HCV core-induced nonobese hepatic steatosis is associated with hypoadiponectinemia and is ameliorated by adiponectin administrationMing Ling Chang
Liver Research Center, Division of Hepatology, Department of Gastroenterology and Hepatology, Chang Gung Memorial Hospital, Linko, Taiwan
Obesity (Silver Spring) 20:1474-80. 2012
..024). In conclusion, HCV core-induced nonobese hepatic steatosis is associated with downregulation of the leptin gene in visceral fat and concurrent hypoadiponectinemia; however, these effects may be ameliorated by adiponectin treatment...
- Cell cycle perturbation in the hepatocytes of HCV core transgenic mice following common bile duct ligation is associated with enhanced p21 expression
Ming Ling Chang
Liver Research Unit, Department of Hepatogastroenterology, Chang Gung Memorial Hospital, Chang Gung University, College of Medicine, Taoyuan, Taiwan
J Med Virol 81:467-72. 2009
..This may account at least partially for the strong association between HCV-related hepatocarcinogenesis and hepatic inflammation/ fibrosis...
- Acute expression of hepatitis C core protein in adult mouse liver: Mitochondrial stress and apoptosis
Ming Ling Chang
Liver Research Center and Department of Hepatogastroenterology, Chang Gung Memorial Hospital, Chang Gung University, College of Medicine, Taoyuan, Taiwan
Scand J Gastroenterol 43:747-55. 2008
..The purpose of this study was to investigate the effects of core produced de novo within adult mouse hepatocytes by using a new transgenic mouse line in which expression of HCV core is regulated by tetracycline (tet-off)...
Hepatic inflammation mediated by hepatitis C virus core protein is ameliorated by blocking complement activationMing Ling Chang
Liver Research Center and Department of Hepatogastroenterology, Chang Gung Memorial Hospital Chang Gung University, College of Medicine, Taoyuan, Taiwan, Republic of China
BMC Med Genomics 2:51. 2009
..These effects mediated by HCV core are reduced by administration of CD55, a regulator of the complement pathway. The model may be valuable in investigating the pathogenesis of liver inflammation in chronic hepatitis C...
- Altered expression patterns of lipid metabolism genes in an animal model of HCV core-related, nonobese, modest hepatic steatosis
Ming Ling Chang
Liver Research Center and Department of Hepatogastroenterology, Chang Gung Memorial Hospital, No 5, Fu Hsing Street, Kuei Shan, Taoyuan, Taiwan
BMC Genomics 9:109. 2008
..Because the gene expression patterns of nonobese hepatic steatosis in affected patients remain unclear, we sought to explore these patterns using an animal model of nonobese hepatic steatosis...
Identification of a novel pre-S2 mutation in a subgroup of chronic carriers with spontaneous clearance of hepatitis B virus surface antigenChau Ting Yeh
Liver Research Unit, Chang Gung Memorial Hospital and Chang Gung University School of Medicine, Taipei, Taiwan
J Gastroenterol Hepatol 18:1129-38. 2003
..The aim of the present study was to investigate whether spontaneous seroclearance of hepatitis B surface antigen (HBsAg) in patients with chronic hepatitis B could be attributed to the presence of pre-S/S gene mutations...
- Emergence and takeover of precore-stop mutant prior to exacerbation of e antigen-negative chronic hepatitis B after withdrawal of lamivudine therapy
Chau Ting Yeh
Liver Research Unit, Chang Gung Memorial Hospital, Taipei, Taiwan
J Med Virol 78:906-10. 2006
..The present data indicate that at least in some patients, the precore-stop mutant is the cause but not the consequence of the flare of HBeAg-negative hepatitis...
- Topological and evolutional relationships between HCV core protein and hepatic lipid vesicles: studies in vitro and in conditionally transgenic mice
Ming Ling Chang
Liver Research Unit, Department of Hepatogastroenterology, Chang Gung Memorial Hospital, No 5 Fu Hsing Street, Kuei Shan, Taoyuan, Taiwan, China
World J Gastroenterol 13:3472-7. 2007
..To investigate a specific association between hepatic steatosis and hepatitis C virus (HCV) core...
- A novel ex vivo assay of interferon-based suppression, to predict the outcome of antiviral therapy for hepatitis C
Chau Ting Yeh
Liver Research Unit, Chang Gung Medical Center, and Department of Surgery, Chang Gung Children s Hospital, Taipei, Taiwan
J Infect Dis 193:1365-70. 2006
..264-14.085]; P=.0192) were independent determinants of sustained virological response. In conclusion, this new assay serves as an independent predictor of sustained virological response in interferon-based antiviral therapy...
- Hydrodynamics-based transfection of the combination of betacellulin and neurogenic differentiation 1 DNA ameliorates hyperglycemia in mice with streptozotocin-induced diabetes
Chang Mu Sung
Liver Research Center and Department of Hepatogastroenterology, Chang Gung Memorial Hospital, College of Medicine, Chang Gung University, Taoyuan, Taiwan
Diabetes Technol Ther 13:519-25. 2011
..We aimed to evaluate the feasibility of hydrodynamics-based transfection (HBT) with Neurod1 and Btc in improving hyperglycemia...
- Gene gun bombardment with DNA-coated gold particles is a potential alternative to hydrodynamics-based transfection for delivering genes into superficial hepatocytes
Ming Ling Chang
Liver Research Center and Department of Hepatogastroenterology, Chang Gung Memorial Hospital, Taoyuan, Taiwan
Hum Gene Ther 19:391-5. 2008
....
- Identification of postoperative prognostic microRNA predictors in hepatocellular carcinoma
Ya Hui Huang
Department of Hepato Gastroenterology, Liver Research Center, Chang Gung Memorial Hospital, Taoyuan, Taiwan
PLoS ONE 7:e37188. 2012
..Functional analysis of a miRNA predictor, miR-155, suggested that the prognostic miRNA predictors identified under this strategy could serve as potential molecular targets for anticancer therapy...
- The various impacts of the hepatitis C virus core protein upon hepatic oxidative stress after common bile duct ligation and partial hepatectomy
Ming Yu Chang
Division of Pediatric Critical Care and Emergency Medicine, Chang Gung Children s Hospital, Taoyuan, Taiwan
Redox Rep 13:172-8. 2008
....
- Hydrodynamics-based transfection of pancreatic duodenal homeobox 1 DNA improves hyperglycemia and is associated with limited complications in diabetic mice
Tsung Hsing Chen
Liver Research Center and Department of Hepatogastroenterology, Chang Gung Memorial Hospital, Kuei Shan, Taoyuan, Taiwan
Endocr J 56:783-90. 2009
..In studies on the short-term biological effects of Pdx1 in vivo, HBT is a potential alternative to viral delivery of Pdx1 to the murine liver...
- Identification of NV-F virus DNA in hepatocellular carcinoma
Chau Ting Yeh
Liver Research Unit, Chang Gung Medical Center, Taipei, Taiwan
J Med Virol 79:92-6. 2007
..In conclusion, NV-F virus DNA was identified in 15.4% of HCC tissues. HCC patients with NV-F virus infection were significantly older than those without NV-F virus infection...
- Identification of a hepatitis B virus S gene mutant in lamivudine-treated patients experiencing HBsAg seroclearance
Chao Wei Hsu
Liver Research Unit, Chang Gung Memorial Hospital, Taipei, Taiwan
Gastroenterology 132:543-50. 2007
..It is generally believed to be a benevolent sign, implicating clearance of viremia. The aim of this study is to examine the authenticity of this dogma...
- Hepatitis B virus-DNA level and basal core promoter A1762T/G1764A mutation in liver tissue independently predict postoperative survival in hepatocellular carcinoma
Chau Ting Yeh
Liver Research Center, Department of Hepato Gastroenterology, Chang Gung Memorial Hospital, Taipei, Taiwan
Hepatology 52:1922-33. 2010
..A short stretch pre-S deletion located between codons 107 and 141 was strongly associated with a poorer postoperative prognosis...
- Characterization of a HCV NS5A protein derived from a patient with hepatoma
Chau Ting Yeh
Liver Research Unit, Chang Gung Medical Center, Taipei, Taiwan
Biochem Biophys Res Commun 327:516-22. 2005
..Our results suggested that other cytosolic pathways independent of Grb2-mediated mechanisms were involved in the transactivation activity of HCV NS5A...
- HURP expression-assisted risk scores identify prognosis distinguishable subgroups in early stage liver cancer
Ming Ling Chang
Liver Research Center and Department of Hepatology, Chang Gung Memorial Hospital, Taoyuan, Taiwan
PLoS ONE 6:e26323. 2011
..Hepatoma up-regulated protein (HURP) is a component of the chromatin-dependent pathway for spindle assembly. We examined the prognostic predictive value of HURP in human hepatocellular carcinoma (HCC)...
- Impact of the novel hepatotropic viruslike agent NV-F during chronic hepatitis C virus infection
Chau Ting Yeh
Liver Research Unit, Chang Gung Memorial Hospital, Taipei, Taiwan
J Infect Dis 198:1742-8. 2008
..In conclusion, coinfection of the NV-F agent in chronic HCV infection is associated with more severe hepatitis activity...
- Sustained eradication of hepatitis C virus by low-dose long-term interferon therapy in a renal transplant recipient with dual infection with hepatitis B and C viruses: a case report
Ming Ling Chang
Liver Cancer Research Center, Chang Gung Memorial Hospital, 6J Laboratory, Linko Medical Center, 199 Tung Hwa North Road, Taipei, Taiwan Graduate Institute of Clinical Medical Sciences, Chang Gung University, College of Medicine, Taoyuan, Taiwan
J Med Case Reports 5:246. 2011
..abstract:..
