Evaluation of the genotoxic potential of standardized extract of Glycyrrhiza glabra (GutGard™)C V Chandrasekaran
R and D Centre, Natural Remedies Pvt Ltd, Bangalore, India
Regul Toxicol Pharmacol 61:373-80. 2011
..In CA and MN studies, GutGard™ did not show clastogenic effect at 4 and 18 h treatments with and without S9 fraction. Results indicated that GutGard™ is not mutagenic in a battery of genotoxicity tests...
In Vitro Comparative Evaluation of Non-Leaves and Leaves Extracts of Andrographis paniculata on Modulation of Inflammatory MediatorsC V Chandrasekaran
Veerasandra Indl Area, 19th K M Stone, Hosur Road, Bangalore 560100, India
Antiinflamm Antiallergy Agents Med Chem 11:191-7. 2012
..Further, we observed that the magnitude of inhibitory effect displayed by A. paniculata extracts depends on the andrographolide content, although, it does not appear to influence the inhibitory effect towards LTB4 production...
- Optimization of cell-based assays to quantify the anti-inflammatory/allergic potential of test substances in 96-well format
C V Chandrasekaran
Department of Cellular Assay, R and D Centre, Natural Remedies Pvt Ltd, Veerasandra Industrial Area, Bangalore, India
Inflammopharmacology 19:169-81. 2011
..The present study describes about the optimization of eight cell-based assays utilizing mammalian cell lines in 96-well format for quantifying anti-inflammatory/allergic drug candidates...
- In vitro modulation of LPS/calcimycin induced inflammatory and allergic mediators by pure compounds of Andrographis paniculata (King of bitters) extract
C V Chandrasekaran
R and D Centre, Natural Remedies Pvt Ltd, Bangalore, India
Int Immunopharmacol 11:79-84. 2011
..Hence, these phytoconstituents might provide useful phytomedical treatment against variety of inflammatory and allergic disorders...
- Dual inhibitory effect of Glycyrrhiza glabra (GutGard™) on COX and LOX products
C V Chandrasekaran
R and D Centre, Natural Remedies Pvt Ltd, Bangalore, India
Phytomedicine 18:278-84. 2011
..glabra (almost devoid of glycyrrhizin) exhibits anti-inflammatory property likely through the inhibition of PGE(2), TXB(2) and LTB(4) in mammalian cell assay system, which could be influenced in part by glabridin and isoliquiritigenin...
- Effect of an extract of Andrographis paniculata leaves on inflammatory and allergic mediators in vitro
C V Chandrasekaran
Department of Cellular Assay, R and D Centre, Natural Remedies Pvt Ltd, Bangalore, India
J Ethnopharmacol 129:203-7. 2010
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- In vitro efficacy and safety of poly-herbal formulations
C V Chandrasekaran
Department of Cellular Assay, R and D Centre, Natural Remedies Pvt Ltd, Bangalore 560 100, Karnataka, India
Toxicol In Vitro 24:885-97. 2010
..Results epitomize that all the three poly-herbal formulations were devoid of significant mutagenic effect in TA98, and TAMix strains of Salmonella typhimurium under our experimental conditions...
- Tinospora cordifolia, a safety evaluation
C V Chandrasekaran
Department of Cellular Assay, R and D Centre, Natural Remedies Pvt Ltd, Plot No 5B, Veerasandra Indl Area, 19th K M Stone, Hosur Road, Bangalore 560 100, India
Toxicol In Vitro 23:1220-6. 2009
..The results showed that TC treatment did not display clastogenicity and DNA damaging effect in bone marrow erythrocytes and peripheral blood lymphocytes respectively...
- Evaluation of the genotoxic potential and acute oral toxicity of standardized extract of Andrographis paniculata (KalmCold)
C V Chandrasekaran
R and D Centre, Natural Remedies Pvt Ltd, Plot No 5B, Veerasandra Indl Area, 19th K M Stone, Hosur Road, Bangalore 560100, India
Food Chem Toxicol 47:1892-902. 2009
..Additionally in acute oral toxicity study, female rats were treated at 5000 mg/kg of KalmCold and observed for signs of toxicity for 14 days. KalmCold did not produce any treatment-related toxic effects in rats...
- Modulation of lipopolysaccharide-induced pro-inflammatory mediators by an extract of Glycyrrhiza glabra and its phytoconstituents
P Thiyagarajan
Department of Cellular Assay, R and D Centre, Natural Remedies Pvt Ltd, Plot No 5B, Veerasandra Indl Area, 19th K M Stone, Hosur Road, Bangalore 560100, India
Inflammopharmacology 19:235-41. 2011
..To evaluate the inhibitory property of de-glycyrrhizinated extract of Glycyrrhiza glabra root and its phytoconstituents (glabridin, isoliquiritigenin and glycyrrhizin) on LPS-induced production of pro-inflammatory mediators...
- Hepatoprotective activity of Indian Phyllanthus
R Srirama
School of Ecology and Conservation, University of Agricultural Sciences, GKVK, Bangalore, India
Pharm Biol 50:948-53. 2012
..Phyllanthus (Euphorbiaceae) species are traditionally well-known for their medicinal properties including hepatoprotective activity...
