Mark C Chappell
South A, Shaltout H, Washburn L, Hendricks A, Diz D, Chappell M. Fetal programming and the angiotensin-(1-7) axis: a review of the experimental and clinical data. Clin Sci (Lond). 2019;133:55-74 pubmed publisher
Wilson B, Cruz Diaz N, Marshall A, Pirro N, Su Y, Gwathmey T, et al
. An angiotensin-(1-7) peptidase in the kidney cortex, proximal tubules, and human HK-2 epithelial cells that is distinct from insulin-degrading enzyme. Am J Physiol Renal Physiol. 2015;308:F594-601 pubmed publisher
..We conclude that an ANG-(1-7) peptidase is expressed within the renal proximal tubule and may play a potential role in the renal renin-angiotensin system to regulate ANG-(1-7) tone. ..
Chappell M. Biochemical evaluation of the renin-angiotensin system: the good, bad, and absolute?. Am J Physiol Heart Circ Physiol. 2016;310:H137-52 pubmed publisher
Wilson B, Nautiyal M, Gwathmey T, Rose J, Chappell M. Evidence for a mitochondrial angiotensin-(1-7) system in the kidney. Am J Physiol Renal Physiol. 2016;310:F637-F645 pubmed publisher
Cruz Diaz N, Wilson B, Pirro N, Brosnihan K, Marshall A, Chappell M. Identification of dipeptidyl peptidase 3 as the Angiotensin-(1-7) degrading peptidase in human HK-2 renal epithelial cells. Peptides. 2016;83:29-37 pubmed publisher
..We conclude that DPP 3 may influence the cellular expression of Ang-(1-7) and potentially reflect a therapeutic target to augment the actions of the peptide. ..
Wilson B, Cruz Diaz N, Su Y, Rose J, Gwathmey T, Chappell M. Angiotensinogen import in isolated proximal tubules: evidence for mitochondrial trafficking and uptake. Am J Physiol Renal Physiol. 2017;312:F879-F886 pubmed publisher
..We conclude that this pathway may constitute a source of the angiotensinogen precursor for the mitochondrial expression of angiotensin peptides. ..
Yousif M, Benter I, Diz D, Chappell M. Angiotensin-(1-7)-dependent vasorelaxation of the renal artery exhibits unique angiotensin and bradykinin receptor selectivity. Peptides. 2017;90:10-16 pubmed publisher
..Moreover, Ang-(1-7)-dependent vasorelaxation was sensitive to antagonists against the AT7/Mas, AT1, AT2 and B2 receptor subtypes. ..
Wilson B, Chappell M. Assessment of the Renin-Angiotensin System in Cellular Organelle: New Arenas for Study in the Mitochondria. Methods Mol Biol. 2017;1614:99-121 pubmed publisher
..These approaches are intended to provide a framework to understand the mitochondrial RAS within a cell-free environment. ..