Abha Chauhan

Summary

Publications

  1. doi request reprint Brain region-specific glutathione redox imbalance in autism
    Abha Chauhan
    NYS Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, NY 10314, USA
    Neurochem Res 37:1681-9. 2012
  2. doi request reprint Brain region-specific deficit in mitochondrial electron transport chain complexes in children with autism
    Abha Chauhan
    NYS Institute for Basic Research in Developmental Disabilities, Staten Island, NY 10314, USA
    J Neurochem 117:209-20. 2011
  3. pmc Differences between the pattern of developmental abnormalities in autism associated with duplications 15q11.2-q13 and idiopathic autism
    Jerzy Wegiel
    Department of Developmental Neurobiology, New York State Institute for Basic Research in Developmental Disabilities, Staten Island, New York 10314, USA
    J Neuropathol Exp Neurol 71:382-97. 2012
  4. pmc Gelsolin levels are increased in the brain as a function of age during normal development in children that are further increased in Down syndrome
    Lina Ji
    Department of Neurochemistry, New York State Institute for Basic Research in Developmental Disabilities, Staten Island, 10314, USA
    Alzheimer Dis Assoc Disord 23:319-22. 2009
  5. doi request reprint Gelsolin is proteolytically cleaved in the brains of individuals with Alzheimer's disease
    Lina Ji
    New York State Institute for Basic Research in Developmental Disabilities, Staten Island, NY 10314, USA
    J Alzheimers Dis 18:105-11. 2009
  6. pmc Increased activities of Na+/K+-ATPase and Ca2+/Mg2+-ATPase in the frontal cortex and cerebellum of autistic individuals
    Lina Ji
    NYS Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, New York 10314, USA
    Life Sci 85:788-93. 2009
  7. doi request reprint Cytoplasmic gelsolin in pheochromocytoma-12 cells forms a complex with amyloid beta-protein
    Lina Ji
    New York State Institute for Basic Research in Developmental Disabilities, Staten Island, NY 10314, USA
    Neuroreport 19:463-6. 2008
  8. doi request reprint Upregulation of cytoplasmic gelsolin, an amyloid-beta-binding protein, under oxidative stress conditions: involvement of protein kinase C
    Lina Ji
    New York State Institute for Basic Research in Developmental Disabilities, Staten Island, NY, USA
    J Alzheimers Dis 19:829-38. 2010
  9. doi request reprint Calcium induces expression of cytoplasmic gelsolin in SH-SY5Y and HEK-293 cells
    Lina Ji
    Department of Neurochemistry, New York State Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, NY 10314, USA
    Neurochem Res 35:1075-82. 2010
  10. pmc Abnormal intracellular accumulation and extracellular Aβ deposition in idiopathic and Dup15q11.2-q13 autism spectrum disorders
    Jerzy Wegiel
    Department of Developmental Neurobiology, NYS Institute for Basic Research in Developmental Disabilities, Staten Island, New York, United States of America
    PLoS ONE 7:e35414. 2012

Collaborators

Detail Information

Publications24

  1. doi request reprint Brain region-specific glutathione redox imbalance in autism
    Abha Chauhan
    NYS Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, NY 10314, USA
    Neurochem Res 37:1681-9. 2012
    ....
  2. doi request reprint Brain region-specific deficit in mitochondrial electron transport chain complexes in children with autism
    Abha Chauhan
    NYS Institute for Basic Research in Developmental Disabilities, Staten Island, NY 10314, USA
    J Neurochem 117:209-20. 2011
    ..The deficits observed in the levels of ETC complexes in children with autism may readjust to normal levels by adulthood...
  3. pmc Differences between the pattern of developmental abnormalities in autism associated with duplications 15q11.2-q13 and idiopathic autism
    Jerzy Wegiel
    Department of Developmental Neurobiology, New York State Institute for Basic Research in Developmental Disabilities, Staten Island, New York 10314, USA
    J Neuropathol Exp Neurol 71:382-97. 2012
    ..04). The different spectrum and higher prevalence of developmental neuropathologic findings in the dup(15) cohort than in cases with idiopathic autism may contribute to the high risk of early onset of seizures and sudden death...
  4. pmc Gelsolin levels are increased in the brain as a function of age during normal development in children that are further increased in Down syndrome
    Lina Ji
    Department of Neurochemistry, New York State Institute for Basic Research in Developmental Disabilities, Staten Island, 10314, USA
    Alzheimer Dis Assoc Disord 23:319-22. 2009
    ..Because cytoplasmic gelsolin has 5 free thiol groups (cysteine), and its levels are increased in response to oxidative stress, we propose that gelsolin may serve as an antioxidant protein...
  5. doi request reprint Gelsolin is proteolytically cleaved in the brains of individuals with Alzheimer's disease
    Lina Ji
    New York State Institute for Basic Research in Developmental Disabilities, Staten Island, NY 10314, USA
    J Alzheimers Dis 18:105-11. 2009
    ..Taken together, these results suggest that there may be a link among oxidative stress, neuronal apoptosis, and gelsolin cleavage in AD...
  6. pmc Increased activities of Na+/K+-ATPase and Ca2+/Mg2+-ATPase in the frontal cortex and cerebellum of autistic individuals
    Lina Ji
    NYS Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, New York 10314, USA
    Life Sci 85:788-93. 2009
    ....
  7. doi request reprint Cytoplasmic gelsolin in pheochromocytoma-12 cells forms a complex with amyloid beta-protein
    Lina Ji
    New York State Institute for Basic Research in Developmental Disabilities, Staten Island, NY 10314, USA
    Neuroreport 19:463-6. 2008
    ..This report indicates that structural differences between plasma and cytoplasmic gelsolin do not play a key role in their complex formation with Abeta...
  8. doi request reprint Upregulation of cytoplasmic gelsolin, an amyloid-beta-binding protein, under oxidative stress conditions: involvement of protein kinase C
    Lina Ji
    New York State Institute for Basic Research in Developmental Disabilities, Staten Island, NY, USA
    J Alzheimers Dis 19:829-38. 2010
    ..It is suggested that activators of PKC that induce gelsolin expression may have therapeutic significance in Alzheimer's disease...
  9. doi request reprint Calcium induces expression of cytoplasmic gelsolin in SH-SY5Y and HEK-293 cells
    Lina Ji
    Department of Neurochemistry, New York State Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, NY 10314, USA
    Neurochem Res 35:1075-82. 2010
    ..In addition, phorbol-12-myristate-13-acetate, an activator of PKC, up-regulated c-gelsolin expression. These results suggest that calcium mediates up-regulation of c-gelsolin in a PKC-dependent manner...
  10. pmc Abnormal intracellular accumulation and extracellular Aβ deposition in idiopathic and Dup15q11.2-q13 autism spectrum disorders
    Jerzy Wegiel
    Department of Developmental Neurobiology, NYS Institute for Basic Research in Developmental Disabilities, Staten Island, New York, United States of America
    PLoS ONE 7:e35414. 2012
    ..It has been shown that amyloid ß (Aβ), a product of proteolytic cleavage of the amyloid β precursor protein (APP), accumulates in neuronal cytoplasm in non-affected individuals in a cell type-specific amount...
  11. pmc Protective effects of walnut extract against amyloid beta peptide-induced cell death and oxidative stress in PC12 cells
    Balu Muthaiyah
    Department of Neurochemistry, NYS Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, NY 10314, USA
    Neurochem Res 36:2096-103. 2011
    ..These results suggest that walnut extract can counteract Aβ-induced oxidative stress and associated cell death...
  12. ncbi request reprint Binding of proteases to fibrillar amyloid-beta protein and its inhibition by Congo red
    Harish Chander
    NYS Institute for Basic Research in Developmental Disabilities, Staten Island, New York 10314, USA
    J Alzheimers Dis 12:261-9. 2007
    ..Based on these results, we propose that the inhibition of binding of proteases to amyloid plaques may help in reducing the deposition of Abeta in AD...
  13. doi request reprint Relationship between proteolytically cleaved gelsolin and levels of amyloid-β protein in the brains of Down syndrome subjects
    Lina Ji
    New York State Institute for Basic Research in Developmental Disabilities, Staten Island, NY 10314, USA
    J Alzheimers Dis 22:609-17. 2010
    ..Since soluble non-fibrillar forms of Aβ are neurotoxic, they may be involved in apoptosis and proteolysis of gelsolin...
  14. pmc Reduced activity of protein kinase C in the frontal cortex of subjects with regressive autism: relationship with developmental abnormalities
    Lina Ji
    NYS Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, New York 10314, USA
    Int J Biol Sci 8:1075-84. 2012
    ..These findings suggest that regression in autism may be attributed, in part, to alterations in G-protein-coupled receptor-mediated signal transduction involving PKA and PKC in the frontal cortex...
  15. ncbi request reprint Oxidative stress in autism: increased lipid peroxidation and reduced serum levels of ceruloplasmin and transferrin--the antioxidant proteins
    Abha Chauhan
    NYS Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, New York 10314, USA
    Life Sci 75:2539-49. 2004
    ..It is suggested that such changes may lead to abnormal iron and copper metabolism in autism, and that increased oxidative stress may have pathological role in autism...
  16. pmc The neuropathology of autism: defects of neurogenesis and neuronal migration, and dysplastic changes
    Jerzy Wegiel
    Department of Developmental Neurobiology, NYS Institute for Basic Research in Developmental Disabilities IBR, 1050 Forest Hill Road, Staten Island, NY 10314, USA
    Acta Neuropathol 119:755-70. 2010
    ....
  17. ncbi request reprint Binding of trypsin to fibrillar amyloid beta-protein
    Harish Chander
    NYS Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, NY 10314, USA
    Brain Res 1082:173-81. 2006
    ..These results suggest that fAbeta and fibrillar amylin have strong affinities for trypsin, and chelation of proteases by abnormal aggregated proteins may be a general mechanism for inflicting pathological conditions in various diseases...
  18. pmc Elevated immune response in the brain of autistic patients
    Xiaohong Li
    Department of Neurochemistry, NY State Institute for Basic Research in Developmental Disabilities, NY 10314, New York, USA
    J Neuroimmunol 207:111-6. 2009
    ..Conclusion: ASD patients displayed an increased innate and adaptive immune response through the Th1 pathway, suggesting that localized brain inflammation and autoimmune disorder may be involved in the pathogenesis of ASD...
  19. doi request reprint Anti-amyloidogenic, anti-oxidant and anti-apoptotic role of gelsolin in Alzheimer's disease
    Ved Chauhan
    New York State Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, New York, 10314, USA
    Biogerontology 9:381-9. 2008
    ..In this article, we review evidence of gelsolin as an anti-amyloidogenic agent that can reduce amyloid load by acting as an inhibitor of Abeta fibrillization, and as an antioxidant and anti-apoptotic protein...
  20. doi request reprint BDNF-Akt-Bcl2 antiapoptotic signaling pathway is compromised in the brain of autistic subjects
    Ashfaq M Sheikh
    Department of Neurochemistry, NY State Institute for Basic Research in Developmental Disabilities, New York, New York 10314, USA
    J Neurosci Res 88:2641-7. 2010
    ..These results suggest that down-regulation of the BDNF-Akt-Bcl2 antiapoptotic signaling pathway in the autistic brain could be one of the underlying mechanisms responsible for the pathogenesis of autism...
  21. pmc Brain region-specific decrease in the activity and expression of protein kinase A in the frontal cortex of regressive autism
    Lina Ji
    NYS Institute for Basic Research in Developmental Disabilities, Staten Island, New York, United States of America
    PLoS ONE 6:e23751. 2011
    ..These results suggest that regression in autism may be associated, in part, with decreased PKA-mediated phosphorylation of proteins and abnormalities in cellular signaling...
  22. doi request reprint Impaired synthesis and antioxidant defense of glutathione in the cerebellum of autistic subjects: alterations in the activities and protein expression of glutathione-related enzymes
    Feng Gu
    NYS Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, NY 10314, USA
    Free Radic Biol Med 65:488-96. 2013
    ..These results suggest that enzymes involved in GSH homeostasis have impaired activities in the cerebellum in autism, and lower GCL activity in autism may be related to decreased protein expression of GCLM. ..
  23. ncbi request reprint Fibrillar amyloid beta-protein inhibits the activity of high molecular weight brain protease and trypsin
    Ved Chauhan
    NYS Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, New York 10314, USA
    J Alzheimers Dis 7:37-44. 2005
    ....
  24. ncbi request reprint Alteration in amino-glycerophospholipids levels in the plasma of children with autism: a potential biochemical diagnostic marker
    Ved Chauhan
    NYS Institute for Basic Research in Developmental Disabilities, Staten Island, New York, NY 10314, USA
    Life Sci 74:1635-43. 2004
    ..It is proposed that plasma AGP levels may function as a potential diagnostic marker for autism...