Matteo Cesari

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..In this paper, we present the main characteristics of the newborn Platform for Evaluation of Frailty and Prevention of Disability (Toulouse, France)...

..However, the reasonable uncertainties (derived from exploring a novel field and the exponential acceleration of scientific progress) require the adoption of a cautious and comprehensive approach to the subject...

..The aim of the present study is to assess whether biomarkers representing these mechanisms predicted major adverse health-related events in older persons...

..Aim of the present study was to evaluate whether an ACE inhibitor intervention is able to significantly improve physical performance and muscle strength in a sample of older persons...

..To determine how three different physical performance measures (PPMs) combine for added utility in predicting adverse health events in elders...

..The plasminogen activator system plays a key role in a wide range of physiological and pathological processes...

..The present study evaluates effects of an ACE inhibitor (ie, fosinopril) intervention on novel cardiovascular risk factors...

..Aims of the study were 1) to investigate the association of C-reactive protein (CRP) with lipid (i.e. total, LDL, and HDL cholesterol, triglycerides) concentrations, and to evaluate their predictive value for mortality in very old subjects...

..Special focus is given to skeletal muscle and physical function. Limitations of available scientific evidence on the topic are also discussed...

..In fact, aggressive antineoplastic managements are often denied to older patients, possibly because of the common misconception suggesting older age and/or clinical complexity as absolute contraindications to advanced treatments...

..Sarcopenia, the age-related loss of muscle mass, may not be an isolated process but is associated with an increase in fat mass. The aim of this study was to estimate the mortality risk of sarcopenia in the presence or absence of obesity...

..Aim of the present study is to compare the predictive value for mortality of measures of physical function and SRH status, and test their possible interactions...

..Nevertheless, the possible interaction between them in predicting major outcomes has not been clearly explored...

..the existence of a relationship among inflammation, high-density lipoprotein cholesterol (HDL-C) and physical function has been suggested...

..In conclusion, physical performance and functional status measures are significantly and negatively influenced by the presence of depression in community-dwelling older persons aged 80 years and older...

..Frailty is a common condition in elders and identifies a state of vulnerability for adverse health outcomes...

..Physical function measures have gained increased importance in the evaluation of older persons. The presence of comorbidity is a major and growing issue in geriatrics...

..The aims of the study were to describe the prevalence of physical activity in a sample of older adults in home care in Europe and to examine the relationship between physical activity and incident disability...

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..Although a small number of falls have a single cause, the majority have many different causes resulting from the interactions between intrinsic or extrinsic risk factors...

..Age-related body-composition changes are associated with health-related outcomes in elders. This relation may be explained by inflammation and hemostatic abnormalities...

..The aim of the present study was to explore the relationship between regular walking and the risk of all-cause death in a large population of frail and very old people living in community...

..Anemia represents a major risk factor for adverse health-related events in older persons. The aim of this study was to evaluate the association between hemoglobin levels/anemia and cognitive function in hospitalized older persons...

..The aims of present study were to describe the prevalence of bladder catheter in a population of older women living in community and to examine the relationship between urinary catheter and mortality...

..Because cerebral metabolic abnormalities have been associated with reduced survival in younger patients with advanced heart failure, we assessed the effect of cognitive impairment on the survival of older patients with heart failure...

..We investigated the relationship of alcohol intake with all-cause mortality and cardiac events and evaluated whether this relationship is mediated or modified by inflammatory markers...

..To evaluate the predictive value of hemoglobin levels upon hospital admission on recovery from activity of daily living (ADL) disability during hospital stay in older patients...

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..The aim of the study was to verify which specific physical function measure is a more important predictor of quality of life in these individuals...

..The aim of this study was to assess the predictive value of a lipoprotein peroxidation marker, oxidized low-density lipoprotein (oxLDL) for incident mobility limitation (ML)...

..To define clinically relevant cutpoints for usual gait speed and to investigate their predictive value for health-related events in older persons...

..33; CI = 1.02-5.30). CONCLUSION: Anemia is a predictor of physical disability in older heart failure patients, and in women anemia is associated with increased mortality...

..The aim of the study is (1) to describe the prevalence of vaccination against influenza in older home care patients and (2) to investigate the protective effect of influenza vaccination for hospitalization events...

..This finding suggests that the growth hormone/IGF axis may play an important role in hematopoiesis, and it may be implicated in the age-related decline in hemoglobin concentration...

..We evaluate the relationship of HDL-cholesterol with measures of physical performance, muscle strength, and functional status in older persons aged 80years or older...

..To assess the association between angiotensin converting enzyme inhibitors (ACEis) and improvements in the physical function of older adults in response to chronic exercise training...

..The causal mechanisms and temporal sequence of this association have not been clearly delineated. This study investigated the prospective relationship between DM and depressive symptoms...

..Increasing evidences from experimental and human studies suggest that the activity of the growth hormone (GH/insulin-like growth factor-I) axis may contribute to the age-related cognitive decline and poor cognition in late life...

..High-density lipoprotein (HDL) cholesterol has been hypothesized to be a reliable marker of frailty and poor prognosis among the oldest elderly...

..In conclusion, the present study shows that among old-old subjects living in the community, daily pain is highly prevalent and that this condition is associated with impaired muscle strength and physical performance...

..The aim of this study was to assess whether depression may be a risk factor for adverse drug reactions (ADRs) among hospitalized older adults...

..However, this relationship has only rarely been investigated in humans. The aim of the present cross-sectional study was to assess the association of ACE inhibitors with free IGF-1 and IGFBP-3 in the blood of older hypertensive adults...

..The aim of the present study was to evaluate the relationship of lifetime physical activity with cognitive performance in older persons aged 80 years or older...

..By contrast, no association was observed between IGFBP-3 and study outcomes, independently of BMI. In conclusion, high IGF-I level is associated with better physical function in older persons with obesity, but not in nonobese subjects...

..The aims of the present study were to describe the prevalence of vaccination against influenza in a population of older people living in the community, and to examine the relationship between influenza vaccination and mortality...

..The objective of this study was to examine whether depressive symptoms and anemia are associated among older adults living in the community...

..Our aim was to assess whether starting treatment with ACE-inhibitors might improve cognition in patients with heart failure...

..The present review provides an overlook of the most commonly accepted theories of aging, providing current evidence of those interventions aimed at modifying the aging process...

..To evaluate the effect of medical indicators of health status on functional gain during rehabilitation of frail older patients...

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..The aim of the present study was to examine the relationship between NSAIDs use and AD in a large sample of community-dwelling elderly people...

..The authors describe the prevalence of moderate-intensity physical activity in a population of older persons living in the community. In addition, they explore the relationship between physical activity and mortality...

..The impact of comorbidity on the benefits from physical exercise has not been clearly investigated. Elders with comorbidity may benefit from physical exercise to preserve physical function...

..The aim of this paper is to provide the main basis from which future studies should start and indicate which the main limitations that need to be addressed are...

..Increased risk of death was partly explained by baseline health status and was absent in the healthiest elderly...

..To determine the prevalence of inappropriate medication use among hospitalized older adults and to identify predictors of this use...

..However, few data exist concerning the potentially reversible causes of this condition among frail community-dwelling older individuals...

..Treatment models that put together the assessment and the treatment of both pain and depression are indispensable for better outcomes...

..g., physical activity, dietary restriction, smoking cessation) play an important role in the reduction of oxidative damage levels and are associated with improved physical performance and muscle strength...

..To explore the relationship between cognitive function and the detection of adverse drug reactions (ADRs) and to evaluate whether cognitive function could influence the association between age and ADRs...

..The aim of this study was to determine the prevalence of falls and related intrinsic and extrinsic risk factors in a community-dwelling older population...

..The aim of this study was to estimate the risk of urinary incontinence associated with the use of oxidative or nonoxidative benzodiazepines...

..Objective: To evaluate the efficacy of occupational therapy programs in patients with a recent stroke...

..This study tested whether a weight loss program combined with moderate exercise could improve physical function in obese, older adult women...

..Aim of this study was to compare pulmonary capillary volumes and gas exchange efficiency of CLD patients with and without cirrhosis...

..Management options for pressure ulcers include local wound care; surgical repair; and, more recently, topical application of growth factors...

..Aim of the present paper is to discuss present evidence related to possible benefits of oral antioxidants in the prevention and treatment of sarcopenia...

..Interestingly, the reported case is characterized by a negligible improvement in respiratory function parameters, despite a substantial increase in the 6-min walking test and the oxygen arteriolar partial pressure...

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