E Charmandari

Summary

Publications

  1. ncbi request reprint Novel causes of generalized glucocorticoid resistance
    E Charmandari
    Section on Pediatric Endocrinology, Reproductive Biology and Medicine Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, USA
    Horm Metab Res 39:445-50. 2007
  2. doi request reprint Stress response and child health
    Evangelia Charmandari
    Division of Endocrinology, Metabolism, and Diabetes, First Department of Pediatrics, University of Athens Medical School, Aghia Sophia Children s Hospital, Division of Endocrinology and Metabolism, Athens, Greece
    Sci Signal 5:mr1. 2012
  3. pmc A Novel Point Mutation in the DNA-Binding Domain (DBD) of the Human Glucocorticoid Receptor Causes Primary Generalized Glucocorticoid Resistance by Disrupting the Hydrophobic Structure of its DBD
    Michael L Roberts
    MD, MSc, PhD, MRCP UK, CCST UK, Division of Endocrinology, Metabolism and Diabetes, First Department of Pediatrics, University of Athens Medical School, Aghia Sophia Children s Hospital, Thivon and Papadiamantopoulou Street, Athens, 11527, Greece
    J Clin Endocrinol Metab 98:E790-5. 2013
  4. doi request reprint Primary generalized familial and sporadic glucocorticoid resistance (Chrousos syndrome) and hypersensitivity
    Evangelia Charmandari
    Division of Endocrinology, Metabolism and Diabetes, First Department of Pediatrics, University of Athens Medical School, Aghia Sophia Children s Hospital, Athens, Greece
    Endocr Dev 24:67-85. 2013
  5. doi request reprint Primary generalized glucocorticoid resistance and hypersensitivity: the end-organ involvement in the stress response
    Evangelia Charmandari
    Division of Endocrinology, Metabolism and Diabetes, First Department of Pediatrics, University of Athens Medical School, Aghia Sophia Children s Hospital, Athens 11527, Greece
    Sci Signal 5:pt5. 2012
  6. pmc A novel point mutation in the KCNJ5 gene causing primary hyperaldosteronism and early-onset autosomal dominant hypertension
    Evangelia Charmandari
    Division of Endocrinology, First Department of Pediatrics, University of Athens Medical School, Aghia Sophia Children s Hospital, Athens 11527, Greece
    J Clin Endocrinol Metab 97:E1532-9. 2012
  7. ncbi request reprint A novel point mutation in helix 11 of the ligand-binding domain of the human glucocorticoid receptor gene causing generalized glucocorticoid resistance
    Evangelia Charmandari
    Section on Endocrinology, Reproductive Biology and Medicine Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Clin Endocrinol Metab 92:3986-90. 2007
  8. pmc Generalized glucocorticoid resistance: clinical aspects, molecular mechanisms, and implications of a rare genetic disorder
    Evangelia Charmandari
    Division of Endocrinology and Metabolism, Clinical Research Center, Biomedical Research Foundation of the Academy of Athens, 4 Soranou tou Efessiou Street, Athens, Greece
    J Clin Endocrinol Metab 93:1563-72. 2008
  9. pmc A novel point mutation in the amino terminal domain of the human glucocorticoid receptor (hGR) gene enhancing hGR-mediated gene expression
    Evangelia Charmandari
    Division of Endocrinology and Metabolism, Biomedical Research Foundation of the Academy of Athens, 4 Soranou tou Efessiou Street, Athens 11527, Greece
    J Clin Endocrinol Metab 93:4963-8. 2008
  10. pmc Chrousos syndrome: a seminal report, a phylogenetic enigma and the clinical implications of glucocorticoid signalling changes
    Evangelia Charmandari
    Division of Endocrinology and Metabolism, Clinical Research Center, Biomedical Research Foundation of the Academy of Athens, Athens, Greece
    Eur J Clin Invest 40:932-42. 2010

Collaborators

Detail Information

Publications28

  1. ncbi request reprint Novel causes of generalized glucocorticoid resistance
    E Charmandari
    Section on Pediatric Endocrinology, Reproductive Biology and Medicine Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, USA
    Horm Metab Res 39:445-50. 2007
    ....
  2. doi request reprint Stress response and child health
    Evangelia Charmandari
    Division of Endocrinology, Metabolism, and Diabetes, First Department of Pediatrics, University of Athens Medical School, Aghia Sophia Children s Hospital, Division of Endocrinology and Metabolism, Athens, Greece
    Sci Signal 5:mr1. 2012
    ..This review summarizes the topics presented at the fifth New Inroads to Child Health (NICHe) Conference "Stress Response and Child Health" held at Heraklion, Crete, Greece, in May 2012...
  3. pmc A Novel Point Mutation in the DNA-Binding Domain (DBD) of the Human Glucocorticoid Receptor Causes Primary Generalized Glucocorticoid Resistance by Disrupting the Hydrophobic Structure of its DBD
    Michael L Roberts
    MD, MSc, PhD, MRCP UK, CCST UK, Division of Endocrinology, Metabolism and Diabetes, First Department of Pediatrics, University of Athens Medical School, Aghia Sophia Children s Hospital, Thivon and Papadiamantopoulou Street, Athens, 11527, Greece
    J Clin Endocrinol Metab 98:E790-5. 2013
    ....
  4. doi request reprint Primary generalized familial and sporadic glucocorticoid resistance (Chrousos syndrome) and hypersensitivity
    Evangelia Charmandari
    Division of Endocrinology, Metabolism and Diabetes, First Department of Pediatrics, University of Athens Medical School, Aghia Sophia Children s Hospital, Athens, Greece
    Endocr Dev 24:67-85. 2013
    ..This review summarizes the pathophysiology, molecular mechanisms and clinical aspects of Chrousos syndrome and PGGH...
  5. doi request reprint Primary generalized glucocorticoid resistance and hypersensitivity: the end-organ involvement in the stress response
    Evangelia Charmandari
    Division of Endocrinology, Metabolism and Diabetes, First Department of Pediatrics, University of Athens Medical School, Aghia Sophia Children s Hospital, Athens 11527, Greece
    Sci Signal 5:pt5. 2012
    ..This Presentation summarizes the pathophysiology, clinical manifestations, and molecular mechanisms of the PGGR and PGGH states...
  6. pmc A novel point mutation in the KCNJ5 gene causing primary hyperaldosteronism and early-onset autosomal dominant hypertension
    Evangelia Charmandari
    Division of Endocrinology, First Department of Pediatrics, University of Athens Medical School, Aghia Sophia Children s Hospital, Athens 11527, Greece
    J Clin Endocrinol Metab 97:E1532-9. 2012
    ....
  7. ncbi request reprint A novel point mutation in helix 11 of the ligand-binding domain of the human glucocorticoid receptor gene causing generalized glucocorticoid resistance
    Evangelia Charmandari
    Section on Endocrinology, Reproductive Biology and Medicine Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Clin Endocrinol Metab 92:3986-90. 2007
    ....
  8. pmc Generalized glucocorticoid resistance: clinical aspects, molecular mechanisms, and implications of a rare genetic disorder
    Evangelia Charmandari
    Division of Endocrinology and Metabolism, Clinical Research Center, Biomedical Research Foundation of the Academy of Athens, 4 Soranou tou Efessiou Street, Athens, Greece
    J Clin Endocrinol Metab 93:1563-72. 2008
    ..We review the clinical aspects, molecular mechanisms, and implications of this disorder...
  9. pmc A novel point mutation in the amino terminal domain of the human glucocorticoid receptor (hGR) gene enhancing hGR-mediated gene expression
    Evangelia Charmandari
    Division of Endocrinology and Metabolism, Biomedical Research Foundation of the Academy of Athens, 4 Soranou tou Efessiou Street, Athens 11527, Greece
    J Clin Endocrinol Metab 93:4963-8. 2008
    ..We investigated the molecular mechanisms of action of the natural mutant receptor hGRalphaD401H...
  10. pmc Chrousos syndrome: a seminal report, a phylogenetic enigma and the clinical implications of glucocorticoid signalling changes
    Evangelia Charmandari
    Division of Endocrinology and Metabolism, Clinical Research Center, Biomedical Research Foundation of the Academy of Athens, Athens, Greece
    Eur J Clin Invest 40:932-42. 2010
    ..Glucocorticoids regulate a broad spectrum of physiologic functions and play important roles in resting and stress homeostasis. Their actions are mediated by the nuclear glucocorticoid receptor (GR)...
  11. doi request reprint Primary generalized glucocorticoid resistance and hypersensitivity
    Evangelia Charmandari
    First Department of Pediatrics, Division of Endocrinology, Metabolism and Diabetes, University of Athens Medical School, Aghia Sophia Children s Hospital, Greece
    Horm Res Paediatr 76:145-55. 2011
    ..This review summarizes the pathophysiology, molecular mechanisms and clinical aspects of primary generalized glucocorticoid resistance (PGGR) and hypersensitivity (PGGH)...
  12. ncbi request reprint Functional characterization of the natural human glucocorticoid receptor (hGR) mutants hGRalphaR477H and hGRalphaG679S associated with generalized glucocorticoid resistance
    Evangelia Charmandari
    Pediatric Endocrinology Section, Reproductive Biology and Medicine Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20895, USA
    J Clin Endocrinol Metab 91:1535-43. 2006
    ....
  13. ncbi request reprint Natural glucocorticoid receptor mutants causing generalized glucocorticoid resistance: molecular genotype, genetic transmission, and clinical phenotype
    Evangelia Charmandari
    Pediatric and Reproductive Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Clin Endocrinol Metab 89:1939-49. 2004
    ....
  14. ncbi request reprint Rho family Guanine nucleotide exchange factor Brx couples extracellular signals to the glucocorticoid signaling system
    Tomoshige Kino
    Pediatric Endocrinology Section, Reproductive Biology and Medicine Branch, NICHD, National Institutes of Health, Bethesda Maryland 20892, USA
    J Biol Chem 281:9118-26. 2006
    ..Nuclear Brx might act as a local GRE-GR-transcriptosome activator by mediating the effect of small G-proteins on glucocorticoid-regulated genes...
  15. pmc The human glucocorticoid receptor: molecular basis of biologic function
    Nicolas C Nicolaides
    Division of Endocrinology and Metabolism, Clinical Research Center, Biomedical Research Foundation of the Academy of Athens, 11527, Athens, Greece
    Steroids 75:1-12. 2010
    ..This review summarizes the basic aspects of the structure and actions of the human (h) GR, and the molecular basis of its biologic functions...
  16. pmc Glucocorticoid receptor mutants demonstrate increased motility inside the nucleus of living cells: time of fluorescence recovery after photobleaching (FRAP) is an integrated measure of receptor function
    Tomoshige Kino
    Pediatric Endocrinology Section, Reproductive Biology and Medicine Branch, National Institute of Child Health and Human Development National Institutes of Health, Bethesda, MD 20892 1109, USA
    Mol Med 10:80-8. 2004
    ....
  17. ncbi request reprint Familial/sporadic glucocorticoid resistance syndrome and hypertension
    Tomoshige Kino
    Pediatric and Reproductive Endocrinology Branch, National Institute of Child Health and Human Development NIH, Building 10, Room 9D42, 10 Center Drive MSC 1583, Bethesda, MD 20892, USA
    Ann N Y Acad Sci 970:101-11. 2002
    ..These results suggest that the pathologic mechanisms of glucocorticoid resistance is quite broad, and this is reflected in the wide variability of the clinical picture in patients with the syndrome...
  18. ncbi request reprint The human glucocorticoid receptor (hGR) beta isoform suppresses the transcriptional activity of hGRalpha by interfering with formation of active coactivator complexes
    Evangelia Charmandari
    Pediatric and Reproductive Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, 10 Center Drive, Building 10, Room 9D42, Bethesda, Maryland 20892 1583, USA
    Mol Endocrinol 19:52-64. 2005
    ..These findings suggest that participation of hGRbeta in the formation of a coactivator complex renders this complex ineffective...
  19. pmc Identification of natural human glucocorticoid receptor (hGR) mutations or polymorphisms and their functional consequences at the hormone-receptor interaction level
    Evangelia Charmandari
    Division of Endocrinology and Metabolism, Biomedical Research Foundation of the Academy of Athens, Athens, Greece
    Methods Mol Biol 590:33-60. 2009
    ....
  20. ncbi request reprint Tissue glucocorticoid resistance/hypersensitivity syndromes
    Tomoshige Kino
    Pediatric and Reproductive Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892 1583, USA
    J Steroid Biochem Mol Biol 85:457-67. 2003
    ....
  21. ncbi request reprint Familial/sporadic glucocorticoid resistance: clinical phenotype and molecular mechanisms
    Evangelia Charmandari
    Pediatric and Reproductive Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892 1583, USA
    Ann N Y Acad Sci 1024:168-81. 2004
    ..The present review focuses on the mechanisms of GR action and the clinical manifestations and molecular mechanisms of familial/sporadic glucocorticoid resistance...
  22. pmc Glucocorticoid receptor: implications for rheumatic diseases
    T Kino
    Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Clin Exp Rheumatol 29:S32-41. 2011
    ....
  23. pmc Evaluation of the hypothalamic-pituitary-adrenal axis function in childhood and adolescence
    George P Chrousos
    Division of Endocrinology and Metabolism, Clinical Research Center, Biomedical Research Foundation of the Academy of Athens, Athens, Greece
    Neuroimmunomodulation 16:272-83. 2009
    ..We review the most common endocrinologic investigations used in the evaluation of the HPA axis integrity and function...
  24. ncbi request reprint Endocrinologic and psychologic evaluation of 21-hydroxylase deficiency carriers and matched normal subjects: evidence for physical and/or psychologic vulnerability to stress
    Evangelia Charmandari
    Pediatric and Reproductive Endocrinology Branch, National Institute of Child Health and Human Development, The Warren Grant Magnuson Clinical Center, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Clin Endocrinol Metab 89:2228-36. 2004
    ..These changes might predict mild predisposition of these subjects to physical and psychologic pathology, suggesting that larger studies are necessary...
  25. ncbi request reprint Glucocorticoids and their actions: an introduction
    Evangelia Charmandari
    Pediatric and Reproductive Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892 1583, USA
    Ann N Y Acad Sci 1024:1-8. 2004
  26. ncbi request reprint HIV-1 accessory protein Vpr inhibits the effect of insulin on the Foxo subfamily of forkhead transcription factors by interfering with their binding to 14-3-3 proteins: potential clinical implications regarding the insulin resistance of HIV-1-infected pat
    Tomoshige Kino
    Pediatric and Reproductive Endocrinology Branch, National Institute of Child Health and Human Development, NIH, 10 Center Dr MSC 1109, Building 10, Clinical Research Center, Room 1 3140, Bethesda, MD 20892 1109, USA
    Diabetes 54:23-31. 2005
    ..Vpr thus may contribute to the tissue-selective insulin resistance often observed in HIV-1-infected individuals...
  27. ncbi request reprint A novel point mutation in the ligand-binding domain (LBD) of the human glucocorticoid receptor (hGR) causing generalized glucocorticoid resistance: the importance of the C terminus of hGR LBD in conferring transactivational activity
    Evangelia Charmandari
    Department of Pediatric Endocrinology, Great Ormond Street Hospital for Children, 9th Floor, Southwood Building, Great Ormond Street, London, United Kingdom WC1N 3JH
    J Clin Endocrinol Metab 90:3696-705. 2005
    ..We conclude that the carboxyl terminus of the ligand-binding domain of hGRalpha is extremely important in conferring transactivational activity by altering multiple functions of this composite transcription factor...
  28. ncbi request reprint Glucocorticoid action networks--an introduction to systems biology
    George P Chrousos
    J Clin Endocrinol Metab 89:563-4. 2004