P Celec

Summary

Publications

  1. ncbi request reprint Biological and biomedical aspects of genetically modified food
    Peter Celec
    BiomeD Research and Publishing Group, Bratislava, Slovakia
    Biomed Pharmacother 59:531-40. 2005
  2. doi request reprint Behavioural and endocrine effects of chronic cola intake
    P Celec
    Department of Molecular Biology, Institute of Molecular Biomedicine and Institute of Pathophysiology, Comenius University, Bratislava, Slovak Republic
    J Psychopharmacol 24:1569-72. 2010
  3. doi request reprint Testosterone and estradiol are not affected in male and female patients with obstructive sleep apnea treated with continuous positive airway pressure
    P Celec
    Institute of Molecular Biomedicine, Comenius University, Bratislava, Slovakia
    J Endocrinol Invest 37:9-12. 2014
  4. pmc Fragmentation of DNA affects the accuracy of the DNA quantitation by the commonly used methods
    Tatiana Sedláčková
    Institute of Molecular Biomedicine, Faculty of Medicine, Comenius University, Sasinkova 4, Bratislava, 811 08, Slovakia
    Biol Proced Online 15:5. 2013
  5. doi request reprint Antioxidant vitamins prevent oxidative and carbonyl stress in an animal model of obstructive sleep apnea
    Peter Celec
    Institute of Molecular Biomedicine, Comenius University, Sasinkova 4 811 08, Bratislava, Slovak Republic
    Sleep Breath 17:867-71. 2013
  6. doi request reprint The short-term effects of soybean intake on oxidative and carbonyl stress in men and women
    Peter Celec
    Institute of Molecular Biomedicine, Comenius University, Bratislava 81108, Slovakia
    Molecules 18:5190-200. 2013
  7. pmc Genetic polymorphisms related to testosterone metabolism in intellectually gifted boys
    Peter Celec
    Institute of Molecular Biomedicine, Comenius University, Bratislava, Slovak Republic
    PLoS ONE 8:e54751. 2013
  8. doi request reprint Saliva collection devices affect sex steroid concentrations
    Peter Celec
    Institute of Molecular Biomedicine, Comenius University, Bratislava, Slovakia
    Clin Chim Acta 413:1625-8. 2012
  9. pmc The effects of anti-inflammatory and anti-angiogenic DNA vaccination on diabetic nephropathy in rats
    Peter Celec
    Institute of Molecular Biomedicine, Comenius University, 811 08 Bratislava, Slovakia
    Hum Gene Ther 23:158-66. 2012
  10. doi request reprint Oxidative and carbonyl stress in patients with obstructive sleep apnea treated with continuous positive airway pressure
    Peter Celec
    Institute of Molecular Biomedicine, Comenius University, Sasinkova 4, 811 08, Bratislava, Slovakia
    Sleep Breath 16:393-8. 2012

Collaborators

Detail Information

Publications46

  1. ncbi request reprint Biological and biomedical aspects of genetically modified food
    Peter Celec
    BiomeD Research and Publishing Group, Bratislava, Slovakia
    Biomed Pharmacother 59:531-40. 2005
    ..Recombinant probiotics and the principle of alternative gene therapy represent the latest approach of using GM organisms for biomedical applications. This article tries to summarize and to explain the problematic topic of GM food...
  2. doi request reprint Behavioural and endocrine effects of chronic cola intake
    P Celec
    Department of Molecular Biology, Institute of Molecular Biomedicine and Institute of Pathophysiology, Comenius University, Bratislava, Slovak Republic
    J Psychopharmacol 24:1569-72. 2010
    ..Chronic cola intake increased both oestradiol and testosterone levels suggesting an additional mechanism of action beyond the known effects of caffeine on adenosine receptors...
  3. doi request reprint Testosterone and estradiol are not affected in male and female patients with obstructive sleep apnea treated with continuous positive airway pressure
    P Celec
    Institute of Molecular Biomedicine, Comenius University, Bratislava, Slovakia
    J Endocrinol Invest 37:9-12. 2014
    ..It is currently unclear, whether CPAP also alters endocrine parameters such as sex hormone levels. In a previous study, we have found no changes in sex hormones in patients with OSAS after one night with CPAP...
  4. pmc Fragmentation of DNA affects the accuracy of the DNA quantitation by the commonly used methods
    Tatiana Sedláčková
    Institute of Molecular Biomedicine, Faculty of Medicine, Comenius University, Sasinkova 4, Bratislava, 811 08, Slovakia
    Biol Proced Online 15:5. 2013
    ..abstract:..
  5. doi request reprint Antioxidant vitamins prevent oxidative and carbonyl stress in an animal model of obstructive sleep apnea
    Peter Celec
    Institute of Molecular Biomedicine, Comenius University, Sasinkova 4 811 08, Bratislava, Slovak Republic
    Sleep Breath 17:867-71. 2013
    ..The aim of our study was to analyze the effects of an antioxidant treatment on markers of oxidative and carbonyl stress in a rat model of obstructive sleep apnea...
  6. doi request reprint The short-term effects of soybean intake on oxidative and carbonyl stress in men and women
    Peter Celec
    Institute of Molecular Biomedicine, Comenius University, Bratislava 81108, Slovakia
    Molecules 18:5190-200. 2013
    ..Effects of soybean intake on carbonyl stress should be evaluated in longer studies...
  7. pmc Genetic polymorphisms related to testosterone metabolism in intellectually gifted boys
    Peter Celec
    Institute of Molecular Biomedicine, Comenius University, Bratislava, Slovak Republic
    PLoS ONE 8:e54751. 2013
    ..Increased androgen signaling might explain previous results of lower testosterone levels in intellectually gifted boys and add to the understanding of variability in cognitive abilities...
  8. doi request reprint Saliva collection devices affect sex steroid concentrations
    Peter Celec
    Institute of Molecular Biomedicine, Comenius University, Bratislava, Slovakia
    Clin Chim Acta 413:1625-8. 2012
    ..The aim of our study was to prove the effect of sampling using two different Salivette collection devices on salivary testosterone and estradiol concentrations...
  9. pmc The effects of anti-inflammatory and anti-angiogenic DNA vaccination on diabetic nephropathy in rats
    Peter Celec
    Institute of Molecular Biomedicine, Comenius University, 811 08 Bratislava, Slovakia
    Hum Gene Ther 23:158-66. 2012
    ..Anti-angiogenic and anti-inflammatory DNA vaccination ameliorates the progression of glomerular pathology in an animal model of diabetic nephropathy...
  10. doi request reprint Oxidative and carbonyl stress in patients with obstructive sleep apnea treated with continuous positive airway pressure
    Peter Celec
    Institute of Molecular Biomedicine, Comenius University, Sasinkova 4, 811 08, Bratislava, Slovakia
    Sleep Breath 16:393-8. 2012
    ..Continuous positive airway pressure (CPAP) improves symptoms and prognosis of patients with OSAS...
  11. doi request reprint Advanced glycation end products in myocardial reperfusion injury
    Peter Celec
    Institute of Molecular Biomedicine, Comenius University, Sasinkova 4, 811 08 Bratislava, Slovakia
    Heart Vessels 27:208-15. 2012
    ..Indices pointing towards the involvement of immune system activation and fasting are presented. Further studies focusing on the underlying mechanism and on the clinical value of the observed dynamics of AGEs are needed...
  12. doi request reprint Vascular endothelial growth factor targeted RNA interference as a modulator of angiogenesis
    Peter Celec
    Institute of Pathophysiology, Faculty of Medicine, Comenius University, Bratislava, Slovak Republic
    Biomed Pharmacother 62:349-51. 2008
    ..This article tries to summarize the basic ideas behind the experimental use of RNA interference to regulate angiogenesis...
  13. ncbi request reprint The lack of non-steroid isoprenoids causes oxidative stress in patients with mevalonic aciduria
    Peter Celec
    Institute of Pathophysiology, Faculty of Medicine, Comenius University, Sasinkova 4, 811 08 Bratislava, Slovak Republic
    Med Hypotheses 70:938-40. 2008
    ..Studies focusing on the role of oxidative stress in patients suffering from disorders in cholesterol biosynthesis are needed to support adjuvant antioxidative treatment...
  14. doi request reprint Advanced glycation end products and acute myocardial infarction
    Peter Celec
    Institute of Pathophysiology, Department of Molecular Biology, Faculty of Medicine, Comenius University, and 1st Department of Internal Medicine, Faculty Hospital, Bratislava, Slovak Republic
    Med Princ Pract 19:244-6. 2010
    ..Although the reason for this is currently unknown, this observation may have implications for ongoing studies of AGEs in cardiovascular diseases...
  15. ncbi request reprint Increased one week soybean consumption affects spatial abilities but not sex hormone status in men
    Peter Celec
    Institute of Pathophysiology, Faculty of Medicine, Comenius University, Bratislava, Slovak Republic
    Int J Food Sci Nutr 58:424-8. 2007
    ..Although isolated phytoestrogens have shown these positive effects, the evidence for such influence of increased consumption of soybeans is lacking...
  16. doi request reprint Renal and metabolic effects of three months of decarbonated cola beverages in rats
    Peter Celec
    Department of Molecular Biology, Comenius University, Bratislava, SlovakRepublic
    Exp Biol Med (Maywood) 235:1321-7. 2010
    ..Even more interesting might be the analysis of effects of cola intake in animal models of diabetes...
  17. ncbi request reprint Testosterone and its metabolites--modulators of brain functions
    Jaroslava Durdiakova
    Institute of Molecular Biomedicine, Comenius University, Bratislava, Slovakia
    Acta Neurobiol Exp (Wars) 71:434-54. 2011
    ..In this review we summarize the effects of testosterone on brain physiology and cognition with respect to the underlying molecular mechanisms...
  18. doi request reprint Lack of evidence for meteorological effects on infradian dynamics of testosterone
    Peter Celec
    Department of Molecular Biology, Comenius University, Bratislava, Slovakia
    Int J Biometeorol 53:409-13. 2009
    ..Further longer-term studies concentrating on air temperature, cloudiness and average relative humidity in relation to the sex hormone axis are needed...
  19. ncbi request reprint Recombinant probiotic therapy in experimental colitis in mice
    R Gardlik
    Institute of Molecular Biomedicine, Comenius University, Bratislava, Slovak Republic
    Folia Biol (Praha) 58:238-45. 2012
    ..The results opened a way for upcoming studies using modified probiotics for therapy of systemic diseases...
  20. ncbi request reprint Bacteria in gene therapy: bactofection versus alternative gene therapy
    R Palffy
    BiomeD Research and Publishing Group, Faculty of Natural Sciences, Comenius University, Bratislava, Slovak Republic
    Gene Ther 13:101-5. 2006
    ..Although the procedure of bacterial gene delivery is far from being definitely solved, bactofection remains a promising technique for transfection in human gene therapy...
  21. ncbi request reprint Effect of saliva processing on bacterial DNA extraction
    Kamila Polgárová
    Institute of Pathophysiology, Faculty of Medicine, Comenius University, Bratislava, Slovak Republic
    New Microbiol 33:373-9. 2010
    ..Our results have implications for studies concentrating on salivary microbiome and its role in the pathogenesis of oral diseases...
  22. doi request reprint Renal, vascular and cardiac fibrosis in rats exposed to passive smoking and industrial dust fibre amosite
    Peter Boor
    Department of Clinical and Experimental Pharmacotherapy, Slovak Medical University, Bratislava, Slovakia
    J Cell Mol Med 13:4484-91. 2009
    ..Combination of both pollutants shows additive effects. Our data should be confirmed in subjects exposed to these environmental pollutants, in particular if combined...
  23. doi request reprint Polymorphisms of candidate genes in Slovak autistic patients
    Silvia Kelemenova
    Institute of Physiology, Faculty of Medicine, Comenius University, Bratislava, Slovakia
    Psychiatr Genet 20:137-9. 2010
    ..The only significant association in autistic boys in Slovakia was found with higher number of GGC repeats in the RELN gene (P=0.001) potentially explaining lower RELN levels in blood and brain of autistic patients...
  24. doi request reprint Effects of orally administered bacteria carrying HIF-1α gene in an experimental model of intestinal ischemia
    Roman Gardlik
    Institute of Pathophysiology, Comenius University, Bratislava, Slovakia
    Arch Med Res 41:332-7. 2010
    ..The aim of this study was to prove the effects of bacteria-mediated transfer of hypoxia-inducible factor 1α (HIF-1α) in an experimental model of intestinal ischemia in rats...
  25. ncbi request reprint On the origin of cardiovascular complications of sleep apnea syndrome by the means of molecular interactions
    I Jurkovicova
    1st Department of Internal Medicine, Faculty Hospital, Bratislava, Slovakia
    Bratisl Lek Listy 104:167-73. 2003
    ..Our theoretical assumption should be further proved...
  26. ncbi request reprint The impact of serotonergic stimulation on reelin and glutamate decarboxylase gene expression in adult female rats
    S Lakatosova
    Comenius University in Bratislava, Faculty of Medicine, Institute of Physiology, Slovakia
    Bratisl Lek Listy 112:58-62. 2011
    ..Administration of 5-metoxytryptamine (5MT), an agonist of serotonin receptors, during natal and neonatal periods results in decreased reelin expression. In adulthood, reelin is expressed by GABAergic neurons...
  27. ncbi request reprint Targeting angiogenesis for cancer (gene) therapy
    R Gardlik
    Institute ofPathophysiology, Faculty of Medicine, Comenius University Bratislava, Slovakia
    Bratisl Lek Listy 112:428-34. 2011
    ..Modern approaches focused on gene targeting such as RNA interference and microRNA will show the future direction in the field of angiogenesis inhibition for cancer treatment (Ref. 68)...
  28. doi request reprint Association of biochemical parameters and RAGE gene polymorphisms in healthy infants and their mothers
    P Boor
    Department of Clinical and Experimental Pharmacotherapy, Slovak Medical University, Bratislava, Slovakia
    Clin Chim Acta 411:1034-40. 2010
    ..Infant formulas contain high amounts of advanced glycation end-products (AGEs) - the ligands of RAGE...
  29. ncbi request reprint Oral in vivo bactofection in dextran sulfate sodium treated female Wistar rats
    Roland Palffy
    Institute of Molecular Biomedicine, Comenius University, Bratislava, Slovak Republic
    Folia Biol (Krakow) 58:171-6. 2010
    ..Results showed the potential synergic effect of combined bacteria-mediated antioxidative and anti-inflammatory gene therapy...
  30. ncbi request reprint Endocrine and cognitive effects of short-time soybean consumption in women
    Peter Celec
    Institute of Pathophysiology, Faculty of Medicine, Comenius University, Bratislava, Slovakia
    Gynecol Obstet Invest 59:62-6. 2005
    ..Whether increased soybean intake can affect the endocrine status and cognitive abilities is largely unknown...
  31. ncbi request reprint Salivary sex hormones during the menstrual cycle
    Peter Celec
    Department of Molecular Biology, Comenius University, Bratislava, Slovakia
    Endocr J 56:521-3. 2009
    ..This study shows that analysis of salivary levels of sex steroids are informative and can be used in neuroendocrine, chronobiological and other research areas, when repeated sampling is needed...
  32. ncbi request reprint Vectors and delivery systems in gene therapy
    Roman Gardlik
    BiomeD Research and Publishing Group, Bratislava, Slovakia
    Med Sci Monit 11:RA110-21. 2005
    ..The latest approach, using bacteria as vectors for gene therapy or as in situ producers of therapeutic proteins (alternative gene therapy), must undergo critical evaluation in further experiments...
  33. pmc Salivary thiobarbituric acid reacting substances and malondialdehyde--their relationship to reported smoking and to parodontal status described by the papillary bleeding index
    Peter Celec
    Faculty of Medicine, Comenius University, Bratislava, Slovakia
    Dis Markers 21:133-7. 2005
    ..Whether MDA is the main TBARS in saliva from patients with altered parodontal status is unknown. Aim. To observe the relationship between the parodontal status and TBARS, MDA and the number of epithelial cells in saliva...
  34. ncbi request reprint Short-term soybean intake and its effect on steroid sex hormones and cognitive abilities
    Daniela Ostatnikova
    Institute of Physiology, Faculty of Medicine, Bratislava, Slovak Republic
    Fertil Steril 88:1632-6. 2007
    ..To observe the effects of short-term soybean consumption on cognitive spatial abilities and changes in sex endocrine net in both genders...
  35. ncbi request reprint Preferences of patients with post-menopausal osteoporosis treated with bisphosphonates--the VIVA II study
    J Payer
    Fifth Department of Internal Medicine, Faculty Hospital, Comenius University, Bratislava, Slovakia
    J Int Med Res 37:1225-9. 2009
    ..It is concluded that once-monthly bisphosphonate treatment was preferred due to improved quality of life and should be offered to all patients with post-menopausal osteoporosis...
  36. ncbi request reprint Ubiquitin--the kiss of death goes Nobel. Will you be quitting?
    M Behuliak
    BiomeD Research and Publishing Group, Department of Molecular Biology, Faculty of Natural Sciences, Comenius University, Bratislava, Slovakia
    Bratisl Lek Listy 106:93-100. 2005
    ..This article tries to summarize current knowledge on the molecular basis of the ubiqutin pathway. (Fig. 1, Ref. 52.)..
  37. ncbi request reprint Conformation study of the membrane models by the Maxwell displacement current technique and oxidative stress
    M Weis
    Slovak University of Technology, Faculty of Electrical Engineering and Information Technology, Department of Physics, Bratislava, Slovakia
    J Biochem Biophys Methods 65:81-7. 2005
    ..MDC technique enables to study the changes in molecular orientations and/or conformations of cell membranes. The combination of different methods in structural biology can clarify membrane chemical and physical properties...
  38. ncbi request reprint The use of transformed Escherichia coli for experimental angiogenesis induced by regulated in situ production of vascular endothelial growth factor--an alternative gene therapy
    Peter Celec
    Institute of Pathophysiology, Faculty of Medicine, Comenius University, Bratislava, Slovakia
    Med Hypotheses 64:505-11. 2005
    ..However, especially VEGF gene therapy (naked DNA, plasmids and adenovirus mediated) is associated with adverse side effects regarding the expression regulation...
  39. ncbi request reprint Intelligence and salivary testosterone levels in prepubertal children
    Daniela Ostatnikova
    Institute of Physiology, School of Medicine, Comenius University, Bratislava, Slovak Republic
    Neuropsychologia 45:1378-85. 2007
    ..Testosterone is believed to affect cognition and thinking in humans as well as between-sex differences in cognitive abilities...
  40. doi request reprint Regression of L-NAME-induced hypertension: the role of nitric oxide and endothelium-derived constricting factor
    Ludovit Paulis
    Institute of Pathophysiology, School of Natural Sciences, Comenius University, Bratislava, Slovak Republic
    Hypertens Res 31:793-803. 2008
    ..However, persisting arterial structural alterations and enhanced EDCF formation may decelerate blood pressure reduction even after the restoration of NO synthase activity...
  41. ncbi request reprint Does Enterococcus faecalis contribute to salivary thiobarbituric acid-reacting substances?
    Barbora Vlkova
    Department of Molecular Biology, Faculty of Natural Sciences, Comenius University, Sasinkova 4, 811 08 Bratislava, Slovak Republic
    In Vivo 23:343-5. 2009
    ..faecalis produces an extracellular superoxide causing oxidative damage to membranes of host cells. This lipoperoxidation leads to increased salivary TBARS levels. The hypothesis should be tested in future studies...
  42. ncbi request reprint Oxidative stress and electron spin resonance
    Martin Kopáni
    Comenius University, School of Medicine, Institute of Pathology, Sasinkova 4, 811 08 Bratislava, Slovakia
    Clin Chim Acta 364:61-6. 2006
    ..To study the process of free radical generation is an important step towards reducing the deteriorating effects of oxidative stress...
  43. doi request reprint Does maternal saliva contain fetal DNA usable for prenatal diagnostics?
    Barbora Vlkova
    Geneton Inc, Cabanova 14, Bratislava, Slovakia
    Med Hypotheses 74:258-60. 2010
    ..Caution must be given to the prevention of contamination. If proved in large studies, the presence of fetal DNA fragments in maternal saliva would enable a wide range of applications in prenatal medicine...
  44. ncbi request reprint Advances in the research of fetal DNA in maternal plasma for noninvasive prenatal diagnostics
    Barbora Vlkova
    Geneton Inc, Bratislava, Slovakia
    Med Sci Monit 16:RA85-91. 2010
    ..The discussion and solution of ethical issues beyond early fetal gender or paternity determination is hanging just behind the rapid technical progress of noninvasive prenatal DNA diagnostics...
  45. ncbi request reprint Effects of anabolic steroids and antioxidant vitamins on ethanol-induced tissue injury
    Peter Celec
    Faculty of Medicine, Georg August University, Gottingen, Germany
    Life Sci 74:419-34. 2003
    ..Anabolic steroids protected especially the central nervous tissue against the toxicity of alcohol. Both, antioxidant vitamins and anabolic steroids protect against the ethanol-induced toxicity, however, this effect is tissue specific...
  46. ncbi request reprint Short-term effect of soy consumption on thyroid hormone levels and correlation with phytoestrogen level in healthy subjects
    Richard Hampl
    Institute of Endocrinology, Prague, Czech Republic
    Endocr Regul 42:53-61. 2008
    ..Since soy isoflavones may influence the thyroid hormone feedback system by interference with their biosynthesis, secretion and metabolism, we tested whether their controlled shortterm consumption affects thyroid function...