Jan Cerny

Summary

Publications

  1. ncbi request reprint Chemotherapy alone may lead to a PCR negative stem cell harvest in transformed lymphoma refractory to rituximab
    Jan Cerny
    First Department of Internal Medicine, Institute of Biology, Charles University General Hospital, Prague, Czech Republic
    Haematologica 88:ECR06. 2003
  2. ncbi request reprint Unusual sequence of VDJ rearrangement revealed by molecular analysis in a patient with indolent lymphoma
    Jan Cerny
    Roger Williams Medical Center, Department of Research, 825 Chalkstone Avenue, Providence, Rhode Island, 02908, USA
    Haematologica 88:ECR15. 2003
  3. ncbi request reprint Intrinsic hematopoietic stem cell/progenitor plasticity: Inversions
    Gerald A Colvin
    Roger Williams Medical Center, Department of Research, Adele Decof Cancer Center, Providence, Rhode Island 02908 4735, USA
    J Cell Physiol 199:20-31. 2004
  4. ncbi request reprint Biallelic IgH rearrangements in patients with indolent lymphoproliferative disorders: molecular and practical implications
    Jan Cerny
    1st Department of Internal Medicine, Charles University General Hospital, Prague, Czech Republic
    J Cell Physiol 199:217-26. 2004
  5. ncbi request reprint Chromatin remodeling and stem cell theory of relativity
    Jan Cerny
    Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA
    J Cell Physiol 201:1-16. 2004
  6. doi request reprint Rituximab based therapy followed by autologous stem cell transplantation leads to superior outcome and high rates of PCR negativity in patients with indolent B-cell lymphoproliferative disorders
    Jan Cerny
    Department of Medicine, Division of Hematology and Oncology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA
    Hematology 14:187-97. 2009
  7. ncbi request reprint Prognosis of patients with chronic coronary artery disease and severe left ventricular dysfunction. The importance of myocardial viability
    Jaroslav Meluzin
    First Department of Internal Medicine, Masaryk University, St Anna Hospital, Pekarska 53, Brno, Czech Republic
    Eur J Heart Fail 5:85-93. 2003
  8. pmc Murine allogeneic in vivo stem cell homing(,)
    Gerald A Colvin
    Department of Research, Roger Williams Medical Center, Providence, Rhode Island, USA
    J Cell Physiol 211:386-91. 2007
  9. pmc Mutations in bone marrow-derived stromal stem cells unmask latent malignancy
    JeanMarie Houghton
    Department of Medicine, Division of Gastroenterology, University of Massachusetts Medical School, Worcester, Massachusetts 01635, USA
    Stem Cells Dev 19:1153-66. 2010
  10. doi request reprint Anaplastic lymphoma kinase-positive large B-cell lymphoma with complex karyotype and novel ALK gene rearrangements
    Min Shi
    Department of Pathology and Department of Hospital Laboratories, UMass Memorial Medical Center and University of Massachusetts Medical School, Worcester, MA 01605, USA
    Hum Pathol 42:1562-7. 2011

Collaborators

Detail Information

Publications23

  1. ncbi request reprint Chemotherapy alone may lead to a PCR negative stem cell harvest in transformed lymphoma refractory to rituximab
    Jan Cerny
    First Department of Internal Medicine, Institute of Biology, Charles University General Hospital, Prague, Czech Republic
    Haematologica 88:ECR06. 2003
  2. ncbi request reprint Unusual sequence of VDJ rearrangement revealed by molecular analysis in a patient with indolent lymphoma
    Jan Cerny
    Roger Williams Medical Center, Department of Research, 825 Chalkstone Avenue, Providence, Rhode Island, 02908, USA
    Haematologica 88:ECR15. 2003
    ..Our observations suggest that such a finding in an indolent lymphoma patient may precede transformation into an aggressive disease. Early detection by PCR could have substantial impact on the prognosis of such patients...
  3. ncbi request reprint Intrinsic hematopoietic stem cell/progenitor plasticity: Inversions
    Gerald A Colvin
    Roger Williams Medical Center, Department of Research, Adele Decof Cancer Center, Providence, Rhode Island 02908 4735, USA
    J Cell Physiol 199:20-31. 2004
    ..These studies indicate that primitive marrow cells reversibly shift from ESC to progenitors without differentiation occurring. They exist as a fluctuating continuum...
  4. ncbi request reprint Biallelic IgH rearrangements in patients with indolent lymphoproliferative disorders: molecular and practical implications
    Jan Cerny
    1st Department of Internal Medicine, Charles University General Hospital, Prague, Czech Republic
    J Cell Physiol 199:217-26. 2004
    ..Although we found some minor differences in disease characteristics between both groups, these did not translate into a significantly different overall survival. Our findings suggest that true biclonal cases of CLL are rare...
  5. ncbi request reprint Chromatin remodeling and stem cell theory of relativity
    Jan Cerny
    Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA
    J Cell Physiol 201:1-16. 2004
    ..We are entering a new era of stem cell biology the era of "chromatinomics." We are one step closer to the practical use of cellular therapy for degenerative diseases...
  6. doi request reprint Rituximab based therapy followed by autologous stem cell transplantation leads to superior outcome and high rates of PCR negativity in patients with indolent B-cell lymphoproliferative disorders
    Jan Cerny
    Department of Medicine, Division of Hematology and Oncology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA
    Hematology 14:187-97. 2009
    ..Rituximab based therapy induces MR in high number of patients, which can be further improved by ASCT and patients have an excellent outcome. PCR positive harvest represents a high risk of relapse after ASCT...
  7. ncbi request reprint Prognosis of patients with chronic coronary artery disease and severe left ventricular dysfunction. The importance of myocardial viability
    Jaroslav Meluzin
    First Department of Internal Medicine, Masaryk University, St Anna Hospital, Pekarska 53, Brno, Czech Republic
    Eur J Heart Fail 5:85-93. 2003
    ....
  8. pmc Murine allogeneic in vivo stem cell homing(,)
    Gerald A Colvin
    Department of Research, Roger Williams Medical Center, Providence, Rhode Island, USA
    J Cell Physiol 211:386-91. 2007
    ..These data indicate a rapid homing into allogeneic recipients with a plateau at 1 h. The decline of secondary engraftability over time may indicate a phenotype alteration of homed cells...
  9. pmc Mutations in bone marrow-derived stromal stem cells unmask latent malignancy
    JeanMarie Houghton
    Department of Medicine, Division of Gastroenterology, University of Massachusetts Medical School, Worcester, Massachusetts 01635, USA
    Stem Cells Dev 19:1153-66. 2010
    ..The significant synergy between host immunity and mesenchymal cells identified here may restructure treatments to restore an anticancer microenvironment...
  10. doi request reprint Anaplastic lymphoma kinase-positive large B-cell lymphoma with complex karyotype and novel ALK gene rearrangements
    Min Shi
    Department of Pathology and Department of Hospital Laboratories, UMass Memorial Medical Center and University of Massachusetts Medical School, Worcester, MA 01605, USA
    Hum Pathol 42:1562-7. 2011
    ..1. This case broadens the cytogenetic alterations in anaplastic lymphoma kinase-positive large B-cell lymphoma, and it also demonstrates the high genetic instability of this tumor...
  11. doi request reprint The utility of flow cytometric immunophenotyping in cytopenic patients with a non-diagnostic bone marrow: a prospective study
    Francoise Truong
    Department of Pathology, UMass Memorial Medical Center, University of Massachusetts School of Medicine, Worcester, MA, USA
    Leuk Res 33:1039-46. 2009
    ....
  12. pmc The Blk pathway functions as a tumor suppressor in chronic myeloid leukemia stem cells
    Haojian Zhang
    Department of Medicine, Division of Hematology Oncology, University of Massachusetts Medical School, Worcester, Massachusetts, USA
    Nat Genet 44:861-71. 2012
    ..Blk also suppresses the proliferation of human CML stem cells. Our results show the feasibility of selectively targeting LSCs, an approach that should be applicable to other cancers...
  13. doi request reprint Clinicopathological features of extramedullary recurrence/relapse of multiple myeloma
    Jan Cerny
    Division of Hematology Oncology, Department of Internal Medicine, UMass Memorial Medical Center, University of Massachusetts School of Medicine, Worcester, MA 01605, USA
    Eur J Haematol 81:65-9. 2008
    ..Our case series shows that extramedullary relapse of MM is characterized by high-grade histology, loss of CD56 expression, frequent resistance to current therapeutic regimens, aggressive biological behavior, and very short survival...
  14. ncbi request reprint Current treatment options: impact of cytogenetics on the course of myelodysplasia
    Naomi Galili
    Radhey Khanna MDS Center, Division of Hematology, University of Massachusetts Medical Center, 364 Plantation Street, Worcester, MA 01605, USA
    Curr Treat Options Oncol 8:117-28. 2007
    ..In the absence of these specific cytogenetic abnormalities described above, the two FDA approved hypomethylating agents 5 azacytidine and decitabine should be considered as therapeutic alternatives...
  15. ncbi request reprint Prognostic importance of the quantification of myocardial viability in revascularized patients with coronary artery disease and moderate-to-severe left ventricular dysfunction
    Jaroslav Meluzin
    First Department of Internal Medicine, Masaryk University, St Anna Hospital, Pekarska 53, 65691 Brno, Czech Republic
    Int J Cardiol 90:23-31; discussion 31-2. 2003
    ..In conclusion, in revascularized patients with coronary artery disease and moderate-to-severe left ventricular dysfunction, the presence of >or=6 dysfunctional but viable segments identifies patients with the best prognosis...
  16. doi request reprint New polyene macrolide family produced by submerged culture of Streptomyces durmitorensis
    Eva Stodulkova
    Institute of Microbiology, Academy of Sciences of the Czech Republic v v i, Prague, Czech Republic
    J Antibiot (Tokyo) 64:717-22. 2011
    ..Striking feature of DDHR is its internal fluorescence allowing visualization of labeled plasma membranes and internal membrane structures...
  17. ncbi request reprint Chronic myelomonocytic leukemia evolving from preexisting myelodysplasia shares many features with de novo disease
    Sa A Wang
    Department of Medicine, University of Massachusetts Medical Center, Worcester, MA 01605, USA
    Am J Clin Pathol 126:789-97. 2006
    ..These findings indicate that in some cases of otherwise typical MDS, the progenitor cells may have some capacity for monocytic proliferation at diagnosis and manifest rapid disease progression once a monocytic proliferation supervenes...
  18. doi request reprint Coronary vasospasm with myocardial stunning in a patient with colon cancer receiving adjuvant chemotherapy with FOLFOX regimen
    Jan Cerny
    Department of Medicine, Division of Hematology and Oncology, University of Massachusetts Medical School, Worcester 01655 0002, USA
    Clin Colorectal Cancer 8:55-8. 2009
    ..Similarly, there is no uniform management of this 5-FU-related induced cardiotoxicity. We believe that our case report, with a brief review of related literature, might help fill some of this vacuum...
  19. ncbi request reprint Homing and conversion of murine hematopoietic stem cells to lung
    Mark Dooner
    Department of Research and Medicine and the Decof Cancer Center, Roger Williams Medical Center, Providence, RI 029908 4735, USA
    Blood Cells Mol Dis 32:47-51. 2004
    ..Altogether these data suggest that homing of marrow cell to nonmarrow organs may fluctuate with cell cycle transit and that there is a lung homing hotspot in mid-S...
  20. ncbi request reprint Molecular characterization of chronic lymphocytic leukemia with two distinct cell populations: Evidence for separate clonal origins
    Hong Chang
    Department of Laboratory Hematology, University Health Network and University of Toronto, Toronto, Canada
    Am J Clin Pathol 126:23-8. 2006
    ..Our results demonstrated that the immunophenotypically different cell populations originated from 2 separate clones...
  21. ncbi request reprint Daclizumab in the induction phase of immunosuppression in heart transplant recipients
    Erik Petrikovits
    Center of Cardiovascular and Transplant Surgery, Brno, Czech Republic
    Ann Transplant 10:5-10. 2005
    ..Acute rejection episodes negatively effect both short-term survival and development of graft vasculopathy...
  22. ncbi request reprint Repertoire of antibody response in bone marrow and the memory response are differentially affected in aging mice
    Yi Feng Lu
    Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore 21201, USA
    J Immunol 169:4920-7. 2002
    ..It is postulated that the Ab repertoire maturation in aged mice is delayed and may be notably improved by repeated immunizations...
  23. ncbi request reprint T-cell engagement of dendritic cells rapidly rearranges MHC class II transport
    Marianne Boes
    Department of Pathology, Harvard Medical School, 200 Longwood Avenue, Boston, Massachusetts 02115, USA
    Nature 418:983-8. 2002
    ..We propose that such tubulation serves to facilitate the ensuing T-cell response...