a pCAGGS plasmid vector
Yongping Jiang
Animal Influenza Laboratory of the Ministry of Agriculture, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, 427 Maduan Street, Harbin 150001, People s Republic of China
Antiviral Res 75:234-41. 2007
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- Protective efficacy in chickens, geese and ducks of an H5N1-inactivated vaccine developed by reverse genetics
Guobin Tian
Animal Influenza Laboratory of the Ministry of Agriculture, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin 150001, PR China
Virology 341:153-62. 2005
..These results provide useful information for the application of vaccines to the control of H5N1 avian influenza in poultry, including chickens and domestic waterfowl...
- Reassortant H1N1 influenza virus vaccines protect pigs against pandemic H1N1 influenza virus and H1N2 swine influenza virus challenge
Huanliang Yang
Animal Influenza Laboratory of Ministry of Agriculture, State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin 150001, PR China
Vet Microbiol 152:229-34. 2011
..These results indicated for the first time that a high-growth SC/PR8 reassortant H1N1 virus exhibits properties that are desirable to be a promising vaccine candidate for use in swine in the event of a pandemic H1N1 influenza...
- A single-amino-acid substitution in the NS1 protein changes the pathogenicity of H5N1 avian influenza viruses in mice
Peirong Jiao
Harbin Veterinary Research Institute, CAAS, 427 Maduan Street, Harbin 150001, People s Republic of China
J Virol 82:1146-54. 2008
..Our results indicate that the NS1 protein is critical for the pathogenicity of H5N1 influenza viruses in mammalian hosts and that the amino acid S42 of NS1 plays a key role in undermining the antiviral immune response of the host cell...
- Protective efficacy of H7 subtype avian influenza DNA vaccine
Yongping Jiang
Animal Influenza Laboratory of the Ministry of Agriculture and State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, 427 Maduan Street, Harbin 150001, People s Republic of China
Avian Dis 54:290-3. 2010
..These results provide a strong argument for the continued evaluation of this vaccine in field trials...
- Molecular basis of neurovirulence of flury rabies virus vaccine strains: importance of the polymerase and the glycoprotein R333Q mutation
Lihong Tao
Veterinary Public Health Laboratory of Ministry of Agriculture, Harbin Veterinary Research Institute of Chinese Academy of Agricultural Sciences, Harbin 150001, People s Republic of China
J Virol 84:8926-36. 2010
..These results indicate that attenuation of the RV Flury strain results from the coevolution of G and L elements and provide important information for the generation of safer and more effective modified live rabies vaccine...
- A naturally occurring deletion in its NS gene contributes to the attenuation of an H5N1 swine influenza virus in chickens
Qiyun Zhu
Harbin Veterinary Research Institute, 427 Maduan Street, Harbin 150001, People s Republic of China
J Virol 82:220-8. 2008
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- Identification of amino acids in HA and PB2 critical for the transmission of H5N1 avian influenza viruses in a mammalian host
Yuwei Gao
Animal Influenza Laboratory of the Ministry of Agriculture and National Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, People s Republic of China
PLoS Pathog 5:e1000709. 2009
..These amino acids changes in PB2 and HA could serve as important molecular markers for assessing the pandemic potential of H5N1 field isolates...
- Dogs are highly susceptible to H5N1 avian influenza virus
Ying Chen
Animal Influenza Laboratory of the Ministry of Agriculture and National Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin 150001, People s Republic of China
Virology 405:15-9. 2010
..Our results demonstrate that dogs are highly susceptible to H5N1 AIV and may serve as an intermediate host to transfer this virus to humans...
- The PA protein directly contributes to the virulence of H5N1 avian influenza viruses in domestic ducks
Jiasheng Song
Harbin Veterinary Research Institute, CAAS, Harbin 150001, People s Republic of China
J Virol 85:2180-8. 2011
..Our results provide strong evidence that the polymerase PA subunit is a virulence factor for H5N1 AIVs in ducks...
- A duck enteritis virus-vectored bivalent live vaccine provides fast and complete protection against H5N1 avian influenza virus infection in ducks
Jinxiong Liu
State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, CAAS, 427 Maduan Street, Harbin 150001, People s Republic of China
J Virol 85:10989-98. 2011
..These results demonstrate, for the first time, that recombinant DEV is suitable for use as a bivalent live attenuated vaccine, providing rapid protection against both DEV and H5N1 virus infection in ducks...
- The NS1 gene contributes to the virulence of H5N1 avian influenza viruses
Zejun Li
Harbin Veterinary Research Institute, CAAS, 427 Maduan Street, Harbin 150001, People s Republic of China
J Virol 80:11115-23. 2006
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- Protective efficacy of an H1N1 cold-adapted live vaccine against the 2009 pandemic H1N1, seasonal H1N1, and H5N1 influenza viruses in mice
Jianzhong Shi
Animal Influenza Laboratory, State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, 427 Maduan Street, Harbin 150001, People s Republic of China
Antiviral Res 93:346-53. 2012
..The induction of cross-reactive virus-specific T cell responses may be an effective approach to develop universal influenza vaccines...
- Development of a reverse transcription loop-mediated isothermal amplification method for the rapid detection of avian influenza virus subtype H7
Hongmei Bao
Animal Influenza Laboratory of the Ministry of Agriculture, State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, 427 Maduan Street, Harbin 150001, China
J Virol Methods 179:33-7. 2012
..These results indicate that the RT-LAMP method could facilitate epidemiological surveillance and the rapid diagnosis of the avian influenza subtype H7...
- Molecular basis of replication of duck H5N1 influenza viruses in a mammalian mouse model
Zejun Li
Animal Influenza Laboratory, Ministry of Agriculture, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, 427 Maduan Street, Harbin 150001, People's Republic of China
J Virol 79:12058-64. 2005
..Our findings may help to explain the expansion of the host range and lethality of the H5N1 influenza viruses to humans...
- Protective efficacy of the H5 inactivated vaccine against different highly pathogenic H5N1 avian influenza viruses isolated in China and Vietnam
Guobin Tian
Animal Influenza Laboratory of the Ministry of Agriculture and State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, 427 Maduan Street, Harbin 150001, People s Republic of China
Avian Dis 54:287-9. 2010
..These results indicate that the GS/GD/06-based vaccine provides sound protection against clade 1, 2.2, and 2.3.4 viruses, but not against the CK/SX/06 virus, which emerged in northern China in 2006...
- New avian influenza virus (H5N1) in wild birds, Qinghai, China
Yanbing Li
Harbin Veterinary Research Institute, Harbin, People s Republic of China
Emerg Infect Dis 17:265-7. 2011
..Phylogenetic and antigenic analyses showed that QH09 was clearly distinguishable from classical clade 2.2 viruses and belonged to clade 2.3.2...
- Characterization of an avian influenza virus of subtype H7N2 isolated from chickens in northern China
Yanbing Li
Animal Influenza Laboratory of the Ministry of Agriculture, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, 150001, People's Republic of China
Virus Genes 33:117-22. 2006
..These results suggest that the influenza virus isolated in chickens in northern China in 2002 originated in wild birds and may pose a threat for both avian species and mammalian hosts...
- Newcastle disease virus-based live attenuated vaccine completely protects chickens and mice from lethal challenge of homologous and heterologous H5N1 avian influenza viruses
Jinying Ge
National Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, CAAS, 427 Maduan Street, Harbin 150001, People s Republic of China
J Virol 81:150-8. 2007
..The recombinant NDV vaccine may also have potential use in high-risk human individuals to control the pandemic spread of lethal avian influenza...
- Characterization of immune responses induced by immunization with the HA DNA vaccines of two antigenically distinctive H5N1 HPAIV isolates
Yulong Gao
National Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, People s Republic of China
PLoS ONE 7:e41332. 2012
..These results indicate the existence of original antigenic sin (OAS) between concurrently circulating H5N1 HPAIV strains, which may need to be taken into consideration in vaccine development against the potential H5N1 HPAIV pandemic...
- Human infection from avian-like influenza A (H1N1) viruses in pigs, China
Huanliang Yang
State Key Laboratory of Veterinary Biotechnology Harbin Veterinary Research Institute, Harbin, People s Republic of China
Emerg Infect Dis 18:1144-6. 2012
..Serologic evidence indicated that viral persistence in pigs was the source of infection. Continued surveillance of pigs and systemic analysis of swine influenza isolates are needed...
- Characterization of monoclonal antibodies against Muscovy duck reovirus sigmaB protein
Ming Liu
National Avian Influenza Reference Laboratory, Animal Influenza Laboratory of the Ministry of Agriculture, Harbin Veterinary Research Institute, CAAS, Harbin 150001, China
Virol J 7:133. 2010
..The sigmaB protein of Muscovy duck reovirus (DRV), one of the major structural proteins, is able to induce neutralizing antibody in ducks, but the monoclonal antibody (MAb) against sigmaB protein has never been characterized...
- Pathogenicity of Chinese H5N1 highly pathogenic avian influenza viruses in pigeons
Beibei Jia
Animal Influenza Laboratory of the Ministry of Agriculture and National Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, People s Republic of China
Arch Virol 153:1821-6. 2008
..These results indicate that pigeons are susceptible to the more recent Asian H5N1 HPAI and could be a source of infection to other animals, including humans...
- Efficacy of DNA immunization with F and G protein genes of Nipah virus
Xijun Wang
National Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Science, Harbin 150001, P.R. China
Ann N Y Acad Sci 1081:243-5. 2006
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- Two genotypes of H1N2 swine influenza viruses appeared among pigs in China
Chuantian Xu
Animal Influenza Laboratory of the Ministry of Agriculture and National Key Laborattory of Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, People s Republic of China
J Clin Virol 46:192-5. 2009
..H1N2 is one of the main subtypes of influenza, which circulates in swine all over the world...
- Recombinant duck enteritis virus works as a single-dose vaccine in broilers providing rapid protection against H5N1 influenza infection
Jinxiong Liu
Animal Influenza Laboratory, State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, CAAS, 427 Maduan Street, Harbin 150001, PR China
Antiviral Res 97:329-33. 2013
..We found this new rDEV-re6 virus to be safe in chickens and to induce rapid and solid protection after a single dose. This virus may therefore serve as an ideal single-dose vaccine for broilers...
- Proteomic analysis of the lungs of mice infected with different pathotypes of H5N1 avian influenza viruses
Dongming Zhao
State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, CAAS, Harbin, P R China
Proteomics 12:1970-82. 2012
..Our data provide important information regarding the host response to mild and lethal H5N1 influenza virus infection...
- Generation and evaluation of a Newcastle disease virus-based H9 avian influenza live vaccine
Jinying Ge
Laboratory of Animal Influenza of Ministry of Agriculture, and National Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, 427 Maduan Street, Harbin 150001, People s Republic of China
Avian Dis 54:294-6. 2010
..Our results suggest that recombinant NDV is suitable as a potential bivalent live attenuated vaccine against both NDV and H9 AIV infection in poultry...
- Detection and differentiation of four poultry diseases using asymmetric reverse transcription polymerase chain reaction in combination with oligonucleotide microarrays
Qimeng Tao
Animal Influenza Laboratory of the Ministry of Agriculture and State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute of the Chinese Academy of Agricultural Sciences, Harbin 150001, China
J Vet Diagn Invest 21:623-32. 2009
..No cross-hybridization could be detected. Results demonstrated that microarray based on asymmetric RT-PCR is an effective way to distinguish AIV, IBV, NDV, and IBDV simultaneously...
- Generating vesicular stomatitis virus pseudotype bearing the severe acute respiratory syndrome coronavirus spike envelope glycoprotein for rapid and safe neutralization test or cell-entry assay
Jinying Ge
National Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin 150001, P.R. China
Ann N Y Acad Sci 1081:246-8. 2006
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- Protective efficacy of an H5N1 DNA vaccine against challenge with a lethal H5N1 virus in quail
Junping Li
Animal Influenza Laboratory of the Ministry of Agriculture and State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, 427 Maduan Street, Harbin 150001, People s Republic of China
Avian Dis 56:937-9. 2012
..These results indicate that this DNA vaccine holds promise for use in quail to protect against H5N1 AIV...
- Co-circulation of pandemic 2009 H1N1, classical swine H1N1 and avian-like swine H1N1 influenza viruses in pigs in China
Yan Chen
State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin 150001, China
Infect Genet Evol 13:331-8. 2013
..Multiple genetic lineages of H1N1 viruses are co-circulating in the swine population, which highlights the importance of intensive surveillance for swine influenza in China...
- [Development of one step RT-PCR technique for detection of H7 subtype avian influenza]
Hongmei Bao
State Key Laboratory of Veterinary Biotechnology, Animal Influenza Laboratory of Ministry of Agriculture, Harbin Veterinary Research Institute of CAAS, Harbin 150001, China
Sheng Wu Gong Cheng Xue Bao 25:1658-63. 2009
..Development of one step RT-PCR will provide effective technical support for the rapid diagnosis and surveillance of molecular epidemiology of AIV subtype H7...
- Phylogenetic and pathogenic analyses of avian influenza A H5N1 viruses isolated from poultry in Vietnam
Dongming Zhao
State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, People s Republic of China
PLoS ONE 7:e50959. 2012
..Our results provide important information regarding the diversity of H5N1 viruses in nature...
- Evolution of H9N2 influenza viruses from domestic poultry in Mainland China
Chengjun Li
Animal Influenza Laboratory of the Ministry of Agriculture and National Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin 150001, People's Republic of China
Virology 340:70-83. 2005
..Our findings suggest that urgent attention should be paid to the control of H9N2 influenza viruses in animals and to the human's influenza pandemic preparedness...
- [Typing and subtyping avian influenza virus using DNA microarrays]
Zhongping Yang
Animal Influenza Laboratory of Ministry of Agriculture and National Key Laboratory of Veterinary Biotechnology of Harbin Veterinary Research Institute of CAAS, Harbin 150001, China
Wei Sheng Wu Xue Bao 48:935-40. 2008
..We described a simultaneous approach using microarray to detect and subtype avian influenza virus (AIV)...
- Generation and evaluation of a high-growth reassortant H9N2 influenza A virus as a pandemic vaccine candidate
Hualan Chen
Influenza Branch, Mailstop G-16, Centers for Disease Control and Prevention, 1600 Clifton Road, Atlanta, GA 30333, USA
Vaccine 21:1974-9. 2003
..These results indicate that the high growth G9/PR8 reassortant has properties that are desirable in a vaccine seed virus and is suitable for evaluation in humans for use in the event of an H9 pandemic...
- Evaluation of a genetically modified reassortant H5N1 influenza A virus vaccine candidate generated by plasmid-based reverse genetics
Kanta Subbarao
Influenza Branch, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
Virology 305:192-200. 2003
..This is the first successful attempt to develop an H5N1 vaccine seed virus resembling those used in currently licensed influenza A vaccines with properties that make it a promising candidate for further evaluation in humans...
- The first confirmed human case of avian influenza A (H5N1) in Mainland China
Hongjie Yu
Office for Disease Control and Emergency Response, Chinese Center for Disease Control and Prevention (China CDC, 27 Nanwei Road, Beijing, 100050, PR China
Lancet 367:84. 2006
- Limited compatibility between the RNA polymerase components of influenza virus type A and B
Kiyoko Iwatsuki-Horimoto
Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Tokyo Japan
Virus Res 135:161-5. 2008
..Taken together, these data suggest that incompatibility among components of the polymerase machinery for RNA transcription and replication alone is not responsible for the lack of heterotypic reassortants...
- Single-amino-acid mutation in the HA alters the recognition of H9N2 influenza virus by a monoclonal antibody
Jihui Ping
Nangjing Agricultural University, Nanjing 210095, Jiangsu, China
Biochem Biophys Res Commun 371:168-71. 2008
..Our results provide experimental evidence that the glycosylation of HA oligosaccharide attachment sites implicated in antibody binding could have a role in antigenic variation...
- Lack of transmission of H5N1 avian-human reassortant influenza viruses in a ferret model
Taronna R Maines
Influenza Branch, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
Proc Natl Acad Sci U S A 103:12121-6. 2006
..These results highlight the complexity of the genetic basis of influenza virus transmissibility and suggest that H5N1 viruses may require further adaptation to acquire this essential pandemic trait...
- Growth determinants for H5N1 influenza vaccine seed viruses in MDCK cells
Shin Murakami
Department of Microbiology and Immunology, Division of Virology, Institute of Medical Science, University of Tokyo, Tokyo, Japan
J Virol 82:10502-9. 2008
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- Polygenic virulence factors involved in pathogenesis of 1997 Hong Kong H5N1 influenza viruses in mice
Hualan Chen
Influenza Division, Centers for Disease Control and Prevention, 1600 Clifton Road, N E, MS G16, Atlanta, GA 30333, USA
Virus Res 128:159-63. 2007
..Multiple genes are involved in virulence of Hong Kong H5N1 influenza A viruses for mice with the presence of lysine at aa627 in the PB2 gene exhibiting a significantly larger effect than the HA and NA genes...
