Genomes and Genes


Yeong Renn Chen



  1. Kang P, Chen C, Chen Y. Increased mitochondrial prooxidant activity mediates up-regulation of Complex I S-glutathionylation via protein thiyl radical in the murine heart of eNOS(-/-). Free Radic Biol Med. 2015;79:56-68 pubmed publisher
  2. Kang P, Chen C, Lin P, Zhang L, Zweier J, Chen Y. Mitochondrial complex I in the post-ischemic heart: reperfusion-mediated oxidative injury and protein cysteine sulfonation. J Mol Cell Cardiol. 2018;121:190-204 pubmed publisher
  3. Kang P, Chen C, Ohanyan V, Luther D, Meszaros J, Chilian W, et al. Overexpressing superoxide dismutase 2 induces a supernormal cardiac function by enhancing redox-dependent mitochondrial function and metabolic dilation. J Mol Cell Cardiol. 2015;88:14-28 pubmed publisher
    ..We conclude that SOD2 overexpression in myocytes enhances mitochondrial function and metabolic vasodilation, leading to a phenotype of supernormal cardiac function. ..
  4. Zhang L, Chen C, Kang P, Jin Z, Chen Y. Differential protein acetylation assists import of excess SOD2 into mitochondria and mediates SOD2 aggregation associated with cardiac hypertrophy in the murine SOD2-tg heart. Free Radic Biol Med. 2017;108:595-609 pubmed publisher
    ..Downregulation of Sirt3, HSP 60, and presequence protease in the mitochondria of the SOD2-tg heart promoted protein misfolding that led to pentameric aggregation. ..
  5. Kang P, Chen C, Lin P, Chilian W, Chen Y. Impairment of pH gradient and membrane potential mediates redox dysfunction in the mitochondria of the post-ischemic heart. Basic Res Cardiol. 2017;112:36 pubmed publisher