Trine Celius

Summary

Publications

  1. pmc Flavin-containing monooxygenase-3: induction by 3-methylcholanthrene and complex regulation by xenobiotic chemicals in hepatoma cells and mouse liver
    Trine Celius
    Department of Pharmacology and Toxicology, University of Toronto, Toronto, Canada
    Toxicol Appl Pharmacol 247:60-9. 2010
  2. doi request reprint Aryl hydrocarbon receptor-dependent induction of flavin-containing monooxygenase mRNAs in mouse liver
    Trine Celius
    Department of Pharmacology and Toxicology, Medical Sciences Building, 1 King s College Circle, University of Toronto, Toronto, ON, Canada M5S1A8
    Drug Metab Dispos 36:2499-505. 2008
  3. doi request reprint Functional analysis of six human aryl hydrocarbon receptor variants in human breast cancer and mouse hepatoma cell lines
    Trine Celius
    Department of Pharmacology and Toxicology, Medical Science Building, University of Toronto, Toronto, ON M5S1A8, Canada
    Toxicology 277:59-65. 2010
  4. ncbi request reprint microRNAs in adult rodent liver are refractory to dioxin treatment
    Ivy D Moffat
    Department of Pharmacology, University of Toronto, Toronto, Canada M5S 1A8
    Toxicol Sci 99:470-87. 2007
  5. doi request reprint Differential ligand-dependent activation and a role for Y322 in aryl hydrocarbon receptor-mediated regulation of gene expression
    Melanie Powis
    Department of Pharmacology and Toxicology, Medical Sciences Building, University of Toronto, Toronto, Ontario, Canada M5S 1A8
    Biochem Biophys Res Commun 410:859-65. 2011
  6. doi request reprint Identification of aryl hydrocarbon receptor binding targets in mouse hepatic tissue treated with 2,3,7,8-tetrachlorodibenzo-p-dioxin
    Raymond Lo
    Department of Pharmacology and Toxicology, University of Toronto, Toronto, Ontario, Canada
    Toxicol Appl Pharmacol 257:38-47. 2011

Detail Information

Publications6

  1. pmc Flavin-containing monooxygenase-3: induction by 3-methylcholanthrene and complex regulation by xenobiotic chemicals in hepatoma cells and mouse liver
    Trine Celius
    Department of Pharmacology and Toxicology, University of Toronto, Toronto, Canada
    Toxicol Appl Pharmacol 247:60-9. 2010
    ..Although FMO3 mRNA is highly induced by 3MC or TCDD in mouse liver and in Hepa-1 cells, FMO protein levels and FMO catalytic function showed only modest elevation...
  2. doi request reprint Aryl hydrocarbon receptor-dependent induction of flavin-containing monooxygenase mRNAs in mouse liver
    Trine Celius
    Department of Pharmacology and Toxicology, Medical Sciences Building, 1 King s College Circle, University of Toronto, Toronto, ON, Canada M5S1A8
    Drug Metab Dispos 36:2499-505. 2008
    ..However, FMO2 and FMO3 mRNAs were highly induced in transgenic mice that express wild-type rat AHR, indicating that lack of induction in rat is not due to an incompetent AHR in this species...
  3. doi request reprint Functional analysis of six human aryl hydrocarbon receptor variants in human breast cancer and mouse hepatoma cell lines
    Trine Celius
    Department of Pharmacology and Toxicology, Medical Science Building, University of Toronto, Toronto, ON M5S1A8, Canada
    Toxicology 277:59-65. 2010
    ....
  4. ncbi request reprint microRNAs in adult rodent liver are refractory to dioxin treatment
    Ivy D Moffat
    Department of Pharmacology, University of Toronto, Toronto, Canada M5S 1A8
    Toxicol Sci 99:470-87. 2007
    ..It is unlikely that mRNA downregulation by dioxins is mediated by miRNAs, nor are miRNAs likely to play a significant role in dioxin toxicity in adult rodent liver...
  5. doi request reprint Differential ligand-dependent activation and a role for Y322 in aryl hydrocarbon receptor-mediated regulation of gene expression
    Melanie Powis
    Department of Pharmacology and Toxicology, Medical Sciences Building, University of Toronto, Toronto, Ontario, Canada M5S 1A8
    Biochem Biophys Res Commun 410:859-65. 2011
    ..In summary, this study provides evidence for context- and ligand-selective differences in coactivator recruitment in AHR-regulated gene expression and reveal an important role of Y322 in AHR activation...
  6. doi request reprint Identification of aryl hydrocarbon receptor binding targets in mouse hepatic tissue treated with 2,3,7,8-tetrachlorodibenzo-p-dioxin
    Raymond Lo
    Department of Pharmacology and Toxicology, University of Toronto, Toronto, Ontario, Canada
    Toxicol Appl Pharmacol 257:38-47. 2011
    ..Our findings identify direct AHR target genes in vivo, highlight in vitro and in vivo differences in AHR signaling and show that AHR recruitment does not necessarily result in changes in target gene expression...