Research Topics

Yuan Chen



  1. request reprint
    Zhao W, Chen Y. Progress in Research of KV1.1 and KV1.3 Channels as Therapeutic Targets. Curr Top Med Chem. 2016;16:1877-85 pubmed
    ..This article seeks to review the distributions of two channels, their roles in diseases, phenotypes of knockout mice, human channelopathies and selective modulators. ..
  2. Ren Y, Pan L, Zhao W, Xu L, Xu J, Lu H, et al. Neochamaejasmin A inhibits KV1.4 channel activity via direct binding to the pore. Brain Res. 2018;1683:17-26 pubmed publisher
    ..In conclusion, data suggest that NCA might inhibit KV1.4 channels via direct binding to the pore domain. ..
  3. Xu J, Zhao W, Pan L, Zhang A, Chen Q, Xu K, et al. Peimine, a main active ingredient of Fritillaria, exhibits anti-inflammatory and pain suppression properties at the cellular level. Fitoterapia. 2016;111:1-6 pubmed publisher
    ..7 ion channel but also preferably inhibited the Kv1.3 ion channel. Thus, the study suggested potential mechanisms of Fritillaria as a pain relieving and anti-inflammatory herb. ..
  4. Zheng J, Zhao W, Xu K, Chen Q, Chen Y, Shen Y, et al. Interaction among hERG channel blockers is a potential mechanism of death in caffeine overdose. Eur J Pharmacol. 2017;800:23-33 pubmed publisher
    ..Our data does not rule out other possibility, however, it suggests that there is a potential causal relationship between caffeine overdose death with hERG channel and the interaction among these hERG blockers. ..
  5. Kan L, Zhao W, Pan L, Xu J, Chen Q, Xu K, et al. Peimine inhibits hERG potassium channels through the channel inactivation states. Biomed Pharmacother. 2017;89:838-844 pubmed publisher
    ..Mutation of Y652 to Alanine reduced sensitivity to Peimine, suggesting that Y652 is an important hERG binding sites for Peimine. ..