Leo L Chan

Summary

Publications

  1. ncbi request reprint Evaluation of the antitumor effects of c-Myc-Max heterodimerization inhibitor 100258-F4 in ovarian cancer cells
    Jiandong Wang
    Department of Gynecological Oncology, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing, China
    J Transl Med 12:226. 2014
  2. ncbi request reprint Automated enumeration and viability measurement of canine stromal vascular fraction cells using fluorescence-based image cytometry method
    Leo Li Ying Chan
    Department of Technology R and D, Nexcelom Bioscience LLC, 360 Merrimack St Building 9, Lawrence, MA, 01843, USA
    J Fluoresc 24:983-9. 2014
  3. ncbi request reprint Discriminating multiplexed GFP reporters in primary articular chondrocyte cultures using image cytometry
    Leo Li Ying Chan
    Department of Technology R and D, Nexcelom Bioscience LLC, 360 Merrimack St Building 9, Lawrence, MA, 01843, USA
    J Fluoresc 24:1041-53. 2014
  4. ncbi request reprint Accurate measurement of peripheral blood mononuclear cell concentration using image cytometry to eliminate RBC-induced counting error
    Leo Li Ying Chan
    Department of Technology R and D, Nexcelom Bioscience LLC, Lawrence, MA 01843, USA
    J Immunol Methods 388:25-32. 2013
  5. ncbi request reprint A novel method for kinetic measurements of rare cell proliferation using Cellometer image-based cytometry
    Leo L Chan
    Department of Technology R and D, Nexcelom Bioscience LLC, Lawrence, MA 01843, United States
    J Immunol Methods 377:8-14. 2012
  6. pmc A novel image-based cytometry method for autophagy detection in living cells
    Leo Li Ying Chan
    Department of Technology R and D, Nexcelom Bioscience, LLC, Lawrence, MA, USA
    Autophagy 8:1371-82. 2012
  7. ncbi request reprint Novel image cytometric method for detection of physiological and metabolic changes in Saccharomyces cerevisiae
    Leo L Chan
    Department of Technology R and D, Nexcelom Bioscience LLC, Lawrence, MA 01843, USA
    J Ind Microbiol Biotechnol 39:1615-23. 2012
  8. ncbi request reprint Rapid image-based cytometry for comparison of fluorescent viability staining methods
    Leo L Chan
    Department of Technology R and D, Nexcelom Bioscience LLC, 360 Merrimack St Building 9, Lawrence, MA 01843, USA
    J Fluoresc 22:1301-11. 2012
  9. ncbi request reprint A rapid detection method for apoptosis and necrosis measurement using the Cellometer imaging cytometry
    Leo Li Ying Chan
    Department of Technology R and D, Nexcelom Bioscience LLC, Lawrence, MA 01843, USA
    Apoptosis 16:1295-303. 2011
  10. ncbi request reprint Cellometer vision as an alternative to flow cytometry for cell cycle analysis, mitochondrial potential, and immunophenotyping
    Leo L Chan
    Department of Technology R and D, Nexcelom Bioscience LLC, Lawrence, Massachusetts 01843, USA
    Cytometry A 79:507-17. 2011

Collaborators

  • Fatma J Al-Saeedi
  • Jiandong Wang
  • Hannah M Jones
  • Fang Song
  • Chunxiao Zhou
  • Victoria L Bae-Jump
  • Xiaoli Ma
  • Weiyuan Zhang

Detail Information

Publications11

  1. ncbi request reprint Evaluation of the antitumor effects of c-Myc-Max heterodimerization inhibitor 100258-F4 in ovarian cancer cells
    Jiandong Wang
    Department of Gynecological Oncology, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing, China
    J Transl Med 12:226. 2014
    ..These novel findings suggest that the growth of ovarian cancer cells is dependent upon c-MYC activity and that targeting c-Myc-Max heterodimerization could be a potential therapeutic strategy for ovarian cancer. ..
  2. ncbi request reprint Automated enumeration and viability measurement of canine stromal vascular fraction cells using fluorescence-based image cytometry method
    Leo Li Ying Chan
    Department of Technology R and D, Nexcelom Bioscience LLC, 360 Merrimack St Building 9, Lawrence, MA, 01843, USA
    J Fluoresc 24:983-9. 2014
    ....
  3. ncbi request reprint Discriminating multiplexed GFP reporters in primary articular chondrocyte cultures using image cytometry
    Leo Li Ying Chan
    Department of Technology R and D, Nexcelom Bioscience LLC, 360 Merrimack St Building 9, Lawrence, MA, 01843, USA
    J Fluoresc 24:1041-53. 2014
    ....
  4. ncbi request reprint Accurate measurement of peripheral blood mononuclear cell concentration using image cytometry to eliminate RBC-induced counting error
    Leo Li Ying Chan
    Department of Technology R and D, Nexcelom Bioscience LLC, Lawrence, MA 01843, USA
    J Immunol Methods 388:25-32. 2013
    ..The results show comparable total PBMC counting among all five methods, which validate the AO/PI staining method for PBMC measurement in the image cytometry method...
  5. ncbi request reprint A novel method for kinetic measurements of rare cell proliferation using Cellometer image-based cytometry
    Leo L Chan
    Department of Technology R and D, Nexcelom Bioscience LLC, Lawrence, MA 01843, United States
    J Immunol Methods 377:8-14. 2012
    ..This novel method allows for kinetic measurements of the rare cell samples such as B1 B cell, which has the potential to revolutionize kinetic analysis of cell proliferation...
  6. pmc A novel image-based cytometry method for autophagy detection in living cells
    Leo Li Ying Chan
    Department of Technology R and D, Nexcelom Bioscience, LLC, Lawrence, MA, USA
    Autophagy 8:1371-82. 2012
    ..The described image-based cytometry/fluorescent dye method should serve as a useful addition to the current arsenal of techniques available in support of autophagy-based drug discovery relating to various pathological disorders...
  7. ncbi request reprint Novel image cytometric method for detection of physiological and metabolic changes in Saccharomyces cerevisiae
    Leo L Chan
    Department of Technology R and D, Nexcelom Bioscience LLC, Lawrence, MA 01843, USA
    J Ind Microbiol Biotechnol 39:1615-23. 2012
    ....
  8. ncbi request reprint Rapid image-based cytometry for comparison of fluorescent viability staining methods
    Leo L Chan
    Department of Technology R and D, Nexcelom Bioscience LLC, 360 Merrimack St Building 9, Lawrence, MA 01843, USA
    J Fluoresc 22:1301-11. 2012
    ..Overall, these image-based fluorescent cell counters can simplify assay procedures as well as capture images for visual confirmation...
  9. ncbi request reprint A rapid detection method for apoptosis and necrosis measurement using the Cellometer imaging cytometry
    Leo Li Ying Chan
    Department of Technology R and D, Nexcelom Bioscience LLC, Lawrence, MA 01843, USA
    Apoptosis 16:1295-303. 2011
    ....
  10. ncbi request reprint Cellometer vision as an alternative to flow cytometry for cell cycle analysis, mitochondrial potential, and immunophenotyping
    Leo L Chan
    Department of Technology R and D, Nexcelom Bioscience LLC, Lawrence, Massachusetts 01843, USA
    Cytometry A 79:507-17. 2011
    ....
  11. ncbi request reprint Direct concentration and viability measurement of yeast in corn mash using a novel imaging cytometry method
    Leo L Chan
    Department of Technology R and D, Nexcelom Bioscience LLC, 360 Merrimack St Building 9, Lawrence, MA 01843, USA
    J Ind Microbiol Biotechnol 38:1109-15. 2011
    ..This method can provide an essential tool for research and development in the biofuel industry and may be incorporated into manufacturing to monitor yeast concentration and viability efficiently during the fermentation process...