Responsiveness of experimental prostate carcinoma bone tumors to neutron or photon radiation combined with cytokine therapyGilda G Hillman
Department of Radiation Oncology, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine and Harper Hospital, Detroit, MI 48201, USA
Int J Radiat Oncol Biol Phys 56:1426-37. 2003
..To improve the outcome of radiotherapy for prostate carcinoma bone tumors, we investigated bone tumor irradiation with photons or neutrons followed by interleukin 2 (IL-2) therapy in a tumor model...
Prognostic value of abnormal p53 expression in locally advanced prostate cancer treated with androgen deprivation and radiotherapy: a study based on RTOG 9202Mingxin Che
Department of Pathology, Wayne State University, Barbara Ann Karmanos Cancer Institute, Detroit, MI, USA
Int J Radiat Oncol Biol Phys 69:1117-23. 2007
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- In vitro and in vivo molecular evidence for better therapeutic efficacy of ABT-627 and taxotere combination in prostate cancer
Sanjeev Banerjee
Department of Pathology, Barbara Ann Karmanos Cancer Institute, 4160 John R Street, Detroit, MI 48201, USA
Cancer Res 67:3818-26. 2007
..Most importantly, the antitumor activity was associated with the down-regulation of molecular markers in tumor tissues that were similar to those observed in vitro...
- Prostate cancer treatment is enhanced by genistein in vitro and in vivo in a syngeneic orthotopic tumor model
Yu Wang
Department of Radiation Oncology, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan, 48201, USA
Radiat Res 166:73-80. 2006
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- Genistein potentiates inhibition of tumor growth by radiation in a prostate cancer orthotopic model
Gilda G Hillman
Department of Radiation Oncology, Barbara Ann Karmanos Cancer Institute at Wayne State University School of Medicine and Harper University Hospital, Detroit, MI 48201, USA
Mol Cancer Ther 3:1271-9. 2004
..We tested this approach in vivo using an orthotopic prostate carcinoma model of PC-3 cells in nude mice...
- Progression of renal cell carcinoma is inhibited by genistein and radiation in an orthotopic model
Gilda G Hillman
Department of Radiation Oncology, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201, USA
BMC Cancer 7:4. 2007
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- Curative antitumor immune response is optimal with tumor irradiation followed by genetic induction of major histocompatibility complex class I and class II molecules and suppression of Ii protein
Yu Wang
Department of Radiation Oncology, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine and Harper Hospital, Detroit, MI 48201, USA
Hum Gene Ther 16:187-99. 2005
..The radiation contributes to the gene therapy by causing tumor debulking and increasing the permeability of tumors to infiltration of inflammatory cells...
- In vitro and in vivo molecular evidence of genistein action in augmenting the efficacy of cisplatin in pancreatic cancer
Sanjeev Banerjee
Department of Pathology, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201, USA
Int J Cancer 120:906-17. 2007
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- Soy isoflavones enhance radiotherapy in a metastatic prostate cancer model
Julian J Raffoul
Department of Radiation Oncology, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201, USA
Int J Cancer 120:2491-8. 2007
..Our studies demonstrate the safety and potential role of soy isoflavones for enhancing the therapeutic effect of radiotherapy in prostate cancer...
- Regulation of gene expression and inhibition of experimental prostate cancer bone metastasis by dietary genistein
Yiwei Li
Department of Pathology, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201, USA
Neoplasia 6:354-63. 2004
..Genistein may thus be a promising agent for the prevention and/or treatment of prostate cancer...
- Expression of cyclooxygenase-2 in advanced stage ovarian serous carcinoma: correlation with tumor cell proliferation, apoptosis, angiogenesis, and survival
Rouba Ali-Fehmi
Department of Pathology, Wayne State University School of Medicine, Detroit, MI 48201, USA
Am J Obstet Gynecol 192:819-25. 2005
..2-3.3; P < .001). CONCLUSION: Expression of cyclo-oxygenase-2 correlates with tumor proliferation and tumor angiogenesis but not with apoptotic markers (bcl-2 expression) in high-grade, advanced-stage serous ovarian carcinoma...
- Tumor irradiation followed by intratumoral cytokine gene therapy for murine renal adenocarcinoma
Gilda G Hillman
Department of Radiation Oncology, Barbara Ann Karmanos Cancer Institute at Wayne State University School of Medicine and Harper Hospital, Detroit, Michigan 48201, USA
Cancer Gene Ther 11:61-72. 2004
..These findings demonstrate that tumor irradiation improves the efficacy of Ad-IL-2 gene therapy for induction of antitumor immune response...
- Matrix metalloproteinase activity and osteoclasts in experimental prostate cancer bone metastasis tissue
Zhong Dong
Department of Urology, Wayne State University School of Medicine, 540 E. Canfield, Detroit, MI 48201, USA
Am J Pathol 166:1173-86. 2005
..These data suggest that osteoclast-derived MMP-9 may represent a potential therapeutic target in bone metastasis and provide a rationale for the development of MMP-9-specific inhibitors...
- Differential expression of thromboxane synthase in prostate carcinoma: role in tumor cell motility
Daotai Nie
Department of Radiation Oncology, Wayne State University School of Medicine and Karmanos Cancer Institute, Detroit, Michigan 48202, USA
Am J Pathol 164:429-39. 2004
..Finally, increased expression of TxS in DU145 cells increased cell motility. Our data suggest that human PCa cells express TxS and that this enzyme may contribute to PCa progression through modulating cell motility...
- The effect of cyclooxygenase-2 expression on tumor vascularity in advanced stage ovarian serous carcinoma
Rouba Ali-Fehmi
Department of Pathology, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
Cancer 98:1423-9. 2003
..Investigations have shown that COX-2 overexpression is associated with increased proliferation, reduced apoptosis, and angiogenesis...
- Antitumor activity of epidermal growth factor receptor-related protein is mediated by inactivation of ErbB receptors and nuclear factor-kappaB in pancreatic cancer
Yuxiang Zhang
Department of Pathology, Karmanos Cancer Institute, Wayne State University of Medicine, Detroit, MI 48201, USA
Cancer Res 66:1025-32. 2006
..In summary, our results suggest that ERRP is an effective pan-erbB inhibitor, which could be a potential therapeutic agent for pancreatic cancers expressing different levels and subclasses of erbB family of proteins...
- Handling and reporting of tumor-containing kidney specimens
Mingxin Che
Department of Pathology, Harper University Hospital, Wayne State University Detroit Medical Center, Detroit, MI 48201, USA
Clin Lab Med 25:417-32. 2005
..A pathologic report of a tumor-containing kidney specimen should include all established or potential prognostic factors, especially tumor types, size, grade, information for pathologic staging, and status of the surgical margin...
- Clear cell renal cell carcinoma
David J Grignon
Department of Pathology, Wayne State University, Harper University Hospital, Detroit, MI, USA
Clin Lab Med 25:305-16. 2005
..Histologically, a wide range of morphologic patterns can be encountered. Those cases with a multi-locular cystic architecture are considered to be a distinct subtype because of the clinicopathologic features...
- Pathologic features the urologist should expect on a prostate biopsy
Mingxin Che
Department of Pathology, Harper University Hospital, Wayne State University, Karmanos Cancer Institute, 3990 John R, Detroit, MI 48201, USA
Urol Oncol 21:153-61. 2003
..In summary, the pathology reports on needle biopsies are far beyond the simple presence or absence of cancer; they contain invaluable information to clinicians on patient management and counseling...
- A novel signaling axis of matriptase/PDGF-D/ß-PDGFR in human prostate cancer
Carolyn V Ustach
Department of Pathology, Barbara Ann Karmanos Cancer Institute, Wayne State University, School of Medicine, Detroit, Michigan 48201, USA
Cancer Res 70:9631-40. 2010
..This study unveiled a novel signaling axis of matriptase/PDGF-D/β-PDGFR in PCa, providing new insights into functional interplay between serine protease and growth factor signaling networks...
- Disseminated malignant solitary fibrous tumor of the pleura
Hongquan Zhang
Department of Pathology, Harper University Hospital, Wayne State University and Karmanos Cancer Institute, Detroit, MI 48201, USA
Pathol Int 54:111-5. 2004
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- Quantification of G250 mRNA expression in renal epithelial neoplasms by real-time reverse transcription-PCR of dissected tissue from paraffin sections
Tarek A Bismar
Department of Pathology, Harper University Hospital, Wayne State University, 3990 John R, Detroit, MI 48201, USA
Pathology 35:513-7. 2003
..Quantification of G250 mRNA expression by real-time RT-PCR using paraffin sections is a feasible approach for future clinical studies in evaluating the prognostic and predictive value of G250 in clear cell RCC...
- A proposal for a new and more practical grading scheme for pancreatic ductal adenocarcinoma
N Volkan Adsay
Department of Pathology, Karmanos Cancer Institute and Harper University Hospital, Wayne State University, 3990 John R Street, Detroit, MI 48201, USA
Am J Surg Pathol 29:724-33. 2005
..Most importantly, it is clinically relevant with good prognostic value. Lastly, it is also applicable for use in research, by utilizing "patterns," even in small specimens like microarrays or biopsies...
- Maspin expression inhibits osteolysis, tumor growth, and angiogenesis in a model of prostate cancer bone metastasis
Michael L Cher
Department of Urology, Protease Program, and Integrated Biostatistics Unit, The Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, 540 East Canfield Avenue, Detroit, MI 48201, USA
Proc Natl Acad Sci U S A 100:7847-52. 2003
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- Pathology of prostate cancer
Mingxin Che
Department of Pathology, Wayne State University School of Medicine, Karmanos Cancer Institute Detroit, MI, USA
Cancer Metastasis Rev 21:381-95. 2002
- Matrix metalloproteinase activity, bone matrix turnover, and tumor cell proliferation in prostate cancer bone metastasis
Jeffrey A Nemeth
Department of Urology, Wayne State University School of Medicine, Detroit, MI 48201, USA
J Natl Cancer Inst 94:17-25. 2002
..Bone matrix turnover and metastatic tumor growth appear to be involved in a mutually supportive cycle that is disrupted by MMP inhibition...
Thromboxane A2 receptors in prostate carcinoma: expression and its role in regulating cell motility via small GTPase RhoDaotai Nie
Department of Medical Microbiology and Immunology, Southern Illinois University School of Medicine and SimmonsCooper Cancer Institute, Springfield, Illinois 62794, USA
Cancer Res 68:115-21. 2008
..Taken together, the data suggest that TPs are expressed in prostate cancer and activation of TPs regulates prostate cancer cell motility and cytoskeleton reorganization through activation of Rho...
