Mingxin Che

Summary

Publications

  1. ncbi request reprint Responsiveness of experimental prostate carcinoma bone tumors to neutron or photon radiation combined with cytokine therapy
    Gilda G Hillman
    Department of Radiation Oncology, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine and Harper Hospital, Detroit, MI 48201, USA
    Int J Radiat Oncol Biol Phys 56:1426-37. 2003
  2. pmc Prognostic value of abnormal p53 expression in locally advanced prostate cancer treated with androgen deprivation and radiotherapy: a study based on RTOG 9202
    Mingxin Che
    Department of Pathology, Wayne State University, Barbara Ann Karmanos Cancer Institute, Detroit, MI, USA
    Int J Radiat Oncol Biol Phys 69:1117-23. 2007
  3. ncbi request reprint In vitro and in vivo molecular evidence for better therapeutic efficacy of ABT-627 and taxotere combination in prostate cancer
    Sanjeev Banerjee
    Department of Pathology, Barbara Ann Karmanos Cancer Institute, 4160 John R Street, Detroit, MI 48201, USA
    Cancer Res 67:3818-26. 2007
  4. ncbi request reprint Prostate cancer treatment is enhanced by genistein in vitro and in vivo in a syngeneic orthotopic tumor model
    Yu Wang
    Department of Radiation Oncology, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan, 48201, USA
    Radiat Res 166:73-80. 2006
  5. ncbi request reprint Genistein potentiates inhibition of tumor growth by radiation in a prostate cancer orthotopic model
    Gilda G Hillman
    Department of Radiation Oncology, Barbara Ann Karmanos Cancer Institute at Wayne State University School of Medicine and Harper University Hospital, Detroit, MI 48201, USA
    Mol Cancer Ther 3:1271-9. 2004
  6. pmc Progression of renal cell carcinoma is inhibited by genistein and radiation in an orthotopic model
    Gilda G Hillman
    Department of Radiation Oncology, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201, USA
    BMC Cancer 7:4. 2007
  7. ncbi request reprint Curative antitumor immune response is optimal with tumor irradiation followed by genetic induction of major histocompatibility complex class I and class II molecules and suppression of Ii protein
    Yu Wang
    Department of Radiation Oncology, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine and Harper Hospital, Detroit, MI 48201, USA
    Hum Gene Ther 16:187-99. 2005
  8. ncbi request reprint In vitro and in vivo molecular evidence of genistein action in augmenting the efficacy of cisplatin in pancreatic cancer
    Sanjeev Banerjee
    Department of Pathology, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Int J Cancer 120:906-17. 2007
  9. ncbi request reprint Soy isoflavones enhance radiotherapy in a metastatic prostate cancer model
    Julian J Raffoul
    Department of Radiation Oncology, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Int J Cancer 120:2491-8. 2007
  10. pmc Regulation of gene expression and inhibition of experimental prostate cancer bone metastasis by dietary genistein
    Yiwei Li
    Department of Pathology, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Neoplasia 6:354-63. 2004

Collaborators

Detail Information

Publications27

  1. ncbi request reprint Responsiveness of experimental prostate carcinoma bone tumors to neutron or photon radiation combined with cytokine therapy
    Gilda G Hillman
    Department of Radiation Oncology, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine and Harper Hospital, Detroit, MI 48201, USA
    Int J Radiat Oncol Biol Phys 56:1426-37. 2003
    ..To improve the outcome of radiotherapy for prostate carcinoma bone tumors, we investigated bone tumor irradiation with photons or neutrons followed by interleukin 2 (IL-2) therapy in a tumor model...
  2. pmc Prognostic value of abnormal p53 expression in locally advanced prostate cancer treated with androgen deprivation and radiotherapy: a study based on RTOG 9202
    Mingxin Che
    Department of Pathology, Wayne State University, Barbara Ann Karmanos Cancer Institute, Detroit, MI, USA
    Int J Radiat Oncol Biol Phys 69:1117-23. 2007
    ....
  3. ncbi request reprint In vitro and in vivo molecular evidence for better therapeutic efficacy of ABT-627 and taxotere combination in prostate cancer
    Sanjeev Banerjee
    Department of Pathology, Barbara Ann Karmanos Cancer Institute, 4160 John R Street, Detroit, MI 48201, USA
    Cancer Res 67:3818-26. 2007
    ..Most importantly, the antitumor activity was associated with the down-regulation of molecular markers in tumor tissues that were similar to those observed in vitro...
  4. ncbi request reprint Prostate cancer treatment is enhanced by genistein in vitro and in vivo in a syngeneic orthotopic tumor model
    Yu Wang
    Department of Radiation Oncology, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan, 48201, USA
    Radiat Res 166:73-80. 2006
    ....
  5. ncbi request reprint Genistein potentiates inhibition of tumor growth by radiation in a prostate cancer orthotopic model
    Gilda G Hillman
    Department of Radiation Oncology, Barbara Ann Karmanos Cancer Institute at Wayne State University School of Medicine and Harper University Hospital, Detroit, MI 48201, USA
    Mol Cancer Ther 3:1271-9. 2004
    ..We tested this approach in vivo using an orthotopic prostate carcinoma model of PC-3 cells in nude mice...
  6. pmc Progression of renal cell carcinoma is inhibited by genistein and radiation in an orthotopic model
    Gilda G Hillman
    Department of Radiation Oncology, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201, USA
    BMC Cancer 7:4. 2007
    ....
  7. ncbi request reprint Curative antitumor immune response is optimal with tumor irradiation followed by genetic induction of major histocompatibility complex class I and class II molecules and suppression of Ii protein
    Yu Wang
    Department of Radiation Oncology, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine and Harper Hospital, Detroit, MI 48201, USA
    Hum Gene Ther 16:187-99. 2005
    ..The radiation contributes to the gene therapy by causing tumor debulking and increasing the permeability of tumors to infiltration of inflammatory cells...
  8. ncbi request reprint In vitro and in vivo molecular evidence of genistein action in augmenting the efficacy of cisplatin in pancreatic cancer
    Sanjeev Banerjee
    Department of Pathology, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Int J Cancer 120:906-17. 2007
    ....
  9. ncbi request reprint Soy isoflavones enhance radiotherapy in a metastatic prostate cancer model
    Julian J Raffoul
    Department of Radiation Oncology, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Int J Cancer 120:2491-8. 2007
    ..Our studies demonstrate the safety and potential role of soy isoflavones for enhancing the therapeutic effect of radiotherapy in prostate cancer...
  10. pmc Regulation of gene expression and inhibition of experimental prostate cancer bone metastasis by dietary genistein
    Yiwei Li
    Department of Pathology, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Neoplasia 6:354-63. 2004
    ..Genistein may thus be a promising agent for the prevention and/or treatment of prostate cancer...
  11. ncbi request reprint Expression of cyclooxygenase-2 in advanced stage ovarian serous carcinoma: correlation with tumor cell proliferation, apoptosis, angiogenesis, and survival
    Rouba Ali-Fehmi
    Department of Pathology, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Am J Obstet Gynecol 192:819-25. 2005
    ..The objective of this study was to examine the relationship between cyclo-oxygenase-2 expression and tumor proliferation, apoptosis and angiogenesis in patients with advanced stage high-grade ovarian carcinoma...
  12. ncbi request reprint Tumor irradiation followed by intratumoral cytokine gene therapy for murine renal adenocarcinoma
    Gilda G Hillman
    Department of Radiation Oncology, Barbara Ann Karmanos Cancer Institute at Wayne State University School of Medicine and Harper Hospital, Detroit, Michigan 48201, USA
    Cancer Gene Ther 11:61-72. 2004
    ..These findings demonstrate that tumor irradiation improves the efficacy of Ad-IL-2 gene therapy for induction of antitumor immune response...
  13. pmc Matrix metalloproteinase activity and osteoclasts in experimental prostate cancer bone metastasis tissue
    Zhong Dong
    Department of Urology, Wayne State University School of Medicine, 540 E Canfield, Detroit, MI 48201, USA
    Am J Pathol 166:1173-86. 2005
    ..These data suggest that osteoclast-derived MMP-9 may represent a potential therapeutic target in bone metastasis and provide a rationale for the development of MMP-9-specific inhibitors...
  14. pmc Differential expression of thromboxane synthase in prostate carcinoma: role in tumor cell motility
    Daotai Nie
    Department of Radiation Oncology, Wayne State University School of Medicine and Karmanos Cancer Institute, Detroit, Michigan 48202, USA
    Am J Pathol 164:429-39. 2004
    ..Finally, increased expression of TxS in DU145 cells increased cell motility. Our data suggest that human PCa cells express TxS and that this enzyme may contribute to PCa progression through modulating cell motility...
  15. ncbi request reprint The effect of cyclooxygenase-2 expression on tumor vascularity in advanced stage ovarian serous carcinoma
    Rouba Ali-Fehmi
    Department of Pathology, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Cancer 98:1423-9. 2003
    ..Investigations have shown that COX-2 overexpression is associated with increased proliferation, reduced apoptosis, and angiogenesis...
  16. ncbi request reprint Antitumor activity of epidermal growth factor receptor-related protein is mediated by inactivation of ErbB receptors and nuclear factor-kappaB in pancreatic cancer
    Yuxiang Zhang
    Department of Pathology, Karmanos Cancer Institute, Wayne State University of Medicine, Detroit, MI 48201, USA
    Cancer Res 66:1025-32. 2006
    ..In summary, our results suggest that ERRP is an effective pan-erbB inhibitor, which could be a potential therapeutic agent for pancreatic cancers expressing different levels and subclasses of erbB family of proteins...
  17. ncbi request reprint Handling and reporting of tumor-containing kidney specimens
    Mingxin Che
    Department of Pathology, Harper University Hospital, Wayne State University Detroit Medical Center, Detroit, MI 48201, USA
    Clin Lab Med 25:417-32. 2005
    ..A pathologic report of a tumor-containing kidney specimen should include all established or potential prognostic factors, especially tumor types, size, grade, information for pathologic staging, and status of the surgical margin...
  18. ncbi request reprint Clear cell renal cell carcinoma
    David J Grignon
    Department of Pathology, Wayne State University, Harper University Hospital, Detroit, MI, USA
    Clin Lab Med 25:305-16. 2005
    ..Histologically, a wide range of morphologic patterns can be encountered. Those cases with a multi-locular cystic architecture are considered to be a distinct subtype because of the clinicopathologic features...
  19. ncbi request reprint Pathologic features the urologist should expect on a prostate biopsy
    Mingxin Che
    Department of Pathology, Harper University Hospital, Wayne State University, Karmanos Cancer Institute, 3990 John R, Detroit, MI 48201, USA
    Urol Oncol 21:153-61. 2003
    ..In summary, the pathology reports on needle biopsies are far beyond the simple presence or absence of cancer; they contain invaluable information to clinicians on patient management and counseling...
  20. pmc A novel signaling axis of matriptase/PDGF-D/ß-PDGFR in human prostate cancer
    Carolyn V Ustach
    Department of Pathology, Barbara Ann Karmanos Cancer Institute, Wayne State University, School of Medicine, Detroit, Michigan 48201, USA
    Cancer Res 70:9631-40. 2010
    ..This study unveiled a novel signaling axis of matriptase/PDGF-D/β-PDGFR in PCa, providing new insights into functional interplay between serine protease and growth factor signaling networks...
  21. ncbi request reprint Disseminated malignant solitary fibrous tumor of the pleura
    Hongquan Zhang
    Department of Pathology, Harper University Hospital, Wayne State University and Karmanos Cancer Institute, Detroit, MI 48201, USA
    Pathol Int 54:111-5. 2004
    ....
  22. ncbi request reprint Quantification of G250 mRNA expression in renal epithelial neoplasms by real-time reverse transcription-PCR of dissected tissue from paraffin sections
    Tarek A Bismar
    Department of Pathology, Harper University Hospital, Wayne State University, 3990 John R, Detroit, MI 48201, USA
    Pathology 35:513-7. 2003
    ..Using this approach, we performed a preliminary study investigating the relationship between G250 expression and tumor behavior in clear cell RCC...
  23. ncbi request reprint A proposal for a new and more practical grading scheme for pancreatic ductal adenocarcinoma
    N Volkan Adsay
    Department of Pathology, Karmanos Cancer Institute and Harper University Hospital, Wayne State University, 3990 John R Street, Detroit, MI 48201, USA
    Am J Surg Pathol 29:724-33. 2005
    ..Most importantly, it is clinically relevant with good prognostic value. Lastly, it is also applicable for use in research, by utilizing "patterns," even in small specimens like microarrays or biopsies...
  24. pmc Maspin expression inhibits osteolysis, tumor growth, and angiogenesis in a model of prostate cancer bone metastasis
    Michael L Cher
    Department of Urology, Protease Program, and Integrated Biostatistics Unit, The Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, 540 East Canfield Avenue, Detroit, MI 48201, USA
    Proc Natl Acad Sci U S A 100:7847-52. 2003
    ....
  25. ncbi request reprint Pathology of prostate cancer
    Mingxin Che
    Department of Pathology, Wayne State University School of Medicine, Karmanos Cancer Institute Detroit, MI, USA
    Cancer Metastasis Rev 21:381-95. 2002
  26. ncbi request reprint Matrix metalloproteinase activity, bone matrix turnover, and tumor cell proliferation in prostate cancer bone metastasis
    Jeffrey A Nemeth
    Department of Urology, Wayne State University School of Medicine, Detroit, MI 48201, USA
    J Natl Cancer Inst 94:17-25. 2002
    ..Matrix metalloproteinases (MMPs) play roles in both normal bone remodeling and invasion and metastasis of prostate cancer. This study was designed to determine the role of MMP activity in prostate cancer that has metastasized to bone...
  27. doi request reprint Thromboxane A2 receptors in prostate carcinoma: expression and its role in regulating cell motility via small GTPase Rho
    Daotai Nie
    Department of Medical Microbiology and Immunology, Southern Illinois University School of Medicine and SimmonsCooper Cancer Institute, Springfield, Illinois 62794, USA
    Cancer Res 68:115-21. 2008
    ..Taken together, the data suggest that TPs are expressed in prostate cancer and activation of TPs regulates prostate cancer cell motility and cytoskeleton reorganization through activation of Rho...