J D Chalmers

Summary

Publications

  1. doi request reprint C-reactive protein is an independent predictor of severity in community-acquired pneumonia
    James D Chalmers
    Department of Respiratory Medicine, Royal Infirmary of Edinburgh, Edinburgh, Scotland, UK
    Am J Med 121:219-25. 2008
  2. doi request reprint Statins in community acquired pneumonia: Evidence from experimental and clinical studies
    James D Chalmers
    University of Edinburgh, Edinburgh, UK
    Respir Med 104:1081-91. 2010
  3. doi request reprint Increasing outpatient treatment of mild community-acquired pneumonia: systematic review and meta-analysis
    J D Chalmers
    Royal Infirmary of Edinburgh, Edinburgh, UK
    Eur Respir J 37:858-64. 2011
  4. doi request reprint Severity assessment tools for predicting mortality in hospitalised patients with community-acquired pneumonia. Systematic review and meta-analysis
    James D Chalmers
    University of Edinburgh, Edinburgh, UK
    Thorax 65:878-83. 2010
  5. doi request reprint Validation of the Infectious Diseases Society of America/American Thoratic Society minor criteria for intensive care unit admission in community-acquired pneumonia patients without major criteria or contraindications to intensive care unit care
    James D Chalmers
    MRC Centre for Inflammation Research, Queens Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom
    Clin Infect Dis 53:503-11. 2011
  6. doi request reprint Mechanisms of immune dysfunction and bacterial persistence in non-cystic fibrosis bronchiectasis
    James D Chalmers
    Tayside Respiratory Research Group, University of Dundee, Ninewells Hospital, Dundee, United Kingdom
    Mol Immunol 55:27-34. 2013
  7. doi request reprint Vitamin-D deficiency is associated with chronic bacterial colonisation and disease severity in bronchiectasis
    James D Chalmers
    The University of Edinburgh MRC Centre for Research Inflammation, The Queen s Medical Research Institute, Edinburgh, UK
    Thorax 68:39-47. 2013
  8. doi request reprint Short- and long-term antibiotic treatment reduces airway and systemic inflammation in non-cystic fibrosis bronchiectasis
    James D Chalmers
    Royal Infirmary of Edinburgh, Department of Respiratory Medicine, Edinburgh, United Kingdom
    Am J Respir Crit Care Med 186:657-65. 2012
  9. doi request reprint Can we use severity assessment tools to increase outpatient management of community-acquired pneumonia?
    James D Chalmers
    MRC Centre for Inflammation Research, Queens Medical Research Centre, University of Edinburgh, Edinburgh, UK
    Eur J Intern Med 23:398-406. 2012
  10. doi request reprint Epidemiology, antibiotic therapy, and clinical outcomes in health care-associated pneumonia: a UK cohort study
    James D Chalmers
    MRC Centre for Inflammation Research, Queen s Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom
    Clin Infect Dis 53:107-13. 2011

Collaborators

Detail Information

Publications34

  1. doi request reprint C-reactive protein is an independent predictor of severity in community-acquired pneumonia
    James D Chalmers
    Department of Respiratory Medicine, Royal Infirmary of Edinburgh, Edinburgh, Scotland, UK
    Am J Med 121:219-25. 2008
    ..Initial studies have suggested that inflammatory markers may have a role in predicting severity. We investigated whether admission and day 4 CRP could predict severity in community-acquired pneumonia...
  2. doi request reprint Statins in community acquired pneumonia: Evidence from experimental and clinical studies
    James D Chalmers
    University of Edinburgh, Edinburgh, UK
    Respir Med 104:1081-91. 2010
    ..Clinical studies have provided conflicting results, but many suggest that statins may have a role in preventing pneumonia, or improving prognosis in hospitalised patients with community-acquired pneumonia...
  3. doi request reprint Increasing outpatient treatment of mild community-acquired pneumonia: systematic review and meta-analysis
    J D Chalmers
    Royal Infirmary of Edinburgh, Edinburgh, UK
    Eur Respir J 37:858-64. 2011
    ..All studies had significant limitations. The available evidence suggests that interventions to increase the proportion of patients treated in the community are safe, effective and acceptable to patients...
  4. doi request reprint Severity assessment tools for predicting mortality in hospitalised patients with community-acquired pneumonia. Systematic review and meta-analysis
    James D Chalmers
    University of Edinburgh, Edinburgh, UK
    Thorax 65:878-83. 2010
    ..The aim of this study was to compare the performance characteristics of these scores for predicting mortality in community-acquired pneumonia...
  5. doi request reprint Validation of the Infectious Diseases Society of America/American Thoratic Society minor criteria for intensive care unit admission in community-acquired pneumonia patients without major criteria or contraindications to intensive care unit care
    James D Chalmers
    MRC Centre for Inflammation Research, Queens Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom
    Clin Infect Dis 53:503-11. 2011
    ..Although the major criteria (requirement for mechanical ventilation or septic shock requiring vasopressor support) are well established, the value of the minor criteria alone have not been fully validated...
  6. doi request reprint Mechanisms of immune dysfunction and bacterial persistence in non-cystic fibrosis bronchiectasis
    James D Chalmers
    Tayside Respiratory Research Group, University of Dundee, Ninewells Hospital, Dundee, United Kingdom
    Mol Immunol 55:27-34. 2013
    ..Greater understanding of the mechanisms underlying chronic colonisation in bronchiectasis will assist in the development of new treatments for this important disease...
  7. doi request reprint Vitamin-D deficiency is associated with chronic bacterial colonisation and disease severity in bronchiectasis
    James D Chalmers
    The University of Edinburgh MRC Centre for Research Inflammation, The Queen s Medical Research Institute, Edinburgh, UK
    Thorax 68:39-47. 2013
    ..Vitamin-D deficiency has been linked to an increased risk of respiratory infections. The objective of this study was to determine the frequency and clinical importance of vitamin-D deficiency in patients with bronchiectasis...
  8. doi request reprint Short- and long-term antibiotic treatment reduces airway and systemic inflammation in non-cystic fibrosis bronchiectasis
    James D Chalmers
    Royal Infirmary of Edinburgh, Department of Respiratory Medicine, Edinburgh, United Kingdom
    Am J Respir Crit Care Med 186:657-65. 2012
    ..There are little data to support this hypothesis in patients with non-cystic fibrosis (CF) bronchiectasis...
  9. doi request reprint Can we use severity assessment tools to increase outpatient management of community-acquired pneumonia?
    James D Chalmers
    MRC Centre for Inflammation Research, Queens Medical Research Centre, University of Edinburgh, Edinburgh, UK
    Eur J Intern Med 23:398-406. 2012
    ..The limitations of severity scores are discussed along with recent attempts to improve predictive tools, with the development of new biomarkers and alternative scoring systems...
  10. doi request reprint Epidemiology, antibiotic therapy, and clinical outcomes in health care-associated pneumonia: a UK cohort study
    James D Chalmers
    MRC Centre for Inflammation Research, Queen s Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom
    Clin Infect Dis 53:107-13. 2011
    ..The recently introduced concept of health care-associated pneumonia (HCAP), referring to patients with frequent healthcare contacts and at higher risk of contracting resistant pathogens, is controversial...
  11. ncbi request reprint Severity assessment tools to guide ICU admission in community-acquired pneumonia: systematic review and meta-analysis
    James D Chalmers
    University of Edinburgh, Edinburgh, UK
    Intensive Care Med 37:1409-20. 2011
    ..The aim of this meta-analysis was to determine if severity assessment tools can be used to guide decisions regarding intensive care unit (ICU) admission of patients with community-acquired pneumonia...
  12. doi request reprint Proposed changes to management of lower respiratory tract infections in response to the Clostridium difficile epidemic
    James D Chalmers
    MRC Centre for Inflammation Research, Queens Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4TJ, UK
    J Antimicrob Chemother 65:608-18. 2010
    ..Simple improvements in the management of LRTIs have the potential to reduce the incidence of healthcare-associated infections...
  13. pmc ICU admission and severity assessment in community-acquired pneumonia
    James D Chalmers
    Queens Medical Research Institute, Centre for Inflammation Research, Little France, Edinburgh EH16 4TJ, UK
    Crit Care 13:156. 2009
    ..This commentary discusses recent attempts to develop useful severity criteria to guide the use of ICU resources in patients with severe CAP...
  14. doi request reprint Systolic blood pressure is superior to other haemodynamic predictors of outcome in community acquired pneumonia
    J D Chalmers
    Department of Respiratory Medicine, Royal Infirmary of Edinburgh, 51 Little France Crescent, Old Dalkeith Road, Edinburgh EH16 4SA, UK
    Thorax 63:698-702. 2008
    ..The aim of this study was to establish which readily available haemodynamic measure on admission is most useful for predicting severity in patients admitted with community acquired pneumonia...
  15. doi request reprint Admission D-dimer can identify low-risk patients with community-acquired pneumonia
    James D Chalmers
    Royal Infirmary of Edinburgh, Edinburgh, United Kingdom
    Ann Emerg Med 53:633-8. 2009
    ..We seek to investigate the association of D-dimer, a fibrinolysis biomarker, and 30-day mortality or the need for mechanical ventilation or vasopressor support in emergency department (ED) patients with community-acquired pneumonia...
  16. ncbi request reprint Risk factors for complicated parapneumonic effusion and empyema on presentation to hospital with community-acquired pneumonia
    J D Chalmers
    Department of Respiratory Medicine, Royal Infirmary of Edinburgh, 51 Little France Crescent, Old Dalkeith Road, Edinburgh EH16 4SA, Scotland, UK
    Thorax 64:592-7. 2009
    ..The aim of this study was to identify key factors on admission predicting the development of complicated parapneumonic effusion or empyema in patients admitted with community-acquired pneumonia...
  17. doi request reprint Prior statin use is associated with improved outcomes in community-acquired pneumonia
    James D Chalmers
    Department of Respiratory Medicine, Royal Infirmary of Edinburgh, Edinburgh, Scotland, UK
    Am J Med 121:1002-1007.e1. 2008
    ..Statins have potent anti-inflammatory effects in laboratory studies of pulmonary inflammation. We investigated whether statin users had improved outcome when admitted with community-acquired pneumonia...
  18. doi request reprint Predicting the need for mechanical ventilation and/or inotropic support for young adults admitted to the hospital with community-acquired pneumonia
    James D Chalmers
    Department of Respiratory Medicine, Royal Infirmary of Edinburgh, Edinburgh, United Kingdom
    Clin Infect Dis 47:1571-4. 2008
    ....
  19. doi request reprint Eight-weekly intravenous antibiotics is beneficial in severe bronchiectasis
    P Mandal
    MRC Centre for Inflammation Research, Queen s Medical Research Institute, Edinburgh, UK
    QJM 106:27-33. 2013
    ..The aim of our study was to assess the impact of 8-weekly intravenous (IV) antibiotics on exacerbation frequency and health-related quality of life in bronchiectasis...
  20. doi request reprint Physician judgement is a crucial adjunct to pneumonia severity scores in low-risk patients
    G Choudhury
    Dept of Respiratory Medicine, Royal Infirmary of Edinburgh, Edinburgh, UK
    Eur Respir J 38:643-8. 2011
    ..54, 95% CI 1.21-17.1; p=0.03). This study supports recommendations from international guidelines that pneumonia severity scores should be used as an adjunct to clinical judgement, when deciding on hospitalisation...
  21. doi request reprint Admission hypoglycaemia is associated with adverse outcome in community-acquired pneumonia
    A Singanayagam
    Dept of Respiratory Medicine, Royal Infirmary of Edinburgh, Edinburgh, UK
    Eur Respir J 34:932-9. 2009
    ..0002) and need for inotropic support (OR, 2.9, 95% CI 1.4-6.3; p = 0.0006). Admission hypoglycaemia is associated with increased 30-day mortality, need for mechanical ventilation and inotropic support in patients presenting with CAP...
  22. doi request reprint Are biomarkers additive to pulmonary embolism severity index for severity assessment in normotensive patients with acute pulmonary embolism?
    A Singanayagam
    Department of Respiratory Medicine, Royal Infirmary of Edinburgh, 51 Little France Crescent, Old Dalkeith Road, Edinburgh, EH16 4SA, UK
    QJM 104:125-31. 2011
    ..Biomarkers and clinical prediction rules have been proposed for severity assessment in acute pulmonary embolism (PE)...
  23. doi request reprint Symptoms of airway reflux predict exacerbations and quality of life in bronchiectasis
    P Mandal
    Centre for Inflammation Research, Queen s Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4TJ, UK
    Respir Med 107:1008-13. 2013
    ..We have explored the association of the upper airway symptoms related to cough with exacerbation frequency, sputum microbiology and inflammatory markers in patients with non cystic fibrosis bronchiectasis...
  24. doi request reprint Does an interferon-gamma release assay change practice in possible latent tuberculosis?
    J F Tiernan
    Department of Respiratory Medicine and TB Clinic, Royal Infirmary of Edinburgh, 51 Little France Crescent, Edinburgh, Midlothian EH16 4SA, UK
    QJM 106:139-46. 2013
    ..The aim of this study is to determine if IGRA changes practice in the management of cases referred to a TB clinic for possible LTBI. Design and..
  25. doi request reprint Impact of inhaled corticosteroid use on outcome in COPD patients admitted with pneumonia
    A Singanayagam
    Dept of Respiratory Medicine, Royal Infirmary of Edinburgh, 51 Little France Crescent, Old Dalkeith Road, Edinburgh EH16 4SA, UK
    Eur Respir J 38:36-41. 2011
    ..73, 95% CI 0.33-1.62; p = 0.4) or development of complicated pneumonia (OR 0.71, 95% CI 0.25-1.99; p = 0.5). Prior ICS use had no impact on outcome in patients with COPD admitted with CAP...
  26. ncbi request reprint An evaluation of clinical stability criteria to predict hospital course in community-acquired pneumonia
    A R Akram
    Department of Respiratory Medicine, New Royal Infirmary of Edinburgh, Edinburgh, UK
    Clin Microbiol Infect 19:1174-80. 2013
    ..All of the criteria performed well in predicting adverse outcomes in patients with pneumonia. Halm's criteria performed best when identifying patients at low risk of complications...
  27. doi request reprint Vascular complications are associated with poor outcome in community-acquired pneumonia
    P Mandal
    Department of Respiratory Medicine, Royal Infirmary of Edinburgh, 51 Little France Crescent, Old Dalkeith Road, Edinburgh, EH16 4SA, UK
    QJM 104:489-95. 2011
    ..Recognition of cardiovascular risk factors is important for primary and secondary prevention strategies. Recent evidence has linked lower respiratory tract infections with the development of acute myocardial infarction...
  28. doi request reprint Seven-day antibiotic courses have similar efficacy to prolonged courses in severe community-acquired pneumonia--a propensity-adjusted analysis
    G Choudhury
    Department of Respiratory Medicine, Royal Infirmary of Edinburgh, Little France Crescent, Edinburgh, UK
    Clin Microbiol Infect 17:1852-8. 2011
    ..This study therefore suggests that, in the majority of severe CAP patients who have clinically responded, antibiotics can be safely discontinued at 7 days...
  29. doi request reprint Severity assessment in community-acquired pneumonia: a review
    A Singanayagam
    Department of Respiratory Medicine, Royal Infirmary of Edinburgh, Edinburgh, UK
    QJM 102:379-88. 2009
    ..However, there is no uniform agreement about the optimum severity assessment tool to use. This review provides a summary of current evidence surrounding severity assessment in adult patients presenting with community-acquired pneumonia...
  30. doi request reprint Incidence and prognostic implications of acute kidney injury on admission in patients with community-acquired pneumonia
    Ahsan R Akram
    Department of Respiratory Medicine, New Royal Infirmary of Edinburgh, Edinburgh, Scotland
    Chest 138:825-32. 2010
    ..We aimed to assess its value on admission in patients with community-acquired pneumonia (CAP)...
  31. doi request reprint Predicting mortality with severity assessment tools in out-patients with community-acquired pneumonia
    A R Akram
    Department of Respiratory Medicine, New Royal Infirmary of Edinburgh, 51 Little France Crescent, Old Dalkeith Road, Edinburgh, UK
    QJM 104:871-9. 2011
    ..We aimed to study the accuracy of these severity tools to predict mortality in patients managed as out-patients...
  32. doi request reprint Contact tracing in pulmonary and non-pulmonary tuberculosis
    P Mandal
    Centre for Inflammation Research, University of Edinburgh, Queen s Medical Research Institute, Edinburgh EH16 4TJ, UK
    QJM 105:741-7. 2012
    ..The aim of our study was to determine the effectiveness of contact tracing for both pulmonary and non-pulmonary tuberculosis (TB)...
  33. ncbi request reprint Inhaled corticosteroids and risk of pneumonia: evidence for and against the proposed association
    A Singanayagam
    Department of Respiratory Medicine, Royal Infirmary of Edinburg, 51 Little France Crescent, Edinburgh EHI64SA, UK
    QJM 103:379-85. 2010
    ..In this review, pro and con arguments for the association between ICS and increased pneumonia risk are discussed, drawing on evidence from experimental and clinical research...
  34. doi request reprint Right ventricular dilation on CT pulmonary angiogram independently predicts mortality in pulmonary embolism
    Aran Singanayagam
    Department of Respiratory Medicine, Royal Infirmary of Edinburgh, 51 Little France Crescent, Old Dalkeith Road, Edinburgh EH16 4SA, UK
    Respir Med 104:1057-62. 2010
    ....