Samuel R Chamberlain

Summary

Publications

  1. doi request reprint Trichotillomania: neurobiology and treatment
    Samuel R Chamberlain
    Department of Psychiatry, University of Cambridge School of Clinical Medicine, Addenbrooke s Hospital, Cambridge, UK
    Neurosci Biobehav Rev 33:831-42. 2009
  2. doi request reprint Noradrenergic modulation of cognition: therapeutic implications
    Samuel R Chamberlain
    Department of Psychiatry, University of Cambridge, Cambridge, UK
    J Psychopharmacol 27:694-718. 2013
  3. doi request reprint Effects of mu opioid receptor antagonism on cognition in obese binge-eating individuals
    Samuel R Chamberlain
    Clinical Unit Cambridge, GlaxoSmithKline, Addenbrooke s Hospital, Cambridge CB0 0QQ, UK
    Psychopharmacology (Berl) 224:501-9. 2012
  4. doi request reprint Orbitofrontal dysfunction in patients with obsessive-compulsive disorder and their unaffected relatives
    Samuel R Chamberlain
    Department of Psychiatry, University of Cambridge, Addenbrooke s Hospital, Box 189, Cambridge CB2 0QQ, UK
    Science 321:421-2. 2008
  5. pmc Grey matter abnormalities in trichotillomania: morphometric magnetic resonance imaging study
    Samuel R Chamberlain
    Department of Psychiatry, University of Cambridge, Cambridge CB2 2QQ, UK
    Br J Psychiatry 193:216-21. 2008
  6. doi request reprint Atomoxetine modulates right inferior frontal activation during inhibitory control: a pharmacological functional magnetic resonance imaging study
    Samuel R Chamberlain
    Department of Psychiatry, University of Cambridge School of Clinical Medicine, Addenbrooke s Hospital, University of Cambridge, Cambridge, UK
    Biol Psychiatry 65:550-5. 2009
  7. ncbi request reprint Atomoxetine improved response inhibition in adults with attention deficit/hyperactivity disorder
    Samuel R Chamberlain
    Department of Psychiatry, University of Cambridge School of Clinical Medicine, Addenbrooke s Hospital, Cambridge, United Kingdom
    Biol Psychiatry 62:977-84. 2007
  8. doi request reprint Endophenotypes of obsessive-compulsive disorder: rationale, evidence and future potential
    Samuel R Chamberlain
    Department of Psychiatry, University of Cambridge, Addenbrooke s Hospital, Cambridge, CB2 2QQ, UK
    Expert Rev Neurother 9:1133-46. 2009
  9. doi request reprint Effects of acute modafinil on cognition in trichotillomania
    Samuel R Chamberlain
    Department of Psychiatry and MRC Wellcome Trust Behavioural and Clinical Neurosciences Institute, University of Cambridge, Cambridge, UK
    Psychopharmacology (Berl) 212:597-601. 2010
  10. doi request reprint Reduced brain white matter integrity in trichotillomania: a diffusion tensor imaging study
    Samuel R Chamberlain
    Department of Psychiatry and Medical Research Council, Wellcome Trust Behavioural and Clinical Neurosciences Institute, University of Cambridge, England
    Arch Gen Psychiatry 67:965-71. 2010

Detail Information

Publications45

  1. doi request reprint Trichotillomania: neurobiology and treatment
    Samuel R Chamberlain
    Department of Psychiatry, University of Cambridge School of Clinical Medicine, Addenbrooke s Hospital, Cambridge, UK
    Neurosci Biobehav Rev 33:831-42. 2009
    ..Finally, we highlight important areas for future neurobiological and treatment research...
  2. doi request reprint Noradrenergic modulation of cognition: therapeutic implications
    Samuel R Chamberlain
    Department of Psychiatry, University of Cambridge, Cambridge, UK
    J Psychopharmacol 27:694-718. 2013
    ..Unanswered questions are also highlighted, along with key avenues for future research, both proof-of-concept and clinical. ..
  3. doi request reprint Effects of mu opioid receptor antagonism on cognition in obese binge-eating individuals
    Samuel R Chamberlain
    Clinical Unit Cambridge, GlaxoSmithKline, Addenbrooke s Hospital, Cambridge CB0 0QQ, UK
    Psychopharmacology (Berl) 224:501-9. 2012
    ..Binge-eating represents a useful model of 'behavioural addiction' for exploring this issue...
  4. doi request reprint Orbitofrontal dysfunction in patients with obsessive-compulsive disorder and their unaffected relatives
    Samuel R Chamberlain
    Department of Psychiatry, University of Cambridge, Addenbrooke s Hospital, Box 189, Cambridge CB2 0QQ, UK
    Science 321:421-2. 2008
    ....
  5. pmc Grey matter abnormalities in trichotillomania: morphometric magnetic resonance imaging study
    Samuel R Chamberlain
    Department of Psychiatry, University of Cambridge, Cambridge CB2 2QQ, UK
    Br J Psychiatry 193:216-21. 2008
    ..Trichotillomania (repetitive hair-pulling) is an Axis I psychiatric disorder whose neurobiological basis is incompletely understood. Whole-brain trichotillomania neuroimaging studies are lacking...
  6. doi request reprint Atomoxetine modulates right inferior frontal activation during inhibitory control: a pharmacological functional magnetic resonance imaging study
    Samuel R Chamberlain
    Department of Psychiatry, University of Cambridge School of Clinical Medicine, Addenbrooke s Hospital, University of Cambridge, Cambridge, UK
    Biol Psychiatry 65:550-5. 2009
    ..However, the mechanisms by which atomoxetine improves inhibitory control have yet to be determined...
  7. ncbi request reprint Atomoxetine improved response inhibition in adults with attention deficit/hyperactivity disorder
    Samuel R Chamberlain
    Department of Psychiatry, University of Cambridge School of Clinical Medicine, Addenbrooke s Hospital, Cambridge, United Kingdom
    Biol Psychiatry 62:977-84. 2007
    ..Compared with psychostimulants, atomoxetine has a distinct mode of brain action and potentially lower addictive potential. Studies have yet to assess whether atomoxetine improves cognition following a single oral dose in ADHD...
  8. doi request reprint Endophenotypes of obsessive-compulsive disorder: rationale, evidence and future potential
    Samuel R Chamberlain
    Department of Psychiatry, University of Cambridge, Addenbrooke s Hospital, Cambridge, CB2 2QQ, UK
    Expert Rev Neurother 9:1133-46. 2009
    ....
  9. doi request reprint Effects of acute modafinil on cognition in trichotillomania
    Samuel R Chamberlain
    Department of Psychiatry and MRC Wellcome Trust Behavioural and Clinical Neurosciences Institute, University of Cambridge, Cambridge, UK
    Psychopharmacology (Berl) 212:597-601. 2010
    ..Individuals with trichotillomania often report significant difficulty resisting the urges and drive to pull hair...
  10. doi request reprint Reduced brain white matter integrity in trichotillomania: a diffusion tensor imaging study
    Samuel R Chamberlain
    Department of Psychiatry and Medical Research Council, Wellcome Trust Behavioural and Clinical Neurosciences Institute, University of Cambridge, England
    Arch Gen Psychiatry 67:965-71. 2010
    ..Trichotillomania is an Axis I disorder characterized by repetitive, pathological hair pulling...
  11. doi request reprint Translational approaches to frontostriatal dysfunction in attention-deficit/hyperactivity disorder using a computerized neuropsychological battery
    Samuel R Chamberlain
    Department of Psychiatry and Medical Research Council Wellcome Trust Behavioural and Clinical Neurosciences Institute, University of Cambridge, Cambridge, United Kingdom
    Biol Psychiatry 69:1192-203. 2011
    ..The findings suggest overlapping but also distinct early cognitive effects of ADHD medications and have important implications for understanding the pathophysiology of ADHD and for future trials...
  12. pmc Translational approaches to obsessive-compulsive disorder: from animal models to clinical treatment
    N A Fineberg
    National OCDs Treatment Service, Hertfordshire Partnership NHS Foundation Trust, Welwyn Garden City, UK
    Br J Pharmacol 164:1044-61. 2011
    ..Finally, key future neurobiological and treatment research areas are highlighted...
  13. ncbi request reprint A neuropsychological comparison of obsessive-compulsive disorder and trichotillomania
    Samuel R Chamberlain
    Department of Psychiatry, University of Cambridge School of Clinical Medicine, Addenbrooke s Hospital, Cambridge, UK
    Neuropsychologia 45:654-62. 2007
    ..However, the extent to which these disorders share a common cognitive phenotype has yet to be elucidated using patients without confounding co-morbidities...
  14. pmc Impaired cognitive flexibility and motor inhibition in unaffected first-degree relatives of patients with obsessive-compulsive disorder
    Samuel R Chamberlain
    Department of Psychiatry, University of Cambridge School of Clinical Medicine, Addenbrooke s Hospital, Box 189, Cambridge, CB2 2QQ UK
    Am J Psychiatry 164:335-8. 2007
    ..The aim was to assess inhibitory control processes in unaffected first-degree relatives of OCD patients for the first time with objective tests...
  15. doi request reprint White matter abnormalities in patients with obsessive-compulsive disorder and their first-degree relatives
    Lara Menzies
    Brain Mapping Unit, Department of Psychiatry, University of Cambridge, Addenbrooke s Hospital, Cambridge CB22QQ, UK
    Am J Psychiatry 165:1308-15. 2008
    ..They also explored whether such abnormalities occur in healthy first-degree relatives of patients, indicating they may be endophenotypes representing increased genetic risk for OCD...
  16. ncbi request reprint Motor inhibition and cognitive flexibility in obsessive-compulsive disorder and trichotillomania
    Samuel R Chamberlain
    Department of Psychiatry, University of Cambridge School of Clinical Medicine, Addenbrooke s Hospital, Box 189, Cambridge, UK
    Am J Psychiatry 163:1282-4. 2006
    ..The authors assessed and compared motor inhibition and cognitive flexibility in OCD and trichotillomania for the first time, to their knowledge...
  17. pmc Probing compulsive and impulsive behaviors, from animal models to endophenotypes: a narrative review
    Naomi A Fineberg
    Department of Psychiatry, National OCDs Specialist Centre, Hertfordshire Partnership NHS Foundation Trust, Queen Elizabeth II Hospital, Welwyn Garden City, Hertfordshire, UK
    Neuropsychopharmacology 35:591-604. 2010
    ..Targeted application of neurocognitive tasks, receptor-specific neurochemical probes, and brain systems neuroimaging techniques have potential for future research in this field...
  18. doi request reprint The roles of dopamine and noradrenaline in the pathophysiology and treatment of attention-deficit/hyperactivity disorder
    Natalia Del Campo
    Department of Psychiatry, University of Cambridge, Cambridge, United Kingdom
    Biol Psychiatry 69:e145-57. 2011
    ....
  19. pmc Neurochemical modulation of response inhibition and probabilistic learning in humans
    Samuel R Chamberlain
    Department of Psychiatry, University of Cambridge School of Clinical Medicine, Addenbrooke s Hospital, Box 189, Cambridge CB2 2QQ, UK
    Science 311:861-3. 2006
    ....
  20. ncbi request reprint Lack of deleterious effects of buspirone on cognition in healthy male volunteers
    Samuel R Chamberlain
    Department of Psychiatry, University of Cambridge School of Clinical Medicine, Cambridge, UK
    J Psychopharmacol 21:210-5. 2007
    ..Future research directions are discussed in relation to acute and chronic studies in neuropsychiatric populations...
  21. ncbi request reprint Neurocognitive endophenotypes of obsessive-compulsive disorder
    Lara Menzies
    Brain Mapping Unit, University of Cambridge, Cambridge, UK
    Brain 130:3223-36. 2007
    ..In summary, structural variation in large-scale brain systems related to motor inhibitory control may mediate genetic risk for OCD, representing the first evidence for a neurocognitive endophenotype of OCD...
  22. pmc Strategy implementation in obsessive-compulsive disorder and trichotillomania
    Samuel R Chamberlain
    Department of Psychiatry, University of Cambridge School of Clinical Medicine, Addenbrooke s Hospital, Cambridge, UK
    Psychol Med 36:91-7. 2006
    ....
  23. ncbi request reprint Neuropharmacological modulation of cognition
    Samuel R Chamberlain
    Department of Psychiatry, University of Cambridge School of Clinical Medicine, Addenbrooke s Hospital, UK
    Curr Opin Neurol 19:607-12. 2006
    ..The purpose of this article is to review recent neuropharmacological manipulation studies in humans relating to these domains...
  24. ncbi request reprint Atomoxetine increases salivary cortisol in healthy volunteers
    Samuel R Chamberlain
    Department of Psychiatry, University of Cambridge School of Clinical Medicine, Addenbrooke s Hospital, Cambridge, UK
    J Psychopharmacol 21:545-9. 2007
    ..Furthermore, the effects of atomoxetine on HPA axis function may have clinical implications given the use of this agent in the treatment of ADHD...
  25. pmc Neural and behavioral effects of a novel mu opioid receptor antagonist in binge-eating obese people
    Victoria C Cambridge
    Department of Psychiatry, Behavioural and Clinical Neuroscience Institute, Cambridge Biomedical Campus, University of Cambridge, United Kingdom
    Biol Psychiatry 73:887-94. 2013
    ..Moreover, relatively few studies have used pharmacologic functional magnetic resonance imaging to probe the underlying basis of altered eating behaviors...
  26. ncbi request reprint Neurocognitive mechanisms in depression: implications for treatment
    Luke Clark
    Behavioural and Clinical Neuroscience Institute BCNI, Department of Experimental Psychology, University of Cambridge, Cambridge CB23EB, United Kingdom
    Annu Rev Neurosci 32:57-74. 2009
    ....
  27. pmc Integrating evidence from neuroimaging and neuropsychological studies of obsessive-compulsive disorder: the orbitofronto-striatal model revisited
    Lara Menzies
    Department of Psychiatry, University of Cambridge, Addenbrooke s Hospital, Cambridge CB2 2QQ, UK
    Neurosci Biobehav Rev 32:525-49. 2008
    ....
  28. doi request reprint Cross-species models of OCD spectrum disorders
    Vasileios Boulougouris
    Department of Experimental Psychology and the Behavioural and Clinical Neuroscience Institute BCNI, University of Cambridge, Downing Street, CB2 3EB, Cambridge, UK
    Psychiatry Res 170:15-21. 2009
    ..We then survey animal models of OC spectrum conditions within this framework, focusing on (i) ethological models; (ii) genetic and pharmacological models; and (iii) behavioral models. Key future research directions are highlighted...
  29. ncbi request reprint Lifting the veil on trichotillomania
    Samuel R Chamberlain
    Department of Psychiatry, University of Cambridge School of Clinical Medicine, Addenbrooke s Hospital, Box 189, Cambridge, CB2 2QQ UK
    Am J Psychiatry 164:568-74. 2007
  30. doi request reprint Association between tobacco smoking and cognitive functioning in young adults
    Samuel R Chamberlain
    Department of Psychiatry and MRC, Wellcome Trust Behavioural and Clinical Neurosciences Institute, University of Cambridge, Cambridge, United Kingdom
    Am J Addict 21:S14-9. 2012
    ..Tobacco smoking represents a considerable public health burden globally. Smoking in older adults is associated with cognitive impairment and more rapid age-associated cognitive decline, but there is a paucity of studies in younger people...
  31. doi request reprint Clinical and neurocognitive markers of suicidality in young adults
    Samuel R Chamberlain
    Department of Psychiatry, University of Cambridge, Cambridge, UK
    J Psychiatr Res 47:586-91. 2013
    ..Although some studies have reported cognitive deficits associated with suicidality, very few studies have been undertaken in young people, especially from non-clinical contexts...
  32. pmc Cognitive dysfunction and anxious-impulsive personality traits are endophenotypes for drug dependence
    Karen D Ersche
    Department of Psychiatry, Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, UK
    Am J Psychiatry 169:926-36. 2012
    ....
  33. pmc The role of the right inferior frontal gyrus: inhibition and attentional control
    Adam Hampshire
    Medical Research Council Cognition and Brain Sciences Unit, Cambridge, UK
    Neuroimage 50:1313-9. 2010
    ..Our results reveal that the RIFG is recruited when important cues are detected, regardless of whether that detection is followed by the inhibition of a motor response, the generation of a motor response, or no external response at all...
  34. doi request reprint Differential cognitive deterioration in dementia: a two year longitudinal study
    Samuel R Chamberlain
    Department of Psychiatry, University of Cambridge School of Clinical Medicine, Addenbrooke s Hospital, Cambridge, UK
    J Alzheimers Dis 24:125-36. 2011
    ..Follow-up studies in independent populations are needed to validate predictive algorithms identified...
  35. ncbi request reprint The neuropsychiatry of impulsivity
    Samuel R Chamberlain
    aDepartment of Psychiatry, University of Cambridge School of Clinical Medicine, Addenbrooke s Hospital, Cambridge, UK
    Curr Opin Psychiatry 20:255-61. 2007
    ..This article considers recent developments in the neuropsychological assessment of impulsivity with a focus on the ability to suppress motor responses (response inhibition)...
  36. doi request reprint A positron emission tomography study of nigro-striatal dopaminergic mechanisms underlying attention: implications for ADHD and its treatment
    Natalia Del Campo
    1 Department of Psychiatry, University of Cambridge, Addenbrooke s Hospital, Cambridge CB2 0QQ, UK
    Brain 136:3252-70. 2013
    ..This conclusion is reinforced by evidence of neuroanatomical changes in the same set of patients with attention deficit/hyperactivity disorder. ..
  37. ncbi request reprint The neuropsychology of mood disorders
    Samuel R Chamberlain
    Department of Psychiatry, University of Cambridge School of Clinical Medicine, Addenbrooke s Hospital, Cambridge, UK
    Curr Psychiatry Rep 8:458-63. 2006
    ..Results are discussed in the context of current conceptualizations of dysfunctional neural circuitry, and in relation to important clinical research implications...
  38. doi request reprint Animal models of obsessive-compulsive spectrum disorders
    Laure Sophie Camilla d'Angelo
    1 Departments of Psychology and Psychiatry, and Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, United Kingdom
    CNS Spectr 19:28-49. 2014
    ..We find that there is a burgeoning literature in these areas with important ramifications, which are considered, along with salient future lines of research. ..
  39. pmc The profile of executive function in OCD hoarders and hoarding disorder
    Sharon Morein-Zamir
    Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, UK Department of Psychiatry, University of Cambridge, Cambridge, UK Department of Psychology, University of Cambridge, Cambridge, UK Electronic address
    Psychiatry Res 215:659-67. 2014
    ....
  40. ncbi request reprint Noradrenergic modulation of working memory and emotional memory in humans
    Samuel R Chamberlain
    Department of Psychiatry, University of Cambridge School of Clinical Medicine, Addenbrooke s Hospital, Cambridge, CB2 2QQ, UK
    Psychopharmacology (Berl) 188:397-407. 2006
    ..NA dysfunction and abnormalities in arousal-dependent memory functions are evident in a variety of neuropsychiatric illnesses...
  41. ncbi request reprint Cognition in mania and depression: psychological models and clinical implications
    Samuel R Chamberlain
    Department of Psychiatry, University of Cambridge, School of Clinical Medicine, UK
    Curr Psychiatry Rep 6:451-8. 2004
    ..The clinical relevance of these developments is discussed...
  42. ncbi request reprint New developments in human neurocognition: clinical, genetic, and brain imaging correlates of impulsivity and compulsivity
    Naomi A Fineberg
    1 Hertfordshire Partnership NHS University Foundation Trust, Queen Elizabeth II Hospital, Howlands, Welwyn Garden City, Hertfordshire, UK
    CNS Spectr 19:69-89. 2014
    ....
  43. doi request reprint Memantine reduces stealing behavior and impulsivity in kleptomania: a pilot study
    Jon E Grant
    Department of Psychiatry and Behavioral Neuroscience, University of Chicago, Chicago, Illinois 60637, USA
    Int Clin Psychopharmacol 28:106-11. 2013
    ..Memantine was generally well tolerated. This study shows the effectiveness of memantine in reducing urges to shoplift and shoplifting behavior along with improving impulsivity, mood, anxiety, and psychosocial functioning...
  44. ncbi request reprint The neurobiology of attention-deficit/hyperactivity disorder
    Samuel R Chamberlain
    Biol Psychiatry 61:1317-9. 2007
  45. ncbi request reprint An A-B-C model of habit disorders: hair-pulling, skin-picking, and other stereotypic conditions
    Dan J Stein
    Department of Mental Health and Psychiatry, University of Cape Town, South Africa
    CNS Spectr 11:824-7. 2006
    ..An affect regulation, behavioral addiction, and cognitive control (A-B-C) approach is outlined to conceptualizing and managing these conditions...