HIV-1 infection in children: a clinical and immunologic overviewRana Chakraborty
Paediatric Infectious Diseases Unit, 5th Floor Lanesborough Wing, St George s Hospital, Blackshaw Rd, Tooting, London SW 17 0QT, UK
Curr HIV Res 3:31-41. 2005
..Our current knowledge of the mechanisms of T cell depletion is summarised and the host immune response to HIV-1 (innate and adaptive) described in the context of Pediatric HIV-1 infection...
- The post-mortem pathology of HIV-1-infected African children
Rana Chakraborty
Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, UK
Ann Trop Paediatr 22:125-31. 2002
..Management should include prompt treatment and, if indicated, prophylaxis for recurrent bacterial infections, and early evaluation and treatment of pulmonary tuberculosis...
- Viral coinfections among African children infected with human immunodeficiency virus type 1
Rana Chakraborty
Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, United Kingdom
Clin Infect Dis 36:922-4. 2003
..A protective role for hepatitis G virus cannot be excluded but likely affects only a minority of HIV-1-infected African children...
- Management of severely immunocompromised human immunodeficiency virus type 1-infected African orphans with structured treatment interruption: another kind of salvage therapy
Rana Chakraborty
Paediatric Infectious Diseases Unit, St George s Hospital and Medical School, London, United Kingdom
Clin Infect Dis 36:1483-5. 2003
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- nef gene sequence variation among HIV-1-infected African children
R Chakraborty
Nyumbani Children s Home, Nairobi, Kenya
HIV Med 7:75-84. 2006
..Genotypic and phenotypic variations in host immunogenetics and HIV-1 negative factor (nef) accessory protein may influence disease progression and have frequently been characterized in subjects infected with clade B HIV-1...
- Infections and other causes of death in HIV-infected children in Africa
Rana Chakraborty
Paediatric Infectious Diseases Unit, 5th Floor Lanesborough Wing, St George s Hospital, Blackshaw Road, Tooting, London SW17 0QT, UK
Paediatr Respir Rev 5:132-9. 2004
..These parameters are contrasted with available data on HIV-infected children residing in community settings in Africa...
- Correlates of delayed disease progression in HIV-1-infected Kenyan children
Rana Chakraborty
Pediatric Infectious Diseases Unit, St George s Hospital, London, United Kingdom
J Immunol 174:8191-9. 2005
..As HIV-1-specific helper cells support anti-HIV-1 effector responses in active disease, their presence may be important in delaying disease progression...
- Syphilis is on the increase: the implications for child health
Rana Chakraborty
Department of Child Health, St George's Hospital, 5th Floor, Lanesborough Wing, Blackshaw Road, Tooting, London SW17 0QT, UK
Arch Dis Child 93:105-9. 2008
- Early diagnosis of tuberculosis using an INF-gamma assay in a child with HIV-1 infection and a very low CD4 count
Nikos Spyridis
Paediatric Infectious Diseases Unit, St George s Hospital, London, UK
Scand J Infect Dis 39:919-21. 2007
..Positive cultures for Mycobacterium tuberculosis followed 6 weeks later. INF-gamma assays should be considered as first line investigations in HIV-1 infected subjects when TB is a diagnostic possibility...
HIV-1 drug resistance in HIV-1-infected children in the United Kingdom from 1998 to 2004Rana Chakraborty
Paediatric Infectious Diseases Unit, St George s Hospital, London
Pediatr Infect Dis J 27:457-9. 2008
..Three-class resistance was noted in 42 samples (14.1%). Our study also highlighted underutilization of testing and the need for prompt genotyping after drug discontinuation which may have lead to an underestimation of HIV-1 resistance...
CD8(+) lymphocytes respond to different HIV epitopes in seronegative and infected subjectsR Kaul
Department of Medical Microbiology, University of Nairobi, Nairobi, Kenya
J Clin Invest 107:1303-10. 2001
..The association between differential recognition of distinct CTL epitopes and protection from HIV-1 infection may have significant implications for vaccine design...
- Enfurvitide prevents vertical transmission of multidrug-resistant HIV-1 in pregnancy but does not cross the placenta
Paul Brennan-Benson
Department of Genitourinary Medicine, St George's Hospital, London, UK
AIDS 20:297-9. 2006
..The measurement of maternal and foetal peripheral blood levels of enfurvitide showed no evidence of transplacental transfer...
- HIV-1-specific CD8 T cell responses in a pediatric slow progressor infected as a premature neonate
Rana Chakraborty
University of Oxford, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Headington, UK
AIDS 16:2085-7. 2002
..HIV-1 infection as early as 25 weeks' gestation may thus results in the development of immune responses that control viral replication and lead to prolonged survival...
- Novel treatment options for pediatric HIV infection
Eleanor Day
St George s Hospital, Paediatric Infectious Diseases Unit, Tooting, London SW17 0QT, UK
Curr Opin Investig Drugs 9:170-5. 2008
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- Managing congenital syphilis again? The more things change
Rana Chakraborty
Paediatric Infectious Diseases Unit, UK
Curr Opin Infect Dis 20:247-52. 2007
..In this article, we review current strategies for the management of maternal and congenital syphilis nationally and in resource-poor settings...
- Persistent non-gastrointestinal metabolic acidosis in pediatric HIV-1 infection
Rana Chakraborty
Department of Child Health, St. George's Hospital and Medical School, London UK
AIDS 17:673-7. 2003
..HIV infection and/or its associated therapies may cause renal tubular damage. The causes of elevated SAG acidosis require further investigation...
- An epidemic of enterovirus 71 infection among HIV-1-infected orphans in Nairobi
Rana Chakraborty
AIDS 18:1968-70. 2004
- Growth, morbidity, and mortality in a cohort of institutionalized HIV-1-infected African children
Lisa M Nathan
School of Medicine, Rush University, Chicago, Illinois, USA
J Acquir Immune Defic Syndr 34:237-41. 2003
..Absence of tuberculosis disease in long-standing residents may have contributed to improved survival. Stunting in the absence of wasting implied that growth was compromised by opportunistic infections and other cofactors...
