P Celec

..Recombinant probiotics and the principle of alternative gene therapy represent the latest approach of using GM organisms for biomedical applications. This article tries to summarize and to explain the problematic topic of GM food...

..Chronic cola intake increased both oestradiol and testosterone levels suggesting an additional mechanism of action beyond the known effects of caffeine on adenosine receptors...

..Effects of soybean intake on carbonyl stress should be evaluated in longer studies...

..Increased androgen signaling might explain previous results of lower testosterone levels in intellectually gifted boys and add to the understanding of variability in cognitive abilities...

..The aim of our study was to prove the effect of sampling using two different Salivette collection devices on salivary testosterone and estradiol concentrations...

..Anti-angiogenic and anti-inflammatory DNA vaccination ameliorates the progression of glomerular pathology in an animal model of diabetic nephropathy...

..Continuous positive airway pressure (CPAP) improves symptoms and prognosis of patients with OSAS...

..Indices pointing towards the involvement of immune system activation and fasting are presented. Further studies focusing on the underlying mechanism and on the clinical value of the observed dynamics of AGEs are needed...

..Although isolated phytoestrogens have shown these positive effects, the evidence for such influence of increased consumption of soybeans is lacking...

..This article tries to summarize the basic ideas behind the experimental use of RNA interference to regulate angiogenesis...

..Studies focusing on the role of oxidative stress in patients suffering from disorders in cholesterol biosynthesis are needed to support adjuvant antioxidative treatment...

..Further longer-term studies concentrating on air temperature, cloudiness and average relative humidity in relation to the sex hormone axis are needed...

..In this review we summarize the effects of testosterone on brain physiology and cognition with respect to the underlying molecular mechanisms...

..Although the reason for this is currently unknown, this observation may have implications for ongoing studies of AGEs in cardiovascular diseases...

..Even more interesting might be the analysis of effects of cola intake in animal models of diabetes...

..Although the procedure of bacterial gene delivery is far from being definitely solved, bactofection remains a promising technique for transfection in human gene therapy...

..The only significant association in autistic boys in Slovakia was found with higher number of GGC repeats in the RELN gene (P=0.001) potentially explaining lower RELN levels in blood and brain of autistic patients...

..Combination of both pollutants shows additive effects. Our data should be confirmed in subjects exposed to these environmental pollutants, in particular if combined...

..The aim of this study was to prove the effects of bacteria-mediated transfer of hypoxia-inducible factor 1α (HIF-1α) in an experimental model of intestinal ischemia in rats...

..Our results have implications for studies concentrating on salivary microbiome and its role in the pathogenesis of oral diseases...

..The results opened a way for upcoming studies using modified probiotics for therapy of systemic diseases...

..Infant formulas contain high amounts of advanced glycation end-products (AGEs) - the ligands of RAGE...

..Modern approaches focused on gene targeting such as RNA interference and microRNA will show the future direction in the field of angiogenesis inhibition for cancer treatment (Ref. 68)...

..Whether increased soybean intake can affect the endocrine status and cognitive abilities is largely unknown...

..The latest approach, using bacteria as vectors for gene therapy or as in situ producers of therapeutic proteins (alternative gene therapy), must undergo critical evaluation in further experiments...

..Results showed the potential synergic effect of combined bacteria-mediated antioxidative and anti-inflammatory gene therapy...

..Whether MDA is the main TBARS in saliva from patients with altered parodontal status is unknown. Aim. To observe the relationship between the parodontal status and TBARS, MDA and the number of epithelial cells in saliva...

..To observe the effects of short-term soybean consumption on cognitive spatial abilities and changes in sex endocrine net in both genders...

..This study shows that analysis of salivary levels of sex steroids are informative and can be used in neuroendocrine, chronobiological and other research areas, when repeated sampling is needed...

..Administration of 5-metoxytryptamine (5MT), an agonist of serotonin receptors, during natal and neonatal periods results in decreased reelin expression. In adulthood, reelin is expressed by GABAergic neurons...

..Our theoretical assumption should be further proved...

..It is concluded that once-monthly bisphosphonate treatment was preferred due to improved quality of life and should be offered to all patients with post-menopausal osteoporosis...

..This article tries to summarize current knowledge on the molecular basis of the ubiqutin pathway. (Fig. 1, Ref. 52.)..

..MDC technique enables to study the changes in molecular orientations and/or conformations of cell membranes. The combination of different methods in structural biology can clarify membrane chemical and physical properties...

..However, especially VEGF gene therapy (naked DNA, plasmids and adenovirus mediated) is associated with adverse side effects regarding the expression regulation...

..Testosterone is believed to affect cognition and thinking in humans as well as between-sex differences in cognitive abilities...

..faecalis produces an extracellular superoxide causing oxidative damage to membranes of host cells. This lipoperoxidation leads to increased salivary TBARS levels. The hypothesis should be tested in future studies...

..However, persisting arterial structural alterations and enhanced EDCF formation may decelerate blood pressure reduction even after the restoration of NO synthase activity...

..The discussion and solution of ethical issues beyond early fetal gender or paternity determination is hanging just behind the rapid technical progress of noninvasive prenatal DNA diagnostics...

..To study the process of free radical generation is an important step towards reducing the deteriorating effects of oxidative stress...

..Caution must be given to the prevention of contamination. If proved in large studies, the presence of fetal DNA fragments in maternal saliva would enable a wide range of applications in prenatal medicine...

..Anabolic steroids protected especially the central nervous tissue against the toxicity of alcohol. Both, antioxidant vitamins and anabolic steroids protect against the ethanol-induced toxicity, however, this effect is tissue specific...

..Since soy isoflavones may influence the thyroid hormone feedback system by interference with their biosynthesis, secretion and metabolism, we tested whether their controlled shortterm consumption affects thyroid function...