Hao Chen

Summary

Publications

  1. pmc Genome-Wide Gene Expression Profiling of Nucleus Accumbens Neurons Projecting to Ventral Pallidum Using both Microarray and Transcriptome Sequencing
    Hao Chen
    Department of Pharmacology, University of Tennessee Health Science Center Memphis, TN, USA
    Front Neurosci 5:98. 2011
  2. pmc Pan-histone deacetylase inhibitors regulate signaling pathways involved in proliferative and pro-inflammatory mechanisms in H9c2 cells
    Gipsy Majumdar
    Department of Veterans Affairs Medical Center, 1030 Jefferson Avenue, Memphis, TN 38104, USA
    BMC Genomics 13:709. 2012
  3. pmc Genetic factors control nicotine self-administration in isogenic adolescent rat strains
    Hao Chen
    Department of Pharmacology, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America
    PLoS ONE 7:e44234. 2012
  4. pmc Social interaction promotes nicotine self-administration with olfactogustatory cues in adolescent rats
    Hao Chen
    Department of Pharmacology, University of Tennessee Health Science Center, Memphis, TN 38163, USA
    Neuropsychopharmacology 36:2629-38. 2011
  5. pmc Nicotine self-administration differentially modulates glutamate and GABA transmission in hypothalamic paraventricular nucleus to enhance the hypothalamic-pituitary-adrenal response to stress
    Guoliang Yu
    Department of Pharmacology, University of Tennessee Health Science Center, Memphis, TN 38163, USA
    J Neurochem 113:919-29. 2010
  6. doi request reprint Full-gestational exposure to nicotine and ethanol augments nicotine self-administration by altering ventral tegmental dopaminergic function due to NMDA receptors in adolescent rats
    Emily E Roguski
    Department of Pharmacology, University of Tennessee Health Science Center, Memphis, TN, USA
    J Neurochem 128:701-12. 2014
  7. pmc Neuroadaptive changes in the mesocortical glutamatergic system during chronic nicotine self-administration and after extinction in rats
    Fan Wang
    Department of Pharmacology, University of Tennessee Health Science Center, Memphis, Tennesse, USA
    J Neurochem 106:943-56. 2008
  8. pmc Fostering itself increases nicotine self-administration in young adult male rats
    Emily E Roguski
    Department of Pharmacology, University of Tennessee Health Science Center, 115 Crowe Research Building, 874 Union Ave, Memphis, TN 38163, USA
    Psychopharmacology (Berl) 229:227-34. 2013
  9. ncbi request reprint Acquisition of nicotine self-administration in adolescent rats given prolonged access to the drug
    Hao Chen
    Department of Pharmacology, University of Tennessee Health Science Center, Memphis, TN 38163, USA
    Neuropsychopharmacology 32:700-9. 2007
  10. ncbi request reprint Combining gene expression QTL mapping and phenotypic spectrum analysis to uncover gene regulatory relationships
    Lei Bao
    Department of Molecular Sciences, University of Tennessee Health Science Center, 858 Madison Avenue, Memphis, TN 38163, USA
    Mamm Genome 17:575-83. 2006

Collaborators

Detail Information

Publications18

  1. pmc Genome-Wide Gene Expression Profiling of Nucleus Accumbens Neurons Projecting to Ventral Pallidum Using both Microarray and Transcriptome Sequencing
    Hao Chen
    Department of Pharmacology, University of Tennessee Health Science Center Memphis, TN, USA
    Front Neurosci 5:98. 2011
    ....
  2. pmc Pan-histone deacetylase inhibitors regulate signaling pathways involved in proliferative and pro-inflammatory mechanisms in H9c2 cells
    Gipsy Majumdar
    Department of Veterans Affairs Medical Center, 1030 Jefferson Avenue, Memphis, TN 38104, USA
    BMC Genomics 13:709. 2012
    ..Therefore, the current study was undertaken with a primary goal of elucidating temporal changes in the transcriptomes of cardiac myocytes exposed to CBHA and TSA...
  3. pmc Genetic factors control nicotine self-administration in isogenic adolescent rat strains
    Hao Chen
    Department of Pharmacology, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America
    PLoS ONE 7:e44234. 2012
    ..Taken together, the behavioral characteristics of this model indicate its strong potential to identify specific genes mediating the human vulnerability to smoke cigarettes...
  4. pmc Social interaction promotes nicotine self-administration with olfactogustatory cues in adolescent rats
    Hao Chen
    Department of Pharmacology, University of Tennessee Health Science Center, Memphis, TN 38163, USA
    Neuropsychopharmacology 36:2629-38. 2011
    ..These findings implicate adolescent social interactions in promoting smoking behavior by surmounting the aversive property of nicotine...
  5. pmc Nicotine self-administration differentially modulates glutamate and GABA transmission in hypothalamic paraventricular nucleus to enhance the hypothalamic-pituitary-adrenal response to stress
    Guoliang Yu
    Department of Pharmacology, University of Tennessee Health Science Center, Memphis, TN 38163, USA
    J Neurochem 113:919-29. 2010
    ..This mechanism, which does not preserve homeostatic plasticity, supports the concept that smoking functions as a chronic stressor that sensitizes the HPA to stress...
  6. doi request reprint Full-gestational exposure to nicotine and ethanol augments nicotine self-administration by altering ventral tegmental dopaminergic function due to NMDA receptors in adolescent rats
    Emily E Roguski
    Department of Pharmacology, University of Tennessee Health Science Center, Memphis, TN, USA
    J Neurochem 128:701-12. 2014
    ..We hypothesized that concurrent gestational exposure to nicotine and ethanol would disrupt the control of VTA dopaminergic circuitry by NMDA receptors. Resulting in the augmented nicotine self-administration (SA) in adolescent offspring...
  7. pmc Neuroadaptive changes in the mesocortical glutamatergic system during chronic nicotine self-administration and after extinction in rats
    Fan Wang
    Department of Pharmacology, University of Tennessee Health Science Center, Memphis, Tennesse, USA
    J Neurochem 106:943-56. 2008
    ..Collectively, these studies indicate that mesocortical glutamate neurotransmission adapts to chronic nicotine self-administration and VTA AMPA-R may be involved in the maintenance of nicotine self-administration...
  8. pmc Fostering itself increases nicotine self-administration in young adult male rats
    Emily E Roguski
    Department of Pharmacology, University of Tennessee Health Science Center, 115 Crowe Research Building, 874 Union Ave, Memphis, TN 38163, USA
    Psychopharmacology (Berl) 229:227-34. 2013
    ..In gestational exposure studies, a fostered group is frequently used to control for drug-induced maternal effects. However, fostering itself has varying effects depending on the parameters under investigation..
  9. ncbi request reprint Acquisition of nicotine self-administration in adolescent rats given prolonged access to the drug
    Hao Chen
    Department of Pharmacology, University of Tennessee Health Science Center, Memphis, TN 38163, USA
    Neuropsychopharmacology 32:700-9. 2007
    ..However, adolescent females acquired the behavior more rapidly and attained higher levels of stable nicotine SA than adults...
  10. ncbi request reprint Combining gene expression QTL mapping and phenotypic spectrum analysis to uncover gene regulatory relationships
    Lei Bao
    Department of Molecular Sciences, University of Tennessee Health Science Center, 858 Madison Avenue, Memphis, TN 38163, USA
    Mamm Genome 17:575-83. 2006
    ..Our results show that the combination of gene eQTL mapping and phenotypic spectrum analysis may provide a valuable approach to uncovering gene regulatory relations underlying mammalian phenotypes...
  11. doi request reprint Nicotine self-administration differentially regulates hypothalamic corticotropin-releasing factor and arginine vasopressin mRNAs and facilitates stress-induced neuronal activation
    Guoliang Yu
    Department of Pharmacology, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA
    J Neurosci 28:2773-82. 2008
    ....
  12. ncbi request reprint Chronic nicotine self-administration augments hypothalamic-pituitary-adrenal responses to mild acute stress
    Hao Chen
    Department of Pharmacology, University of Tennessee Health Science Center, Memphis, TN 38163, USA
    Neuropsychopharmacology 33:721-30. 2008
    ..Furthermore, chronic nicotine SA selectively cross-sensitized the HPA response to a novel stressor. These observations suggest that nicotine may selectively increase the HPA response to stressors in human smokers...
  13. pmc Upregulation of ionotropic glutamate receptor subunits within specific mesocorticolimbic regions during chronic nicotine self-administration
    Fan Wang
    Department of Pharmacology, University of Tennessee Health Science Center, Memphis, TN 38163, USA
    Neuropsychopharmacology 32:103-9. 2007
    ..These findings suggest that chronic nicotine SA selectively increased the levels of ionotropic glutamate receptor subunits in a brain region-specific manner...
  14. pmc Protection genes in nucleus accumbens shell affect vulnerability to nicotine self-administration across isogenic strains of adolescent rat
    Hao Chen
    Department of Pharmacology, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America
    PLoS ONE 9:e86214. 2014
    ..These findings provide new insights into genetic mechanisms that predispose or protect against tobacco addiction. ..
  15. ncbi request reprint Nicotine-induced norepinephrine release in hypothalamic paraventricular nucleus and amygdala is mediated by N-methyl-D-aspartate receptors and nitric oxide in the nucleus tractus solitarius
    Rongjie Zhao
    Department of Pharmacology, University of Tennessee Health Science Center, Memphis TN 38163, USA
    J Pharmacol Exp Ther 320:837-44. 2007
    ..Therefore, nicotine acts indirectly on noradrenergic NTS neurons to elicit NE release in forebrain structures...
  16. doi request reprint Amplified reacquisition of nicotine self-administration in rats by repeated stress during abstinence
    Guoliang Yu
    Department of Pharmacology, University of Tennessee Health Science Center, 874 Union Ave, Memphis, TN, 38163, USA
    Psychopharmacology (Berl) 231:3189-95. 2014
    ..However, whether reacquisition of nicotine taking is amplified by chronic stress during abstinence from nicotine SA has not been determined in animals...
  17. ncbi request reprint Gestational nicotine exposure reduces nicotinic cholinergic receptor (nAChR) expression in dopaminergic brain regions of adolescent rats
    Hao Chen
    Department of Pharmacology, University of Tennessee Health Science Center, Suite 115 Crowe Building, 874 Union Avenue, Memphis, TN 38163, USA
    Eur J Neurosci 22:380-8. 2005
    ..0% (P<0.001). These studies indicate that gestational exposure to nicotine induces long-lasting changes in nAChR expression that may underlie the vulnerability of adolescents to dependence on nicotine...
  18. ncbi request reprint Integrative genetic analysis of transcription modules: towards filling the gap between genetic loci and inherited traits
    Hongqiang Li
    Department of Molecular Sciences, University of Tennessee Health Science Center, 858 Madison Avenue Memphis, TN 38163, USA
    Hum Mol Genet 15:481-92. 2006
    ....