Salmeterol and fluticasone propionate (50/250 microg) administered via combination Diskus inhaler: as effective as when given via separate Diskus inhalersK R Chapman
Toronto Hospital, Western Division, Toronto, Canada
Can Respir J 6:45-51. 1999
..To compare the efficacy and safety of a new combination Diskus inhaler containing both salmeterol 50 mg and fluticasone propionate 250 mg (Seretide) with the two drugs delivered via separate Diskus inhalers...
- Gender bias in the diagnosis of COPD
K R Chapman
Division of Respiratory Medicine, Department of Medicine, University of Toronto, Toronto, Ontario, Canada
Chest 119:1691-5. 2001
..There may also be underdiagnosis and misdiagnosis of COPD in both sexes because objective measures of lung function are underused...
- Control of asthma in Canada: failure to achieve guideline targets
K R Chapman
University of Toronto, Toronto, Canada
Can Respir J 8:35A-40A. 2001
..To assess the degree of asthma control achieved by patients with asthma in Canada and to describe the impact of poor asthma control...
- Defining the asthma phenotype for the purpose of genetic analysis
S Kesten
University of Toronto, Canada
J Asthma 34:483-91. 1997
....
- Exhaled nitric oxide and bronchial reactivity during and after inhaled beclomethasone in mild asthma
P E Silkoff
Division of Respiratory Medicine, Faculty of Medicine, The University of Toronto, Canada
J Asthma 35:473-9. 1998
..3+/-46.1 at 1 week after withdrawal. ENO did not correlate with PC20 or FEV1. The changes in ENO and PC20 were inversely correlated (r2 = 0.325). ENO may be an index of airway inflammation and therapeutic response in bronchial asthma...
- Exhaled nitric oxide in chronic obstructive pulmonary disease: relationship to pulmonary function
K Ansarin
Asthma Centre of the University Health Network, Toronto, Ontario, Canada
Eur Respir J 17:934-8. 2001
..Exhaled nitric oxide is increased in patients with chronic obstructive pulmonary disease, an increase that is influenced by structural abnormalities of tobacco-induced lung damage...
- The patient level cost of asthma in adults in south central Ontario. Pharmacy Medication Monitoring Program Advisory Board
W J Ungar
Department of Health Administration and Division of Respirology, University of Toronto, Toronto, Canada
Can Respir J 5:463-71. 1998
..To assess the annual cost of asthma per adult patient from the perspectives of society, the Ontario Ministry of Health and the patient...
- Respiratory rate during acute asthma
S Kesten
Division of Respiratory Medicine, Toronto Western Hospital, Canada
Chest 97:58-62. 1990
..In the former setting, the respiratory rate is correlated with spirometric measures of airflow obstruction, but the weakness of the correlation does not allow the respiratory rate to be used as a substitute for spirometry...
- Inhaled beclomethasone dipropionate improves acoustic measures of voice in patients with asthma
M S Balter
Asthma Education Clinic, Mt Sinai Hospital, University of Toronto, Toronto, Canada
Chest 120:1829-34. 2001
..Inhaled corticosteroids have the potential to produce upper-airway side effects such as hoarseness. As new compounds and delivery devices are developed and compared, it is difficult to quantify their adverse upper-airway effects...
- Suboptimal asthma control: prevalence, detection and consequences in general practice
K R Chapman
University of Toronto, Canada
Eur Respir J 31:320-5. 2008
..Lack of control can be recognised by physicians who are likely to consider appropriate changes to therapy. A lack of short-term symptom control of asthma is associated with excess healthcare utilisation...
- Exhaled nitric oxide and hydrogen peroxide in patients with chronic obstructive pulmonary disease: effects of inhaled beclomethasone
I M Ferreira
Asthma Centre, University of Toronto, Toronto Western Hospital, University Health Network, Toronto, Ontario, Canada
Am J Respir Crit Care Med 164:1012-5. 2001
..50). We conclude that inhaled beclomethasone reduces ENO levels in stable nonsmoking patients with COPD, a finding compatible with an antiinflammatory mechanism of action...
- Inhaler education for hospital-based pharmacists: how much is required?
C A Jackevicius
The Toronto Hospital and Faculty of Pharmacy, University of Toronto, Toronto, Canada
Can Respir J 6:237-44. 1999
..To compare the effectiveness of a more intensive educational intervention with a less intensive intervention on the ability of hospital pharmacists to be prepared to educate patients regarding inhaled device technique...
- Changes in pulmonary function and cross-sectional area of trachea and bronchi in asthmatics following inhalation of procaterol hydrochloride and ipratropium bromide
V Hoffstein
Department of Medicine, St Michael s Hospital, Toronto, Canada
Am J Respir Crit Care Med 149:81-5. 1994
..abstract truncated at 250 words)..
- The impact of a nationally coordinated pharmacy-based asthma education intervention
S A Diamond
Pedipharm Consultants, Toronto, Ontario
Can Respir J 8:261-5. 2001
..To assess the impact of a nationally coordinated pharmacy-based educational intervention on self-management behaviour and markers of asthma control in self-referred patients with asthma...
- Effectiveness and safety of salmeterol in nonspecialist practice settings
K R Chapman
University of Toronto, Toronto, Ontario, Canada
Chest 119:714-9. 2001
..028). CONCLUSIONS: Salmeterol treatment is effective in subjects typically cared for in the primary-care setting and does not increase the frequency of severe exacerbations...
- Patient handling of a dry-powder inhaler in clinical practice
S Epstein
Asthma Centre, Toronto Western Hospital, University Health Network, Toronto, Ontario, Canada
Chest 120:1480-4. 2001
..The most common handling flaw, suboptimal breath-holding, is not specific to this device and is of uncertain clinical significance...
The clinical impact of single inhaler therapy in asthmaK Czarnecka
Asthma and Airway Centre, University Health Network, Toronto Western Hospital, Toronto, Ontario, Canada
Clin Exp Allergy 42:1006-13. 2012
....
- Maintenance of asthma control by once-daily inhaled ciclesonide in adults with persistent asthma
K R Chapman
Toronto Western Hospital, University Health Network, Toronto, Ontario, Canada
Allergy 60:330-7. 2005
....
- Difficult asthma: consider all of the possibilities
L C Cicutto
Toronto Western Hospital, Toronto, Canada
Can Respir J 7:415-8. 2000
..This led to a surgical resection of a mucoepidermoid carcinoma. This case highlights the need to consider all possibilities during the evaluation of patients with difficult asthma...
- Epidemiology and costs of chronic obstructive pulmonary disease
K R Chapman
Asthma and Airway Centre, Toronto University Health Network, Toronto Western Hospital, Room 7-451 New East Wing, 399 Bathurst Street, Toronto, Ontario M5T 2S8, Canada
Eur Respir J 27:188-207. 2006
- Induced sputum: comparison of postinfectious cough with allergic asthma in children
B Zimmerman
Gage Occupational and Environmental Health Unit, St Michael s Hospital, and the Asthma Centre, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada
J Allergy Clin Immunol 105:495-9. 2000
..Cough persisting after a respiratory infection is common in children and is often managed as asthma. However, little is known about the pathophysiologic mechanisms of such cough and how it compares with asthma...
A 21-year-old man with systemic-onset juvenile rheumatoid arthritis, cough and progressive dyspneaA Leber
Department of Medicine, University Health Network, University of Toronto, Toronto, Ontario, Canada
Can Respir J 17:e42-4. 2010
..Multiple treatment regimens were attempted; however, definitive management was only achieved through double-lung transplantation...
- Corticosteroid therapy for patients with acute exacerbations of chronic obstructive pulmonary disease: a systematic review
J M Singh
Division of Internal Medicine, Room 4-154, St Michael's Hospital, 30 Bond St, Toronto, Ontario, Canada M5B 1W8
Arch Intern Med 162:2527-36. 2002
..CONCLUSION: Short courses of systemic corticosteroids in acute exacerbations of COPD have been shown to improve spirometric outcomes (good-quality evidence) and clinical outcomes (good-quality evidence)...
- The burden of COPD in Canada: results from the Confronting COPD survey
K R Chapman
University of Toronto, Ontario, Canada
Respir Med 97:S23-31. 2003
..Early diagnosis and the application of available but underused interventions (e.g. smoking cessation, inhaled drug therapies and pulmonary rehabilitation) could reduce the morbidity and costs of COPD in this country...
