Ming Ling Chang

Summary

Publications

  1. doi request reprint HCV core-induced nonobese hepatic steatosis is associated with hypoadiponectinemia and is ameliorated by adiponectin administration
    Ming Ling Chang
    Liver Research Center, Division of Hepatology, Department of Gastroenterology and Hepatology, Chang Gung Memorial Hospital, Linko, Taiwan
    Obesity (Silver Spring) 20:1474-80. 2012
  2. doi request reprint Cell cycle perturbation in the hepatocytes of HCV core transgenic mice following common bile duct ligation is associated with enhanced p21 expression
    Ming Ling Chang
    Liver Research Unit, Department of Hepatogastroenterology, Chang Gung Memorial Hospital, Chang Gung University, College of Medicine, Taoyuan, Taiwan
    J Med Virol 81:467-72. 2009
  3. doi request reprint Acute expression of hepatitis C core protein in adult mouse liver: Mitochondrial stress and apoptosis
    Ming Ling Chang
    Liver Research Center and Department of Hepatogastroenterology, Chang Gung Memorial Hospital, Chang Gung University, College of Medicine, Taoyuan, Taiwan
    Scand J Gastroenterol 43:747-55. 2008
  4. pmc Hepatic inflammation mediated by hepatitis C virus core protein is ameliorated by blocking complement activation
    Ming Ling Chang
    Liver Research Center and Department of Hepatogastroenterology, Chang Gung Memorial Hospital Chang Gung University, College of Medicine, Taoyuan, Taiwan, Republic of China
    BMC Med Genomics 2:51. 2009
  5. pmc Altered expression patterns of lipid metabolism genes in an animal model of HCV core-related, nonobese, modest hepatic steatosis
    Ming Ling Chang
    Liver Research Center and Department of Hepatogastroenterology, Chang Gung Memorial Hospital, No 5, Fu Hsing Street, Kuei Shan, Taoyuan, Taiwan
    BMC Genomics 9:109. 2008
  6. ncbi request reprint A novel ex vivo assay of interferon-based suppression, to predict the outcome of antiviral therapy for hepatitis C
    Chau Ting Yeh
    Liver Research Unit, Chang Gung Medical Center, and Department of Surgery, Chang Gung Children s Hospital, Taipei, Taiwan
    J Infect Dis 193:1365-70. 2006
  7. ncbi request reprint Identification of a novel pre-S2 mutation in a subgroup of chronic carriers with spontaneous clearance of hepatitis B virus surface antigen
    Chau Ting Yeh
    Liver Research Unit, Chang Gung Memorial Hospital and Chang Gung University School of Medicine, Taipei, Taiwan
    J Gastroenterol Hepatol 18:1129-38. 2003
  8. ncbi request reprint Topological and evolutional relationships between HCV core protein and hepatic lipid vesicles: studies in vitro and in conditionally transgenic mice
    Ming Ling Chang
    Liver Research Unit, Department of Hepatogastroenterology, Chang Gung Memorial Hospital, No 5 Fu Hsing Street, Kuei Shan, Taoyuan, Taiwan, China
    World J Gastroenterol 13:3472-7. 2007
  9. ncbi request reprint Hydrodynamics-based transfection of pancreatic duodenal homeobox 1 DNA improves hyperglycemia and is associated with limited complications in diabetic mice
    Tsung Hsing Chen
    Liver Research Center and Department of Hepatogastroenterology, Chang Gung Memorial Hospital, Kuei Shan, Taoyuan, Taiwan
    Endocr J 56:783-90. 2009
  10. doi request reprint The various impacts of the hepatitis C virus core protein upon hepatic oxidative stress after common bile duct ligation and partial hepatectomy
    Ming Yu Chang
    Division of Pediatric Critical Care and Emergency Medicine, Chang Gung Children s Hospital, Taoyuan, Taiwan
    Redox Rep 13:172-8. 2008

Collaborators

Detail Information

Publications30

  1. doi request reprint HCV core-induced nonobese hepatic steatosis is associated with hypoadiponectinemia and is ameliorated by adiponectin administration
    Ming Ling Chang
    Liver Research Center, Division of Hepatology, Department of Gastroenterology and Hepatology, Chang Gung Memorial Hospital, Linko, Taiwan
    Obesity (Silver Spring) 20:1474-80. 2012
    ..024). In conclusion, HCV core-induced nonobese hepatic steatosis is associated with downregulation of the leptin gene in visceral fat and concurrent hypoadiponectinemia; however, these effects may be ameliorated by adiponectin treatment...
  2. doi request reprint Cell cycle perturbation in the hepatocytes of HCV core transgenic mice following common bile duct ligation is associated with enhanced p21 expression
    Ming Ling Chang
    Liver Research Unit, Department of Hepatogastroenterology, Chang Gung Memorial Hospital, Chang Gung University, College of Medicine, Taoyuan, Taiwan
    J Med Virol 81:467-72. 2009
    ..This may account at least partially for the strong association between HCV-related hepatocarcinogenesis and hepatic inflammation/ fibrosis...
  3. doi request reprint Acute expression of hepatitis C core protein in adult mouse liver: Mitochondrial stress and apoptosis
    Ming Ling Chang
    Liver Research Center and Department of Hepatogastroenterology, Chang Gung Memorial Hospital, Chang Gung University, College of Medicine, Taoyuan, Taiwan
    Scand J Gastroenterol 43:747-55. 2008
    ..The purpose of this study was to investigate the effects of core produced de novo within adult mouse hepatocytes by using a new transgenic mouse line in which expression of HCV core is regulated by tetracycline (tet-off)...
  4. pmc Hepatic inflammation mediated by hepatitis C virus core protein is ameliorated by blocking complement activation
    Ming Ling Chang
    Liver Research Center and Department of Hepatogastroenterology, Chang Gung Memorial Hospital Chang Gung University, College of Medicine, Taoyuan, Taiwan, Republic of China
    BMC Med Genomics 2:51. 2009
    ..These effects mediated by HCV core are reduced by administration of CD55, a regulator of the complement pathway. The model may be valuable in investigating the pathogenesis of liver inflammation in chronic hepatitis C...
  5. pmc Altered expression patterns of lipid metabolism genes in an animal model of HCV core-related, nonobese, modest hepatic steatosis
    Ming Ling Chang
    Liver Research Center and Department of Hepatogastroenterology, Chang Gung Memorial Hospital, No 5, Fu Hsing Street, Kuei Shan, Taoyuan, Taiwan
    BMC Genomics 9:109. 2008
    ..Because the gene expression patterns of nonobese hepatic steatosis in affected patients remain unclear, we sought to explore these patterns using an animal model of nonobese hepatic steatosis...
  6. ncbi request reprint A novel ex vivo assay of interferon-based suppression, to predict the outcome of antiviral therapy for hepatitis C
    Chau Ting Yeh
    Liver Research Unit, Chang Gung Medical Center, and Department of Surgery, Chang Gung Children s Hospital, Taipei, Taiwan
    J Infect Dis 193:1365-70. 2006
    ..264-14.085]; P=.0192) were independent determinants of sustained virological response. In conclusion, this new assay serves as an independent predictor of sustained virological response in interferon-based antiviral therapy...
  7. ncbi request reprint Identification of a novel pre-S2 mutation in a subgroup of chronic carriers with spontaneous clearance of hepatitis B virus surface antigen
    Chau Ting Yeh
    Liver Research Unit, Chang Gung Memorial Hospital and Chang Gung University School of Medicine, Taipei, Taiwan
    J Gastroenterol Hepatol 18:1129-38. 2003
    ..The aim of the present study was to investigate whether spontaneous seroclearance of hepatitis B surface antigen (HBsAg) in patients with chronic hepatitis B could be attributed to the presence of pre-S/S gene mutations...
  8. ncbi request reprint Topological and evolutional relationships between HCV core protein and hepatic lipid vesicles: studies in vitro and in conditionally transgenic mice
    Ming Ling Chang
    Liver Research Unit, Department of Hepatogastroenterology, Chang Gung Memorial Hospital, No 5 Fu Hsing Street, Kuei Shan, Taoyuan, Taiwan, China
    World J Gastroenterol 13:3472-7. 2007
    ..To investigate a specific association between hepatic steatosis and hepatitis C virus (HCV) core...
  9. ncbi request reprint Hydrodynamics-based transfection of pancreatic duodenal homeobox 1 DNA improves hyperglycemia and is associated with limited complications in diabetic mice
    Tsung Hsing Chen
    Liver Research Center and Department of Hepatogastroenterology, Chang Gung Memorial Hospital, Kuei Shan, Taoyuan, Taiwan
    Endocr J 56:783-90. 2009
    ..In studies on the short-term biological effects of Pdx1 in vivo, HBT is a potential alternative to viral delivery of Pdx1 to the murine liver...
  10. doi request reprint The various impacts of the hepatitis C virus core protein upon hepatic oxidative stress after common bile duct ligation and partial hepatectomy
    Ming Yu Chang
    Division of Pediatric Critical Care and Emergency Medicine, Chang Gung Children s Hospital, Taoyuan, Taiwan
    Redox Rep 13:172-8. 2008
    ....
  11. ncbi request reprint Emergence and takeover of precore-stop mutant prior to exacerbation of e antigen-negative chronic hepatitis B after withdrawal of lamivudine therapy
    Chau Ting Yeh
    Liver Research Unit, Chang Gung Memorial Hospital, Taipei, Taiwan
    J Med Virol 78:906-10. 2006
    ..The present data indicate that at least in some patients, the precore-stop mutant is the cause but not the consequence of the flare of HBeAg-negative hepatitis...
  12. doi request reprint Hydrodynamics-based transfection of the combination of betacellulin and neurogenic differentiation 1 DNA ameliorates hyperglycemia in mice with streptozotocin-induced diabetes
    Chang Mu Sung
    Liver Research Center and Department of Hepatogastroenterology, Chang Gung Memorial Hospital, College of Medicine, Chang Gung University, Taoyuan, Taiwan
    Diabetes Technol Ther 13:519-25. 2011
    ..We aimed to evaluate the feasibility of hydrodynamics-based transfection (HBT) with Neurod1 and Btc in improving hyperglycemia...
  13. ncbi request reprint Virus and transaminase levels determine the emergence of drug resistance during long-term lamivudine therapy in chronic hepatitis B
    Ming Ling Chang
    Liver Research Unit, Chang Gung Memorial Hospital and University, 199, Tung Hwa North Road, Taipei, Taiwan
    J Hepatol 43:72-7. 2005
    ..The aim was to evaluate the impact of viral factors, host factors, host-viral interaction and drug factor on the emergence of rtM204 I/V...
  14. pmc Identification of postoperative prognostic microRNA predictors in hepatocellular carcinoma
    Ya Hui Huang
    Department of Hepato Gastroenterology, Liver Research Center, Chang Gung Memorial Hospital, Taoyuan, Taiwan
    PLoS ONE 7:e37188. 2012
    ..Functional analysis of a miRNA predictor, miR-155, suggested that the prognostic miRNA predictors identified under this strategy could serve as potential molecular targets for anticancer therapy...
  15. doi request reprint Segregation of signaling proteins as prognostic predictors for local recurrence and distant metastasis in hepatocellular carcinoma
    Chau Ting Yeh
    Liver Research Center, Department of Hepato Gastroenterology, Chang Gung Memorial Hospital, Taipei 105, Taiwan, R O C
    Int J Oncol 44:491-504. 2014
    ..004) were associated with EHM-free survival. These factors were further examined in the verification cohort. In conclusion, postoperative LR and EHM in HCC were associated with separable sets of clinical and molecular predictors. ..
  16. doi request reprint Gene gun bombardment with DNA-coated gold particles is a potential alternative to hydrodynamics-based transfection for delivering genes into superficial hepatocytes
    Ming Ling Chang
    Liver Research Center and Department of Hepatogastroenterology, Chang Gung Memorial Hospital, Taoyuan, Taiwan
    Hum Gene Ther 19:391-5. 2008
    ....
  17. doi request reprint Hepatitis B virus-DNA level and basal core promoter A1762T/G1764A mutation in liver tissue independently predict postoperative survival in hepatocellular carcinoma
    Chau Ting Yeh
    Liver Research Center, Department of Hepato Gastroenterology, Chang Gung Memorial Hospital, Taipei, Taiwan
    Hepatology 52:1922-33. 2010
    ..A short stretch pre-S deletion located between codons 107 and 141 was strongly associated with a poorer postoperative prognosis...
  18. ncbi request reprint Identification of NV-F virus DNA in hepatocellular carcinoma
    Chau Ting Yeh
    Liver Research Unit, Chang Gung Medical Center, Taipei, Taiwan
    J Med Virol 79:92-6. 2007
    ..In conclusion, NV-F virus DNA was identified in 15.4% of HCC tissues. HCC patients with NV-F virus infection were significantly older than those without NV-F virus infection...
  19. ncbi request reprint Identification of a hepatitis B virus S gene mutant in lamivudine-treated patients experiencing HBsAg seroclearance
    Chao Wei Hsu
    Liver Research Unit, Chang Gung Memorial Hospital, Taipei, Taiwan
    Gastroenterology 132:543-50. 2007
    ..It is generally believed to be a benevolent sign, implicating clearance of viremia. The aim of this study is to examine the authenticity of this dogma...
  20. ncbi request reprint Comparison of murine cirrhosis models induced by hepatotoxin administration and common bile duct ligation
    Ming Ling Chang
    Liver Research Unit, Department of Hepatogastroenterology, Chang Gung Memorial Hospital, Taoyuan, Taiwan, China
    World J Gastroenterol 11:4167-72. 2005
    ..To build up the research models of hepatic fibrosis in mice...
  21. doi request reprint Impact of the novel hepatotropic viruslike agent NV-F during chronic hepatitis C virus infection
    Chau Ting Yeh
    Liver Research Unit, Chang Gung Memorial Hospital, Taipei, Taiwan
    J Infect Dis 198:1742-8. 2008
    ..In conclusion, coinfection of the NV-F agent in chronic HCV infection is associated with more severe hepatitis activity...
  22. ncbi request reprint Disproportional exaggerated aspartate transaminase is a useful prognostic parameter in late leptospirosis
    Ming Ling Chang
    Department of Hepatogastr oenterology, Chang Gung Memorial Hospital, 5 Fu Shin Street, Kweishan, Taoyuan, Taiwan, China
    World J Gastroenterol 11:5553-6. 2005
    ..To evaluate the hepatic dysfunction in leptospirosis is usually mild and resolved eventually. However, sequential follow-up of liver biochemical data remained lacking....
  23. ncbi request reprint Characterization of a HCV NS5A protein derived from a patient with hepatoma
    Chau Ting Yeh
    Liver Research Unit, Chang Gung Medical Center, Taipei, Taiwan
    Biochem Biophys Res Commun 327:516-22. 2005
    ..Our results suggested that other cytosolic pathways independent of Grb2-mediated mechanisms were involved in the transactivation activity of HCV NS5A...
  24. doi request reprint A single nucleotide polymorphism on the GALNT14 gene as an effective predictor of response to chemotherapy in advanced hepatocellular carcinoma
    Chau Ting Yeh
    Liver Research Unit, Department of Hepato Gastroenterology, Chang Gung Memorial Hospital, Taipei, Taiwan Molecular Medicine Research Center, Chang Gung University, Taoyuan, Taiwan
    Int J Cancer 134:1214-24. 2014
    ..Combining GALNT14 genotype and clinical parameters, a subgroup of patients with excellent outcome was identified. ..
  25. ncbi request reprint Comparison of childhood hepatic malignancies in a hepatitis B hyper-endemic area
    Jeng Chang Chen
    Department of Surgery, Chang Gung Children s Hospital, 5 Fu Shin Street, Kweishan, 333, Taoyuan, Taiwan, China
    World J Gastroenterol 11:5289-94. 2005
    ..To examine the differences of clinical behaviors between hepatocellular carcinomas (HCC) and hepatoblastomas (HB) in children...
  26. pmc HURP expression-assisted risk scores identify prognosis distinguishable subgroups in early stage liver cancer
    Ming Ling Chang
    Liver Research Center and Department of Hepatology, Chang Gung Memorial Hospital, Taoyuan, Taiwan
    PLoS ONE 6:e26323. 2011
    ..Hepatoma up-regulated protein (HURP) is a component of the chromatin-dependent pathway for spindle assembly. We examined the prognostic predictive value of HURP in human hepatocellular carcinoma (HCC)...
  27. ncbi request reprint Prenatal tolerance induction: relationship between cell dose, marrow T-cells, chimerism, and tolerance
    Jeng Chang Chen
    Department of Surgery, Chang Gung Children s Hospital, Chang Gung University College of Medicine, Taoyuan, Taiwan
    Cell Transplant 17:495-506. 2008
    ..Thus, peripheral chimerism level can be a simple and straightforward test to predict the degree of prenatal immune tolerance...
  28. ncbi request reprint Dense packing of portal lymphocytes predicts favorable treatment outcome in hepatitis C
    Ming Ling Chang
    Liver Research Unit, Chang Gung Medical Center, 199, Tung Hwa North Road, Taipei, Taiwan
    Hepatogastroenterology 55:1716-20. 2008
    ..To identify pre-therapeutic predictors of sustained virological response (SVR) in Taiwanese patients with chronic hepatitis C...
  29. ncbi request reprint Esophageal perforation caused by fish vertebra ingestion in a seven-month-old infant demanded surgical intervention: A case report
    Ming Yu Chang
    Division of Pediatric Critical Care and Emergency Medicine, Chang Gung Children s Hospital, No 5, Fu Hsing Street, Kuei Shan, Taoyuan, Taiwan, China
    World J Gastroenterol 12:7213-5. 2006
    ..In addition to particular caution that has to be taken when feeding the innocent, young victim, it may indicate the importance of surgical intervention for complicated esophageal perforation in infancy...
  30. pmc Sustained eradication of hepatitis C virus by low-dose long-term interferon therapy in a renal transplant recipient with dual infection with hepatitis B and C viruses: a case report
    Ming Ling Chang
    Liver Cancer Research Center, Chang Gung Memorial Hospital, 6J Laboratory, Linko Medical Center, 199 Tung Hwa North Road, Taipei, Taiwan Graduate Institute of Clinical Medical Sciences, Chang Gung University, College of Medicine, Taoyuan, Taiwan
    J Med Case Reports 5:246. 2011
    ..abstract:..